Bile acid diarrhoea and FGF19: new views on diagnosis, pathogenesis and therapy

An Evaluation of the Use of Serum 7-alpha-hydroxycholestenone as a Diagnostic Test of Bile Acid Malabsorption Causing Watery Diarrhea

(2016) W Gordon Brydon et al.   CANADIAN JOURNAL OF GASTROENTEROLOGY

271 A New Therapy for Chronic Diarrhea? A Proof of Concept Study of the FXR Agonist Obeticholic Acid in Patients With Primary Bile Acid Diarrhea

(2015) Ian M. Johnston et al.   GASTROENTEROLOGY

Fibroblast growth factor 19 in patients with bile acid diarrhoea: a prospective comparison of FGF19 serum assay and SeHCAT retention

(2013) S. S. Pattni et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Potent stimulation of fibroblast growth factor 19 expression in the human ileum by bile acids

(2013) Justine H. Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Diet1 Functions in the FGF15/19 Enterohepatic Signaling Axis to Modulate Bile Acid and Lipid Levels

(2013) Laurent Vergnes et al.   Cell Metabolism

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Bowel Functions, Fecal Unconjugated Primary and Secondary Bile Acids, and Colonic Transit in Patients With Irritable Bowel Syndrome

(2013) Andrea Shin et al.   Clinical Gastroenterology and Hepatology

Methods for Diagnosis of Bile Acid Malabsorption in Clinical Practice

(2013) Priya Vijayvargiya et al.   Clinical Gastroenterology and Hepatology

Bile acid malabsoption: a forgotten diagnosis?

(2013) U. Khalid et al.   CLINICAL MEDICINE

Recycling rate of bile acids in the enterohepatic recirculation as a major determinant of whole body 75SeHCAT retention

(2013) A. Michael Peters et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

(2013) Sunder Mudaliar et al.   GASTROENTEROLOGY

The bile acid receptor, TGR5, regulates basal and cholinergic-induced secretory responses in rat colon

(2013) J. B. J. Ward et al.   NEUROGASTROENTEROLOGY AND MOTILITY

A survey of the clinical use of SeHCAT in the UK

(2013) Michael J. Smith et al.   NUCLEAR MEDICINE COMMUNICATIONS

Peripheral Reduction of FGFR4 with Antisense Oligonucleotides Increases Metabolic Rate and Lowers Adiposity in Diet-Induced Obese Mice

(2013) Xing Xian Yu et al.   PLoS One

Application of a Novel Tool for Diagnosing Bile Acid Diarrhoea

(2013) James Covington et al.   SENSORS

Increased Bile Acid Biosynthesis Is Associated With Irritable Bowel Syndrome With Diarrhea

(2012) Banny S. Wong et al.   Clinical Gastroenterology and Hepatology

Pharmacogenetics of the Effects of Colesevelam on Colonic Transit in Irritable Bowel Syndrome with Diarrhea

(2012) Banny S. Wong et al.   DIGESTIVE DISEASES AND SCIENCES

The Role of Bile After Roux-en-Y Gastric Bypass in Promoting Weight Loss and Improving Glycaemic Control

(2012) Dimitri J. Pournaras et al.   ENDOCRINOLOGY

The Receptor TGR5 Mediates the Prokinetic Actions of Intestinal Bile Acids and Is Required for Normal Defecation in Mice

(2012) Farzad Alemi et al.   GASTROENTEROLOGY

Involvement of multiple elements in FXR-mediated transcriptional activation of FGF19

(2012) Masaaki Miyata et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Prevalence of, and predictors of, bile acid malabsorption in outpatients with chronic diarrhea

(2012) D. J. Gracie et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Increase in fecal primary bile acids and dysbiosis in patients with diarrhea-predominant irritable bowel syndrome

(2012) H. Duboc et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor  -Klotho

(2012) T. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody-Mediated Inhibition of Fibroblast Growth Factor 19 Results in Increased Bile Acids Synthesis and Ileal Malabsorption of Bile Acids in Cynomolgus Monkeys

(2012) Rama Pai et al.   TOXICOLOGICAL SCIENCES

Altered enterohepatic circulation of bile acids in Crohn’s disease and their clinical significance: a new perspective

(2012) Jonathan D Nolan et al.   Expert Review of Gastroenterology & Hepatology

Fibroblast Growth Factor 19 and 7α-Hydroxy-4-Cholesten-3-one in the Diagnosis of Patients With Possible Bile Acid Diarrhea

(2012) Sanjeev S Pattni et al.   Clinical and Translational Gastroenterology

Effects of Chemical Modification of Ursodeoxycholic Acid on TGR5 Activation

(2011) Yusuke Iguchi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Bile acid malabsorption investigated by selenium-75-homocholic acid taurine (75SeHCAT) scans: Causes and treatment responses to cholestyramine in 298 patients with chronic watery diarrhoea

(2011) Märta K. Borghede et al.   European Journal of Internal Medicine

A Klothoβ Variant Mediates Protein Stability and Associates With Colon Transit in Irritable Bowel Syndrome With Diarrhea

(2011) Banny S. Wong et al.   GASTROENTEROLOGY

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

(2011) R. M. Gadaleta et al.   GUT

Pronounced variation in bile acid synthesis in humans is related to gender, hypertriglyceridaemia and circulating levels of fibroblast growth factor 19

(2011) C. Gälman et al.   JOURNAL OF INTERNAL MEDICINE

Association of bile acid receptor TGR5 variation and transit in health and lower functional gastrointestinal disorders

(2011) M. Camilleri et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Bile acid malabsorption: An under-investigated differential diagnosis in patients presenting with diarrhea predominant irritable bowel syndrome type symptoms

(2011) Matthew Kurien et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

(2011) S. Kir et al.   SCIENCE

Bowel Disorders

(2010) Robin C Spiller et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Chenodeoxycholate in Females With Irritable Bowel Syndrome-Constipation: A Pharmacodynamic and Pharmacogenetic Analysis

(2010) Archana S. Rao et al.   GASTROENTEROLOGY

Bile acid malabsorption in inflammatory bowel disease

(2010) Martin Lenicek et al.   INFLAMMATORY BOWEL DISEASES

Regulation of Bile Acid Synthesis by Fat-soluble Vitamins A and D

(2010) Daniel R. Schmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining primary bile acid diarrhea: making the diagnosis and recognizing the disorder

(2010) Julian RF Walters   Expert Review of Gastroenterology & Hepatology

Managing bile acid diarrhoea

(2010) Julian R. F. Walters et al.   Therapeutic Advances in Gastroenterology

Systematic review: the prevalence of idiopathic bile acid malabsorption as diagnosed by SeHCAT scanning in patients with diarrhoea-predominant irritable bowel syndrome

(2009) L. WEDLAKE et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

A New Mechanism for Bile Acid Diarrhea: Defective Feedback Inhibition of Bile Acid Biosynthesis

(2009) Julian R.F. Walters et al.   Clinical Gastroenterology and Hepatology

Discovery of 6α-Ethyl-23(S)-methylcholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity

(2009) Roberto Pellicciari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Measurement of serum 7α-hydroxy-4-cholesten-3-one (or 7αC4), a surrogate test for bile acid malabsorption in health, ileal disease and irritable bowel syndrome using liquid chromatography-tandem mass spectrometry

(2009) m. camilleri et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Chronic diarrhea caused by idiopathic bile acid malabsorption: an explanation at last

(2009) Alan F Hofmann   Expert Review of Gastroenterology & Hepatology

Fibroblast growth factor‐19: Development, analytical characterization and clinical evaluation of a new ELISA test

(2008) D. Stejskal et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION