Article
Multidisciplinary Sciences
Brett A. McCray, Erika Diehl, Jeremy M. Sullivan, William H. Aisenberg, Nicholas W. Zaccor, Alexander R. Lau, Dominick J. Rich, Benedikt Goretzki, Ute A. Hellmich, Thomas E. Lloyd, Charlotte J. Sumner
Summary: TRPV4 interacts with RhoA, affecting cell structure. The neuropathy effects of TRPV4 are related to incorrect binding with RhoA. Inhibition of RhoA can restore neurite length.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Lu-Lu Xue, Ruo-Lan Du, Yue Hu, Liu-Lin Xiong, Zhang-Yu Su, Zheng Ma, Ya-Xin Tan, Jia Liu, Qiao Hu, Zhao-Qiong Zhu, Xue-Zheng Liu, Ting-Hua Wang
Summary: Neonatal hypoxic-ischemic encephalopathy (HIE) is a major neurological disorder in newborns with unclear mechanisms. This study demonstrated that hypoxia and ischemia (HI) caused significant neurological damage in neonatal rats, with brain-derived neurotrophic factor (BDNF) being down-regulated and potentially playing a role in promoting neurite regrowth after injury. These findings suggest a novel strategy for treating neurological defects induced by cerebral ischemia and hypoxia.
BRAIN RESEARCH BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Lara Russo, Chiara Giacomelli, Mariagrazia Fortino, Tiziano Marzo, Gianmarco Ferri, Mariantonietta Calvello, Alessandro Viegi, Antonio Magri, Alessandro Pratesi, Adriana Pietropaolo, Francesco Cardarelli, Claudia Martini, Enrico Rizzarelli, Laura Marchetti, Diego La Mendola, Maria Letizia Trincavelli
Summary: A novel BDNF mimetic peptide was synthesized and shown to act as an agonist by promoting phosphorylation of TrkB and activation of downstream signaling pathways, demonstrating its neurotrophic activity and ability to promote neurite outgrowth.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ramon Martinez-Marmol, YeJin Chai, Jacinta N. Conroy, Zahra Khan, Seong-Min Hong, Seon Beom Kim, Rachel S. Gormal, Dae Hee Lee, Jae Kang Lee, Elizabeth J. Coulson, Mi Kyeong Lee, Sun Yeou Kim, Frederic A. Meunier
Summary: The traditional medicinal mushroom Hericium erinaceus enhances peripheral nerve regeneration through neurotrophic activity. We identified N-de phenylethyl isohericerin (NDPIH) and hericene A as biologically active compounds from this mushroom that promote neurite outgrowth in hippocampal neurons. NDPIH acts through a neurotrophic pathway independent of TrkB with ERK1/2 activation, while hericene A acts through a novel pan-neurotrophic signaling pathway, leading to improved cognitive performance in mice.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Neurosciences
Marina F. Souza, Katty A. A. L. Medeiros, Livia C. R. F. Lins, Jose M. M. Bispo, Auderlan M. Gois, Edson R. Santos, Thiago H. Almeida-Souza, Joao E. C. Melo, Heitor S. Franco, Rodolfo S. Silva, Eduardo A. Pereira-Filho, Marco Aurelio M. Freire, Jose R. Santos
Summary: This study evaluated the motor, cognitive, and emotional changes associated with dopaminergic and BDNF imbalance after exposure to deltamethrin in rats. The results showed that inhalation of deltamethrin at different periods induced motor and cognitive impairments in rats, accompanied by damage to the dopaminergic system and possible dysfunction in synaptic plasticity.
BRAIN RESEARCH BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Elif Unal, Ekrem Sulukan, Onur Senol, Alper Baran, Hayrunnisa Nadaroglu, Meryem Kankaynar, Tuba Kiziltan, Saltuk Bugrahan Ceyhun
Summary: In this study, the antioxidant capacity of carob pods water extract (CPWE) against deltamethrin (DM)-induced oxidative stress was investigated using in vitro and in vivo experiments in a zebrafish model. The results showed that exposure to DM during zebrafish development caused significant body malformations, decreased survival rate, reduced eye size, shortened body length, and decreased locomotor activity in the dark period. In addition, DM increased the levels of free oxygen radicals and apoptotic cells, while CPWE application reduced DM-induced toxicity and oxidative stress.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Editorial Material
Cell Biology
Ulrich Theopold, Antonio Barragan
Summary: The study identified a TRP-like channel in Toxoplasma gondii and demonstrated its involvement in crucial processes such as parasite invasion and egress from host cells, shedding light on how parasites sense and respond to changes in the cellular environments.
Article
Biochemical Research Methods
Ji Woon Kim, Yoon Young Choi, Si-Hyung Park, Jang Ho Ha, Hee Uk Lee, Taewook Kang, Woong Sun, Bong Geun Chung
Summary: Researchers have developed a microfluidic chip integrated with a microelectrode array as an axonal guidance platform, enabling precise manipulation of neural differentiation. They demonstrated the synergistic effects of electrical stimulation and neurotrophic factors on axonal outgrowth, making this chip a potential model for central nervous system injury and regeneration.
Article
Physiology
Daichi Saitoh, Kotoku Kawaguchi, Shinji Asano, Toshio Inui, Yoshinori Marunaka, Takashi Nakahari
Summary: Acetylcholine enhances airway ciliary beating by activating muscarinic ACh receptors and nicotinic ACh receptors, leading to an increase in intracellular calcium concentration. This study reveals the involvement of alpha 7-nAChRs and voltage-gated calcium channels in airway ciliary beating, providing a novel Ca2+ signaling pathway that contributes to the maintenance of healthy airways.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
JungKwon Lee, Jesusa L. Rosales, Hee-Guk Byun, Ki-Young Lee
Summary: The study demonstrates that d,l-methadone induces leukemic cell apoptosis by activating the mu1 subtype of opioid receptors (OPRM1) and influencing intracellular Ca2+ levels, specifically through the calpain-1-Bid-cytochrome C-caspase-3/12 apoptotic pathway.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ralf Kleene, Gabriele Loers, Melitta Schachner
Summary: Abnormal functions of L1 are associated with neural diseases. L1-55 fragment interacts with MeCP2, HP1, HistH1e, and other proteins via the KDET motif. These interactions regulate neurite outgrowth and neuronal survival, indicating the importance of L1 in neural system functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Clarisse M. Fligor, Sailee S. Lavekar, Jade Harkin, Priya K. Shields, Kirstin B. VanderWall, Kang-Chieh Huang, Catia Gomes, Jason S. Meyer
Summary: By generating in vitro models consisting of retinal organoids, cortical and thalamic organoids, researchers have successfully simulated the projections of the human visual system. This approach not only enhances RGC survival in long-term models but also facilitates studies on human visual system development and related diseases.
Article
Cell Biology
Jia-Jian Liang, Yu-Fen Liu, TszKin Ng, Ci-Yan Xu, Mingzhi Zhang, ChiPui Pang, Ling-Ping Cen
Summary: Inflammation plays a crucial role in regulating neuronal survival in the central nervous system, and this study showed that primary rat peritoneal macrophages attenuated retinal ganglion cell survival and neurite outgrowth, with further exacerbation by macrophage activation.
NEURAL REGENERATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Wenting You, Tos T. J. M. Berendschot, Kevin Knoops, Marc A. M. J. van Zandvoort, Carroll A. B. Webers, Chris P. M. Reutelingsperger, Theo G. M. F. Gorgels
Summary: Neurodegenerative diseases are characterized by the loss of certain neurons and a slow progressive course. Our study indicates that damaged neurons in the process of cell death can be recovered.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Feng Zhendong, Zhang Xiaopei, Liu Na, Wang Yue, Zhou Ziyi, O. Oleg Glebov, Wu Tong
Summary: A general strategy was developed to create injectable welded nanofibers for promoting the outgrowth and extension of neurites. By welding short nanofibers at their cross points, the viability and neurite outgrowth of neuroblastoma cells were enhanced. This approach has the potential to impact nerve repair and neurite extension in the central nervous system.
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
(2021)
Article
Pharmacology & Pharmacy
Ichiro Takasaki, Ai Watanabe, Masafumi Yokai, Yurie Watanabe, Daichi Hayakawa, Ryota Nagashima, Mamoru Fukuchi, Takuya Okada, Naoki Toyooka, Atsuro Miyata, Hiroaki Gouda, Takashi Kurihara
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2018)
Article
Multidisciplinary Sciences
Marisa Kaneda, Hiroyuki Sakagami, Yamato Hida, Toshihisa Ohtsuka, Natsumi Satou, Yuta Ishibashi, Mamoru Fukuchi, Anna Krysiak, Mitsuru Ishikawa, Daisuke Ihara, Katarzyna Kalita, Akiko Tabuchi
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Keietsu Kikuchi, Daisuke Ihara, Mamoru Fukuchi, Hiroki Tanabe, Yuta Ishibashi, Junya Tsujii, Masaaki Tsuda, Marisa Kaneda, Hiroyuki Sakagami, Hiroyuki Okuno, Haruhiko Bito, Yuya Yamazaki, Mitsuru Ishikawa, Akiko Tabuchi
JOURNAL OF NEUROCHEMISTRY
(2019)
Review
Biochemistry & Molecular Biology
Hidetoshi Komatsu, Mamoru Fukuchi, Yugo Habata
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Multidisciplinary Sciences
Mamoru Fukuchi, Yui Okuno, Hironori Nakayama, Aoi Nakano, Hisashi Mori, Satoru Mitazakil, Yuka Nakano, Kazufumi Toume, Michiko Jo, Ichiro Takasaki, Kazuki Watanabe, Naotoshi Shibahara, Katsuko Komatsu, Akiko Tabuchi, Masaaki Tsuda
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Mamoru Fukuchi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Tomoaki Miyata, Keietsu Kikuchi, Daisuke Ihara, Maki Kaito, Yuta Ishibashi, Tomoyuki Hakamata, Tetsuya Yamada, Mitsuru Ishikawa, Miho Mizukoshi, Shizuku Shoji, Mamoru Fukuchi, Masaaki Tsuda, Yamato Hida, Toshihisa Ohtsuka, Marisa Kaneda, Akiko Tabuchi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Miho Mizukoshi, Ayaka Nozawa, Serina Oomizo, Daisuke Ihara, Jun Shiota, Keietsu Kikuchi, Maki Kaito, Yuta Ishibashi, Mitsuru Ishikawa, Mamoru Fukuchi, Masaaki Tsuda, Ichiro Takasaki, Akiko Tabuchi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Yuta Ishibashi, Shizuku Shoji, Daisuke Ihara, Yukimi Kubo, Takuro Tanaka, Hiroki Tanabe, Tomoyuki Hakamata, Tomoaki Miyata, Natsumi Satou, Hiroyuki Sakagami, Mineyuki Mizuguchi, Keietsu Kikuchi, Mamoru Fukuchi, Masaaki Tsuda, Ichiro Takasaki, Akiko Tabuchi
Summary: The MRTFB isoforms play unique roles in gene expression and dendritic complexity regulation, with different expression patterns and effects on shaping neuronal circuits.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Neurosciences
Mamoru Fukuchi, Ryohei Saito, Shojiro Maki, Nami Hagiwara, Yumena Nakajima, Satoru Mitazaki, Hironori Izumi, Hisashi Mori
Review
Biochemistry & Molecular Biology
Hidetoshi Komatsu, Emi Watanabe, Mamoru Fukuchi
Summary: Learning and environmental adaptation are crucial for survival and quality of life, with decision-making involving coordination among multiple neural network systems. Neurological and psychiatric disorders often impact these processes, but machine learning approaches have the potential to redefine mental illnesses and improve therapeutic outcomes. Early disease detection and personalized treatment regimes may be possible through measurable endophenotypes and the application of artificial intelligence in psychiatric practice.
Article
Chemistry, Medicinal
Hironori Nakayama, Daisuke Ihara, Mamoru Fukuchi, Kazufumi Toume, Chisato Yuri, Masaaki Tsuda, Naotoshi Shibahara, Akiko Tabuchi
Summary: The study found that the herbal formula daikenchuto (DKT) extract can increase the expression of BDNF in neurons and improve neurological dysfunctions. The extract works by mediating calcium signaling and promoting neuronal survival and neurite complexity. Therefore, DKT extract may have therapeutic potential in diseases associated with reduced BDNF in the brain.
JOURNAL OF NATURAL MEDICINES
(2023)
Article
Biochemistry & Molecular Biology
Kurumi Sakata, Takehiro Kobayashi, Saki Yokokura, Mamoru Fukuchi
Summary: This study found that the expression of BDNF in adipose tissues increased after a high-fat diet and was significantly correlated with body weight gain. The expression of Bdnf may be mediated by macrophages and play a role in the early stages of obesity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Mamoru Fukuchi, Kazuki Watanabe, Satoru Mitazaki, Momoko Fukuda, Satoshi Matsumoto
Summary: The study found that a food-derived product, Aminothioneine (AT), could enhance BDNF expression in rat cortical neurons by inducing CREB-dependent transcription through Ca2+ signaling.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Mamoru Fukuchi, Tomofumi Sanabe, Toshifumi Watanabe, Takane Kubota, Akiko Tabuchi, Masaaki Tsuda
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.