Targeting Macrophage Subsets for Infarct Repair

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

(2014) Slava Epelman et al.   IMMUNITY

Cardiac Macrophages: How to Mend a Broken Heart

(2014) Heather B. Cohen et al.   IMMUNITY

Macrophages are required for neonatal heart regeneration

(2014) Arin B. Aurora et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcriptional Control of Macrophage Polarization

(2013) Derin Tugal et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The pathogenesis of cardiac fibrosis

(2013) Ping Kong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Developing insights into cardiac regeneration

(2013) Vincent M. Christoffels et al.   DEVELOPMENT

Cardiovascular disease in Europe: epidemiological update

(2013) Melanie Nichols et al.   EUROPEAN HEART JOURNAL

Monocytes and macrophages as nanomedicinal targets for improved diagnosis and treatment of disease

(2013) Marnix A Lameijer et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Monocyte/macrophage interactions with myogenic precursor cells during skeletal muscle regeneration

(2013) Marielle Saclier et al.   FEBS Journal

Cardiovascular science: opportunities for translating research into improved care

(2013) Eugene Braunwald   JOURNAL OF CLINICAL INVESTIGATION

Cardiac immune cell remodeling after myocardial infarction

(2013) Mohamed Ameen Ismahil et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Macrophage-Stem Cell Crosstalk After Myocardial Infarction∗

(2013) Filip K. Swirski et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Macrophage Subpopulations Are Essential for Infarct Repair With and Without Stem Cell Therapy

(2013) Tamar Ben-Mordechai et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Macrophage Plasticity and the Role of Inflammation in Skeletal Muscle Repair

(2013) Yacine Kharraz et al.   MEDIATORS OF INFLAMMATION

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Eric Olson

(2013)   NATURE REVIEWS GENETICS

Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair

(2013) Mei Xin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Treatment of Glucocorticoids Inhibited Early Immune Responses and Impaired Cardiac Repair in Adult Zebrafish

(2013) Wei-Chang Huang et al.   PLoS One

Macrophages are required for adult salamander limb regeneration

(2013) James W. Godwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beyond Stem Cells: Self-Renewal of Differentiated Macrophages

(2013) M. H. Sieweke et al.   SCIENCE

Leukocyte Behavior in Atherosclerosis, Myocardial Infarction, and Heart Failure

(2013) F. K. Swirski et al.   SCIENCE

Microglia and monocyte-derived macrophages: functionally distinct populations that act in concert in CNS plasticity and repair

(2013) Anat London et al.   Frontiers in Cellular Neuroscience

Thymosin β4-sulfoxide attenuates inflammatory cell infiltration and promotes cardiac wound healing

(2013) Mark A. Evans et al.   Nature Communications

Macrophages and CSF-1

(2013) Christina V Jones et al.   Organogenesis

Cardiac stem cell therapy to modulate inflammation upon myocardial infarction

(2012) F. van den Akker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Macrophages and fibrosis: How resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair

(2012) Maciej Lech et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart

(2012) Konstantinos Malliaras et al.   EMBO Molecular Medicine

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Human Macrophage Regulation Via Interaction With Cardiac Adipose Tissue-Derived Mesenchymal Stromal Cells

(2012) Shimrit Adutler-Lieber et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis

(2012) Florian Leuschner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hemin ameliorates indomethacin-induced small intestinal injury in mice through the induction of heme oxygenase-1

(2012) Hiroyuki Yoriki et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

PET/MRI of Inflammation in Myocardial Infarction

(2012) Won Woo Lee et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Tissues Use Resident Dendritic Cells and Macrophages to Maintain Homeostasis and to Regain Homeostasis upon Tissue Injury: The Immunoregulatory Role of Changing Tissue Environments

(2012) Maciej Lech et al.   MEDIATORS OF INFLAMMATION

Mammalian heart renewal by pre-existing cardiomyocytes

(2012) Samuel E. Senyo et al.   NATURE

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

(2012) Luke Boulter et al.   NATURE MEDICINE

Mononuclear phagocyte system in kidney disease and repair

(2012) Maliha A Alikhan et al.   NEPHROLOGY

Differentially Activated Macrophages Orchestrate Myogenic Precursor Cell Fate During Human Skeletal Muscle Regeneration

(2012) Marielle Saclier et al.   STEM CELLS

Toll-Like Receptors as Modulators of Mesenchymal Stem Cells

(2012) Olga DelaRosa et al.   Frontiers in Immunology

C-Reactive Protein Polarizes Human Macrophages to an M1 Phenotype and Inhibits Transformation to the M2 Phenotype

(2011) Sridevi Devaraj et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mesenchymal stromal cells mediate a switch to alternatively activated monocytes/macrophages after acute myocardial infarction

(2011) Victor Dayan et al.   BASIC RESEARCH IN CARDIOLOGY

Oncostatin M Is a Major Mediator of Cardiomyocyte Dedifferentiation and Remodeling

(2011) Thomas Kubin et al.   Cell Stem Cell

Early Macrophage Recruitment and Alternative Activation Are Critical for the Later Development of Hypoxia-Induced Pulmonary Hypertension

(2011) Eleni Vergadi et al.   CIRCULATION

Hyaluronan-modified and regular multilamellar liposomes provide sub-cellular targeting to macrophages, without eliciting a pro-inflammatory response

(2011) Yifat Glucksam-Galnoy et al.   JOURNAL OF CONTROLLED RELEASE

Distinct Macrophage Phenotypes Contribute to Kidney Injury and Repair

(2011) S. Lee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mesenchymal stromal cell ‘licensing’: a multistep process

(2011) M Krampera   LEUKEMIA

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

Therapeutic siRNA silencing in inflammatory monocytes in mice

(2011) Florian Leuschner et al.   NATURE BIOTECHNOLOGY

Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

(2011) Stephen J Galli et al.   NATURE IMMUNOLOGY

Modulation of cardiac macrophages by phosphatidylserine-presenting liposomes improves infarct repair

(2011) Tamar Harel-Adar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient Regenerative Potential of the Neonatal Mouse Heart

(2011) E. R. Porrello et al.   SCIENCE

Therapeutic Applications of Mesenchymal Stromal Cells: Paracrine Effects and Potential Improvements

(2011) Joyce Doorn et al.   TISSUE ENGINEERING PART B-REVIEWS

Metchnikoff's policemen: macrophages in development, homeostasis and regeneration

(2011) James A. Stefater et al.   TRENDS IN MOLECULAR MEDICINE

Heterogeneity of Human Monocytes: An Optimized Four-Color Flow Cytometry Protocol for Analysis of Monocyte Subsets

(2011) Tiziano Tallone et al.   Journal of Cardiovascular Translational Research

Heme oxygenase-1 is induced in peripheral blood mononuclear cells of patients with acute pancreatitis: a potential therapeutic target

(2010) Aida Habtezion et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Nomenclature of monocytes and dendritic cells in blood

(2010) L. Ziegler-Heitbrock et al.   BLOOD

Monocytes: Protagonists of Infarct Inflammation and Repair After Myocardial Infarction

(2010) Matthias Nahrendorf et al.   CIRCULATION

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Macrophages heterogeneity in atherosclerosis - implications for therapy

(2010) Heather M. Wilson   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

When Monocytes Come (Too) Close to Our Hearts⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.

(2010) Larissa Cardilo-Reis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Impaired Infarct Healing in Atherosclerotic Mice With Ly-6ChiMonocytosis

(2010) Peter Panizzi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mouse Bone Marrow-Derived Mesenchymal Stromal Cells Turn Activated Macrophages into a Regulatory-Like Profile

(2010) Julian Maggini et al.   PLoS One

Prevention of Muscle Aging by Myofiber-Associated Satellite Cell Transplantation

(2010) J. K. Hall et al.   Science Translational Medicine

Human Gingiva-Derived Mesenchymal Stem Cells Elicit Polarization of M2 Macrophages and Enhance Cutaneous Wound Healing

(2010) Qun-Zhou Zhang et al.   STEM CELLS

Tissue repair

(2010) Kristine P. Krafts   Organogenesis

Fibroblast Growth Factors: Biology, Function, and Application for Tissue Regeneration

(2010) Ye-Rang Yun et al.   Journal of Tissue Engineering

Heterogeneous In Vivo Behavior of Monocyte Subsets in Atherosclerosis

(2009) Filip K. Swirski et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophage Diversity and Polarization in Atherosclerosis

(2009) Alberto Mantovani et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component

(2009) Bryan N. Brown et al.   BIOMATERIALS

Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16- monocyte subsets

(2009) Petronela Ancuta et al.   BMC GENOMICS

Monocytes in heart failure: relationship to a deteriorating immune overreaction or a desperate attempt for tissue repair?

(2009) S. Apostolakis et al.   CARDIOVASCULAR RESEARCH

Macrophages and Inflammatory Mediators in Chemical Toxicity: A Battle of Forces

(2009) Debra L. Laskin   CHEMICAL RESEARCH IN TOXICOLOGY

Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology

(2009) Stephane Heymans et al.   EUROPEAN JOURNAL OF HEART FAILURE

Mesenchymal stem cell–educated macrophages: A novel type of alternatively activated macrophages

(2009) Jaehyup Kim et al.   EXPERIMENTAL HEMATOLOGY

Liposomal dexamethasone–diclofenac combinations for local osteoarthritis treatment

(2009) Inbar Elron-Gross et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Classically and alternatively activated macrophages contribute to tissue remodelling after myocardial infarction

(2009) C. Troidl et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Role of Macrophage-Derived IL-1 in Induction and Maintenance of Angiogenesis

(2009) Y. Carmi et al.   JOURNAL OF IMMUNOLOGY

Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

(2009) G. Solinas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Impact of Heterogeneity of Human Peripheral Blood Monocyte Subsets on Myocardial Salvage in Patients With Primary Acute Myocardial Infarction

(2009) Hiroto Tsujioka et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Heme Oxygenase-1 Contributes to an Alternative Macrophage Activation Profile Induced by Apoptotic Cell Supernatants

(2009) Nicole Weis et al.   MOLECULAR BIOLOGY OF THE CELL

Repair of Tissues by Adult Stem/Progenitor Cells (MSCs): Controversies, Myths, and Changing Paradigms

(2009) Darwin J Prockop   MOLECULAR THERAPY

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

(2009) Myriam Aouadi et al.   NATURE

The promises and pitfalls of RNA-interference-based therapeutics

(2009) Daniela Castanotto et al.   NATURE

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Solid polymeric microparticles enhance the delivery of siRNA to macrophages in vivo

(2009) S. Lee et al.   NUCLEIC ACIDS RESEARCH

Post-infarct remodelling: contribution of wound healing and inflammation

(2008) S. Frantz et al.   CARDIOVASCULAR RESEARCH

Tumor Necrosis Factor-α and Mortality in Heart Failure

(2008) Shannon M. Dunlay et al.   CIRCULATION

P-Selectin Glycoprotein Ligand-1 Is Highly Expressed on Ly-6C hi Monocytes and a Major Determinant for Ly-6C hi Monocyte Recruitment to Sites of Atherosclerosis in Mice

(2008) Guangyu An et al.   CIRCULATION

Immediate Mineralocorticoid Receptor Blockade Improves Myocardial Infarct Healing by Modulation of the Inflammatory Response

(2008) Daniela Fraccarollo et al.   HYPERTENSION

Macrophage roles following myocardial infarction

(2008) Jessica M. Lambert et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Macrophage diversity in renal injury and repair

(2008) Sharon D. Ricardo et al.   JOURNAL OF CLINICAL INVESTIGATION

Chitosan/siRNA Nanoparticle–mediated TNF-α Knockdown in Peritoneal Macrophages for Anti-inflammatory Treatment in a Murine Arthritis Model

(2008) Kenneth A Howard et al.   MOLECULAR THERAPY

Stem-cell therapy for cardiac disease

(2008) Vincent F. M. Segers et al.   NATURE

Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production

(2008) Krisztián Németh et al.   NATURE MEDICINE

The immune system and cardiac repair

(2008) N FRANGOGIANNIS   PHARMACOLOGICAL RESEARCH

The heme oxygenase inducer hemin protects against cardiac dysfunction and ventricular fibrillation in ischaemic/reperfused rat hearts: role of connexin 43

(2008) Päivi Lakkisto et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Macrophage Phenotype as a Determinant of Biologic Scaffold Remodeling

(2008) Stephen F. Badylak et al.   TISSUE ENGINEERING PART A

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark