Self-assembly of the full-length amyloid Aβ42 protein in dimers

High-speed atomic force microscopy reveals structural dynamics of amyloid β1–42aggregates

(2016) Takahiro Watanabe-Nakayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tackling amyloidogenesis in Alzheimer’s disease with A2V variants of Amyloid-β

(2016) Giuseppe Di Fede et al.   Scientific Reports

Test and Evaluation of ff99IDPs Force Field for Intrinsically Disordered Proteins

(2015) Wei Ye et al.   Journal of Chemical Information and Modeling

Antiparallel β-Sheet Structure within the C-Terminal Region of 42-Residue Alzheimer's Amyloid-β Peptides When They Form 150-kDa Oligomers

(2015) Danting Huang et al.   JOURNAL OF MOLECULAR BIOLOGY

A novel form of β-strand assembly observed in Aβ33–42adsorbed onto graphene

(2015) Xiaofeng Wang et al.   Nanoscale

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration

(2015) Peng Liu et al.   Cell Reports

Effect of the English Familial Disease Mutation (H6R) on the Monomers and Dimers of Aβ40 and Aβ42

(2014) Man Hoang Viet et al.   ACS Chemical Neuroscience

The Structure of Misfolded Amyloidogenic Dimers: Computational Analysis of Force Spectroscopy Data

(2014) Yuliang Zhang et al.   BIOPHYSICAL JOURNAL

Balanced Protein–Water Interactions Improve Properties of Disordered Proteins and Non-Specific Protein Association

(2014) Robert B. Best et al.   Journal of Chemical Theory and Computation

Fibril Elongation by Aβ17–42: Kinetic Network Analysis of Hybrid-Resolution Molecular Dynamics Simulations

(2014) Wei Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cross Dimerization of Amyloid-β and αSynuclein Proteins in Aqueous Environment: A Molecular Dynamics Simulations Study

(2014) Jaya C. Jose et al.   PLoS One

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

(2014) Georg Meisl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic and Dynamic Insights into the Beneficial Effect of the 1,4-Naphthoquinon-2-yl-l-tryptophan Inhibitor on Alzheimer’s Aβ1–42 Dimer in Terms of Aggregation and Toxicity

(2013) Tong Zhang et al.   ACS Chemical Neuroscience

Mechanical Resistance in Unstructured Proteins

(2013) Sigurður Ægir Jónsson et al.   BIOPHYSICAL JOURNAL

Molecular Mechanism of Misfolding and Aggregation of Aβ(13–23)

(2013) Sándor Lovas et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Molecular Mechanism of the Inhibition of EGCG on the Alzheimer Aβ1–42 Dimer

(2013) Tong Zhang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Nanoprobing of misfolding and interactions of amyloid β 42 protein

(2013) Bo-Hyun Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Mechanism of amyloid β−protein dimerization determined using single−molecule AFM force spectroscopy

(2013) Zhengjian Lv et al.   Scientific Reports

Routine Access to Millisecond Time Scale Events with Accelerated Molecular Dynamics

(2012) Levi C.T. Pierce et al.   Journal of Chemical Theory and Computation

C-Terminal Turn Stability Determines Assembly Differences between Aβ40 and Aβ42

(2012) Robin Roychaudhuri et al.   JOURNAL OF MOLECULAR BIOLOGY

Dimerization of the Full-Length Alzheimer Amyloid β-Peptide (Aβ42) in Explicit Aqueous Solution: A Molecular Dynamics Study

(2012) Xiaoxia Zhu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Dimer Formation Enhances Structural Differences between Amyloid β-Protein (1–40) and (1–42): An Explicit-Solvent Molecular Dynamics Study

(2012) Bogdan Barz et al.   PLoS One

Effect of Spermidine on Misfolding and Interactions of Alpha-Synuclein

(2012) Alexey V. Krasnoslobodtsev et al.   PLoS One

Toxic fibrillar oligomers of amyloid-  have cross-  structure

(2012) J. C. Stroud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Out-of-register  -sheets suggest a pathway to toxic amyloid aggregates

(2012) C. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Side-chain hydrophobicity and the stability of Aβ16-22aggregates

(2012) Workalemahu M. Berhanu et al.   PROTEIN SCIENCE

Atomic View of a Toxic Amyloid Small Oligomer

(2012) Arthur Laganowsky et al.   SCIENCE

A partially folded structure of amyloid-beta(1–40) in an aqueous environment

(2011) Subramanian Vivekanandan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Amyloid-β peptide structure in aqueous solution varies with fragment size

(2011) Olivia Wise-Scira et al.   JOURNAL OF CHEMICAL PHYSICS

Monte Carlo Study of the Formation and Conformational Properties of Dimers of Aβ42 Variants

(2011) Simon Mitternacht et al.   JOURNAL OF MOLECULAR BIOLOGY

Using Selectively Applied Accelerated Molecular Dynamics to Enhance Free Energy Calculations

(2010) Jeff Wereszczynski et al.   Journal of Chemical Theory and Computation

Atomic-Level Characterization of the Ensemble of the Aβ(1–42) Monomer in Water Using Unbiased Molecular Dynamics Simulations and Spectral Algorithms

(2010) Nikolaos G. Sgourakis et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural conversion of neurotoxic amyloid-β1–42 oligomers to fibrils

(2010) Mahiuddin Ahmed et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stabilization of neurotoxic Alzheimer amyloid-  oligomers by protein engineering

(2010) A. Sandberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hollow core of Alzheimer's A 42 amyloid observed by cryoEM is relevant at physiological pH

(2010) Y. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dry amyloid fibril assembly in a yeast prion peptide is mediated by long-lived structures containing water wires

(2010) G. Reddy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic-Level Characterization of the Structural Dynamics of Proteins

(2010) D. E. Shaw et al.   SCIENCE

Antiparallel β-sheet: a signature structure of the oligomeric amyloid β-peptide

(2009) Emilie Cerf et al.   BIOCHEMICAL JOURNAL

Structural Characterization of a Soluble Amyloid β-Peptide Oligomer

(2009) Liping Yu et al.   BIOCHEMISTRY

Dynamics of locking of peptides onto growing amyloid fibrils

(2009) G. Reddy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-neurotoxicity relationships of amyloid  -protein oligomers

(2009) K. Ono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE