Recent Advances by In Silico and In Vitro Studies of Amyloid-β 1-42 Fibril Depicted a S-Shape Conformation

Conformational Dynamics and Stability of U-Shaped and S-Shaped Amyloid β Assemblies

(2018) Gianvito Grasso et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Energetics Underlying Twist Polymorphisms in Amyloid Fibrils

(2018) Xavier Periole et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The Effects of N-terminal Mutations on β-amyloid Peptide Aggregation and Toxicity

(2018) B.V. Foroutanpay et al.   NEUROSCIENCE

Dihydrochalcone molecules destabilize Alzheimer's amyloid-β protofibrils through binding to the protofibril cavity

(2018) Yibo Jin et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

A specific form of prefibrillar aggregates that functions as a precursor of amyloid nucleation

(2018) Naoki Yamamoto et al.   Scientific Reports

Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors

(2017) Pascal Krotee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NSAIDs as potential treatment option for preventing amyloid β toxicity in Alzheimer’s disease: an investigation by docking, molecular dynamics, and DFT studies

(2017) Faizul Azam et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Spectroscopic Signature for Stable β-Amyloid Fibrils versus β-Sheet-Rich Oligomers

(2017) Justin P. Lomont et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Conformational Ensembles of the Wild-Type and S8C Aβ1–42 Dimers

(2017) Viet Hoang Man et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Comparing the Aggregation Free Energy Landscapes of Amyloid Beta(1–42) and Amyloid Beta(1–40)

(2017) Weihua Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Studies for Improving a Rat Model of Alzheimer’s Disease: Icv Administration of Well-Characterized β-Amyloid 1-42 Oligomers Induce Dysfunction in Spatial Memory

(2017) Ágnes Kasza et al.   MOLECULES

In vitro monitoring of amyloid β-peptide oligomerization by Electrospray differential mobility analysis: An alternative tool to evaluate Alzheimer's disease drug candidates

(2017) Dimitri Brinet et al.   TALANTA

Ring-like N-fold Models of Aβ42 fibrils

(2017) Wenhui Xi et al.   Scientific Reports

Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity

(2017) Pascal Krotee et al.   eLife

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s amyloid-β A2T variant and its N-terminal peptides inhibit amyloid-β fibrillization and rescue the induced cytotoxicity

(2017) Tien-Wei Lin et al.   PLoS One

Aβ42 pentamers/hexamers are the smallest detectable oligomers in solution

(2017) Martin Wolff et al.   Scientific Reports

The A2V mutation as a new tool for hindering Aβ aggregation: A neutron and x-ray diffraction study

(2017) Laura Cantu’ et al.   Scientific Reports

Nuclear magnetic resonance evidence for the dimer formation of beta amyloid peptide 1–42 in 1,1,1,3,3,3-hexafluoro-2-propanol

(2016) Yoshiki Shigemitsu et al.   ANALYTICAL BIOCHEMISTRY

Monomeric Aβ1–40 and Aβ1–42 Peptides in Solution Adopt Very Similar Ramachandran Map Distributions That Closely Resemble Random Coil

(2016) Julien Roche et al.   BIOCHEMISTRY

Understanding Amyloid-β Oligomerization at the Molecular Level: The Role of the Fibril Surface

(2016) Bogdan Barz et al.   CHEMISTRY-A EUROPEAN JOURNAL

Amyloid-βpeptide aggregation and the influence of carbon nanoparticles

(2016) Wen-Hui Xi et al.   Chinese Physics B

Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils

(2016) Michael T. Colvin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-assembly of the full-length amyloid Aβ42 protein in dimers

(2016) Yuliang Zhang et al.   Nanoscale

An infrared spectroscopy approach to follow β-sheet formation in peptide amyloid assemblies

(2016) Jongcheol Seo et al.   Nature Chemistry

Implications for Alzheimer’s disease of an atomic resolution structure of amyloid-β(1–42) fibrils

(2016) David S. Eisenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-speed atomic force microscopy reveals structural dynamics of amyloid β1–42aggregates

(2016) Takahiro Watanabe-Nakayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril

(2016) Marielle Aulikki Wälti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

Polymorphism of fibrillar structures depending on the size of assembled Aβ17-42 peptides

(2016) Mookyung Cheon et al.   Scientific Reports

Analyzing dendritic spine pathology in Alzheimer’s disease: problems and opportunities

(2015) Mario M. Dorostkar et al.   ACTA NEUROPATHOLOGICA

Structural and nanomechanical comparison of epitaxially and solution-grown amyloid β25–35 fibrils

(2015) Ünige Murvai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Neuronal response in Alzheimer’s and Parkinson’s disease: the effect of toxic proteins on intracellular pathways

(2015) Shohreh Majd et al.   BMC NEUROSCIENCE

Two distinct β-sheet structures in Italian-mutant amyloid-beta fibrils: a potential link to different clinical phenotypes

(2015) Ellen Hubin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Supersaturation-limited and Unlimited Phase Transitions Compete to Produce the Pathway Complexity in Amyloid Fibrillation

(2015) Masayuki Adachi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Amyloid Polymorphism: Structural Basis and Neurobiological Relevance

(2015) Robert Tycko   NEURON

Clinical impact of 11C-Pittsburgh compound-B positron emission tomography carried out in addition to magnetic resonance imaging and single-photon emission computed tomography on the diagnosis of Alzheimer's disease in patients with dementia and mild cogni

(2015) Yoshie Omachi et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SDS-PAGE analysis of Aβ oligomers is disserving research into Alzheimer´s disease: appealing for ESI-IM-MS

(2015) Rosa Pujol-Pina et al.   Scientific Reports

In-vivoandin-vitrotechniques used to investigate Alzheimer's disease

(2015) Vishvanath Tiwari et al.   Frontiers in Life Science

Atomic force microscopy to study molecular mechanisms of amyloid fibril formation and toxicity in Alzheimer’s disease

(2014) Elizabeth Drolle et al.   DRUG METABOLISM REVIEWS

An improved capillary electrophoresis method for in vitro monitoring of the challenging early steps of Aβ1-42peptide oligomerization: Application to anti-Alzheimer's drug discovery

(2014) Dimitri Brinet et al.   ELECTROPHORESIS

The Alzheimer Disease Protective Mutation A2T Modulates Kinetic and Thermodynamic Properties of Amyloid-β (Aβ) Aggregation

(2014) Iryna Benilova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A brief overview of amyloids and Alzheimer's disease

(2014) Sian-Yang Ow et al.   PROTEIN SCIENCE

Oligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples

(2013) Andrew D. Watt et al.   ACTA NEUROPATHOLOGICA

Different effects of Alzheimer's peptide Aβ(1–40) oligomers and fibrils on supported lipid membranes

(2013) Claudio Canale et al.   BIOPHYSICAL CHEMISTRY

Brain amyloid-β oligomers in ageing and Alzheimer’s disease

(2013) Sylvain E. Lesné et al.   BRAIN

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

(2013) Jun-Xia Lu et al.   CELL

Novel Mechanistic Insight into the Molecular Basis of Amyloid Polymorphism and Secondary Nucleation during Amyloid Formation

(2013) Jae Sun Jeong et al.   JOURNAL OF MOLECULAR BIOLOGY

Alzheimer disease therapy—moving from amyloid-β to tau

(2013) Ezio Giacobini et al.   Nature Reviews Neurology

A Structure-Toxicity Study of Aß42 Reveals a New Anti-Parallel Aggregation Pathway

(2013) Hélène Vignaud et al.   PLoS One

Brain Imaging in Alzheimer Disease

(2013) K. A. Johnson et al.   Cold Spring Harbor Perspectives in Medicine

Unraveling the Early Events of Amyloid-β Protein (Aβ) Aggregation: Techniques for the Determination of Aβ Aggregate Size

(2012) N. Elizabeth Pryor et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aggregation and fibril morphology of the Arctic mutation of Alzheimer’s Aβ peptide by CD, TEM, STEM and in situ AFM

(2012) Nils Norlin et al.   JOURNAL OF STRUCTURAL BIOLOGY

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Multivariate Analyses of Amyloid-Beta Oligomer Populations Indicate a Connection between Pore Formation and Cytotoxicity

(2012) Panchika Prangkio et al.   PLoS One

Antiparallel  -sheet architecture in Iowa-mutant  -amyloid fibrils

(2012) W. Qiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Out-of-register  -sheets suggest a pathway to toxic amyloid aggregates

(2012) C. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic View of a Toxic Amyloid Small Oligomer

(2012) Arthur Laganowsky et al.   SCIENCE

Correlation of Amyloid PET Ligand Florbetapir F 18 Binding With Aβ Aggregation and Neuritic Plaque Deposition in Postmortem Brain Tissue

(2011) Seok Rye Choi et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

A New Structural Model of Aβ40Fibrils

(2011) Ivano Bertini et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antimicrobial Properties of Amyloid Peptides

(2011) Bruce L. Kagan et al.   MOLECULAR PHARMACEUTICS

Molecular basis for amyloid-  polymorphism

(2011) J.-P. Colletier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Environmental Conditions Affect the Kinetics of Nucleation of Amyloid Fibrils and Determine Their Morphology

(2010) Bertrand Morel et al.   BIOPHYSICAL JOURNAL

Amyloid structure and assembly: Insights from scanning transmission electron microscopy

(2010) Claire Goldsbury et al.   JOURNAL OF STRUCTURAL BIOLOGY

Structural conversion of neurotoxic amyloid-β1–42 oligomers to fibrils

(2010) Mahiuddin Ahmed et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hollow core of Alzheimer's A 42 amyloid observed by cryoEM is relevant at physiological pH

(2010) Y. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Common Architecture of Cross-β Amyloid

(2009) Thomas R. Jahn et al.   JOURNAL OF MOLECULAR BIOLOGY

Thermodynamic Perspective on the Dock−Lock Growth Mechanism of Amyloid Fibrils

(2009) Edward P. O’Brien et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Comparison of Alzheimer A (1-40) and A (1-42) amyloid fibrils reveals similar protofilament structures

(2009) M. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

(2008) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA