Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias

Treatment of chronic myeloid leukemia when imatinib fails

(2011) Rüdiger Hehlmann et al.   EXPERT OPINION ON PHARMACOTHERAPY

Functional Interplay of the Mre11 Nuclease and Ku in the Response to Replication-Associated DNA Damage

(2011) S. S. Foster et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting Abnormal DNA Repair in Therapy-Resistant Breast Cancers

(2011) L. A. Tobin et al.   MOLECULAR CANCER RESEARCH

Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair

(2011) Deniz Simsek et al.   NATURE

DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair

(2011) Yankun Gao et al.   NATURE

Cells expressing FLT3/ITD mutations exhibit elevated repair errors generated through alternative NHEJ pathways: implications for genomic instability and therapy

(2010) J. Fan et al.   BLOOD

Practical advice for determining the role of BCR-ABL mutations in guiding tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia

(2010) Elias Jabbour et al.   CANCER

CtIP promotes microhomology-mediated alternative end joining during class-switch recombination

(2010) Mieun Lee-Theilen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway

(2010) Yu Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ku Regulates the Non-Homologous End Joining Pathway Choice of DNA Double-Strand Break Repair in Human Somatic Cells

(2010) Farjana Fattah et al.   PLoS Genetics

Up-regulation of WRN and DNA ligase III  in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks

(2008) A. Sallmyr et al.   BLOOD

Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair

(2008) X. Chen et al.   CANCER RESEARCH

Targeted therapy for cancer using PARP inhibitors

(2008) Christopher J Lord et al.   CURRENT OPINION IN PHARMACOLOGY

Identification and Validation of Human DNA Ligase Inhibitors Using Computer-Aided Drug Design

(2008) Shijun Zhong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reciprocal Binding of PARP-1 and Histone H1 at Promoters Specifies Transcriptional Outcomes

(2008) R. Krishnakumar et al.   SCIENCE

Effect of double-strand break DNA sequence on the PARP-1 NHEJ pathway

(2007) Marc Audebert et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS