Application of Aptamers for Targeted Therapeutics

Near-Infrared Light-Triggered, Targeted Drug Delivery to Cancer Cells by Aptamer Gated Nanovehicles

(2012) Xinjian Yang et al.   ADVANCED MATERIALS

Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles

(2012) Huile Gao et al.   BIOMATERIALS

Whole-cell SELEX aptamer-functionalised poly(ethyleneglycol)-poly(ε-caprolactone) nanoparticles for enhanced targeted glioblastoma therapy

(2012) Huile Gao et al.   BIOMATERIALS

AS1411 aptamer tagged PLGA-lecithin-PEG nanoparticles for tumor cell targeting and drug delivery

(2012) Athulya Aravind et al.   BIOTECHNOLOGY AND BIOENGINEERING

Self-Assembled Aptamer-Based Drug Carriers for Bispecific Cytotoxicity to Cancer Cells

(2012) Guizhi Zhu et al.   Chemistry-An Asian Journal

Generating Aptamers by Cell-SELEX for Applications in Molecular Medicine

(2012) Mao Ye et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Designer Tridentate Mucin 1 Aptamer for Targeted Drug Delivery

(2012) Lihan Tan et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A phase 1 ascending dose study of a subcutaneously administered factor IXa inhibitor and its active control agent

(2012) J. P. VAVALLE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

UCLA1, a Synthetic Derivative of a gp120 RNA Aptamer, Inhibits Entry of Human Immunodeficiency Virus Type 1 Subtype C

(2012) H. T. Mufhandu et al.   JOURNAL OF VIROLOGY

Prodrug Strategy for PSMA-Targeted Delivery of TGX-221 to Prostate Cancer Cells

(2012) Yunqi Zhao et al.   MOLECULAR PHARMACEUTICS

Targeting Axl With an High-affinity Inhibitory Aptamer

(2012) Laura Cerchia et al.   MOLECULAR THERAPY

Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers

(2012) Kristina W. Thiel et al.   NUCLEIC ACIDS RESEARCH

Novel MUC1 Aptamer Selectively Delivers Cytotoxic Agent to Cancer Cells In Vitro

(2012) Yan Hu et al.   PLoS One

Targeted Delivery of Chemotherapy Agents Using a Liver Cancer-Specific Aptamer

(2012) Ling Meng et al.   PLoS One

In Vitro Selection of DNA Aptamers to Glioblastoma Multiforme

(2011) Abdullah Tahir Bayrac et al.   ACS Chemical Neuroscience

Near-Infrared Light-Responsive Core–Shell Nanogels for Targeted Drug Delivery

(2011) Huaizhi Kang et al.   ACS Nano

Aptamer-incorporated hydrogels for visual detection, controlled drug release, and targeted cancer therapy

(2011) Jun Liu et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Gold nanoparticle-assisted delivery of small, highly structured RNA into the nuclei of human cells

(2011) Sang-Mi Ryou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of cellular iron metabolism

(2011) Jian Wang et al.   BIOCHEMICAL JOURNAL

Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides

(2011) Jingwei Li et al.   BIOMATERIALS

Aptamer-functionalized PEG–PLGA nanoparticles for enhanced anti-glioma drug delivery

(2011) Jianwei Guo et al.   BIOMATERIALS

Molecular imaging of a cancer-targeting theragnostics probe using a nucleolin aptamer- and microRNA-221 molecular beacon-conjugated nanoparticle

(2011) Jin Kyeoung Kim et al.   BIOMATERIALS

Aptamer-conjugated and drug-loaded acoustic droplets for ultrasound theranosis

(2011) Chung-Hsin Wang et al.   BIOMATERIALS

Nanotextured substrates with immobilized aptamers for cancer cell isolation and cytology

(2011) Yuan Wan et al.   CANCER

RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule

(2011) Sarah Shigdar et al.   CANCER SCIENCE

Advances in tenascin-C biology

(2011) Kim S. Midwood et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Novel Aptamer Developed for Breast Cancer Cell Internalization

(2011) Kejing Zhang et al.   ChemMedChem

Nucleic Acid Aptamers: Clinical Applications and Promising New Horizons

(2011) X. Ni et al.   CURRENT MEDICINAL CHEMISTRY

Self-assemble gene delivery system for molecular targeting using nucleic acid aptamer

(2011) Tomoaki Kurosaki et al.   GENE

Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts

(2011) Xiaohua Ni et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras

(2011) Lee Adam Wheeler et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeted chemoimmunotherapy using drug-loaded aptamer–dendrimer bioconjugates

(2011) In-Hyun Lee et al.   JOURNAL OF CONTROLLED RELEASE

Aptamer-Conjugated Nanobubbles for Targeted Ultrasound Molecular Imaging

(2011) Chung-Hsin Wang et al.   LANGMUIR

PEGylated Anti-MUC1 Aptamer-Doxorubicin Complex for Targeted Drug Delivery to MCF7 Breast Cancer Cells

(2011) Lihan Tan et al.   MACROMOLECULAR BIOSCIENCE

Dual functional RNA nanoparticles containing phi29 motor pRNA and anti-gp120 aptamer for cell-type specific delivery and HIV-1 Inhibition

(2011) Jiehua Zhou et al.   METHODS

One-step engineering of silver nanoclusters–aptamer assemblies as luminescent labels to target tumor cells

(2011) Jinjin Yin et al.   Nanoscale

Broad-spectrum aptamer inhibitors of HIV reverse transcriptase closely mimic natural substrates

(2011) Mark A. Ditzler et al.   NUCLEIC ACIDS RESEARCH

Inhibition of Cell Proliferation by an Anti-EGFR Aptamer

(2011) Na Li et al.   PLoS One

A Neutralizing RNA Aptamer against EGFR Causes Selective Apoptotic Cell Death

(2011) Carla Lucia Esposito et al.   PLoS One

Novel Aptamer-Nanoparticle Bioconjugates Enhances Delivery of Anticancer Drug to MUC1-Positive Cancer Cells In Vitro

(2011) Chenchen Yu et al.   PLoS One

Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo

(2011) Shanta Dhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Aptamer-siRNA Chimera Suppresses HIV-1 Viral Loads and Protects from Helper CD4+ T Cell Decline in Humanized Mice

(2011) C. P. Neff et al.   Science Translational Medicine

Image-Guided Prostate Cancer Therapy Using Aptamer-Functionalized Thermally Cross-Linked Superparamagnetic Iron Oxide Nanoparticles

(2011) Mi Kyung Yu et al.   Small

A nanocomplex that is both tumor cell-selective and cancer gene-specific for anaplastic large cell lymphoma

(2011) Nianxi Zhao et al.   JOURNAL OF NANOBIOTECHNOLOGY

Fluorescent, Superparamagnetic Nanospheres for Drug Storage, Targeting, and Imaging: A Multifunctional Nanocarrier System for Cancer Diagnosis and Treatment

(2010) Hoon-Sung Cho et al.   ACS Nano

Aptamer-Based Tumor-Targeted Drug Delivery for Photodynamic Therapy

(2010) Yen-An Shieh et al.   ACS Nano

A Drug-Loaded Aptamer−Gold Nanoparticle Bioconjugate for Combined CT Imaging and Therapy of Prostate Cancer

(2010) Dongkyu Kim et al.   ACS Nano

Aptamer-Functionalized In Situ Injectable Hydrogel for Controlled Protein Release

(2010) Boonchoy Soontornworajit et al.   BIOMACROMOLECULES

Prostate cancer cell death produced by the co-delivery of Bcl-xL shRNA and doxorubicin using an aptamer-conjugated polyplex

(2010) Eunjung Kim et al.   BIOMATERIALS

Dual-aptamer-based delivery vehicle of doxorubicin to both PSMA (+) and PSMA (−) prostate cancers

(2010) Kyoungin Min et al.   BIOMATERIALS

Surface-Immobilized Aptamers for Cancer Cell Isolation and Microscopic Cytology

(2010) Y. Wan et al.   CANCER RESEARCH

Hydrogel functionalization with DNA aptamers for sustained PDGF-BB release

(2010) Boonchoy Soontornworajit et al.   CHEMICAL COMMUNICATIONS

Development of aptamer therapeutics

(2010) David HJ Bunka et al.   CURRENT OPINION IN PHARMACOLOGY

Immunoglobulin-like cell adhesion molecules: Novel signaling players in epithelial ovarian cancer

(2010) Lorenzo Bombardelli et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Metastasis-focused cell-based SELEX generates aptamers inhibiting cell migration and invasion

(2010) Elina Zueva et al.   INTERNATIONAL JOURNAL OF CANCER

Protection of HIV Neutralizing Aptamers against Rectal and Vaginal Nucleases

(2010) Michael D. Moore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA Aptamers Directed to Human Immunodeficiency Virus Type 1 Gag Polyprotein Bind to the Matrix and Nucleocapsid Domains and Inhibit Virus Production

(2010) D. Ramalingam et al.   JOURNAL OF VIROLOGY

Photoresponsive DNA-Cross-Linked Hydrogels for Controllable Release and Cancer Therapy

(2010) Huaizhi Kang et al.   LANGMUIR

A multivalent DNA aptamer specific for the B-cell receptor on human lymphoma and leukemia

(2010) Prabodhika R. Mallikaratchy et al.   NUCLEIC ACIDS RESEARCH

Surface Expressed Nucleolin Is Constantly Induced in Tumor Cells to Mediate Calcium-Dependent Ligand Internalization

(2010) Ara G. Hovanessian et al.   PLoS One

Delivery of Chlorambucil Using an Acoustically-Triggered Perfluoropentane Emulsion

(2010) Mario L. Fabiilli et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Initial Investigation of Acoustic Droplet Vaporization for Occlusion in Canine Kidney

(2010) M. Zhang et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Multifunctional Magnetic Nanoparticles: Design, Synthesis, and Biomedical Applications

(2009) Jinhao Gao et al.   ACCOUNTS OF CHEMICAL RESEARCH

Heat-sensitive microbubbles for intraoperative assessment of cancer ablation margins

(2009) Jiwei Huang et al.   BIOMATERIALS

Molecular Assembly of an Aptamer-Drug Conjugate for Targeted Drug Delivery to Tumor Cells

(2009) Yu-Fen Huang et al.   CHEMBIOCHEM

A liposome-based nanostructure for aptamer directed delivery

(2009) Huaizhi Kang et al.   CHEMICAL COMMUNICATIONS

Directed evolution of gold nanoparticle delivery to cells

(2009) Na Li et al.   CHEMICAL COMMUNICATIONS

Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer

(2009) Paula J. Bates et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles

(2009) Natalya Y. Rapoport et al.   JOURNAL OF CONTROLLED RELEASE

Targeted delivery of daunorubicin to T-cell acute lymphoblastic leukemia by aptamer

(2009) Seyed Mohammad Taghdisi et al.   JOURNAL OF DRUG TARGETING

Modifications Incorporated in CpG Motifs of Oligodeoxynucleotides Lead to Antagonist Activity of Toll-like Receptors 7 and 9

(2009) Dong Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Viral Capsid DNA Aptamer Conjugates as Multivalent Cell-Targeting Vehicles

(2009) Gary J. Tong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Using an RNA aptamer probe for flow cytometry detection of CD30-expressing lymphoma cells

(2009) Peng Zhang et al.   LABORATORY INVESTIGATION

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors

(2009) Justin P Dassie et al.   NATURE BIOTECHNOLOGY

In vivo selection of tumor-targeting RNA motifs

(2009) Jing Mi et al.   Nature Chemical Biology

Development of universal antidotes to control aptamer activity

(2009) Sabah Oney et al.   NATURE MEDICINE

Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

(2009) Jiehua Zhou et al.   NUCLEIC ACIDS RESEARCH

DNA aptamer-micelle as an efficient detection/delivery vehicle toward cancer cells

(2009) Y. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Liver Cancer-Specific Aptamers Using Whole Live Cells

(2008) Dihua Shangguan et al.   ANALYTICAL CHEMISTRY

The Nucleolin Targeting Aptamer AS1411 Destabilizes Bcl-2 Messenger RNA in Human Breast Cancer Cells

(2008) S. Soundararajan et al.   CANCER RESEARCH

Post-SELEX Chemical Optimization of a Trypanosome-Specific RNA Aptamer

(2008) H. Goringer et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

SELEX with modified nucleotides

(2008) Anthony D Keefe et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Cell-Specific Aptamer Probes for Membrane Protein Elucidation in Cancer Cells

(2008) Dihua Shangguan et al.   JOURNAL OF PROTEOME RESEARCH

Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles

(2008) Frank Alexis et al.   MOLECULAR PHARMACEUTICS

Novel Dual Inhibitory Function Aptamer–siRNA Delivery System for HIV-1 Therapy

(2008) Jiehua Zhou et al.   MOLECULAR THERAPY

Phototoxic aptamers selectively enter and kill epithelial cancer cells

(2008) Cátia S. M. Ferreira et al.   NUCLEIC ACIDS RESEARCH

Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles

(2008) S. Dhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aptamer-based endocytosis of a lysosomal enzyme

(2008) C.-h. B. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of an RNA aptamer bound to thrombin

(2008) S. B. Long et al.   RNA

An aptamer that neutralizes R5 strains of HIV-1 binds to core residues of gp120 in the CCR5 binding site

(2008) Carla Cohen et al.   VIROLOGY

Cell-Specific Internalization Study of an Aptamer from Whole Cell Selection

(2007) Zeyu Xiao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cell Specific Aptamer–Photosensitizer Conjugates as a Molecular Tool in Photodynamic Therapy

(2007) Prabodhika Mallikaratchy et al.   ChemMedChem