Article
Medicine, Research & Experimental
Hyungyeong Choi, Jeong-Hyun Yoon, Kumju Youn, Mira Jun
Summary: This study investigated the anti-melanogenic effects of decursin and its underlying mechanism. Decursin was found to inhibit melanin synthesis and exert its effects through the regulation of MITF and multiple signaling pathways. The anti-melanogenic effects of decursin were confirmed in ex vivo 3D human skin models, suggesting its potential as a protective agent against hyperpigmentation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Lei An, Mengxue Li, Cunen Zou, Ke Wang, Wei Zhang, Xiaolong Huang, Yousheng Wang
Summary: Accumulating evidence suggests that walnut polyphenols (WP) and their metabolites urolithins have protective effects on oxidative stress-induced damage in human neuroblastoma cells. The activation of cAMP-response element binding protein (CREB)-mediated signaling pathway, as well as the up-regulation of brain-derived neurotrophic factor (BDNF), is involved in the neuroprotective effects of WP and urolithin A (UroA). This study provides new insights into the beneficial effects of WP and UroA on brain function.
Article
Environmental Sciences
Jie Liu, Benke Liu, Ping Yuan, Li Cheng, Hong Sun, Jianxiong Gui, Yanan Pan, Dishu Huang, Hengsheng Chen, Li Jiang
Summary: Exposure to PM2.5 has been found to induce neurodevelopmental damage in primary cultured hippocampal neurons, including decreased viability, apoptosis, and synaptic damage. The PKA/CREB/BDNF pathways may play a vital role in PM2.5-mediated neurodevelopmental toxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Plant Sciences
Ming-yang Cai, Zhen Yang, Xian-ju Huang, Jing Li, Wu-ye Bao, Hurilebagen, Wulanqiqige, Wuyunsiriguleng, Jing-wen Cui, Li-qun Ma, Hai-ying Tong
Summary: Areca Thirteen Pill (GY-13) is a traditional Mongolian herbal formula used to treat depression. It exerts a potent antidepressant action by activating the cAMP/CREB/BDNF signaling pathway, promoting proliferation, and suppressing apoptosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Neurosciences
Shih-Ya Hung, Hsin-Yi Chung, Sih-Ting Luo, Yu-Ting Chu, Yu-Hsin Chen, Iona J. MacDonald, Szu-Yu Chien, Peddanna Kotha, Liang-Yo Yang, Ling-Ling Hwang, Nae J. Dun, De-Maw Chuang, Yi-Hung Chen
Summary: The study showed that acupuncture can reverse behavioral dysfunction caused by TBI, reduce the overexpression of HDAC1 and HDAC3, repair the downregulation of BDNF-associated signaling pathways, and help restore biochemical effects in the cortex of TBI mice.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Luting Yu, Shixi Liu, Ruixi Zhou, Hao Sun, Xiaojuan Su, Qian Liu, Shiping Li, Junjie Ying, Fengyan Zhao, Dezhi Mu, Yi Qu
Summary: Atorvastatin inhibits hypoxic-ischemia-induced neuronal apoptosis and alleviates brain injury in neonatal rats mainly by activating the cAMP/PKA/p-CREB/BDNF pathway, suggesting its potential as a therapeutic drug for neonatal HIE.
Article
Pharmacology & Pharmacy
Seyede Nazanin Zarneshan, Sajad Fakhri, Haroon Khan
Summary: Neurodegenerative diseases are major causes of death and morbidity in the elderly population, with oxidative stress, inflammation, and apoptosis playing detrimental roles in their pathogenesis. This review highlights the importance of the Akt/CREB/BDNF pathway as a therapeutic target for neurodegenerative diseases, and explores the potential neuroprotective effects of ginsenosides and their nanoformulations through targeting this pathway.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Cigdem Cicek, Emine Eren-Kocak, Pelin Telkoparan-Akillilar, Muslum Gok, Ebru Bodur
Summary: This study investigated the gender-specific differences in the PKA/CREB/BDNF signaling pathway in the hippocampus of chemically induced PKU rats. The results showed reduced locomotor activity in male PKU rats and decreased pCREB/CREB levels in female PKU rats, with no differences in learning and memory between males and females. The findings suggest a differential activation of the cAMP/PKA-CREB-BDNF signaling pathway in hippocampus of PKU rats based on gender, providing insights into disease pathophysiology.
METABOLIC BRAIN DISEASE
(2022)
Article
Agriculture, Dairy & Animal Science
Yuxiang Song, Kexin Wang, Juan J. Loor, Qianming Jiang, Yuchen Yang, Shang Jiang, Siyuan Liu, Jiyuan He, Xiancheng Feng, Xiliang Du, Lin Lei, Wenwen Gao, Guowen Liu, Xinwei Li
Summary: This study investigated the effects of BHB on neutrophil apoptosis and the underlying regulatory mechanisms during ketosis. The results showed that high concentrations of BHB inhibit apoptosis in bovine neutrophils by activating the ERK1/2 and AKT signaling pathways. These findings have important implications for understanding systemic inflammation in ketotic cows.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Behavioral Sciences
Nishant Ranjan Chauhan, Rahul Kumar, Avinash Gupta, Ramesh Chand Meena, Sarita Nanda, Kamla Prasad Mishra, Shashi Bala Singh
Summary: This study investigated the effects of heat stress on the hippocampus and spatial memory in rats, revealing that heat exposure can lead to oxidative damage, neuronal apoptosis and spatial memory deficits in the hippocampus. Furthermore, the dysregulation of the BDNF/ERK1/2/CREB axis was found to be associated with cognitive decline under heat stress.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Chemistry, Medicinal
Yu Shimada, Motofumi Kumazoe, Yushi Otsuka, Rin Tetsuzen, Yoshinori Fujimura, Hirofumi Tachibana
Summary: The number of patients diagnosed with dementia is increasing, but there is currently no cure for this disease. However, a recent study found that isoaldehyde, an aroma component of cacao nib extract, can upregulate the expression of brain-derived neurotrophic factor (BDNF) and potentially help prevent dementia.
JOURNAL OF NATURAL MEDICINES
(2023)
Article
Pharmacology & Pharmacy
Changxiang Li, Conglu Sui, Wei Wang, Juntang Yan, Nan Deng, Xin Du, Fafeng Cheng, Xiaona Ma, Xueqian Wang, Qingguo Wang
Summary: This study showed that baicalin protects neurons from oxidative stress, inflammation, and apoptosis by promoting astrocytes to release more BDNF. The neuroprotective effect is mainly mediated through the BDNF-TrkB pathway and downstream signaling regulators PI3K/Akt and MAPK/ERK1/2.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Li Ren, Hailou Zhang, Weiwei Tao, Yin Chen, Zhilu Zou, XiaoYan Guo, Qinqin Shen, Quansheng Feng, Jingqing Hu
Summary: Lag periods of therapeutic efficacy cause poor compliance of patients, making rapid antidepressants the most urgent need in depression study field. Through research, it has been discovered that Gardenia jasminoides J.Ellis and its iridoid fraction (GJ-IF) have rapid antidepressant effects. These effects are dependent on the activation of the PKA-CREB signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiao Zuo, Qing Li, Fuli Ya, Li-Juan Ma, Zezhong Tian, Mingzhu Zhao, Die Fan, Yimin Zhao, Yu-Heng Mao, Jian-Bo Wan, Yan Yang
Summary: This study showed that G-Rb2 and G-Rd2 derived from Panax notoginseng flowers effectively inhibited platelet aggregation and activation by modulating P2Y(12) signaling pathways, leading to attenuation of platelet hyperactivity and suppression of thrombus formation in vivo. G-Rd2 exhibited more potent inhibitory effects than G-Rb2, suggesting their potential preventive roles in thrombotic diseases.
Article
Oncology
Xinyu Li, Wen Chen, Chunkang Yang, Yisen Huang, Jing Jia, Rongyu Xu, Shen Guan, Ruijun Ma, Haitao Yang, Lifeng Xie
Summary: IGHG1 acts as an oncogene in gastric cancer by promoting cellular proliferation, migration, and chemo-resistance, and it activates the AKT/GSK-3/beta-Catenin axis to regulate these behaviors in gastric cancer cells.
CANCER CELL INTERNATIONAL
(2021)
Review
Neurosciences
Luana M. Manosso, Anderson Camargo, Alcir L. Dafre, Ana Lucia S. Rodrigues
Summary: Vitamin E has been found to play a role in the prevention and/or treatment of major depressive disorder (MDD) by modulating oxidative stress and neuroinflammation. This narrative review presents evidence from clinical and preclinical studies showing the relationship between low vitamin E status and MDD symptoms. More research is needed to determine the efficacy of vitamin E for alleviating depressive symptoms.
NUTRITIONAL NEUROSCIENCE
(2022)
Review
Neurosciences
Morgana Moretti, Ana Lucia S. Rodrigues
Summary: Ascorbic acid is a crucial neuroprotective compound that can prevent and treat neurodegenerative diseases and psychiatric disorders, with mechanisms involving neurogenesis and synaptic plasticity.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Ana Belen Ramos-Hryb, Francis L. Pazini, Ana Paula Costa, Mauricio P. Cunha, Manuella P. Kaster, Ana Lucia S. Rodrigues
Summary: The study discovered the crucial role of HO-1 in mediating the antidepressant-like effects of UA, and revealed a synergistic antidepressant effect when UA was combined with CoPP. Interestingly, fluoxetine did not show a significant correlation with the activity of HO-1.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Clinical Neurology
Anderson Camargo, Ana Paula Dalmagro, Eslen Delanogare, Daiane B. Fraga, Ingrid A. Wolin, Ana Lucia B. Zeni, Patricia S. Brocardo, Ana Lucia S. Rodrigues
Summary: The mTORC1 signaling pathway plays a key role in the antidepressant effects of ketamine and guanosine combination therapy, promoting fast and sustained antidepressant responses and dendritic spine formation.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Vivian B. Neis, Isabel Werle, Morgana Moretti, Priscila B. Rosa, Anderson Camargo, Yasmim de O. Dalsenter, Nicolle Platt, Axel F. Rosado, William D. Engel, Gudrian Ricardo L. de Almeida, Ingrid Selhorst, Alcir Luiz Dafre, Ana Lucia S. Rodrigues
Summary: Cholecalciferol deficiency has been associated with stress-related psychiatric disorders, particularly depression. However, this study found that cholecalciferol has an antidepressant-like effect in female mice and may exert its effects through modulation of the serotonergic system.
METABOLIC BRAIN DISEASE
(2022)
Review
Psychiatry
Anna Julie de Mello, Morgana Moretti, Ana Lucia S. Rodrigues
Summary: The COVID-19 pandemic is associated with an increased prevalence of mental health disorders, particularly anxiety and depression. The pandemic has caused stress due to factors such as fear of infection, social isolation, difficulty in adapting to new routines, misinformation, and economic impact. COVID-19 patients have elevated levels of pro-inflammatory cytokines, and the virus may invade the central nervous system, potentially leading to neuroinflammatory alterations.
WORLD JOURNAL OF PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Anderson Camargo, Luis E. B. Bettio, Priscila B. Rosa, Julia M. Rosa, Glorister A. Alte, Ana Lucia S. Rodrigues
Summary: This study reveals the antidepressant-like effect of Guanosine and the modulation of A(1)R and A(2A)R in its antidepressant action. Guanosine interacts with A(1)R and A(2A)R at the adenosine binding site.
PURINERGIC SIGNALLING
(2023)
Article
Biochemistry & Molecular Biology
Benildo Sousa Cavada, Messias Vital Oliveira, Vinicius Jose Silva Osterne, Vanir Reis Pinto-Junior, Francisco William Viana Martins, Cornevile Correia-Neto, Ronald Feitosa Pinheiro, Rodrigo Bainy Leal, Kyria Santiago Nascimento
Summary: Poor lifestyle choices and genetic predisposition contribute to the increase in cancer cases, such as breast cancer. The development of new strategies for early detection and treatment options is needed to improve survival rates. Glycans on cancer cell surfaces serve as efficient tumor cell markers and can be recognized by lectins. Plant lectins have potential applications in diagnosing and treating breast cancer by detecting and sorting glycans in healthy and malignant cells. Furthermore, lectins can be utilized in various ways, such as mapping differentially expressed glycans, histochemistry/cytochemistry analysis, lectin arrays, chromatographic matrices, drug delivery, and biosensing.
Article
Biochemistry & Molecular Biology
Ingrid A. V. Wolin, Ana Paula M. Nascimento, Rodrigo Seeger, Gabriela G. G. Poluceno, Alfeu Zanotto-Filho, Claudia B. B. Nedel, Carla I. I. Tasca, Sarah Elizabeth Gomes Correia, Messias Vital Oliveira, Vanir Reis Pinto-Junior, Vinicius Jose Silva Osterne, Kyria Santiago Nascimento, Benildo Sousa Cavada, Rodrigo Bainy Leal
Summary: Glioblastoma multiforme (GBM) is a highly aggressive type of glioma, and the study evaluated the antitumor capacity of the lectin DrfL on glioma cell cultures. DrfL induced morphological changes and cytotoxic effects in glioma cell cultures, and its action was dependent on interaction with glycans and required a carbohydrate recognition domain (CRD). DrfL inhibited tumor cell migration, adhesion, proliferation, and survival, while not affecting primary astrocytes.
GLYCOCONJUGATE JOURNAL
(2023)
Article
Clinical Neurology
German Josuet Lapo-Talledo, Jorge Andres Talledo-Delgado, Diego Portalanza, Ana Lucia S. Rodrigues, Aline Siteneski
Summary: Suicide rates and choice of suicide method have increased in Ecuador after natural disasters such as earthquakes and the COVID-19 confinement. Hanging accounted for the majority of suicide cases in the country. The province most severely affected by the 2016 earthquake saw an increased suicide rate.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Endocrinology & Metabolism
Bruna R. Kouba, Ana Clara N. C. Torra, Anderson Camargo, Ana Lucia S. Rodrigues
Summary: Vitamin D-3 has shown antidepressant-like responses in mice, possibly through increasing BDNF levels and synaptic protein synthesis.
METABOLIC BRAIN DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Anderson Camargo, Ana P. Dalmagro, Glorister A. Alte, Ana Lucia B. Zeni, Carla I. Tasca, Ana Lucia S. Rodrigues
Summary: This study investigated the antidepressant-like and neuroprotective effects of guanosine and ketamine in mice and found that both substances showed protective effects against glutamate-induced damage. The combination of guanosine and ketamine exhibited enhanced antidepressant-like effects and increased glutamine synthetase activity and GLT-1 levels. The findings suggest that guanosine has potential as a treatment for depression and should be further studied.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Endocrinology & Metabolism
Bruna R. Kouba, Anderson Camargo, Ana Lucia S. Rodrigues
Summary: Alzheimer's disease is primarily caused by neuroinflammation, as evidenced by the co-localization of amyloid-beta plaques with activated glial cells and increased levels of inflammatory cytokines. Current pharmacological treatments are challenging, hence compounds with anti-inflammatory and antioxidant properties are being explored as potential therapies. Vitamin D, due to its neuroprotective effects and high prevalence of deficiency, has emerged as a promising candidate. This review highlights the antioxidant and anti-inflammatory properties of vitamin D, and its potential effects on the neuroinflammatory process in Alzheimer's disease.
METABOLIC BRAIN DISEASE
(2023)
Article
Psychiatry
Yafit Levin, Rahel Bachem, Dorit Brafman, Menachem Ben-Ezra
Summary: Negative symptoms of schizophrenia have been overlooked, and this study found an association between negative symptoms and the risk of dissociative disorder, independently of depression and anxiety symptoms. It is important to consider both negative symptoms and dissociative symptoms in clinical practice to better understand their interaction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Review
Psychiatry
Roland Mergl, Sarah M. Quaatz, Vanessa Lemke, Antje-Kathrin Allgaier
Summary: Women who have had miscarriages or stillbirths have an increased risk for depressive symptoms and disorders, with a wide range of prevalence rates. However, depressive symptoms tend to diminish over time.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Hai-Yang Wang, Lin Zhang, Bei-Yan Guan, Shi-Yao Wang, Cui-Hong Zhang, Ming-Fei Ni, Yan-Wei Miao, Bing-Wei Zhang
Summary: This study investigates the association between cognitive reappraisal and panic disorder (PD), and finds that PD patients have weakened functional connectivity between the prefrontal cortex (PFC) and the amygdala, which is associated with the severity of PD symptoms. Additionally, cognitive reappraisal is negatively correlated with PD severity, and the PFC-amygdala functional connectivity plays a mediating role in this association.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Yanqiang Tao, Xinyuan Zou, Qihui Tang, Wenxin Hou, Shujian Wang, Zijuan Ma, Gang Liu, Xiangping Liu
Summary: Depression and anxiety are prevalent mental disorders among adolescents. The study utilized network analysis to examine the symptom dimension of depression and anxiety in different age groups of adolescents. The results indicated that different age groups have different key symptoms and bridging symptoms, highlighting the importance of targeting specific symptoms at different stages of adolescence in treatment to alleviate the comorbidity of anxiety and depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Philip J. Batterham, Aliza Werner-Seidler, Bridianne O'Dea, Alison L. Calear, Kate Maston, Andrew Mackinnon, Helen Christensen
Summary: Screening for psychological distress in adolescents is important, and the Distress Questionnaire-5 (DQ5) is a reliable measure for this purpose. The study found that DQ5 had good fit to a unidimensional construct, strong criterion and predictive validity, and sensitivity to change. The brevity and ease of interpretation of DQ5 make it suitable for screening in schools.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Xiaoli Liu, Qianqian Chen, Fang Cheng, Wenhao Zhuang, Wenwu Zhang, Yiping Tang, Dongsheng Zhou
Summary: This study found working memory defects in adolescents with major depressive disorder compared to healthy controls based on mean oxy-hemoglobin changes, which can be useful for distinguishing adolescents with MDD from healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Anders Nordahl-Hansen, Hugo Cogo-Moreira, Sareh Panjeh, Daniel S. Quintana
Summary: This article aims to determine empirically-derived effect size thresholds associated with psychotherapy for depressive disorders by calculating the effect size distribution. The findings indicate that the observed effect size thresholds are larger than the suggested guidelines, which has implications for interpreting study effects and planning future research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Guangli Zhao, Liyong Yu, Peixin Chen, Keli Zhu, Lu Yang, Wenting Lin, Yucai Luo, Zeyang Dou, Hao Xu, Pan Zhang, Tianmin Zhu, Siyi Yu
Summary: This study investigated the neural mechanisms underlying emotional attention bias in patients with CID using ERP and rs-FC approaches. The results revealed abnormalities in attention processing and connectivity in the emotion-cognition networks of CID patients. This study provides a neural basis for understanding attention bias in CID.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Major depressive disorder is a prevalent condition worldwide, but the proportion of patients receiving treatment has not increased. Biomarkers related to drug-treatment responses can be used to monitor the effectiveness of medication. Serum protein levels were compared among patients with depression who received medication, those who did not, and a control group. Eight biomarkers were identified, which can be used to monitor the effectiveness of drug treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Alfredo L. Sklar, Fang -Cheng Yeh, Mark Curtis, Dylan Seebold, Brian A. Coffman, Dean F. Salisbury
Summary: This study investigated semantic verbal fluency (SVF) impairments in first-episode psychosis patients within the schizophrenia spectrum. The findings revealed disruptions in both functional and structural connectivity in these patients, as well as an association between enhanced connectivity in the right hemisphere and worse SVF performance and longer disease duration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Maksymilian Rejek, Blazej Misiak
Summary: This study investigates the association of the exposome score (ES) with psychosis risk in a non-clinical population. The results show that the ES is associated with the extended psychosis phenotype, suggesting its potential to identify individuals who may benefit from further psychosis risk assessment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)