MDM4 is a key therapeutic target in cutaneous melanoma

Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma

(2011) Inna V. Fedorenko et al.   BIOCHEMICAL PHARMACOLOGY

Validation of MdmX as a therapeutic target for reactivating p53 in tumors

(2011) D. Garcia et al.   GENES & DEVELOPMENT

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE

High-Level Expression of Wild-Type p53 in Melanoma Cells is Frequently Associated with Inactivity in p53 Reporter Gene Assays

(2011) Roland Houben et al.   PLoS One

A Stapled p53 Helix Overcomes HDMX-Mediated Suppression of p53

(2010) Federico Bernal et al.   CANCER CELL

Widespread Overexpression of Epitope-Tagged Mdm4 Does Not Accelerate Tumor Formation In Vivo

(2010) S. De Clercq et al.   MOLECULAR AND CELLULAR BIOLOGY

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

(2010) Ramin Nazarian et al.   NATURE

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

(2010) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of Mdm4 in drug sensitivity of breast cancer cells

(2010) S Lam et al.   ONCOGENE

Differential roles of the pRb and Arf/p53 pathways in murine naevus and melanoma genesis

(2010) Blake Ferguson et al.   Pigment Cell & Melanoma Research

p53-based Cancer Therapy

(2010) D. P. Lane et al.   Cold Spring Harbor Perspectives in Biology

MI-63: A novel small-molecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wild-type p53

(2009) J A Canner et al.   BRITISH JOURNAL OF CANCER

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Mdm2-mediated ubiquitylation: p53 and beyond

(2009) J-C Marine et al.   CELL DEATH AND DIFFERENTIATION

Targeting Mdm2 and Mdmx in Cancer Therapy: Better Living through Medicinal Chemistry?

(2009) Mark Wade et al.   MOLECULAR CANCER RESEARCH

Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice

(2009) V K Goel et al.   ONCOGENE

Oncogenic NRAS Cooperates with p53 Loss to Generate Melanoma in Zebrafish

(2009) Michael Dovey et al.   Zebrafish

Molecular Pathogenesis of Cutaneous Melanocytic Neoplasms

(2008) Nageatte Ibrahim et al.   Annual Review of Pathology-Mechanisms of Disease

Tumor-specific induction of apoptosis by a p53-reactivating compound

(2008) Elisabeth Hedström et al.   EXPERIMENTAL CELL RESEARCH

Immunohistochemical characteristics of melanoma

(2008) Steven J. Ohsie et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer

(2008) Sanjeev Shangary et al.   MOLECULAR CANCER THERAPEUTICS