Cardiac sodium channelopathy associated withSCN5Amutations: electrophysiological, molecular and genetic aspects

Late Sodium Current Inhibition in Acquired and Inherited Ventricular (dys)function and Arrhythmias

(2013) Carol Ann Remme et al.   CARDIOVASCULAR DRUGS AND THERAPY

Cardiac sodium channel NaV1.5 distribution in myocytes via interacting proteins: The multiple pool model

(2012) Diana Shy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Intercalated disc abnormalities, reduced Na+ current density, and conduction slowing in desmoglein-2 mutant mice prior to cardiomyopathic changes

(2012) Stefania Rizzo et al.   CARDIOVASCULAR RESEARCH

Cardiomyocytes Derived From Pluripotent Stem Cells Recapitulate Electrophysiological Characteristics of an Overlap Syndrome of Cardiac Sodium Channel Disease

(2012) Richard P. Davis et al.   CIRCULATION

A Novel Disease Gene for Brugada Syndrome

(2012) Taisuke Ishikawa et al.   Circulation-Arrhythmia and Electrophysiology

Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Regulates Cardiac Sodium Channel NaV1.5 Gating by Multiple Phosphorylation Sites

(2012) Nicole M. Ashpole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer

(2012) Malou van den Boogaard et al.   JOURNAL OF CLINICAL INVESTIGATION

TBX5 drives Scn5a expression to regulate cardiac conduction system function

(2012) David E. Arnolds et al.   JOURNAL OF CLINICAL INVESTIGATION

Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics

(2012) Cecile Terrenoire et al.   JOURNAL OF GENERAL PHYSIOLOGY

Common genetic variation modulating cardiac ECG parameters and susceptibility to sudden cardiac death

(2012) Iris C.R.M. Kolder et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Frequency distribution analysis of activation times and regional fibrosis in murine Scn5a+/− hearts: The effects of ageing and sex

(2012) Kamalan Jeevaratnam et al.   MECHANISMS OF AGEING AND DEVELOPMENT

A Proton Leak Current through the Cardiac Sodium Channel Is Linked to Mixed Arrhythmia and the Dilated Cardiomyopathy Phenotype

(2012) Pascal Gosselin-Badaroudine et al.   PLoS One

Dynamic reciprocity of sodium and potassium channel expression in a macromolecular complex controls cardiac excitability and arrhythmia

(2012) M. L. Milstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissection of a Quantitative Trait Locus for PR Interval Duration Identifies Tnni3k as a Novel Modulator of Cardiac Conduction

(2012) Elisabeth M. Lodder et al.   PLoS Genetics

Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythmias

(2012) Maaike Hoekstra et al.   Frontiers in Physiology

Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice

(2011) Lina Yao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Activation of protein kinase C alters the intracellular distribution and mobility of cardiac Na+ channels

(2011) Haifa Hallaq et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Extracellular Proton Modulation of the Cardiac Voltage-Gated Sodium Channel, NaV1.5

(2011) D.K. Jones et al.   BIOPHYSICAL JOURNAL

Biology of cardiac sodium channel Nav1.5 expression

(2011) M. B. Rook et al.   CARDIOVASCULAR RESEARCH

Striking In Vivo Phenotype of a Disease-Associated Human SCN5A Mutation Producing Minimal Changes in Vitro

(2011) Hiroshi Watanabe et al.   CIRCULATION

Fibroblast Growth Factor Homologous Factor 13 Regulates Na + Channels and Conduction Velocity in Murine Hearts

(2011) Chuan Wang et al.   CIRCULATION RESEARCH

Cardiomyocytes Obtained From Induced Pluripotent Stem Cells With Long-QT Syndrome 3 Recapitulate Typical Disease-Specific Features In Vitro

(2011) Daniela Malan et al.   CIRCULATION RESEARCH

TGF-β 1 -Mediated Fibrosis and Ion Channel Remodeling Are Key Mechanisms in Producing the Sinus Node Dysfunction Associated With SCN5A Deficiency and Aging

(2011) Xiaojin Hao et al.   Circulation-Arrhythmia and Electrophysiology

MOG1

(2011) Darouna Kattygnarath et al.   Circulation-Cardiovascular Genetics

Subcellular heterogeneity of sodium current properties in adult cardiac ventricular myocytes

(2011) Xianming Lin et al.   HEART RHYTHM

Membrane-select regulation of cardiac Nav channel isoforms

(2011) Peter J. Mohler et al.   HEART RHYTHM

Developmentally regulated SCN5A splice variant potentiates dysfunction of a novel mutation associated with severe fetal arrhythmia

(2011) Lisa L. Murphy et al.   HEART RHYTHM

SCN1Bb R214Q found in 3 patients: 1 with Brugada syndrome and 2 with lone atrial fibrillation

(2011) Morten S. Olesen et al.   HEART RHYTHM

SCN5A Mutations Associate With Arrhythmic Dilated Cardiomyopathy and Commonly Localize to the Voltage-Sensing Mechanism

(2011) William P. McNair et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mutations in sodium channel β-subunit SCN3B are associated with early-onset lone atrial fibrillation

(2010) Morten S. Olesen et al.   CARDIOVASCULAR RESEARCH

REVIEW: Sodium Channel (Dys)Function and Cardiac Arrhythmias

(2010) Carol Ann Remme et al.   Cardiovascular Therapeutics

Voltage-Gated Sodium Channels Are Required for Heart Development in Zebrafish

(2010) Sameer S. Chopra et al.   CIRCULATION RESEARCH

Reactive Oxygen Species Originating From Mitochondria Regulate the Cardiac Sodium Channel

(2010) Man Liu et al.   CIRCULATION RESEARCH

SAP97 and Dystrophin Macromolecular Complexes Determine Two Pools of Cardiac Sodium Channels Na v 1.5 in Cardiomyocytes

(2010) Séverine Petitprez et al.   CIRCULATION RESEARCH

A ZASP Missense Mutation, S196L, Leads to Cytoskeletal and Electrical Abnormalities in a Mouse Model of Cardiomyopathy

(2010) Zhaohui Li et al.   Circulation-Arrhythmia and Electrophysiology

Homozygous mutation in SCN5A associated with atrial quiescence, recalcitrant arrhythmias, and poor capture thresholds

(2010) Keila N. Lopez et al.   HEART RHYTHM

Structure and function of splice variants of the cardiac voltage-gated sodium channel Nav1.5

(2010) Annett Schroeter et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Quantitative trait loci for electrocardiographic parameters and arrhythmia in the mouse

(2010) Brendon P. Scicluna et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel

(2010) Arthur Beyder et al.   JOURNAL OF PHYSIOLOGY-LONDON

Fever-Induced Life-Threatening Arrhythmias in Children Harboring an SCN5A Mutation

(2010) P. Chockalingam et al.   PEDIATRICS

The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium

(2009) C. A. Remme et al.   BASIC RESEARCH IN CARDIOLOGY

Gain-of-function mutation of Na v 1.5 in atrial fibrillation enhances cellular excitability and lowers the threshold for action potential firing

(2009) Qiuju Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cell Membrane Expression of Cardiac Sodium Channel Nav1.5 Is Modulated by α-Actinin-2 Interaction

(2009) Rahima Ziane et al.   BIOCHEMISTRY

Tubulin polymerization modifies cardiac sodium channel expression and gating

(2009) Simona Casini et al.   CARDIOVASCULAR RESEARCH

Loss-of-function mutation of the SCN3B-encoded sodium channel  3 subunit associated with a case of idiopathic ventricular fibrillation

(2009) C. R. Valdivia et al.   CARDIOVASCULAR RESEARCH

Genetically Determined Differences in Sodium Current Characteristics Modulate Conduction Disease Severity in Mice With Cardiac Sodium Channelopathy

(2009) Carol Ann Remme et al.   CIRCULATION RESEARCH

Loss of Plakophilin-2 Expression Leads to Decreased Sodium Current and Slower Conduction Velocity in Cultured Cardiac Myocytes

(2009) Priscila Y. Sato et al.   CIRCULATION RESEARCH

Mutations in Sodium Channel β1- and β2-Subunits Associated With Atrial Fibrillation

(2009) Hiroshi Watanabe et al.   Circulation-Arrhythmia and Electrophysiology

SCN5A Mutations and the Role of Genetic Background in the Pathophysiology of Brugada Syndrome

(2009) Vincent Probst et al.   Circulation-Cardiovascular Genetics

A Mutation in the β3 Subunit of the Cardiac Sodium Channel Associated With Brugada ECG Phenotype

(2009) Dan Hu et al.   Circulation-Cardiovascular Genetics

An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing

(2009) Jamie D. Kapplinger et al.   HEART RHYTHM

Mechanism of right precordial ST-segment elevation in structural heart disease: Excitation failure by current-to-load mismatch

(2009) Mark G. Hoogendijk et al.   HEART RHYTHM

LQTS mutation N1325S in cardiac sodium channel gene SCN5A causes cardiomyocyte apoptosis, cardiac fibrosis and contractile dysfunction in mice

(2009) Teng Zhang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Diastolic transient inward current in long QT syndrome type 3 is caused by Ca2+ overload and inhibited by ranolazine

(2009) N. Lindegger et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac sodium channel Nav1.5 and interacting proteins: Physiology and pathophysiology

(2009) Hugues Abriel   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Regulated and aberrant glycosylation modulate cardiac electrical signaling

(2009) M. L. Montpetit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functionally distinct sodium channels in ventricular epicardial and endocardial cells contribute to a greater sensitivity of the epicardium to electrical depression

(2008) J. M. Cordeiro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Intracellular calcium modulation of voltage-gated sodium channels in ventricular myocytes

(2008) Simona Casini et al.   CARDIOVASCULAR RESEARCH

Cardiac Sodium Channel ( SCN5A ) Variants Associated with Atrial Fibrillation

(2008) Dawood Darbar et al.   CIRCULATION

Molecular and Clinical Characterization of a Novel SCN5A Mutation Associated With Atrioventricular Block and Dilated Cardiomyopathy

(2008) Junbo Ge et al.   Circulation-Arrhythmia and Electrophysiology

Dilated Cardiomyopathy due to Sodium Channel Dysfunction

(2008) Connie R. Bezzina et al.   Circulation-Arrhythmia and Electrophysiology

α-1-Syntrophin Mutation and the Long-QT Syndrome

(2008) Geru Wu et al.   Circulation-Arrhythmia and Electrophysiology

Type of SCN5A mutation determines clinical severity and degree of conduction slowing in loss-of-function sodium channelopathies

(2008) Paola G. Meregalli et al.   HEART RHYTHM

A Mutation in Telethonin Alters Nav1.5 Function

(2008) Amelia Mazzone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ranolazine Shortens Repolarization in Patients with Sustained Inward Sodium Current Due to Type-3 Long-QT Syndrome

(2008) ARTHUR J. MOSS et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

A Novel SCN5A Gain-of-Function Mutation M1875T Associated With Familial Atrial Fibrillation

(2008) Takeru Makiyama et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genetic Na+ channelopathies and sinus node dysfunction

(2008) Ming Lei et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Cardiac Sodium Channel Overlap Syndromes: Different Faces of SCN5A Mutations

(2008) Carol Ann Remme et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Divergent Biophysical Defects Caused by Mutant Sodium Channels in Dilated Cardiomyopathy With Arrhythmia

(2007) Thao P. Nguyen et al.   CIRCULATION RESEARCH

Cardiac sodium channel mutation in atrial fibrillation

(2007) Patrick T. Ellinor et al.   HEART RHYTHM

Molecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of action

(2006) Sandra Fredj et al.   BRITISH JOURNAL OF PHARMACOLOGY