Neurotrophin Strategies for Neuroprotection: Are They Sufficient?

M30, a brain permeable multi target neurorestorative drug in post nigrostriatal dopamine neuron lesion of parkinsonism animal models

(2015) Moussa B.H. Youdim   PARKINSONISM & RELATED DISORDERS

Influences of chronic venlafaxine, olanzapine and nicotine on the hippocampal and cortical concentrations of brain-derived neurotrophic factor (BDNF)

(2014) Anna Czubak et al.   Pharmacological Reports

Impaired neurogenesis and neurite outgrowth in an HIV-gp120 transgenic model is reversed by exercise via BDNF production and Cdk5 regulation

(2013) Myoung-Hwa Lee et al.   JOURNAL OF NEUROVIROLOGY

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

(2013) Bai Lu et al.   NATURE REVIEWS NEUROSCIENCE

GDNF, NGF and BDNF as therapeutic options for neurodegeneration

(2013) Shelley J. Allen et al.   PHARMACOLOGY & THERAPEUTICS

Neurogenic and Neurotrophic Effects of BDNF Peptides in Mouse Hippocampal Primary Neuronal Cell Cultures

(2013) Maria del Carmen Cardenas-Aguayo et al.   PLoS One

Fingolimod Phosphate Attenuates Oligomeric Amyloid β–Induced Neurotoxicity via Increased Brain-Derived Neurotrophic Factor Expression in Neurons

(2013) Yukiko Doi et al.   PLoS One

Dietary Levels of Pure Flavonoids Improve Spatial Memory Performance and Increase Hippocampal Brain-Derived Neurotrophic Factor

(2013) Catarina Rendeiro et al.   PLoS One

The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice

(2013) Marguerite Prior et al.   Alzheimers Research & Therapy

From Molecular to Nanotechnology Strategies for Delivery of Neurotrophins: Emphasis on Brain-Derived Neurotrophic Factor (BDNF)

(2013) Claire Géral et al.   Pharmaceutics

Caffeic acid phenethyl ester protects nigral dopaminergic neurons via dual mechanisms involving haem oxygenase-1 and brain-derived neurotrophic factor

(2012) Y Kurauchi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Resveratrol promotes neurotrophic factor release from astroglia

(2012) Feng Zhang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Human Immunodeficiency Virus Type 1 Alters Brain-Derived Neurotrophic Factor Processing in Neurons

(2012) A. Bachis et al.   JOURNAL OF NEUROSCIENCE

Sendai virus vector-mediated brain-derived neurotrophic factor expression ameliorates memory deficits and synaptic degeneration in a transgenic mouse model of Alzheimer's disease

(2012) Yuki Iwasaki et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Catechins protect neurons against mitochondrial toxins and HIV proteins via activation of the BDNF pathway

(2012) Samir Nath et al.   JOURNAL OF NEUROVIROLOGY

Nerve growth factor: from the early discoveries to the potential clinical use

(2012) Luigi Aloe et al.   Journal of Translational Medicine

Memantine treatment reverses anhedonia, normalizes corticosterone levels and increases BDNF levels in the prefrontal cortex induced by chronic mild stress in rats

(2012) Gislaine Z. Réus et al.   METABOLIC BRAIN DISEASE

Quercetin Attenuates Cell Apoptosis in Focal Cerebral Ischemia Rat Brain Via Activation of BDNF–TrkB–PI3K/Akt Signaling Pathway

(2012) Rui-Qin Yao et al.   NEUROCHEMICAL RESEARCH

Reduced Tissue Levels of Noradrenaline Are Associated with Behavioral Phenotypes of the TgCRND8 Mouse Model of Alzheimer's Disease

(2012) Beverly M Francis et al.   NEUROPSYCHOPHARMACOLOGY

Smilagenin attenuates beta amyloid (25–35)-induced degeneration of neuronal cells via stimulating the gene expression of brain-derived neurotrophic factor

(2012) R. Zhang et al.   NEUROSCIENCE

Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome

(2012) R. Deogracias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Psychotropic drug effects on gene transcriptomics relevant to Parkinson's disease

(2012) Edward C. Lauterbach   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Experimental evidence of Ginkgo biloba extract EGB as a neuroprotective agent in ischemia stroke rats

(2011) Zhanjun Zhang et al.   BRAIN RESEARCH BULLETIN

Facilitated Neurogenesis in the Developing Hippocampus After Intake of Theanine, an Amino Acid in Tea Leaves, and Object Recognition Memory

(2011) Atsushi Takeda et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

(2011) Alan H. Nagahara et al.   NATURE REVIEWS DRUG DISCOVERY

Effect of Oral Resveratrol on the BDNF Gene Expression in the Hippocampus of the Rat Brain

(2011) Mostafa Rahvar et al.   NEUROCHEMICAL RESEARCH

Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus

(2011) Henri Autio et al.   NEUROPHARMACOLOGY

Deltamethrin, a type II pyrethroid insecticide, has neurotrophic effects on neurons with continuous activation of the Bdnf promoter

(2011) Daisuke Ihara et al.   NEUROPHARMACOLOGY

Antidepressant-like effect of hyperoside isolated from Apocynum venetum leaves: Possible cellular mechanisms

(2011) Meizhu Zheng et al.   PHYTOMEDICINE

Agomelatine (S20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and BDNF in the rat hippocampus, amygdala and PFC

(2011) Nataly Ladurelle et al.   PSYCHOPHARMACOLOGY

Intranigral Transplantation of Epigenetically Induced BDNF-Secreting Human Mesenchymal Stem Cells: Implications for Cell-Based Therapies in Parkinson's Disease

(2010) Rodrigo Somoza et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Up-Regulation of Hypoxia-Inducible Factor (HIF)-1α and HIF-Target Genes in Cortical Neurons by the Novel Multifunctional Iron Chelator Anti-Alzheimer Drug, M30

(2010) Y. Avramovich-Tirosh et al.   Current Alzheimer Research

BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease

(2010) A Giralt et al.   GENE THERAPY

Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

(2010) Stephen M. Massa et al.   JOURNAL OF CLINICAL INVESTIGATION

Psychotropic Drugs on In Vitro Brain-Derived Neurotrophic Factor Production in Whole Blood Cell Cultures From Healthy Subjects

(2010) Bun-Hee Lee et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Paroxetine Rapidly Modulates the Expression of Brain-Derived Neurotrophic Factor mRNA and Protein in a Human Glioblastoma-Astrocytoma Cell Line

(2010) Francesco Angelucci et al.   PHARMACOLOGY

Modified low molecular weight cyclic peptides as mimetics of BDNF with improved potency, proteolytic stability and transmembrane passage in vitro

(2009) Jordan M. Fletcher et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Review of Lithium Effects on Brain and Blood

(2009) Wise Young   CELL TRANSPLANTATION

Evidence for a release of brain-derived neurotrophic factor from the brain during exercise

(2009) Peter Rasmussen et al.   EXPERIMENTAL PHYSIOLOGY

Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis

(2009) Lana Kupershmidt et al.   FASEB JOURNAL

Reduced peripheral brain-derived neurotrophic factor mRNA levels are normalized by antidepressant treatment

(2009) Annamaria Cattaneo et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Intranasal delivery of neurotrophic factors BDNF, CNTF, EPO, and NT-4 to the CNS

(2009) Sandra R. Alcalá-Barraza et al.   JOURNAL OF DRUG TARGETING

Brain-derived neurotrophic factor gene delivery in an animal model of multiple sclerosis using bone marrow stem cells as a vehicle

(2009) Tapas K. Makar et al.   JOURNAL OF NEUROIMMUNOLOGY

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

Opposite effects of milnacipran, a serotonin norepinephrine reuptake inhibitor, on the levels of nitric oxide and brain-derived neurotrophic factor in mouse brain cortex

(2009) Atsuko Ikenouchi-Sugita et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Activation of EP2 prostanoid receptors in human glial cell lines stimulates the secretion of BDNF

(2009) Anthony J. Hutchinson et al.   NEUROCHEMISTRY INTERNATIONAL

Anti-depressant natural flavonols modulate BDNF and beta amyloid in neurons and hippocampus of double TgAD mice

(2009) Yan Hou et al.   NEUROPHARMACOLOGY

Venlafaxine treatment stimulates expression of brain-derived neurotrophic factor protein in frontal cortex and inhibits long-term potentiation in hippocampus

(2009) J.D. Cooke et al.   NEUROSCIENCE

Long-term green tea catechin administration prevents spatial learning and memory impairment in senescence-accelerated mouse prone-8 mice by decreasing Aβ1-42 oligomers and upregulating synaptic plasticity–related proteins in the hippocampus

(2009) Q. Li et al.   NEUROSCIENCE

Catalpol ameliorates beta amyloid–induced degeneration of cholinergic neurons by elevating brain-derived neurotrophic factors

(2009) Z. Wang et al.   NEUROSCIENCE

Ferulic acid induces neural progenitor cell proliferation in vitro and in vivo

(2009) T. Yabe et al.   NEUROSCIENCE

Using Polymer Chemistry to Modulate the Delivery of Neurotrophic Factors from Degradable Microspheres: Delivery of BDNF

(2009) James P. Bertram et al.   PHARMACEUTICAL RESEARCH

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

(2009) M. Blurton-Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linear Ordered Collagen Scaffolds Loaded with Collagen-Binding Brain-Derived Neurotrophic Factor Improve the Recovery of Spinal Cord Injury in Rats

(2009) Qianqian Han et al.   TISSUE ENGINEERING PART A

Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB

(2008) Rui Wang et al.   BRAIN RESEARCH

BDNF Level in the Rat Prefrontal Cortex Increases Following Chronic but Not Acute Treatment with Duloxetine, a Dual Acting Inhibitor of Noradrenaline and Serotonin Re-uptake

(2008) Claudio Mannari et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson’s disease

(2008) Naomi P. Visanji et al.   FASEB JOURNAL

Acute risperidone treatment did not increase daily cigarette consumption or plasma levels of cotinine and caffeine: a pilot study

(2008) Reiji Yoshimura et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons

(2008) Xuefei Wu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Design of a Conformationally Defined and Proteolytically Stable Circular Mimetic of Brain-derived Neurotrophic Factor

(2008) Jordan M. Fletcher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution

(2008) Ryan G. Soderquist et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington’s disease phenotypes in mice

(2008) Kusumika Gharami et al.   JOURNAL OF NEUROCHEMISTRY

Simvastatin-Mediated Upregulation of VEGF and BDNF, Activation of the PI3K/Akt Pathway, and Increase of Neurogenesis Are Associated with Therapeutic Improvement after Traumatic Brain Injury

(2008) Hongtao Wu et al.   JOURNAL OF NEUROTRAUMA

Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine

(2008) Francesco Matrisciano et al.   JOURNAL OF PSYCHIATRIC RESEARCH

CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice

(2008) Barbara L. Apostol et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington's disease: Restoration by the neuroprotective compound CEP-1347

(2008) Paola Conforti et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Chronic Administration of Mood Stabilizers Upregulates BDNF and Bcl-2 Expression Levels in Rat Frontal Cortex

(2008) Yunyoung C. Chang et al.   NEUROCHEMICAL RESEARCH

Ampakines cause sustained increases in brain-derived neurotrophic factor signaling at excitatory synapses without changes in AMPA receptor subunit expression

(2008) J.C. Lauterborn et al.   NEUROSCIENCE

Protective effect of the green tea component, l-theanine on environmental toxins-induced neuronal cell death

(2008) Hong-Suk Cho et al.   NEUROTOXICOLOGY

BDNF is essential to promote persistence of long-term memory storage

(2008) P. Bekinschtein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroprotection by Imipramine against lipopolysaccharide-induced apoptosis in hippocampus-derived neural stem cells mediated by activation of BDNF and the MAPK pathway

(2007) Chi-Hsien Peng et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model

(2007) Qi Peng et al.   EXPERIMENTAL NEUROLOGY