hPso4/hPrp19: a critical component of DNA repair and DNA damage checkpoint complexes

ATM-dependent phosphorylation of SNEVhPrp19/hPso4 is involved in extending cellular life span and suppression of apoptosis

(2016) Hanna Dellago et al.   Aging-US

Mechanisms of ATM Activation

(2015) Tanya T. Paull   Annual Review of Biochemistry

The core spliceosome as target and effector of non-canonical ATM signalling

(2015) Maria Tresini et al.   NATURE

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

(2015) Raphael Ceccaldi et al.   NATURE

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

DNA interstrand cross-link repair requires replication-fork convergence

(2015) Jieqiong Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA interstrand cross-link repair requires replication-fork convergence

(2015) Jieqiong Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining

(2015) Sean M. Howard et al.   PLoS Genetics

DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes

(2015) Peter Sykora et al.   NUCLEIC ACIDS RESEARCH

PRP19 upregulation inhibits cell proliferation in lung adenocarcinomas by p21-mediated induction of cell cycle arrest

(2014) Arko-Boham Benjamin et al.   BIOMEDICINE & PHARMACOTHERAPY

Aging: not all DNA damage is equal

(2014) Wilbert P Vermeij et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The PSO4 Protein Complex Associates with Replication Protein A (RPA) and Modulates the Activation of Ataxia Telangiectasia-mutated and Rad3-related (ATR)

(2014) Li Wan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of the Human Psoralen 4 (hPso4) Protein Complex in Replication Stress and Homologous Recombination

(2014) Mohammad Abbas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CSB interacts with SNM1A and promotes DNA interstrand crosslink processing

(2014) Teruaki Iyama et al.   NUCLEIC ACIDS RESEARCH

Mechanisms of genome instability induced by RNA-processing defects

(2014) Yujia A. Chan et al.   TRENDS IN GENETICS

ATM specifically mediates repair of double-strand breaks with blocked DNA ends

(2014) Alejandro Álvarez-Quilón et al.   Nature Communications

DNA DSB repair pathway choice: an orchestrated handover mechanism

(2013) A Kakarougkas et al.   BRITISH JOURNAL OF RADIOLOGY

BRCA1-Ku80 Protein Interaction Enhances End-joining Fidelity of Chromosomal Double-strand Breaks in the G1Phase of the Cell Cycle

(2013) Guochun Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The MLL recombinome of acute leukemias in 2013

(2013) C Meyer et al.   LEUKEMIA

Functional Intersection of ATM and DNA-Dependent Protein Kinase Catalytic Subunit in Coding End Joining during V(D)J Recombination

(2013) B.-S. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

The Mre11 Complex Suppresses Oncogene-Driven Breast Tumorigenesis and Metastasis

(2013) Gaorav P. Gupta et al.   MOLECULAR CELL

PRP19 Transforms into a Sensor of RPA-ssDNA after DNA Damage and Drives ATR Activation via a Ubiquitin-Mediated Circuitry

(2013) Alexandre Maréchal et al.   MOLECULAR CELL

The Prp19 Complex Directly Functions in Mitotic Spindle Assembly

(2013) Jennifer C. Hofmann et al.   PLoS One

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Checkpoint Kinases Regulate a Global Network of Transcription Factors in Response to DNA Damage

(2013) Eric J. Jaehnig et al.   Cell Reports

Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias

(2012) L A Tobin et al.   ONCOGENE

Charting the Landscape of Tandem BRCT Domain-Mediated Protein Interactions

(2012) N. T. Woods et al.   Science Signaling

The p53 network: cellular and systemic DNA damage responses in aging and cancer

(2012) H. Christian Reinhardt et al.   TRENDS IN GENETICS

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Exo70, a subunit of the exocyst complex, interacts with SNEVhPrp19/hPso4and is involved in pre-mRNA splicing

(2011) Hanna Dellago et al.   BIOCHEMICAL JOURNAL

Biochemical Characterization of Metnase’s Endonuclease Activity and Its Role in NHEJ Repair

(2011) Brian D. Beck et al.   BIOCHEMISTRY

The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair

(2011) Katja Lammens et al.   CELL

The Pso4 complex splices into the DNA damage response

(2011) Randy J. Legerski   CELL CYCLE

The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex

(2011) C. J. David et al.   GENES & DEVELOPMENT

Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions

(2011) Shan Zha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Metnase’s TIR binding activity by its binding partner, Pso4

(2010) Brian D. Beck et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Ancient origin of animal U-box ubiquitin ligases

(2010) Ignacio Marín   BMC EVOLUTIONARY BIOLOGY

The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome

(2010) E. J. Song et al.   GENES & DEVELOPMENT

Molecular Architecture of the Human Prp19/CDC5L Complex

(2010) M. Grote et al.   MOLECULAR AND CELLULAR BIOLOGY

ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks

(2010) Shan Zha et al.   NATURE

The Prp19 WD40 Domain Contains a Conserved Protein Interaction Region Essential for Its Function

(2010) Craig W. Vander Kooi et al.   STRUCTURE

Breast Cancer Amplified Sequence 2, a Novel Negative Regulator of the p53 Tumor Suppressor

(2009) P.-C. Kuo et al.   CANCER RESEARCH

The human intra-S checkpoint response to UVC-induced DNA damage

(2009) William K. Kaufmann   CARCINOGENESIS

Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint

(2009) Nianxiang Zhang et al.   EMBO REPORTS

Blom7α Is a Novel Heterogeneous Nuclear Ribonucleoprotein K Homology Domain Protein Involved in Pre-mRNA Splicing That Interacts with SNEVPrp19-Pso4

(2009) Johannes Grillari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PLRG1 Is an Essential Regulator of Cell Proliferation and Apoptosis during Vertebrate Development and Tissue Homeostasis

(2009) A. Kleinridders et al.   MOLECULAR AND CELLULAR BIOLOGY

Metnase Mediates Resistance to Topoisomerase II Inhibitors in Breast Cancer Cells

(2009) Justin Wray et al.   PLoS One

Human Pso4 Is a Metnase (SETMAR)-binding Partner That Regulates Metnase Function in DNA Repair

(2008) Brian D. Beck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA damage and ageing: new-age ideas for an age-old problem

(2008) George A. Garinis et al.   NATURE CELL BIOLOGY

The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation

(2008) E. A. Williamson et al.   NUCLEIC ACIDS RESEARCH

Haploinsufficiency of SNEV Causes Defects of Hematopoietic Stem Cells Functions

(2008) Elisabeth Schraml et al.   STEM CELLS AND DEVELOPMENT

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics