Mitochondrial metabolism in pulmonary hypertension: beyond mountains there are mountains

Isolation and characterization of endothelial-to-mesenchymal transition cells in pulmonary arterial hypertension

(2018) Toshio Suzuki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Contributions of BMPR2 Mutations and Extrinsic Factors to Cellular Phenotypes of Pulmonary Arterial Hypertension Revealed by Induced Pluripotent Stem Cell Modeling

(2018) Fedir N. Kiskin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Features and Outcomes of Methamphetamine-associated Pulmonary Arterial Hypertension

(2018) Roham T. Zamanian et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

PPARγ Regulates Mitochondrial Structure and Function and Human Pulmonary Artery Smooth Muscle Cell Proliferation

(2018) Samantha M. Yeligar et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming

(2018) Angelo D'Alessandro et al.   ANTIOXIDANTS & REDOX SIGNALING

NMDA-Type Glutamate Receptor Activation Promotes Vascular Remodeling and Pulmonary Arterial Hypertension

(2018) Sébastien J. Dumas et al.   CIRCULATION

Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension

(2018) Kuang-Hueih Chen et al.   CIRCULATION

E2F1 Suppresses Oxidative Metabolism and Endothelial Differentiation of Bone Marrow Progenitor CellsNovelty and Significance

(2018) Shiyue Xu et al.   CIRCULATION RESEARCH

Sirtuin 1 regulates pulmonary artery smooth muscle cell proliferation

(2018) Giada Zurlo et al.   JOURNAL OF HYPERTENSION

A Metabolic Basis for Endothelial-to-Mesenchymal Transition

(2018) Jianhua Xiong et al.   MOLECULAR CELL

Oxidative stress increases M1dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA

(2018) Orrette R Wauchope et al.   NUCLEIC ACIDS RESEARCH

Endothelial Cell Metabolism in Health and Disease

(2018) Katerina Rohlenova et al.   TRENDS IN CELL BIOLOGY

Fatty acid synthase modulates proliferation, metabolic functions and angiogenesis in hypoxic pulmonary artery endothelial cells

(2017) Neetu Singh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health

(2017) Carl D. Koch et al.   FREE RADICAL BIOLOGY AND MEDICINE

PET-CMR in heart failure - synergistic or redundant imaging?

(2017) Michael A. Quail et al.   HEART FAILURE REVIEWS

Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension

(2017) Lian Tian et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Chronic complications of venous thromboembolism

(2017) M.-P. Winter et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients

(2017) Evangelos D. Michelakis et al.   Science Translational Medicine

Plasma acylcarnitines are associated with pulmonary hypertension

(2017) Nancy Luo et al.   Pulmonary Circulation

Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension

(2017) Robert A. Egnatchik et al.   Pulmonary Circulation

Emerging Metabolic Therapies in Pulmonary Arterial Hypertension

(2017) Lloyd Harvey et al.   Journal of Clinical Medicine

Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation

(2016) Jason Boehme et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Suppression of endothelial PGC-1α is associated with hypoxia-induced endothelial dysfunction and provides a new therapeutic target in pulmonary arterial hypertension

(2016) Jia-Xin Ye et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Decreased endothelial nitric oxide synthase expression and function contribute to impaired mitochondrial biogenesis and oxidative stress in fetal lambs with persistent pulmonary hypertension

(2016) Adeleye J. Afolayan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

HIPPO–Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension

(2016) Tatiana V. Kudryashova et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mechanisms of Lipid Accumulation in the Bone Morphogenetic Protein Receptor Type 2 Mutant Right Ventricle

(2016) Megha H. Talati et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Bone Marrow–derived Cells Contribute to the Pathogenesis of Pulmonary Arterial Hypertension

(2016) Ling Yan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhibition of fatty acid synthase is protective in pulmonary hypertension

(2016) Neetu Singh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1Clinical Perspective

(2016) Min Li et al.   CIRCULATION

Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial HypertensionClinical Perspective

(2016) Evan L. Brittain et al.   CIRCULATION

Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2αCLINICAL PERSPECTIVE

(2016) Zhiyu Dai et al.   CIRCULATION

Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial HypertensionClinical Perspective

(2016) Christopher J. Rhodes et al.   CIRCULATION

Mitochondria in lung disease

(2016) Suzanne M. Cloonan et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical iron deficiency disturbs normal human responses to hypoxia

(2016) Matthew C. Frise et al.   JOURNAL OF CLINICAL INVESTIGATION

Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension

(2016) Thomas Bertero et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic Profiling of Right Ventricular-Pulmonary Vascular Function Reveals Circulating Biomarkers of Pulmonary Hypertension

(2016) Gregory D. Lewis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Endothelial Prolyl-4-Hydroxylase Domain 2/Hypoxia-Inducible Factor 2 Axis Regulates Pulmonary Artery Pressure in Mice

(2016) Pinelopi P. Kapitsinou et al.   MOLECULAR AND CELLULAR BIOLOGY

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

New Biochemical Insights into the Mechanisms of Pulmonary Arterial Hypertension in Humans

(2016) Renata Bujak et al.   PLoS One

HIF2α–arginase axis is essential for the development of pulmonary hypertension

(2016) Andrew S. Cowburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-induced glucose-6-phosphate dehydrogenase overexpression and -activation in pulmonary artery smooth muscle cells: implication in pulmonary hypertension

(2015) Sukrutha Chettimada et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Vasculopathy and pulmonary hypertension in sickle cell disease

(2015) Karin P. Potoka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

RNA Sequencing Analysis Detection of a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension

(2015) Christopher J. Rhodes et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Endothelial Uncoupling Protein 2 Regulates Mitophagy and Pulmonary Hypertension During Intermittent Hypoxia

(2015) M. Haslip et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

BMPR2 Preserves Mitochondrial Function and DNA during Reoxygenation to Promote Endothelial Cell Survival and Reverse Pulmonary Hypertension

(2015) Isabel Diebold et al.   Cell Metabolism

Hypoxia-Mediated Increases in l -2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress

(2015) William M. Oldham et al.   Cell Metabolism

Five-Year Outcomes of Patients Enrolled in the REVEAL Registry

(2015) Harrison W. Farber et al.   CHEST

Maintaining Ancient Organelles: Mitochondrial Biogenesis and Maturation

(2015) R. B. Vega et al.   CIRCULATION RESEARCH

Iron Homeostasis and Pulmonary Hypertension: Iron Deficiency Leads to Pulmonary Vascular Remodeling in the Rat

(2015) E. Cotroneo et al.   CIRCULATION RESEARCH

Prevalence of metabolic syndrome in patients with pulmonary hypertension

(2015) Kamonpun Ussavarungsi et al.   Clinical Respiratory Journal

Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension

(2015) K. White et al.   EMBO Molecular Medicine

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

(2015) Sandra Schoors et al.   NATURE

Smooth muscle cell progenitors are primed to muscularize in pulmonary hypertension

(2015) Abdul Q. Sheikh et al.   Science Translational Medicine

Contribution of metabolic reprogramming to macrophage plasticity and function

(2015) Karim C. EL Kasmi et al.   SEMINARS IN IMMUNOLOGY

MtDNA mutagenesis impairs elimination of mitochondria during erythroid maturation leading to enhanced erythrocyte destruction

(2015) K.J. Ahlqvist et al.   Nature Communications

Increased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertension

(2015) John H. Newman et al.   Nature Communications

Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit

(2015) Thomas Bertero et al.   Cell Reports

Impaired Right Ventricular Hemodynamics Indicate Preclinical Pulmonary Hypertension in Patients With Metabolic Syndrome

(2015) D. M. Gopal et al.   Journal of the American Heart Association

Clinical, biochemical, and genetic spectrum of seven patients with NFU1 deficiency

(2015) Uwe Ahting et al.   Frontiers in Genetics

Effects of Ranolazine on Exercise Capacity, Right Ventricular Indices, and Hemodynamic Characteristics in Pulmonary Arterial Hypertension: A Pilot Study

(2015) Sadiya S. Khan et al.   Pulmonary Circulation

Intravenous Iron Therapy in Patients with Idiopathic Pulmonary Arterial Hypertension and Iron Deficiency

(2015) Gerrina Ruiter et al.   Pulmonary Circulation

Glucose-6-phosphate dehydrogenase plays a critical role in hypoxia-induced CD133+ progenitor cells self-renewal and stimulates their accumulation in the lungs of pulmonary hypertensive rats

(2014) Sukrutha Chettimada et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Kruppel-like factor

(2014) X. Wang et al.   BLOOD

Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice

(2014) XiuJie Li-Harms et al.   BLOOD

Sirtuin 3 Deficiency Is Associated with Inhibited Mitochondrial Function and Pulmonary Arterial Hypertension in Rodents and Humans

(2014) Roxane Paulin et al.   Cell Metabolism

The Metabolic Basis of Pulmonary Arterial Hypertension

(2014) Gopinath Sutendra et al.   Cell Metabolism

The Metabolic Theory of Pulmonary Arterial Hypertension

(2014) Roxane Paulin et al.   CIRCULATION RESEARCH

Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension

(2014) Marlene Rabinovitch et al.   CIRCULATION RESEARCH

Pulmonary Arterial Hypertension

(2014) Yen-Chun Lai et al.   CIRCULATION RESEARCH

Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension

(2014) Thomas Bertero et al.   JOURNAL OF CLINICAL INVESTIGATION

Adventitial Fibroblasts Induce a Distinct Proinflammatory/Profibrotic Macrophage Phenotype in Pulmonary Hypertension

(2014) Karim C. El Kasmi et al.   JOURNAL OF IMMUNOLOGY

Skeletal muscle proteomic signature and metabolic impairment in pulmonary hypertension

(2014) Simon Malenfant et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Four-dimensional flow assessment of pulmonary artery flow and wall shear stress in adult pulmonary arterial hypertension: Results from two institutions

(2014) Alex J. Barker et al.   MAGNETIC RESONANCE IN MEDICINE

Hypoxia-Inducible Factor 3 Is an Oxygen-Dependent Transcription Activator and Regulates a Distinct Transcriptional Response to Hypoxia

(2014) Peng Zhang et al.   Cell Reports

PGC1α-mediated Mitofusin-2 Deficiency in Female Rats and Humans with Pulmonary Arterial Hypertension

(2013) John J. Ryan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Superoxide Generated at Mitochondrial Complex III Triggers Acute Responses to Hypoxia in the Pulmonary Circulation

(2013) Gregory B. Waypa et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulation of Hypoxia-induced Pulmonary Hypertension by Vascular Smooth Muscle Hypoxia-Inducible Factor-1α

(2013) Molly K. Ball et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Evidence for Right Ventricular Lipotoxicity in Heritable Pulmonary Arterial Hypertension

(2013) Anna R. Hemnes et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mitochondrial Hyperpolarization in Pulmonary Vascular Remodeling. Mitochondrial Uncoupling Protein Deficiency as Disease Model

(2013) Oleg Pak et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Differential Regulation of Pulmonary Vascular Cell Growth by Hypoxia-Inducible Transcription Factor–1α and Hypoxia-Inducible Transcription Factor–2α

(2013) Aftab Ahmad et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2α

(2013) Manik C. Ghosh et al.   Cell Metabolism

Uncoupling Protein 2 Deficiency Mimics the Effects of Hypoxia and Endoplasmic Reticulum Stress on Mitochondria and Triggers Pseudohypoxic Pulmonary Vascular Remodeling and Pulmonary Hypertension

(2013) Peter Dromparis et al.   CIRCULATION RESEARCH

Pulmonary Hypertension Associated with Chronic Hemolytic Anemia and Other Blood Disorders

(2013) Roberto F. Machado et al.   CLINICS IN CHEST MEDICINE

Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension

(2013) Lin Piao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A metabolic remodeling in right ventricular hypertrophy is associated with decreased angiogenesis and a transition from a compensated to a decompensated state in pulmonary hypertension

(2013) Gopinath Sutendra et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Updated Clinical Classification of Pulmonary Hypertension

(2013) Gerald Simonneau et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Decreases in manganese superoxide dismutase expression and activity contribute to oxidative stress in persistent pulmonary hypertension of the newborn

(2012) Adeleye J. Afolayan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lung18F-Fluorodeoxyglucose Positron Emission Tomography for Diagnosis and Monitoring of Pulmonary Arterial Hypertension

(2012) Glenn Marsboom et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Modern Age Pathology of Pulmonary Arterial Hypertension

(2012) Elvira Stacher et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Immune and Inflammatory Cell Involvement in the Pathology of Idiopathic Pulmonary Arterial Hypertension

(2012) Rajkumar Savai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Disruption of Endothelial Cell Mitochondrial Bioenergetics in Lambs with Increased Pulmonary Blood Flow

(2012) Xutong Sun et al.   ANTIOXIDANTS & REDOX SIGNALING

Superoxide Dismutase Mimetic, MnTE-2-PyP, Attenuates Chronic Hypoxia-Induced Pulmonary Hypertension, Pulmonary Vascular Remodeling, and Activation of the NALP3 Inflammasome

(2012) Leah R. Villegas et al.   ANTIOXIDANTS & REDOX SIGNALING

Reversible Pulmonary Hypertension Associated With Vitamin C Deficiency

(2012) Markku Kupari et al.   CHEST

Dynamin-Related Protein 1–Mediated Mitochondrial Mitotic Fission Permits Hyperproliferation of Vascular Smooth Muscle Cells and Offers a Novel Therapeutic Target in Pulmonary Hypertension

(2012) Glenn Marsboom et al.   CIRCULATION RESEARCH

Metabolic Gene Remodeling and Mitochondrial Dysfunction in Failing Right Ventricular Hypertrophy Secondary to Pulmonary Arterial Hypertension

(2012) Jose Gomez-Arroyo et al.   Circulation-Heart Failure

Hyperpolarized13C magnetic resonance reveals early- and late-onset changes toin vivopyruvate metabolism in the failing heart

(2012) Marie A. Schroeder et al.   EUROPEAN JOURNAL OF HEART FAILURE

Reactive oxygen and nitrogen species in pulmonary hypertension

(2012) Diana M. Tabima et al.   FREE RADICAL BIOLOGY AND MEDICINE

Skeletal muscle mitochondrial dysfunction precedes right ventricular impairment in experimental pulmonary hypertension

(2012) Irina Enache et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

(2012) Kook Hwan Kim et al.   NATURE MEDICINE

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Metabolomic Analysis of Bone Morphogenetic Protein Receptor Type 2 Mutations in Human Pulmonary Endothelium Reveals Widespread Metabolic Reprogramming

(2012) Joshua P. Fessel et al.   Pulmonary Circulation

A Fatal Mitochondrial Disease Is Associated with Defective NFU1 Function in the Maturation of a Subset of Mitochondrial Fe-S Proteins

(2011) Aleix Navarro-Sastre et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Molecular Signature of a Right Heart Failure Program in Chronic Severe Pulmonary Hypertension

(2011) Jennifer I. Drake et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Iron deficiency in pulmonary arterial hypertension: a potential therapeutic target

(2011) C. J. Rhodes et al.   EUROPEAN RESPIRATORY JOURNAL

Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation

(2011) Federico Formenti et al.   FASEB JOURNAL

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Therapeutic inhibition of fatty acid oxidation in right ventricular hypertrophy: exploiting Randle’s cycle

(2011) Yong-Hu Fang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Iron Deficiency and Raised Hepcidin in Idiopathic Pulmonary Arterial Hypertension

(2011) Christopher J. Rhodes et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

The Role of Nogo and the Mitochondria-Endoplasmic Reticulum Unit in Pulmonary Hypertension

(2011) G. Sutendra et al.   Science Translational Medicine

Hypoxia Inducible-Factor1α Regulates the Metabolic Shift of Pulmonary Hypertensive Endothelial Cells

(2010) Iwona Fijalkowska et al.   AMERICAN JOURNAL OF PATHOLOGY

Plasma Levels of High-Density Lipoprotein Cholesterol and Outcomes in Pulmonary Arterial Hypertension

(2010) Gustavo A. Heresi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 in Pulmonary Arterial Hypertension

(2010) Stephen L. Archer et al.   CIRCULATION

The von Hippel–Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice

(2010) Michele M. Hickey et al.   JOURNAL OF CLINICAL INVESTIGATION

The Metabolic Syndrome and Cardiovascular Risk

(2010) Salvatore Mottillo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

(2010) D. R. Richardson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fatty Acid Oxidation and Malonyl-CoA Decarboxylase in the Vascular Remodeling of Pulmonary Hypertension

(2010) G. Sutendra et al.   Science Translational Medicine

Prolonged Hypoxia Increases ROS Signaling and RhoA Activation in Pulmonary Artery Smooth Muscle and Endothelial Cells

(2009) Annie Y. Chi et al.   ANTIOXIDANTS & REDOX SIGNALING

MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2

(2009) Stephen Y. Chan et al.   Cell Metabolism

Chronic Pulmonary Artery Pressure Elevation Is Insufficient to Explain Right Heart Failure

(2009) Harm J. Bogaard et al.   CIRCULATION

Age-Associated Increases in Pulmonary Artery Systolic Pressure in the General Population

(2009) Carolyn S.P. Lam et al.   CIRCULATION

Hypoxia Triggers Subcellular Compartmental Redox Signaling in Vascular Smooth Muscle Cells

(2009) Gregory B. Waypa et al.   CIRCULATION RESEARCH

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

(2009) R. A. DeFronzo et al.   DIABETES CARE

The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle

(2009) Lin Piao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Function and biogenesis of iron–sulphur proteins

(2009) Roland Lill   NATURE

The polymorphisms of UCP2 and UCP3 genes associated with fat metabolism, obesity and diabetes

(2009) J.-J. Jia et al.   Obesity Reviews

Pulmonary hypertension in children and young adults with sickle cell disease: Evidence for familial clustering

(2009) Hanane A. Dahoui et al.   PEDIATRIC BLOOD & CANCER

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Peripheral muscle dysfunction in idiopathic pulmonary arterial hypertension

(2009) V. Mainguy et al.   THORAX

Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling

(2008) Eva Nozik-Grayck et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2  mutation

(2008) D. P. Gale et al.   BLOOD

Insulin resistance in pulmonary arterial hypertension

(2008) R. T. Zamanian et al.   EUROPEAN RESPIRATORY JOURNAL

Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice

(2008) M. C. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1α-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer

(2007) Stephen L. Archer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY