PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis

Influence of NADPH oxidase on inflammatory response in primary intestinal epithelial cells in patients with ulcerative colitis

(2013) Rima Ramonaite et al.   BMC GASTROENTEROLOGY

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Profiling Serum Bile Acid Glucuronides in Humans: Gender Divergences, Genetic Determinants, and Response to Fenofibrate

(2013) J Trottier et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Disturbance of Hepatic and Intestinal UDP-glucuronosyltransferase in Rats with Trinitrobenzene Sulfonic Acid-induced Colitis

(2013) Xueyan Zhou et al.   Drug Metabolism and Pharmacokinetics

Endothelial PAS Domain Protein 1 Activates the Inflammatory Response in the Intestinal Epithelium to Promote Colitis in Mice

(2013) Xiang Xue et al.   GASTROENTEROLOGY

Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

(2012) Henri Duboc et al.   GUT

Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice

(2012) Bo Kong et al.   HEPATOLOGY

Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis

(2012) Fei Li et al.   JOURNAL OF LIPID RESEARCH

FXR signaling in the enterohepatic system

(2012) Tsutomu Matsubara et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

(2012) Taoufiq Harach et al.   Scientific Reports

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

(2011) Matthew J. Potthoff et al.   Cell Metabolism

Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity

(2011) J. Prawitt et al.   DIABETES

Selective Activation of Nuclear Bile Acid Receptor FXR in the Intestine Protects Mice Against Cholestasis

(2011) Salvatore Modica et al.   GASTROENTEROLOGY

Development and validation of a sensitive LC/MS/MS method for the simultaneous determination of naloxone and its metabolites in mouse plasma

(2011) Hongliang Jiang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Regioselective Glucuronidation of Tanshinone IIa after Quinone Reduction: Identification of Human UDP-Glucuronosyltransferases, Species Differences, and Interaction Potential

(2010) Q. Wang et al.   DRUG METABOLISM AND DISPOSITION

PPARα contributes to colonic protection in mice with DSS-induced colitis

(2010) Yasu-Taka Azuma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

(2010) Thijs W.H. Pols et al.   JOURNAL OF HEPATOLOGY

Induction of Mouse UDP-Glucuronosyltransferase mRNA Expression in Liver and Intestine by Activators of Aryl-Hydrocarbon Receptor, Constitutive Androstane Receptor, Pregnane X Receptor, Peroxisome Proliferator-Activated Receptor  , and Nuclear Factor Erythroid 2-Related Factor 2

(2009) D. B. Buckley et al.   DRUG METABOLISM AND DISPOSITION

Regulation of endobiotics glucuronidation by ligand-activated transcription factors: physiological function and therapeutic potential

(2009) Mélanie Verreault et al.   DRUG METABOLISM REVIEWS

Mechanisms of Resistance of Hepatocyte Retinoid X Receptor α-Null Mice to WY-14,643-induced Hepatocyte Proliferation and Cholestasis

(2009) Maxwell Afari Gyamfi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bile acids: regulation of synthesis

(2009) John Y. L. Chiang   JOURNAL OF LIPID RESEARCH

Lipid-activated transcription factors control bile acid glucuronidation

(2009) Olivier Barbier et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Basal and Fasting/Refeeding-regulated Tissue Levels of Endogenous PPAR-α Ligands in Zucker Rats

(2009) Angelo A. Izzo et al.   Obesity

Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

(2009) Philippe Lefebvre et al.   PHYSIOLOGICAL REVIEWS

Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease

(2009) Carsten Gnewuch et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Dietary Induction of Colonic Tumors in a Mouse Model of Sporadic Colon Cancer

(2008) K. Yang et al.   CANCER RESEARCH

Species Differences in UDP-Glucuronosyltransferase Activities in Mice and Rats

(2008) H. Shiratani et al.   DRUG METABOLISM AND DISPOSITION

Role and regulation of acylethanolamides in energy balance: focus on adipocytes and β-cells

(2007) I Matias et al.   BRITISH JOURNAL OF PHARMACOLOGY