6-Azido hyacinthacine A2gives a straightforward access to the first multivalent pyrrolizidine architectures

The Multivalent Effect in Glycosidase Inhibition: A New, Rapidly Emerging Topic in Glycoscience

(2014) Philippe Compain et al.   CHEMBIOCHEM

A Convergent Strategy for the Synthesis of Second-Generation Iminosugar Clusters Using “Clickable” Trivalent Dendrons

(2014) Antoine Joosten et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A Systematic Investigation of Iminosugar Click Clusters as Pharmacological Chaperones for the Treatment of Gaucher Disease

(2013) Antoine Joosten et al.   CHEMBIOCHEM

The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Valency, Peripheral Ligand Structure, and Topology with Cyclodextrin-Based Iminosugar Click Clusters

(2013) Camille Decroocq et al.   CHEMBIOCHEM

Rescue of Functional CFTR Channels in Cystic Fibrosis: A Dramatic Multivalent Effect Using Iminosugar Cluster-Based Correctors

(2013) Philippe Compain et al.   CHEMBIOCHEM

Stereocomplementary Routes to Hydroxylated Nitrogen Heterocycles: Total Syntheses of Casuarine, Australine, and 7-epi-Australine

(2013) Camilla Parmeggiani et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fullerene-sp2-Iminosugar Balls as Multimodal Ligands for Lectins and Glycosidases: A Mechanistic Hypothesis for the Inhibitory Multivalent Effect

(2013) Rocío Rísquez-Cuadro et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and Glycosidase Inhibition Studies of 5-Methyl-Substituted Tetrahydroxyindolizidines and -pyrrolizidines Related to Natural Hyacinthacines B

(2013) Daniele Martella et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Exploring a Multivalent Approach to α-L-Fucosidase Inhibition

(2013) Elena Moreno-Clavijo et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Topological Effects and Binding Modes Operating with Multivalent Iminosugar-Based Glycoclusters and Mannosidases

(2013) Yoan Brissonnet et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multivalency as a Chemical Organization and Action Principle

(2012) Carlo Fasting et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Low-generation dendrimers with a calixarene core and based on a chiralC2-symmetric pyrrolidine as iminosugar mimics

(2012) Marco Marradi et al.   Beilstein Journal of Organic Chemistry

Cyclodextrin-Based Iminosugar Click Clusters: The First Examples of Multivalent Pharmacological Chaperones for the Treatment of Lysosomal Storage Disorders

(2012) Camille Decroocq et al.   CHEMBIOCHEM

Building Multivalent Iminosugar-Based Ligands on Calixarene Cores via Nitrone Cycloadditions

(2012) Francesca Cardona et al.   JOURNAL OF ORGANIC CHEMISTRY

Selective oxidative debenzylation of mono- and oligosaccharides in the presence of azides

(2011) Mathäus Niemietz et al.   CHEMICAL COMMUNICATIONS

The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Architectural Parameters with Cyclodextrin-based Iminosugar Click Clusters

(2011) Camille Decroocq et al.   CHEMISTRY-A EUROPEAN JOURNAL

Combining Glycomimetic and Multivalent Strategies toward Designing Potent Bacterial Lectin Inhibitors

(2011) Yoann M. Chabre et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Synthesis of (+)-Hyacinthacine A1, (+)-7a-epi-Hyacinthacine A1, (6R)-6-Hydroxyhyacinthacine A1 and (6S)-6-Hydroxy-7a-epi-hyacinthacine A1

(2011) Giampiero D'Adamio et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Glycosidase Inhibition with Fullerene Iminosugar Balls: A Dramatic Multivalent Effect

(2010) Philippe Compain et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Casuarine-6-O-α-d-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases

(2010) Francesca Cardona et al.   CHEMICAL COMMUNICATIONS

Synthesis, Biological Evaluation and Docking Studies of Casuarine Analogues: Effects of Structural Modifications at Ring B on Inhibitory Activity Towards Glucoamylase

(2010) Claudia Bonaccini et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A membrane-bound trehalase from Chironomus riparius larvae: purification and sensitivity to inhibition

(2010) M. Forcella et al.   GLYCOBIOLOGY

Insights in the rational design of synthetic multivalent glycoconjugates as lectin ligands

(2010) David Deniaud et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of the New 7S-Aminolentiginosine and Derivatives

(2009) Franca M. Cordero et al.   ADVANCED SYNTHESIS & CATALYSIS

Stereocontrolled Cyclic Nitrone Cycloaddition Strategy for the Synthesis of Pyrrolizidine and Indolizidine Alkaloids

(2009) Alberto Brandi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Syntheses of Casuarine and Its 6-O-α-Glucoside: Complementary Inhibition towards Glycoside Hydrolases of the GH31 and GH37 Families

(2009) Francesca Cardona et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Synthesis of (−)-Uniflorine A⊥

(2009) Camilla Parmeggiani et al.   JOURNAL OF NATURAL PRODUCTS

Maximising multivalency effects in protein–carbohydrate interactions

(2009) Roland J. Pieters   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and evaluation of dimeric lipophilic iminosugars as inhibitors of glucosylceramide metabolism

(2009) Tom Wennekes et al.   TETRAHEDRON-ASYMMETRY

Effects of Clustered Epitopes in Multivalent Ligand−Receptor Interactions†

(2008) Tarun K. Dam et al.   BIOCHEMISTRY

Modular synthesis of multivalent glycoarchitectures and their unique selectin binding behavior

(2008) Ilona Papp et al.   CHEMICAL COMMUNICATIONS

Cu-Catalyzed Azide−Alkyne Cycloaddition

(2008) Morten Meldal et al.   CHEMICAL REVIEWS

Glycomimetics and Glycodendrimers as High Affinity Microbial Anti-adhesins

(2008) Anne Imberty et al.   CHEMISTRY-A EUROPEAN JOURNAL

Easily Accessible Mono- and Polytopic ­β-Cyclodextrin Hosts by Click Chemistry

(2008) Maxime Mourer et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Expeditive Synthesis of Glycodendrimer Scaffolds Based on Versatile TRIS and Mannoside Derivatives

(2008) Yoann M. Chabre et al.   JOURNAL OF ORGANIC CHEMISTRY

Multivalent iminosugars to modulate affinity and selectivity for glycosidases

(2008) Jennifer Diot et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A convenient approach toward the synthesis of enantiopure isomers of DMDP and ADMDP

(2008) En-Lun Tsou et al.   TETRAHEDRON