Identification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis

The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys

(2013) F. Schwoebel et al.   BLOOD

A Mixed Mirror-image DNA/RNA Aptamer Inhibits Glucagon and Acutely Improves Glucose Tolerance in Models of Type 1 and Type 2 Diabetes

(2013) Axel Vater et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bioactive Lipids S1P and C1P Are Prometastatic Factors in Human Rhabdomyosarcoma, and Their Tissue Levels Increase in Response to Radio/Chemotherapy

(2013) Gabriela Schneider et al.   MOLECULAR CANCER RESEARCH

A Novel C5a-neutralizing Mirror-image (l-)Aptamer Prevents Organ Failure and Improves Survival in Experimental Sepsis

(2013) Kai Hoehlig et al.   MOLECULAR THERAPY

Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs

(2012) Jason G. Cyster et al.   Annual Review of Immunology

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis

(2012) Suriyan Ponnusamy et al.   EMBO Molecular Medicine

Dual Blockade of the Homeostatic Chemokine CXCL12 and the Proinflammatory Chemokine CCL2 Has Additive Protective Effects on Diabetic Kidney Disease

(2011) Murthy N. Darisipudi et al.   AMERICAN JOURNAL OF PATHOLOGY

In vitro selection of Escherichia coli O157:H7-specific RNA aptamer

(2011) Young Ju Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sphingosine 1-phosphate induces vesicular endothelial growth factor expression in endothelial cells

(2011) Kyun Heo et al.   BMB Reports

Sphingolipids in cancer

(2011) Hideki Furuya et al.   CANCER AND METASTASIS REVIEWS

A Phase I Clinical Trial of Safingol in Combination with Cisplatin in Advanced Solid Tumors

(2011) M. A. Dickson et al.   CLINICAL CANCER RESEARCH

Development of a Sphingosylphosphorylcholine Detection System Using RNA Aptamers

(2011) Katsunori Horii et al.   MOLECULES

Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration

(2010) Roger A. Sabbadini   BRITISH JOURNAL OF PHARMACOLOGY

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

A novel lipopolysaccharide-antagonizing aptamer protects mice against endotoxemia

(2009) Ai-qing Wen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor- -stimulated collagen production by cardiac fibroblasts

(2009) N. Gellings Lowe et al.   CARDIOVASCULAR RESEARCH

Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies

(2009) Nicole O'Brien et al.   JOURNAL OF LIPID RESEARCH

Single-Stranded DNA Oligoaptamers: Molecular Recognition and LPS Antagonism Are Length- and Secondary Structure-Dependent

(2008) J.L. Ding et al.   Journal of Innate Immunity

"Inside-Out" Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

(2008) K. Takabe et al.   PHARMACOLOGICAL REVIEWS

Inhibition of stimulated meningeal blood flow by a calcitonin gene-related peptide binding mirror-image RNA oligonucleotide

(2006) Thomas Denekas et al.   BRITISH JOURNAL OF PHARMACOLOGY