Article
Food Science & Technology
Li-Tao Yi, Man-Man Zhang, Jie Cheng, Hui-Qi Wan, Cheng-Fu Li, Ji-Xiao Zhu, Qiu-Ping Zhang, Qing Liu, Guang-Hui Xu
Summary: Degraded porphyran extracted from Porphyra haitanensis has shown potential antidepressant effects by inhibiting neuroinflammation and enhancing neurogenesis in the central nervous system.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Clinical Neurology
Thibaut Gelle, Rayhanatou Altine Samey, Brigitte Plansont, Barbara Bessette, Marie-Odile Jauberteau-Marchan, Fabrice Lalloue, Murielle Girard
Summary: This study found that BDNF levels were decreased and proBDNF levels were increased in both serum and exosomes in patients with Major Depression (MD). During antidepressant treatment, there was an inverse relationship in the levels of BDNF and proBDNF in serum and exosomes. However, these levels were not related to clinical improvement or depression scales.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychiatry
Geovan Menezes de Sousa, Vagner Deuel de Oliveira Tavares, Ana Cecilia de Menezes Galvao, Raissa Nobrega de Almeida, Fernanda Palhano-Fontes, Bruno Lobao-Soares, Fulvio Aurelio de Morais Freire, Emerson Arcoverde Nunes, Joao Paulo Maia-de-Oliveira, Daniel Perkins, Jerome Sarris, Draulio Barros de Araujo, Nicole Leite Galvao-Coelho
Summary: This study investigates the effects of emotional, cognitive, and physiological parameters on the antidepressant potential of ayahuasca. The results suggest that changes in depressive symptoms and salivary cortisol levels during the dosing session are associated with improvements in mood and brain-derived neurotrophic factor levels. These findings contribute to our understanding of the biological response to psychedelic therapy as an antidepressant treatment.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Susana Cubillos, Olivia Engmann, Anna Brancato
Summary: This narrative review provides an up-to-date overview of the interplay between antidepressant treatment and BDNF signaling, emphasizing the impact of lifestyle choices on depression treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Dong Xu, Li-Na Gao, Xu-Jiao Song, Qin-Wei Dong, Yi-Bing Chen, Yuan-Lu Cui, Qiangsong Wang
Summary: The study demonstrates that quercetin nanogels, when delivered intranasally, effectively transport BDNF to the brain and protect it from oxidative damage. These nanogels exhibit antioxidant and anti-inflammatory activities, potentially playing a role in the treatment of depressive disorders.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Songbai Xu, Xiaoxiao Yao, Bingjin Li, Ranji Cui, Cuilin Zhu, Yao Wang, Wei Yang
Summary: Ketamine has rapid and sustained antidepressant-like actions, but its dissociation and psychotomimetic propensities limit its use for psychiatric indications. This review explores the mechanisms by which ketamine exerts its antidepressant effects, including enhancing AMPAR-mediated transmission and activating neuroplasticity and synaptogenesis pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Leon Jesus German-Ponciano, Gilberto Uriel Rosas-Sanchez, Jonathan Cueto-Escobedo, Rafael Fernandez-Demeneghi, Gabriel Guillen-Ruiz, Cesar Soria-Fregozo, Emma Virginia Herrera-Huerta, Juan Francisco Rodriguez-Landa
Summary: Depressive disorders are a highly disabling global disease, with increasing incidence in recent decades. Flavonoids hold promise as potential antidepressants, with mechanisms that are not fully understood. Individuals with depression have low levels of serotonin and BDNF, which can be reversed by flavonoids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Eero Castren, Lisa M. Monteggia
Summary: Neurotrophic factors, especially BDNF, are associated with depression and the action of antidepressant drugs, with impaired BDNF signaling linked to mood disorders. Increased BDNF expression and signaling have been linked to the mechanisms of antidepressant drugs, and BDNF regulates various types of neuronal plasticities in the brain, which are connected to antidepressant action. The hypothesis of a connection between neurotrophic factors and neuronal plasticity with mood disorders and antidepressant action has been further supported by recent evidence.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Immunology
Xu Lu, Huijun Liu, Zixuan Cai, Zhichao Hu, Minxiu Ye, Yue Gu, Yue Wang, Dan Wang, Qun Lu, Zhongxia Shen, Xinhua Shen, Chao Huang
Summary: Depressed mice have lower numbers of microglia in the dentate gyrus. Reversing this decline with a single low dose of lipopolysaccharide has antidepressant effects. The antidepressant effect is related to the synthesis and signaling pathway of brain-derived neurotrophic factor.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Clinical Neurology
Mengnan Huang, Yuanyuan He, Lin Tian, Lu Yu, Qi Cheng, Zhu Li, Lina Gao, Shan Gao, Chunquan Yu
Summary: The study aimed to explore the anti-depressant mechanisms of berberine (BBR) in chronic unpredictable mild stress (CUMS)-induced depressive rats. The results showed that BBR improved depressive behaviors in CUMS rats by modulating the gut microbiota-SCFAs-monoamine neurotransmitters/BDNF.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Huitao Li, Jiannan Li, Tong Zhang, Xiaoyan Xie, Jiyu Gong
Summary: The study showed that JuA has an antidepressant effect on CORT-induced depression in mice by increasing protein expression levels of BDNF, TrkB, CREB, and improving the viability of hippocampal cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Benneth Ben-Azu, Christian Uruaka, Abayomi M. Ajayi, Thiophilus Aghogho Jarikre, Kingsley E. Nwangwa, Kingsley C. Chilaka, Bienose S. Chijioke, Marymagdalene G. Omonyeme, Chineye B. Ozege, Emmanuella C. Ofili, Ebidenara B. Warekoromor, Nwanneka L. Edigbue, Ufoma Esiekpe, Dabrechi E. Akaenyi, Gladys O. Agu
Summary: Schizophrenia is a severe neuropsychiatric disorder caused by complex neurobiological changes. Taurine has shown potential in reducing symptoms and protecting against schizophrenia through modulation of neurochemicals and neurotrophic factors, and inhibition of inflammatory cytokines.
NEUROCHEMICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Jan Lazur, Kamil Hnatyk, Katarzyna Kala, Katarzyna Sulkowska-Ziaja, Bozena Muszynska
Summary: Major Depression Disease is a common mental illness that affects more than 322 million people worldwide and it is one of the leading causes of mental and physical disability. Current psychopharmacotherapy is based on the monoamine theory, but due to the low efficacy of typical antidepressants, seeking new ways of treatment is a priority. Medicinal mushrooms, considered as functional foods, have been found to have antidepressant effects due to their ability to synthesize various metabolites that impact neurotrophin expression and the gut-brain axis.
Article
Biochemistry & Molecular Biology
Danielle M. Diniz, Francesca Calabrese, Paola Brivio, Marco A. Riva, Joanes Grandjean, Judith R. Homberg
Summary: BDNF plays a crucial role in neuroplasticity, vulnerability and resilience to stress-related disorders. Modulation of BDNF levels in the ventral hippocampus of SERT-/- rats led to positive behavioral outcomes, suggesting BDNF upregulation as a potential target for new therapeutic approaches in improving depressive symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Integrative & Complementary Medicine
Pan Meng, Xi Zhang, Tong-tong Liu, Jian Liu, Yan Luo, Ming-xia Xie, Hui Yang, Rui Fang, Dong-wei Guo, Zi-yan Zhong, Yu-hong Wang, Jin-Wen Ge
Summary: In this study, the antidepressant effects of Xiaoyaosan (XYS) were demonstrated in a rat model of depression. Whole transcriptome sequencing was used to analyze the expression profiles of miRNAs, lncRNAs, circRNAs, and mRNAs, and the GO and KEGG pathway analysis revealed the potential mechanisms of XYS in treating depression. Additionally, in vivo experiments showed that XYS improved synaptic morphology and increased the expression of the BDNF/trkB/PI3K signaling axis.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Review
Clinical Neurology
Yong-Ku Kim, Meysam Amidfar, Eunsoo Won
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2019)
Review
Clinical Neurology
Kyu-Man Han, Domenico De Berardis, Michele Fornaro, Yong-Ku Kim
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2019)
Review
Clinical Neurology
Yong-Ku Kim, Byung-Joo Ham, Kyu-Man Han
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2019)
Editorial Material
Clinical Neurology
Kyu-Man Han, Yong-Ku Kim
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2019)
Review
Psychiatry
Seon-Cheol Park, Yong-Ku Kim
PSYCHIATRY INVESTIGATION
(2019)
Review
Pharmacology & Pharmacy
Carmine Tomasetti, Chiara Montemitro, Annastasia L. C. Fiengo, Cristina Santone, Laura Orsolini, Alessandro Valchera, Alessandro Carano, Maurizio Pompili, Gianluca Serafini, Giampaolo Perna, Federica Vellante, Giovanni Martinotti, Massimo D. Giannantonio, Yong-Ku Kim, Marco D. Nicola, Antonello Bellomo, Antonio Ventriglio, Michele Fornaro, Domenico D. Berardis
CURRENT PHARMACEUTICAL DESIGN
(2019)
Article
Clinical Neurology
Kyu-Man Han, Hee-Jung Jee, Hyonggin An, Cheolmin Shin, Ho-Kyoung Yoon, Young-Hoon Ko, Byung-Joo Ham, Yong-Ku Kim, Changsu Han
JOURNAL OF AFFECTIVE DISORDERS
(2019)
Review
Clinical Neurology
Meysam Amidfar, Marie Woelfer, Gislaine Z. Reus, Joao Quevedo, Martin Walter, Yong-Ku Kim
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2019)
Editorial Material
Neurosciences
Youn Jung Lee, Yong-Ku Kim
CURRENT NEUROPHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Cheolmin Shin, Yong-Ku Kim
CURRENT OPINION IN PHARMACOLOGY
(2019)
Article
Clinical Neurology
Cheolmin Shin, Moon Ho Park, Seung-Hoon Lee, Young-Hoon Ko, Yong-Ku Kim, Kyu-Man Han, Hyun-Ghang Jeong, Changsu Han
JOURNAL OF AFFECTIVE DISORDERS
(2019)
Review
Biochemistry & Molecular Biology
Eunsoo Won, Yong-Ku Kim
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Junhyung Kim, Yong-Ku Kim
Summary: Alzheimer's disease is the most common type of dementia, with depression being a risk factor for its development. While depression patients often recover without residual symptoms, late-life depression patients may show residual cognitive impairment. Understanding how risk factors impact the course of Alzheimer's disease is crucial for its management.
Review
Biochemistry & Molecular Biology
Lorenza Lucidi, Mauro Pettorruso, Federica Vellante, Francesco Di Carlo, Franca Ceci, Maria Chiara Santovito, Ilenia Di Muzio, Michele Fornaro, Antonio Ventriglio, Carmine Tomasetti, Alessandro Valchera, Alessandro Gentile, Yong-Ku Kim, Giovanni Martinotti, Silvia Fraticelli, Massimo Di Giannantonio, Domenico De Berardis
Summary: The gut microbiota plays a crucial role in maintaining homeostasis, growth, and digestive processes. It also influences the intercommunication system between the gut and the brain, potentially impacting the pathogenesis and clinical management of Bipolar Disorder. Current literature suggests a relationship between compositional alterations in the gut microbiota and BD, with potential benefits in treating BD symptoms through modifications in the microbiota composition. Further research is needed to explore the potential of correcting gut microbiota alterations as a novel strategy in BD management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Eunsoo Won, Kyoung-Sae Na, Yong-Ku Kim
Summary: Inflammatory conditions and disruptions in circadian rhythms, including alterations in the melatonin system, have been suggested as mechanisms underlying major depressive disorder. Melatonin, with its immunological and non-immunological actions, can suppress inflammation and influence neuroinflammation and neurotoxicity, leading to alterations in brain regions implicated in depression. Further research on the associations between melatonin, immune markers, and brain structure and function may help identify potential biomarkers for MDD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)