Journal
TRENDS IN BIOTECHNOLOGY
Volume 32, Issue 6, Pages 321-328Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2014.03.010
Keywords
-
Categories
Funding
- Medical Research Council [MC_U105178804] Funding Source: Medline
- Medical Research Council [MC_U105178804] Funding Source: researchfish
- MRC [MC_U105178804] Funding Source: UKRI
Ask authors/readers for more resources
Nucleic acids display remarkable properties beyond information storage and propagation. The well-understood base pairing rules have enabled nucleic acids to be assembled into nanostructures of ever increasing complexity. Although nanostructures can be constructed using other building blocks, including peptides and lipids, it is the capacity to evolve that sets nucleic acids apart from all other nanoscale building materials. Nonetheless, the poor chemical and biological stability of DNA and RNA constrain their applications. Recent advances in nucleic acid chemistry and polymerase engineering enable the synthesis, replication, and evolution of a range of synthetic genetic polymers (XNAs) with improved chemical and biological stability. We discuss the impact of this technology on the generation of XNA ligands, enzymes, and nanostructures with tailor-made chemistry.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available