Generation of Aptamers with an Expanded Chemical Repertoire

Aptamer Nanomedicine for Cancer Therapeutics: Barriers and Potential for Translation

(2015) Yeh-Hsing Lao et al.   ACS Nano

Polymerase incorporation of a 2′-deoxynucleoside-5′-triphosphate bearing a 4-hydroxy-2-mercaptobenzimidazole nucleobase analogue

(2015) Kunihiko Morihiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Current approaches in SELEX: An update to aptamer selection technology

(2015) Mariia Darmostuk et al.   BIOTECHNOLOGY ADVANCES

Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition

(2015) Stacey L. Edwards et al.   CHEMICAL COMMUNICATIONS

A method for selecting modified DNAzymes without the use of modified DNA as a template in PCR

(2015) Marleen Renders et al.   CHEMICAL COMMUNICATIONS

Nucleic acid aptamers in cancer research, diagnosis and therapy

(2015) Haitao Ma et al.   CHEMICAL SOCIETY REVIEWS

Cell-Specific RNA Aptamer against Human CCR5 Specifically Targets HIV-1 Susceptible Cells and Inhibits HIV-1 Infectivity

(2015) Jiehua Zhou et al.   CHEMISTRY & BIOLOGY

Isoguanine and 5-Methyl-Isocytosine Bases, In Vitro and In Vivo

(2015) Omprakash Bande et al.   CHEMISTRY-A EUROPEAN JOURNAL

Turning mirror-image oligonucleotides into drugs: the evolution of Spiegelmer® therapeutics

(2015) Axel Vater et al.   DRUG DISCOVERY TODAY

Structural Basis for a Six Nucleotide Genetic Alphabet

(2015) Millie M. Georgiadis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evolution of Functional Six-Nucleotide DNA

(2015) Liqin Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA Polymerase-Mediated Synthesis of Unbiased Threose Nucleic Acid (TNA) Polymers Requires 7-Deazaguanine To Suppress G:G Mispairing during TNA Transcription

(2015) Matthew R. Dunn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selection of LNA-containing DNA aptamers against recombinant human CD73

(2015) Ida C. Elle et al.   Molecular BioSystems

In vitro selection of DNA-based aptamers that exhibit RNA-like conformations using a chimeric oligonucleotide library that contains two different xeno-nucleic acids

(2015) Kenta Hagiwara et al.   Molecular BioSystems

Predicting the Uncertain Future of Aptamer-Based Diagnostics and Therapeutics

(2015) John Bruno   MOLECULES

A Highlight of Recent Advances in Aptamer Technology and Its Application

(2015) Hongguang Sun et al.   MOLECULES

Methods for the directed evolution of proteins

(2015) Michael S. Packer et al.   NATURE REVIEWS GENETICS

Synthesis of DNA fragments containing 2′-deoxy-4′-selenonucleoside units using DNA polymerases: comparison of dNTPs with O, S and Se at the 4′-position in replication

(2015) N. Tarashima et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Exploring the potential impact of an expanded genetic code on protein function

(2015) Han Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy

(2015) Yetrib Hathout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diagnostic applications of gastric carcinoma cell aptamers in vitro and in vivo

(2015) Fei Ding et al.   TALANTA

Identification and Characterization of an Agonistic Aptamer Against the T Cell Costimulatory Receptor, OX40

(2015) Elizabeth D. Pratico et al.   Nucleic Acid Therapeutics

Scaffolding along Nucleic Acid Duplexes Using 2′-Amino-Locked Nucleic Acids

(2014) I. Kira Astakhova et al.   ACCOUNTS OF CHEMICAL RESEARCH

RNA Based Antagonist of NMDA Receptors

(2014) Garam Lee et al.   ACS Chemical Neuroscience

Thioaptamers targeting dengue virus type-2 envelope protein domain III

(2014) Sai Hari A. Gandham et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis

(2014) Werner G. Purschke et al.   BIOCHEMICAL JOURNAL

Nucleolin-targeting liposomes guided by aptamer AS1411 for the delivery of siRNA for the treatment of malignant melanomas

(2014) Liyu Li et al.   BIOMATERIALS

Synergistic inhibition of lung cancer cell invasion, tumor growth and angiogenesis using aptamer-siRNA chimeras

(2014) Wei-Yun Lai et al.   BIOMATERIALS

Crystal Structure of Interleukin-6 in Complex with a Modified Nucleic Acid Ligand

(2014) Amy D. Gelinas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemically Modified DNA Aptamers Bind Interleukin-6 with High Affinity and Inhibit Signaling by Blocking Its Interaction with Interleukin-6 Receptor

(2014) Shashi Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells

(2014) Andreas Herrmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Synthesis of Base-Modified 2′-Deoxyribonucleoside Triphosphates and Their Use in Enzymatic Synthesis of Modified DNA for Applications in Bioanalysis and Chemical Biology

(2014) Michal Hocek   JOURNAL OF ORGANIC CHEMISTRY

High Temperature SELMA: Evolution of DNA-Supported Oligomannose Clusters Which Are Tightly Recognized by HIV bnAb 2G12

(2014) J. Sebastian Temme et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of Receptor Signaling and of Glioblastoma-derived Tumor Growth by a Novel PDGFRβ Aptamer

(2014) Simona Camorani et al.   MOLECULAR THERAPY

A semi-synthetic organism with an expanded genetic alphabet

(2014) Denis A. Malyshev et al.   NATURE

Catalysts from synthetic genetic polymers

(2014) Alexander I. Taylor et al.   NATURE

A cross-chiral RNA polymerase ribozyme

(2014) Jonathan T. Sczepanski et al.   NATURE

Recent strategies targeting HIV glycans in vaccine design

(2014) Satoru Horiya et al.   Nature Chemical Biology

A synthetic approach to abiogenesis

(2014) James Attwater et al.   NATURE METHODS

Aptamer photoregulation in vivo

(2014) Lele Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilized Interleukin-6 receptor binding RNA aptamers

(2014) Cindy Meyer et al.   RNA Biology

Towards XNA nanotechnology: new materials from synthetic genetic polymers

(2014) Vitor B. Pinheiro et al.   TRENDS IN BIOTECHNOLOGY

Aptamer-conjugated nanomaterials for specific cancer cell recognition and targeted cancer therapy

(2014) Qiaoling Liu et al.   NPG Asia Materials

The synthesis and application of a diazirine-modified uridine analogue for investigating RNA–protein interactions

(2014) Christine C. Smith et al.   RSC Advances

DNA polymerases engineered by directed evolution to incorporate non-standard nucleotides

(2014) Roberto Laos et al.   Frontiers in Microbiology

New Technologies Provide Quantum Changes in the Scale, Speed, and Success of SELEX Methods and Aptamer Characterization

(2014) Abdullah Ozer et al.   Molecular Therapy-Nucleic Acids

Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents

(2014) John C Rohloff et al.   Molecular Therapy-Nucleic Acids

Selection of 2′F-modified RNA aptamers against prostate-specific antigen and their evaluation for diagnostic and therapeutic applications

(2013) M. Svobodova et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Application of Aptamers for Targeted Therapeutics

(2013) Partha Ray et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

2′,4′-BNA/LNA aptamers: CE-SELEX using a DNA-based library of full-length 2′-O,4′-C-methylene-bridged/linked bicyclic ribonucleotides

(2013) Yuuya Kasahara et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Directed Evolution of 2G12-Targeted Nonamannose Glycoclusters by SELMA

(2013) J. Sebastian Temme et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Mixed Mirror-image DNA/RNA Aptamer Inhibits Glucagon and Acutely Improves Glucose Tolerance in Models of Type 1 and Type 2 Diabetes

(2013) Axel Vater et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficacy of Base-Modification on Target Binding of Small Molecule DNA Aptamers

(2013) Yuri Imaizumi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Binding of a Structured d-RNA Molecule by an l-RNA Aptamer

(2013) Jonathan T. Sczepanski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of Hepatitis C Virus (HCV) Replication by Specific RNA Aptamers against HCV NS5B RNA Replicase

(2013) C. H. Lee et al.   JOURNAL OF VIROLOGY

Generation of high-affinity DNA aptamers using an expanded genetic alphabet

(2013) Michiko Kimoto et al.   NATURE BIOTECHNOLOGY

Deoxynucleoside triphosphates bearing histamine, carboxylic acid, and hydroxyl residues – synthesis and biochemical characterization

(2013) Marcel Hollenstein   ORGANIC & BIOMOLECULAR CHEMISTRY

Selection of an Aptamer Antidote to the Anticoagulant Drug Bivalirudin

(2013) Jennifer A. Martin et al.   PLoS One

In vitro selection with artificial expanded genetic information systems

(2013) K. Sefah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vitro Selection of Modified RNA Aptamers Against CD44 Cancer Stem Cell Marker

(2013) Nidaa Ababneh et al.   Nucleic Acid Therapeutics

PCR Amplification of 4′-ThioDNA Using 2′-Deoxy-4′-thionucleoside 5′-Triphosphates

(2013) Takamitsu Kojima et al.   ACS Synthetic Biology

CD28 Aptamers as Powerful Immune Response Modulators

(2013) Fernando Pastor et al.   Molecular Therapy-Nucleic Acids

In vivo SELEX for Identification of Brain-penetrating Aptamers

(2013) Congsheng Cheng et al.   Molecular Therapy-Nucleic Acids

Engineering of Targeted Nanoparticles for Cancer Therapy Using Internalizing Aptamers Isolated by Cell-Uptake Selection

(2012) Zeyu Xiao et al.   ACS Nano

Selection Strategy to Generate Aptamer Pairs that Bind to Distinct Sites on Protein Targets

(2012) Qiang Gong et al.   ANALYTICAL CHEMISTRY

X-Aptamers: A Bead-Based Selection Method for Random Incorporation of Druglike Moieties onto Next-Generation Aptamers for Enhanced Binding

(2012) Weiguo He et al.   BIOCHEMISTRY

The synthesis of 2′-methylseleno adenosine and guanosine 5′-triphosphates

(2012) Tobias Santner et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Screening mutant libraries of T7 RNA polymerase for candidates with increased acceptance of 2′-modified nucleotides

(2012) Vanessa Siegmund et al.   CHEMICAL COMMUNICATIONS

Synthesis of Deoxynucleoside Triphosphates that Include Proline, Urea, or Sulfonamide Groups and Their Polymerase Incorporation into DNA

(2012) Marcel Hollenstein   CHEMISTRY-A EUROPEAN JOURNAL

The XNA world: progress towards replication and evolution of synthetic genetic polymers

(2012) Vitor B Pinheiro et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Life's Simple Measures: Unlocking the Proteome

(2012) Edward Brody et al.   JOURNAL OF MOLECULAR BIOLOGY

Targeting Axl With an High-affinity Inhibitory Aptamer

(2012) Laura Cerchia et al.   MOLECULAR THERAPY

Amplification and Re-Generation of LNA-Modified Libraries

(2012) Holger Doessing et al.   MOLECULES

Nucleoside Triphosphates — Building Blocks for the Modification of Nucleic Acids

(2012) Marcel Hollenstein   MOLECULES

Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenitor

(2012) Hanyang Yu et al.   Nature Chemistry

Efficient Reverse Transcription Using Locked Nucleic Acid Nucleotides towards the Evolution of Nuclease Resistant RNA Aptamers

(2012) Lucile Crouzier et al.   PLoS One

Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets

(2012) D. R. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic Genetic Polymers Capable of Heredity and Evolution

(2012) V. B. Pinheiro et al.   SCIENCE

Dressed for success – applying chemistry to modulate aptamer functionality

(2012) Fabian Tolle et al.   Chemical Science

Multivalent Glycocluster Design through Directed Evolution

(2011) Iain S. MacPherson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Quantitative, High-Resolution Proteomics for Data-Driven Systems Biology

(2011) Jürgen Cox et al.   Annual Review of Biochemistry

Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor

(2011) E. K. Waters et al.   BLOOD

Enzymatic Recognition of 2′-Modified Ribonucleoside 5′-Triphosphates: Towards the Evolution of Versatile Aptamers

(2011) Lasse H. Lauridsen et al.   CHEMBIOCHEM

l-Pentoses in Biological and Medicinal Applications

(2011) Jonas J. Forsman et al.   CHEMICAL REVIEWS

Protein-inspired modified DNAzymes: dramatic effects of shortening side-chain length of 8-imidazolyl modified deoxyadenosines in selecting RNaseA mimicking DNAzymes

(2011) Christopher J. Hipolito et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

(2011) Larry Gold et al.   PLoS One

Inhibition of Cell Proliferation by an Anti-EGFR Aptamer

(2011) Na Li et al.   PLoS One

A Neutralizing RNA Aptamer against EGFR Causes Selective Apoptotic Cell Death

(2011) Carla Lucia Esposito et al.   PLoS One

Enzymatic synthesis of 2′-methylseleno-modified RNA

(2011) Vanessa Siegmund et al.   Chemical Science

Combinatorial Selection of DNA Thioaptamers Targeted to the HA Binding Domain of Human CD44

(2010) Anoma Somasunderam et al.   BIOCHEMISTRY

Polymerase-directed synthesis of C5-ethynyl locked nucleic acids

(2010) Rakesh N. Veedu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Engineered DNA Polymerases in Biotechnology

(2010) Ramon Kranaster  et al.   CHEMBIOCHEM

Nucleic Acids with a Six-Membered ‘Carbohydrate’ Mimic in the Backbone

(2010) Piet Herdewijn   CHEMISTRY & BIODIVERSITY

In vivo Fluorescence Imaging of Tumors using Molecular Aptamers Generated by Cell-SELEX

(2010) Hui Shi et al.   Chemistry-An Asian Journal

Expanding the Chemistry of DNA for in Vitro Selection

(2010) Jonathan D. Vaught et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Evolution of Functional Nucleic Acids with Chemical Modifications

(2010) Masayasu Kuwahara et al.   MOLECULES

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of Thioaptamer Ligand against E-Selectin: Potential Application for Inflamed Vasculature Targeting

(2010) Aman P. Mann et al.   PLoS One

The Chemical Biology of Aptamers

(2009) Günter Mayer   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polymerase engineering: towards the encoded synthesis of unnatural biopolymers

(2009) David Loakes et al.   CHEMICAL COMMUNICATIONS

Toward Safe Genetically Modified Organisms through the Chemical Diversification of Nucleic Acids

(2009) Piet Herdewijn et al.   CHEMISTRY & BIODIVERSITY

In vivo selection of tumor-targeting RNA motifs

(2009) Jing Mi et al.   Nature Chemical Biology

Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

(2009) Jiehua Zhou et al.   NUCLEIC ACIDS RESEARCH

Differential SELEX in Human Glioma Cell Lines

(2009) Laura Cerchia et al.   PLoS One

DNA aptamer-micelle as an efficient detection/delivery vehicle toward cancer cells

(2009) Y. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginine-modified DNA Aptamers That Show Enantioselective Recognition of the Dicarboxylic Acid Moiety of Glutamic Acid

(2008) Kazuomi OHSAWA et al.   ANALYTICAL SCIENCES

Investigations toward the selection of fully-modified 4′-thioRNA aptamers: Optimization of in vitro transcription steps in the presence of 4′-thioNTPs

(2008) Noriaki Minakawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Catalytic DNA (deoxyribozymes) for synthetic applications—current abilities and future prospects

(2008) Scott K. Silverman   CHEMICAL COMMUNICATIONS

SELEX with modified nucleotides

(2008) Anthony D Keefe et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Polymerase Chain Reaction and Transcription Using Locked Nucleic Acid Nucleotide Triphosphates

(2008) Rakesh N. Veedu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selecting Aptamers for a Glycoprotein through the Incorporation of the Boronic Acid Moiety

(2008) Minyong Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY