Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation

Granzyme A activates another way to die

(2015) Judy Lieberman   IMMUNOLOGICAL REVIEWS

Toll-like receptor 4 activity protects against hepatocellular tumorigenesis and progression by regulating expression of DNA repair protein Ku70 in mice

(2013) Ziyan Wang et al.   HEPATOLOGY

Heat Shock Protein 90 Is Critical for Regulation of Phenotype and Functional Activity of Human T Lymphocytes and NK Cells

(2013) J. Bae et al.   JOURNAL OF IMMUNOLOGY

Phase II study of the HSP90-inhibitor BIIB021 in gastrointestinal stromal tumors

(2012) M. A. Dickson et al.   ANNALS OF ONCOLOGY

Role of NADPH oxidase/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases

(2012) I-Ta Lee et al.   BIOCHEMICAL PHARMACOLOGY

Heat Shock Protein 27 Mediated Signaling in Viral Infection

(2012) Jaya Rajaiya et al.   BIOCHEMISTRY

Targeting heat shock factor 1 with a triazole nucleoside analog to elicit potent anticancer activity on drug-resistant pancreatic cancer

(2012) Yi Xia et al.   CANCER LETTERS

Inhibition of HSP70: A challenging anti-cancer strategy

(2012) Anastasia R. Goloudina et al.   CANCER LETTERS

The stress-activated protein kinases p38α/β and JNK1/2 cooperate with Chk1 to inhibit mitotic entry upon DNA replication arrest

(2012) Alba Llopis et al.   CELL CYCLE

ATF4 is directly recruited by TLR4 signaling and positively regulates TLR4-trigged cytokine production in human monocytes

(2012) Chunyan Zhang et al.   Cellular & Molecular Immunology

Interleukin-1 (IL-1) family of cytokines: Role in Type 2 Diabetes

(2012) Monisha Banerjee et al.   CLINICA CHIMICA ACTA

Regulation of innate immunity by NADPH oxidase

(2012) Brahm H. Segal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sterile Inflammation in the Liver

(2012) Paul Kubes et al.   GASTROENTEROLOGY

The rhapsody of NLRPs: master players of inflammation … and a lot more

(2012) Lia Paola Zambetti et al.   IMMUNOLOGIC RESEARCH

Induction of type I IFNs by intracellular DNA-sensing pathways

(2012) Taner Cavlar et al.   IMMUNOLOGY AND CELL BIOLOGY

Inducible Heat Shock Protein 70 Reduces T Cell Responses and Stimulatory Capacity of Monocyte-derived Dendritic Cells

(2012) Pawel Stocki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactive Oxygen Species in Health and Disease

(2012) Assim A. Alfadda et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

New Insights into p53 Signaling and Cancer Cell Response to DNA Damage: Implications for Cancer Therapy

(2012) Razmik Mirzayans et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

DNA viruses and the cellular DNA-damage response

(2012) A. S. Turnell et al.   JOURNAL OF GENERAL VIROLOGY

Endoplasmic Reticulum Stress Regulates the Innate Immunity Critical Transcription Factor IRF3

(2012) Yi-Ping Liu et al.   JOURNAL OF IMMUNOLOGY

ATF6 Signaling Is Required for Efficient West Nile Virus Replication by Promoting Cell Survival and Inhibition of Innate Immune Responses

(2012) R. L. Ambrose et al.   JOURNAL OF VIROLOGY

Murine Cytomegalovirus Targets Transcription Factor ATF4 To Exploit the Unfolded-Protein Response

(2012) Z. Qian et al.   JOURNAL OF VIROLOGY

Interferon beta modulates major histocompatibility complex class I (MHC I) and CD3-zeta expression in PC12 cells

(2012) Rodrigo Fabrizzio Inácio et al.   NEUROSCIENCE LETTERS

DNA-PKcs Interacts with Aire and Regulates the Expression of Toll-Like Receptors in RAW264.7 Cells

(2012) J. Wu et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Signaling in Innate Immunity and Inflammation

(2012) K. Newton et al.   Cold Spring Harbor Perspectives in Biology

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway

(2012) P Menu et al.   Cell Death & Disease

DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

(2012) Brian J Ferguson et al.   eLife

Intestinal secretory cell ER stress and inflammation: Figure 1

(2011) Michael A. McGuckin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A review of the mammalian unfolded protein response

(2011) Anirikh Chakrabarti et al.   BIOTECHNOLOGY AND BIOENGINEERING

Circulating Heat Shock Protein 70 in Health, Aging and Disease

(2011) Rose Njemini et al.   BMC IMMUNOLOGY

New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress

(2011) Benjamin P.C. Chen et al.   CANCER LETTERS

Identification of new Rel/NFκB regulatory networks by focused genome location analysis

(2011) Adriana De Siervi et al.   CELL CYCLE

ATM protein kinase: the linchpin of cellular defenses to stress

(2011) Shahzad Bhatti et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses

(2011) Glen N Barber   CURRENT OPINION IN IMMUNOLOGY

The role of TLRs in neutrophil activation

(2011) Lynne R Prince et al.   CURRENT OPINION IN PHARMACOLOGY

Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins

(2011) Taro Kawai et al.   EMBO Molecular Medicine

The Cell Biology of the Unfolded Protein Response

(2011) J. Alan Diehl et al.   GASTROENTEROLOGY

Role of Heat Shock Proteins in Diseases and Their Therapeutic Potential

(2011) Gautam Kaul et al.   INDIAN JOURNAL OF MICROBIOLOGY

Pathogen Recognition by the Innate Immune System

(2011) Himanshu Kumar et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Mitochondrial reactive oxygen species drive proinflammatory cytokine production: Figure 1.

(2011) Edwina Naik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts

(2011) Hartmut Jaeschke   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Tumor Stress Inside Out: Cell-Extrinsic Effects of the Unfolded Protein Response in Tumor Cells Modulate the Immunological Landscape of the Tumor Microenvironment

(2011) N. R. Mahadevan et al.   JOURNAL OF IMMUNOLOGY

Selective Abrogation of BiP/GRP78 Blunts Activation of NF- B through the ATF6 Branch of the UPR: Involvement of C/EBP  and mTOR-Dependent Dephosphorylation of Akt

(2011) S. Nakajima et al.   MOLECULAR AND CELLULAR BIOLOGY

Choosing the right path: Does DNA-PK help make the decision?

(2011) Jessica A. Neal et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

NF-κB regulates DNA double-strand break repair in conjunction with BRCA1–CtIP complexes

(2011) Meta Volcic et al.   NUCLEIC ACIDS RESEARCH

The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α

(2011) Claudio Hetz et al.   PHYSIOLOGICAL REVIEWS

Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells

(2011) N. R. Mahadevan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Toll-Like Receptor Gene Family Is Integrated into Human DNA Damage and p53 Networks

(2011) Daniel Menendez et al.   PLoS Genetics

HSV Infection Induces Production of ROS, which Potentiate Signaling from Pattern Recognition Receptors: Role for S-glutathionylation of TRAF3 and 6

(2011) Regina Gonzalez-Dosal et al.   PLoS Pathogens

Inhibition of Nox2 Oxidase Activity Ameliorates Influenza A Virus-Induced Lung Inflammation

(2011) Ross Vlahos et al.   PLoS Pathogens

Glutathione peroxidase-1 protects against cigarette smoke-induced lung inflammation in mice

(2010) Chi Duong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mechanisms of the Hsp70 chaperone systemThis paper is one of a selection of papers published in this special issue entitled “Canadian Society of Biochemistry, Molecular & Cellular Biology 52nd Annual Meeting — Protein Folding: Principles and Diseases” and has undergone the Journal's usual peer review process.

(2010) Jason C. Young   Biochemistry and Cell Biology

Hsp60 expression, new locations, functions, and perspectives for cancer diagnosis and therapy

(2010) Francesco Cappello et al.   CANCER BIOLOGY & THERAPY

Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress

(2010) Ulrike Seifert et al.   CELL

The DNA-dependent protein kinase (DNA-PK): More than just a case of making ends meet?

(2010) Richard Hill et al.   CELL CYCLE

TNF-α-induced ROS production triggering apoptosis is directly linked to Romo1 and Bcl-XL

(2010) J J Kim et al.   CELL DEATH AND DIFFERENTIATION

LPS-induced cytokine levels are repressed by elevated expression of HSP70 in rats: possible role of NF-κB

(2010) Karol Dokladny et al.   CELL STRESS & CHAPERONES

Linking oxidative stress to inflammation: Toll-like receptors

(2010) Roop Gill et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

Negative Regulation of IRF7 Activation by Activating Transcription Factor 4 Suggests a Cross-Regulation between the IFN Responses and the Cellular Integrated Stress Responses

(2010) Q. Liang et al.   JOURNAL OF IMMUNOLOGY

XBP-1 Couples Endoplasmic Reticulum Stress to Augmented IFN-  Induction via a cis-Acting Enhancer in Macrophages

(2010) L. Zeng et al.   JOURNAL OF IMMUNOLOGY

ATM- and NEMO-Dependent ELKS Ubiquitination Coordinates TAK1-Mediated IKK Activation in Response to Genotoxic Stress

(2010) Zhao-Hui Wu et al.   MOLECULAR CELL

A Cytoplasmic ATM-TRAF6-cIAP1 Module Links Nuclear DNA Damage Signaling to Ubiquitin-Mediated NF-κB Activation

(2010) Michael Hinz et al.   MOLECULAR CELL

The phosphoproteome of toll-like receptor-activated macrophages

(2010) Gabriele Weintz et al.   Molecular Systems Biology

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Identification of gp96 as a Novel Target for Treatment of Autoimmune Disease in Mice

(2010) Jung Min Han et al.   PLoS One

Requirement of NOX2 and Reactive Oxygen Species for Efficient RIG-I-Mediated Antiviral Response through Regulation of MAVS Expression

(2010) Anton Soucy-Faulkner et al.   PLoS Pathogens

Oxidative Stress Enhances Toll-Like Receptor 3 Response to Double-Stranded RNA in Airway Epithelial Cells

(2009) Akira Koarai et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats

(2009) Monica L. DeLay et al.   ARTHRITIS AND RHEUMATISM

ER stress affects processing of MHC class I-associated peptides

(2009) Diana P Granados et al.   BMC IMMUNOLOGY

MRN and the race to the break

(2009) Agnieszka Rupnik et al.   CHROMOSOMA

Multi-faceted role of HSP40 in cancer

(2009) Aparna Mitra et al.   CLINICAL & EXPERIMENTAL METASTASIS

Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies

(2009) Shivaani Kummar et al.   EUROPEAN JOURNAL OF CANCER

Heat shock proteins and immunity: Application of hyperthermia for immunomodulation

(2009) Toshihiko Torigoe et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Selective and direct activation of human neutrophils but not eosinophils by Toll-like receptor 8

(2009) Markus Janke et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The SWI/SNF Chromatin-remodeling Complex Modulates Peripheral T Cell Activation and Proliferation by Controlling AP-1 Expression

(2009) Seung Min Jeong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses

(2009) S. Lipinski et al.   JOURNAL OF CELL SCIENCE

Activation of the Akt-NF- B Pathway by Subtilase Cytotoxin through the ATF6 Branch of the Unfolded Protein Response

(2009) H. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Adaptive suppression of the ATF4–CHOP branch of the unfolded protein response by toll-like receptor signalling

(2009) Connie W. Woo et al.   NATURE CELL BIOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation

(2009) S. Z. Ben-Sasson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIG-I-like receptors: Sensing and responding to RNA virus infection

(2009) Peyman Nakhaei et al.   SEMINARS IN IMMUNOLOGY

The role of mitochondria in cellular defense against microbial infection

(2009) Damien Arnoult et al.   SEMINARS IN IMMUNOLOGY

The protective role of ROS in autoimmune disease

(2009) Malin Hultqvist et al.   TRENDS IN IMMUNOLOGY

Intrinsic Cellular Defenses against Virus Infection by Antiviral Type I Interferon

(2009) Kyung-Hyun Boo et al.   YONSEI MEDICAL JOURNAL

The HSP90-SGT1 Chaperone Complex for NLR Immune Sensors

(2008) Ken Shirasu   Annual Review of Plant Biology

Neutrophil recognition of bacterial DNA and Toll-like receptor 9-dependent and -independent regulation of neutrophil function

(2008) Driss El Kebir et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis

(2008) John W. Rice et al.   ARTHRITIS AND RHEUMATISM

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

Macrophages Generate Reactive Oxygen Species in Response to Minimally Oxidized Low-Density Lipoprotein

(2008) Yun Soo Bae et al.   CIRCULATION RESEARCH

NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-κB and JNK pathways by inducing reactive oxygen species production

(2008) Ivan Tattoli et al.   EMBO REPORTS

Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-β inductionvia X-box binding protein 1

(2008) Judith A. Smith et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cytokine-induced β-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-XL

(2008) C. Holohan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Heat shock factor 1 inhibits nuclear factor–κB nuclear binding activity during endotoxin tolerance and heat shock

(2008) Mingchen Song et al.   JOURNAL OF CRITICAL CARE

Critical role of the NADPH oxidase subunit p47phox on vascular TLR expression and neointimal lesion formation in high-fat diet-induced obesity

(2008) Jian-Xiong Chen et al.   LABORATORY INVESTIGATION

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cytokine-based transformation of immune surveillance into tumor-promoting inflammation

(2008) J B Mumm et al.   ONCOGENE

Extracellular Superoxide Dismutase Protects Against Matrix Degradation of Heparan Sulfate in the Lung

(2007) Corrine R. Kliment et al.   ANTIOXIDANTS & REDOX SIGNALING