Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain

H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO–TRPA1–CGRP signalling pathway

(2015) Mirjam Eberhardt et al.   Nature Communications

Directionality of Temperature Activation in Mouse TRPA1 Ion Channel Can Be Inverted by Single-Point Mutations in Ankyrin Repeat Six

(2014) Sairam Jabba et al.   NEURON

A Genetic Program Promotes C. elegans Longevity at Cold Temperatures via a Thermosensitive TRP Channel

(2013) Rui Xiao et al.   CELL

TRPV1 Channels Are Intrinsically Heat Sensitive and Negatively Regulated by Phosphoinositide Lipids

(2013) Erhu Cao et al.   NEURON

Species differences and molecular determinant of TRPA1 cold sensitivity

(2013) Jun Chen et al.   Nature Communications

Differential Expression and Functionality of TRPA1 Protein Genetic Variants in Conditions of Thermal Stimulation

(2012) Denisa May et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methylglyoxal Activates Nociceptors through Transient Receptor Potential Channel A1 (TRPA1)

(2012) Mirjam J. Eberhardt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Residues in the pore region ofDrosophilatransient receptor potential A1 dictate sensitivity to thermal stimuli

(2012) Hong Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Prostaglandin Metabolite Induces Inhibition of TRPA1 and Channel-Dependent Nociception

(2012) Yingqi Weng et al.   Molecular Pain

Molecular Architecture and Subunit Organization of TRPA1 Ion Channel Revealed by Electron Microscopy

(2011) Teresa L. Cvetkov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification ofin VivoDisulfide Conformation of TRPA1 Ion Channel

(2011) Liwen Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of TRPA1 thermal sensitivity enables sensory discrimination in Drosophila

(2011) Kyeongjin Kang et al.   NATURE

Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli

(2011) J. F. Cordero-Morales et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels

(2011) D. E. Clapham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ9-tetrahydrocannabiorcol

(2011) David A Andersson et al.   Nature Communications

Gating of Transient Receptor Potential Melastatin 8 (TRPM8) Channels Activated by Cold and Chemical Agonists in Planar Lipid Bilayers

(2010) E. Zakharian et al.   JOURNAL OF NEUROSCIENCE

Irritating channels: the case of TRPA1

(2010) Bernd Nilius et al.   JOURNAL OF PHYSIOLOGY-LONDON

Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception

(2010) Kyeongjin Kang et al.   NATURE

Molecular basis of infrared detection by snakes

(2010) Elena O. Gracheva et al.   NATURE

A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome

(2010) Barbara Kremeyer et al.   NEURON

Infrared Snake Eyes: TRPA1 and the Thermal Sensitivity of the Snake Pit Organ

(2010) V. C. Panzano et al.   Science Signaling

TRPA1 acts as a cold sensor in vitro and in vivo

(2009) Y. Karashima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of transient receptor potential A1 channel by phosphatidylinositol-4,5-bisphosphate

(2008) Donghee Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

TRPA1 Mediates the Noxious Effects of Natural Sesquiterpene Deterrents

(2008) Jasmine Escalera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Transmembrane Domain 5 as a Critical Molecular Determinant of Menthol Sensitivity in Mammalian TRPA1 Channels

(2008) B. Xiao et al.   JOURNAL OF NEUROSCIENCE