Marine natural products with anti-inflammatory activity

Marine lectins and their medicinal applications

(2015) Randy Chi Fai Cheung et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Antibacterial products of marine organisms

(2015) Tzi Bun Ng et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance

(2015) Philip C. Calder   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Omega 3 Polyunsaturated Fatty Acids Suppress the Development of Aortic Aneurysms Through the Inhibition of Macrophage-Mediated Inflammation

(2015) Takuma Yoshihara et al.   CIRCULATION JOURNAL

Neuroinflammation, Microglia and Mast Cells in the Pathophysiology of Neurocognitive Disorders: A Review

(2015) Stephen Skaper et al.   CNS & Neurological Disorders-Drug Targets

Rational Drug Design Paradigms: The Odyssey for Designing Better Drugs

(2015) Tahsin Kellici et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Therapeutic Effects of Herbal Chemicals in Traditional Chinese Medicine on Alzheimer’s Disease

(2015) T.S. Cheung et al.   CURRENT MEDICINAL CHEMISTRY

Recent contributions of structure-based drug design to the development of antibacterial compounds

(2015) Bart L Staker et al.   CURRENT OPINION IN MICROBIOLOGY

Analgesic and Anti-inflammatory Activities of the Ethanol Extract ofTaxillus tsaiiChiu in Mice

(2015) Chia-Yu Liu et al.   DRUG DEVELOPMENT RESEARCH

Heme Oxygenase-1 Induction Prevents Autoimmune Diabetes in Association With Pancreatic Recruitment of M2-Like Macrophages, Mesenchymal Cells, and Fibrocytes

(2015) Mahmoud Husseini et al.   ENDOCRINOLOGY

Drug-target based cross-sectional analysis of olfactory drug effects

(2015) Jörn Lötsch et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Quantitative structure–activity relationship: promising advances in drug discovery platforms

(2015) Tao Wang et al.   Expert Opinion on Drug Discovery

Anti-inflammatory dimeric furanocoumarins from the roots of Angelica dahurica

(2015) Wan-Qing Yang et al.   FITOTERAPIA

The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update

(2015) Shatadal Ghosh et al.   FOOD AND CHEMICAL TOXICOLOGY

Suppression of Th2 immune responses by the sulfated polysaccharide from Porphyra haitanensis in tropomyosin-sensitized mice

(2015) Chaolan Shi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Anti-inflammatory activity studies on the stems and roots of Jasminum lanceolarium Roxb

(2015) Wen-xia Yan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration

(2015) Renier van der Westhuyzen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-Inflammatory and Analgesic Effects of the Marine-Derived Compound Excavatolide B Isolated from the Culture-Type Formosan Gorgonian Briareum excavatum

(2015) Yen-You Lin et al.   Marine Drugs

Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta

(2015) Tzu-Zin Huang et al.   Marine Drugs

Marine Polysaccharides from Algae with Potential Biomedical Applications

(2015) Maria de Jesus Raposo et al.   Marine Drugs

Drug Development from Natural Resource: A Systematic Approach

(2015) S.B. Sharma et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Impact of IL-1 inhibition on fatigue associated with autoinflammatory syndromes

(2015) Sujani Yadlapati et al.   Modern Rheumatology

Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?

(2015) Yan He et al.   MOLECULES

Marine natural products

(2015) John W. Blunt et al.   NATURAL PRODUCT REPORTS

siRNA screen identifies QPCT as a druggable target for Huntington's disease

(2015) Maria Jimenez-Sanchez et al.   Nature Chemical Biology

Inflammation and cancer: advances and new agents

(2015) Shanthini M. Crusz et al.   Nature Reviews Clinical Oncology

Inflammation, Iron, Energy Failure, and Oxidative Stress in the Pathogenesis of Multiple Sclerosis

(2015) Lukas Haider   Oxidative Medicine and Cellular Longevity

Host-defense peptides of the skin with therapeutic potential: From hagfish to human

(2015) J. Michael Conlon   PEPTIDES

The immunomodulatory effects of fish-oil supplementation in elite paddlers: A pilot randomized double blind placebo-controlled trial

(2015) Maryam Delfan et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

A novel chalcone derivative attenuates the diabetes-induced renal injury via inhibition of high glucose-mediated inflammatory response and macrophage infiltration

(2015) Qilu Fang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease

(2015) Shilpi Khare et al.   PLoS Pathogens

Eicosapentaenoic Acid Reduces Adipocyte Hypertrophy and Inflammation in Diet-Induced Obese Mice in an Adiposity-Independent Manner

(2015) Monique J LeMieux et al.   JOURNAL OF NUTRITION

Peripheral Antinociception and Anti-Inflammatory Effects of Sulphated Polysaccharides from the AlgaCaulerpa mexicana

(2014) José Gerardo Carneiro et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Polysaccharides isolated from Digenea simplex inhibit inflammatory and nociceptive responses

(2014) Juliana G. Pereira et al.   CARBOHYDRATE POLYMERS

Cembranoid Diterpenes from the Soft Coral Lobophytum crassum and Their Anti-inflammatory Activities

(2014) Nguyen Xuan Cuong et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Recent Studies on the Antimicrobial Peptides Lactoferricin and Lactoferrampin

(2014) C. Yin et al.   CURRENT MOLECULAR MEDICINE

Protective Effects of Garlic Extract, PMK-S005, Against Nonsteroidal Anti-inflammatory Drugs–Induced Acute Gastric Damage in Rats

(2014) Yoon Jeong Choi et al.   DIGESTIVE DISEASES AND SCIENCES

Protective effects of crocetin pretreatment on myocardial injury in an ischemia/reperfusion rat model

(2014) Yanyan Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Specific therapy to regulate inflammation in rheumatoid arthritis: molecular aspects

(2014) Mariana H García-Hernández et al.   Immunotherapy

Sulfated polysaccharides isolated from the green seaweed Caulerpa racemosa plays antinociceptive and anti-inflammatory activities in a way dependent on HO-1 pathway activation

(2014) Natássia Albuquerque Ribeiro et al.   INFLAMMATION RESEARCH

A lectin from the green seaweed Caulerpa cupressoides reduces mechanical hyper-nociception and inflammation in the rat temporomandibular joint during zymosan-induced arthritis

(2014) Renata Line da Conceição Rivanor et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Rumphellols A and B, New Caryophyllene Sesquiterpenoids from a Formosan Gorgonian Coral, Rumphella antipathies

(2014) Hsu-Ming Chung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sesquiterpenoids and xanthones derivatives produced by sponge-derived fungus Stachybotry sp. HH1 ZSDS1F1-2

(2014) Chun Qin et al.   JOURNAL OF ANTIBIOTICS

Anti-inflammatory properties of convolutamydine A and two structural analogues

(2014) Patricia D. Fernandes et al.   LIFE SCIENCES

Marketed Marine Natural Products in the Pharmaceutical and Cosmeceutical Industries: Tips for Success

(2014) Ana Martins et al.   Marine Drugs

The beneficial properties of marine polysaccharides in alleviation of allergic responses

(2014) Thanh-Sang Vo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Rumphellaones B and C, New 4,5-Seco-Caryophyllane Sesquiterpenoids from Rumphella

(2014) Hsu-Ming Chung et al.   MOLECULES

Protective Effects of Astragaloside IV against Ovalbumin-Induced Lung Inflammation Are Regulated/Mediated by T-bet/GATA-3

(2014) Yu-Ying Qiu et al.   PHARMACOLOGY

Anti-Inflammatory Effect of Unsaturated Fatty Acids and Ergosta-7,22-dien-3-ol from Marthasterias glacialis: Prevention of CHOP-Mediated ER-Stress and NF-κB Activation

(2014) David M. Pereira et al.   PLoS One

Host defense peptides: front-line immunomodulators

(2014) Sarah C. Mansour et al.   TRENDS IN IMMUNOLOGY

Synthesis, Characterization andIn VitroAnticancer Activity of C-5 Curcumin Analogues with Potential to Inhibit TNF-α-Induced NF-κB Activation

(2014) Amit Anthwal et al.   Biomed Research International

Development of Anti-Inflammatory Drugs - the Research and Development Process

(2013) Richard Graham Knowles   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

New anti-inflammatory cembranoid diterpenoids from the Vietnamese soft coral Lobophytum crassum

(2013) Nguyen Phuong Thao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inflammation in Obesity and Diabetes: Islet Dysfunction and Therapeutic Opportunity

(2013) Marc Y. Donath et al.   Cell Metabolism

Nausea and the quest for the perfect anti-emetic

(2013) Paul L.R. Andrews et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

5-Hydroxy-3,6,7,8,3′4′-hexamethoxyflavone inhibits nitric oxide production in lipopolysaccharide-stimulated BV2 microglia via NF-κB suppression and Nrf-2-dependent heme oxygenase-1 induction

(2013) Chang-Hee Kang et al.   FOOD AND CHEMICAL TOXICOLOGY

Strepsesquitriol, a Rearranged Zizaane-Type Sesquiterpenoid from the Deep-Sea-Derived Actinomycete Streptomyces sp. SCSIO 10355

(2013) Xian-Wen Yang et al.   JOURNAL OF NATURAL PRODUCTS

Cytotoxic and Anti-Inflammatory Metabolites from the Soft Coral Scleronephthya gracillimum

(2013) Hui-Yu Fang et al.   Marine Drugs

Solomonsterol A, a Marine Pregnane-X-Receptor Agonist, Attenuates Inflammation and Immune Dysfunction in a Mouse Model of Arthritis

(2013) Andrea Mencarelli et al.   Marine Drugs

Anti-Inflammatory Components of the Starfish Astropecten polyacanthus

(2013) Nguyen Thao et al.   Marine Drugs

Soft Coral-Derived Lemnalol Alleviates Monosodium Urate-Induced Gouty Arthritis in Rats by Inhibiting Leukocyte Infiltration and iNOS, COX-2 and c-Fos Protein Expression

(2013) Hsin-Pai Lee et al.   Marine Drugs

Marine Pharmacology in 2009–2011: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and other Miscellaneous Mechanisms of Action

(2013) Alejandro Mayer et al.   Marine Drugs

Anti-Inflammatory Activities of Natural Products Isolated from Soft Corals of Taiwan between 2008 and 2012

(2013) Wen-Chi Wei et al.   Marine Drugs

Anti-Inflammatory Effect of Neoechinulin A from the Marine Fungus Eurotium sp. SF-5989 through the Suppression of NF-кB and p38 MAPK Pathways in Lipopolysaccharide-Stimulated RAW264.7 Macrophages

(2013) Kyoung-Su Kim et al.   MOLECULES

Characterization and Pharmacological Properties of a Novel Multifunctional Kunitz Inhibitor from Erythrina velutina Seeds

(2013) Richele J. A. Machado et al.   PLoS One

A Pseudopterane Diterpene Isolated From the Octocoral Pseudopterogorgia acerosa Inhibits the Inflammatory Response Mediated by TLR-Ligands and TNF-Alpha in Macrophages

(2013) Yisett González et al.   PLoS One

Marine lipid fraction PCSO-524™ (lyprinol®/omega XL®) of the New Zealand green lipped mussel attenuates hyperpnea-induced bronchoconstriction in asthma

(2013) Timothy D. Mickleborough et al.   RESPIRATORY MEDICINE

Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development

(2013) Allison Jones et al.   PLOS MEDICINE

Pharmacologically prospective antibiotic agents and their sources: A marine microbial perspective

(2012) Ira Bhatnagar et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Strategies for the generation, validation and application ofin silicoADMET models in lead generation and optimization

(2012) Matthew Paul Gleeson et al.   Expert Opinion on Drug Metabolism & Toxicology

Holothuria griseaagglutinin (HGA): the first invertebrate lectin with anti-inflammatory effects

(2012) Raniere da M. Moura et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Antiinflammatory, analgesic and antioxidant activities of Cyathula prostrata (Linn.) Blume (Amaranthaceae)

(2012) Bolanle Ibrahim et al.   JOURNAL OF ETHNOPHARMACOLOGY

Protective effects of cathelicidin-encoding Lactococcus lactis in murine ulcerative colitis

(2012) Clover Ching Man Wong et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Glutamate Receptor 1 Phosphorylation at Serine 831 and 845 Modulates Seizure Susceptibility and Hippocampal Hyperexcitability after Early Life Seizures

(2012) S. N. Rakhade et al.   JOURNAL OF NEUROSCIENCE

Lochmolins A–G, New Sesquiterpenoids from the Soft Coral Sinularia lochmodes

(2012) Yen-Ju Tseng et al.   Marine Drugs

Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity

(2012) Pradeep Dewapriya et al.   NEUROTOXICOLOGY

The antimicrobial peptide, epinecidin-1, mediates secretion of cytokines in the immune response to bacterial infection in mice

(2012) Shang-Chun Lee et al.   PEPTIDES

Modelling Neuroinflammation In Vitro: A Tool to Test the Potential Neuroprotective Effect of Anti-Inflammatory Agents

(2012) Núria Gresa-Arribas et al.   PLoS One

Cytokine Production Induced by Marine Algae Lectins in BALB/c Mice Splenocytes

(2012) Ticiana Monteiro Abreu et al.   PROTEIN AND PEPTIDE LETTERS

Marine sponge steroids as nuclear receptor ligands

(2012) Stefano Fiorucci et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Chaetoglobosin Fex from the Marine-Derived Endophytic Fungus Inhibits Induction of Inflammatory Mediators via Toll-Like Receptor 4 Signaling in Macrophages

(2011) Huan Dou et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Anti-inflammatory activity of polysaccharide purified from AMG-assistant extract of Ecklonia cava in LPS-stimulated RAW 264.7 macrophages

(2011) Sung-Myung Kang et al.   CARBOHYDRATE POLYMERS

Modern Drug Discovery Technologies: Opportunities and Challenges in Lead Discovery

(2011) Rafael V. C. Guido et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Target discovery from data mining approaches

(2011) Yongliang Yang et al.   DRUG DISCOVERY TODAY

Total Synthesis and Pharmacological Characterization of Solomonsterol A, a Potent Marine Pregnane-X-Receptor Agonist Endowed with Anti-Inflammatory Activity

(2011) Valentina Sepe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nardosinane Sesquiterpenoids from the Formosan Soft CoralLemnalia flava

(2011) Yi Lu et al.   JOURNAL OF NATURAL PRODUCTS

Trends in the exploitation of novel drug targets

(2011) Mathias Rask-Andersen et al.   NATURE REVIEWS DRUG DISCOVERY

Characteristics of the antitumor activities in tumor cells and modulation of the inflammatory response in RAW264.7 cells of a novel antimicrobial peptide, chrysophsin-1, from the red sea bream (Chrysophrys major)

(2011) Jung-Chieh Hsu et al.   PEPTIDES

Docosahexaenoic acid and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acyl ethanolamines with anti-inflammatory properties

(2010) Michiel G.J. Balvers et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Principles of early drug discovery

(2010) JP Hughes et al.   BRITISH JOURNAL OF PHARMACOLOGY

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

Lyprinol reduces inflammation and improves lung function in a mouse model of allergic airways disease

(2010) L. G. Wood et al.   CLINICAL AND EXPERIMENTAL ALLERGY

A neuroprotective sulfone of marine origin and the in vivo anti-inflammatory activity of an analogue

(2010) Zhi-Hong Wen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Marine natural product drug discovery: Leads for treatment of inflammation, cancer, infections, and neurological disorders

(2010) Francisco A. Villa et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Alkaloids in Marine Algae

(2010) Kasım Cemal Güven et al.   Marine Drugs

Herba Epimedii: Anti-Oxidative Properties and Its Medical Implications

(2010) Stephen Cho Wing Sze et al.   MOLECULES

Klysimplexins I–T, eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex

(2010) Bo-Wei Chen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The odyssey of marine pharmaceuticals: a current pipeline perspective

(2010) Alejandro M.S. Mayer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice

(2009) Marjolein A. van Maanen et al.   ARTHRITIS AND RHEUMATISM

Suppression of superoxide anion and elastase release by C18unsaturated fatty acids in human neutrophils

(2009) Tsong-Long Hwang et al.   JOURNAL OF LIPID RESEARCH

Inflammation in Atherosclerosis

(2009) Peter Libby et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Recent developments in anti-inflammatory natural products

(2009) Raju Gautam et al.   MEDICINAL RESEARCH REVIEWS

Assessment of Zymosan-Induced Leukocyte Influx in a Rat Model using Sulfated Polysaccharides

(2009) Maria Cardoso et al.   PLANTA MEDICA

Initial Phase 2 Trial of a Nicotinic Agonist in Schizophrenia

(2008) Robert Freedman et al.   AMERICAN JOURNAL OF PSYCHIATRY

In Vivo and In Vitro Inhibition of Monocyte Adhesion to Endothelial Cells and Endothelial Adhesion Molecules by Eicosapentaenoic Acid

(2008) Hideto Yamada et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sulfated galactofucan from Lobophora variegata: Anticoagulant and anti-inflammatory properties

(2008) V. P. Medeiros et al.   BIOCHEMISTRY-MOSCOW

Dietary fish oil decreases secretion of T helper (Th) 1-type cytokines by a direct effect on murine splenic T cells but enhances secretion of a Th2-type cytokine by an effect on accessory cells

(2008) Dagbjort H. Petursdottir et al.   BRITISH JOURNAL OF NUTRITION

Alpha7 cholinergic-agonist prevents systemic inflammation and improves survival during resuscitation

(2008) Bolin Cai et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Drug development from marine natural products

(2008) Tadeusz F. Molinski et al.   NATURE REVIEWS DRUG DISCOVERY

Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory and analgesic effects of the natural marine compound lemnalol from Formosan soft coral Lemnalia cervicorni

(2007) Yen-Hsuan Jean et al.   EUROPEAN JOURNAL OF PHARMACOLOGY