Genetics of melanoma progression: the rise and fall of cell senescence

Mutational status of naevus-associated melanomas

(2015) D. Shitara et al.   BRITISH JOURNAL OF DERMATOLOGY

Genomic Classification of Cutaneous Melanoma

(2015) Rehan Akbani et al.   CELL

Histologic features of melanoma associated with CDKN2A genotype

(2015) Michael R. Sargen et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Peripheral Blood Leukocyte Telomere Length and Mortality Among 64 637 Individuals From the General Population

(2015) Line Rode et al.   JNCI-Journal of the National Cancer Institute

High-throughput oncogene mutation profiling shows demographic differences in BRAF mutation rates among melanoma patients

(2015) Karin van den Hurk et al.   MELANOMA RESEARCH

Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas

(2015) Michael Krauthammer et al.   NATURE GENETICS

Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetics of familial melanoma: 20 years afterCDKN2A

(2015) Lauren G. Aoude et al.   Pigment Cell & Melanoma Research

Microphthalmia-associated transcription factor in melanoma development and MAP-kinase pathway targeted therapy

(2015) Claudia Wellbrock et al.   Pigment Cell & Melanoma Research

The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer

(2015) R. J. A. Bell et al.   SCIENCE

A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity

(2015) Alejandro Conde-Perez et al.   Nature Communications

Peripheral Blood Leukocyte Telomere Length and Mortality Among 64 637 Individuals From the General Population

(2015) Line Rode et al.   JNCI-Journal of the National Cancer Institute

The Molecular Pathology of Melanoma: An Integrated Taxonomy of Melanocytic Neoplasia

(2014) Boris C. Bastian   Annual Review of Pathology-Mechanisms of Disease

Mutation frequencies of GNAQ, GNA11, BAP1, SF3B1, EIF1AX and TERT in uveal melanoma: detection of an activating mutation in the TERT gene promoter in a single case of uveal melanoma

(2014) M Dono et al.   BRITISH JOURNAL OF CANCER

Activation of the Glutamate Receptor GRM1 Enhances Angiogenic Signaling to Drive Melanoma Progression

(2014) Y. Wen et al.   CANCER RESEARCH

Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing

(2014) Francesca Rossiello et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Cellular senescence and its effector programs

(2014) R. Salama et al.   GENES & DEVELOPMENT

Fine mapping of genetic susceptibility loci for melanoma reveals a mixture of single variant and multiple variant regions

(2014) Jennifer H. Barrett et al.   INTERNATIONAL JOURNAL OF CANCER

Immunohistochemical analysis of molecular drivers in melanoma identifies p16 as an independent prognostic biomarker

(2014) Johanne Lade-Keller et al.   JOURNAL OF CLINICAL PATHOLOGY

High risk of tobacco-related cancers inCDKN2Amutation-positive melanoma families

(2014) Hildur Helgadottir et al.   JOURNAL OF MEDICAL GENETICS

TERT Promoter Mutation Status as an Independent Prognostic Factor in Cutaneous Melanoma

(2014) Klaus G. Griewank et al.   JNCI-Journal of the National Cancer Institute

The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length

(2014) Mark M. Iles et al.   JNCI-Journal of the National Cancer Institute

A Meta-analysis of Somatic Mutations from Next Generation Sequencing of 241 Melanomas: A Road Map for the Study of Genes with Potential Clinical Relevance

(2014) J. Xia et al.   MOLECULAR CANCER THERAPEUTICS

Necessary and Sufficient Role for a Mitosis Skip in Senescence Induction

(2014) Yoshikazu Johmura et al.   MOLECULAR CELL

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

POT1 loss-of-function variants predispose to familial melanoma

(2014) Carla Daniela Robles-Espinoza et al.   NATURE GENETICS

Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma

(2014) Jianxin Shi et al.   NATURE GENETICS

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

(2014) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Clonal Architectures and Driver Mutations in Metastatic Melanomas

(2014) Li Ding et al.   PLoS One

A short acidic motif in ARF guards against mitochondrial dysfunction and melanoma susceptibility

(2014) Claus Christensen et al.   Nature Communications

Stressing the cell cycle in senescence and aging

(2013) Hollie Chandler et al.   CURRENT OPINION IN CELL BIOLOGY

Another Option in Our KIT of Effective Therapies for Advanced Melanoma

(2013) Richard D. Carvajal   JOURNAL OF CLINICAL ONCOLOGY

MC1R Is a Potent Regulator of PTEN after UV Exposure in Melanocytes

(2013) Juxiang Cao et al.   MOLECULAR CELL

Cellular senescence mediated by p16INK4A-coupled miRNA pathways

(2013) Marita G. Overhoff et al.   NUCLEIC ACIDS RESEARCH

DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma

(2013) Sandra Pavey et al.   Pigment Cell & Melanoma Research

p16INK4adeficiency promotes DNA hyper-replication and genetic instability in melanocytes

(2013) Carina Fung et al.   Pigment Cell & Melanoma Research

Wnt signaling potentiates nevogenesis

(2013) J. S. Pawlikowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TERT Promoter Mutations in Familial and Sporadic Melanoma

(2013) S. Horn et al.   SCIENCE

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

Review: a meta-analysis of GWAS and age-associated diseases

(2012) William R. Jeck et al.   AGING CELL

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Cancer cell senescence: a new frontier in drug development

(2012) Claire J. Cairney et al.   DRUG DISCOVERY TODAY

Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions

(2012) Anitha Suram et al.   EMBO JOURNAL

Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis

(2012) L. C. W. Vredeveld et al.   GENES & DEVELOPMENT

Melanoma: from mutations to medicine

(2012) H. Tsao et al.   GENES & DEVELOPMENT

Absence of Distinguishing Senescence Traits in Human Melanocytic Nevi

(2012) Sieu L. Tran et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

MDM4 is a key therapeutic target in cutaneous melanoma

(2012) Agnieszka Gembarska et al.   NATURE MEDICINE

A Notch1–neuregulin1 autocrine signaling loop contributes to melanoma growth

(2012) K Zhang et al.   ONCOGENE

Systematic classification of melanoma cells by phenotype-specific gene expression mapping

(2012) Daniel S. Widmer et al.   Pigment Cell & Melanoma Research

Senescence evasion in melanoma progression: uncoupling of DNA-damage signaling from p53 activation and p21 expression

(2012) Alastair D. MacKenzie Ross et al.   Pigment Cell & Melanoma Research

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Prevalence of the Alternative Lengthening of Telomeres Telomere Maintenance Mechanism in Human Cancer Subtypes

(2011) Christopher M. Heaphy et al.   AMERICAN JOURNAL OF PATHOLOGY

A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to Senescence Suppression in Cancer Cells

(2011) Lars Anders et al.   CANCER CELL

Shorter Telomeres Associate with a Reduced Risk of Melanoma Development

(2011) H. Nan et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Melanomagenesis: Overcoming the barrier of melanocyte senescence

(2011) Linan Ha et al.   CELL CYCLE

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

Senescent cells develop a PARP-1 and nuclear factor- B-associated secretome (PNAS)

(2011) M. Ohanna et al.   GENES & DEVELOPMENT

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Tumor Suppressor and Aging Biomarker p16INK4aInduces Cellular Senescence without the Associated Inflammatory Secretory Phenotype

(2011) Jean-Philippe Coppé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melanoma risk for CDKN2A mutation carriers who are relatives of population-based case carriers in Australia and the UK

(2011) A. E. Cust et al.   JOURNAL OF MEDICAL GENETICS

Clinical and histologic characteristics of malignant melanoma in families with a germline mutation in CDKN2A

(2011) Jasper I. van der Rhee et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

The Atr Protein Kinase Controls UV-Dependent Upregulation of p16INK4A Through Inhibition of Skp2-Related Polyubiquitination/Degradation

(2011) H. H. Al-Khalaf et al.   MOLECULAR CANCER RESEARCH

Activation of nuclear factor-kappa B signalling promotes cellular senescence

(2011) E Rovillain et al.   ONCOGENE

Receptor tyrosine kinases and their activation in melanoma

(2011) David J. Easty et al.   Pigment Cell & Melanoma Research

Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression

(2011) Julia K. Soo et al.   Pigment Cell & Melanoma Research

Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor

(2011) Glen M. Boyle et al.   Pigment Cell & Melanoma Research

Role of telomeres and telomerase in cancer

(2011) Jerry W. Shay et al.   SEMINARS IN CANCER BIOLOGY

Deregulation of the telomerase reverse transcriptase (TERT) gene by chromosomal translocations in B-cell malignancies

(2010) I. Nagel et al.   BLOOD

Melanocytic Nevi, Nevus Genes, and Melanoma Risk in a Large Case-Control Study in the United Kingdom

(2010) J. A. Newton-Bishop et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

(2010) Andrea Alimonti et al.   JOURNAL OF CLINICAL INVESTIGATION

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

(2010) Hui-Kuan Lin et al.   NATURE

Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis

(2010) C Nogueira et al.   ONCOGENE

Cancer stem cells versus phenotype-switching in melanoma

(2010) Keith S. Hoek et al.   Pigment Cell & Melanoma Research

Oncogenic Braf Induces Melanocyte Senescence and Melanoma in Mice

(2009) Nathalie Dhomen et al.   CANCER CELL

Senescence: an antiviral defense that is tumor suppressive?

(2009) R. R. Reddel   CARCINOGENESIS

Telomeres and telomerase in cancer

(2009) S. E. Artandi et al.   CARCINOGENESIS

Functional neurons and melanocytes induced from immortal lines of postnatal neural crest-like stem cells

(2009) Elena V. Sviderskaya et al.   FASEB JOURNAL

KIT as a Therapeutic Target in Melanoma

(2009) Maria C. Garrido et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Polyclonality of BRAF Mutations in Acquired Melanocytic Nevi

(2009) Jingrong Lin et al.   JNCI-Journal of the National Cancer Institute

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4

(2009) Todd D Prickett et al.   NATURE GENETICS

BrafV600E cooperates with Pten loss to induce metastatic melanoma

(2009) David Dankort et al.   NATURE GENETICS

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Detection of Copy Number Alterations in Metastatic Melanoma by a DNA Fluorescence In situ Hybridization Probe Panel and Array Comparative Genomic Hybridization: A Southwest Oncology Group Study (S9431)

(2008) S. R. Moore et al.   CLINICAL CANCER RESEARCH

Increased Risk of Cancer Other Than Melanoma in CDKN2A Founder Mutation (p16-Leiden)-Positive Melanoma Families

(2008) F. A. de Snoo et al.   CLINICAL CANCER RESEARCH

G1 cell cycle regulators in congenital melanocytic nevi. Comparison with acquired nevi and melanomas

(2008) Christina Stefanaki et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY