Intersection of AHR and Wnt Signaling in Development, Health, and Disease

Indirubin-3′-oxime, an activator of Wnt/β-catenin signaling, enhances osteogenic commitment of ST2 cells and restores bone loss in high-fat diet-induced obese male mice

(2014) Muhammad Zahoor et al.   BONE

In Utero Exposure to TCDD Alters Wnt Signaling During Mouse Prostate Development: Linking Ventral Prostate Agenesis to Downregulated β-Catenin Signaling

(2014) Andrew J. Schneider et al.   TOXICOLOGICAL SCIENCES

The aryl hydrocarbon receptor mediates raloxifene-induced apoptosis in estrogen receptor-negative hepatoma and breast cancer cells

(2014) E F O'Donnell et al.   Cell Death & Disease

Noncanonical Wnt5a enhances Wnt/β-catenin signaling during osteoblastogenesis

(2014) Masanori Okamoto et al.   Scientific Reports

Regulation of Wnt/β-catenin signaling by posttranslational modifications

(2014) Chenxi Gao et al.   Cell and Bioscience

Adult T-cell leukemia cells overexpress Wnt5a and promote osteoclast differentiation

(2013) M. Bellon et al.   BLOOD

Beta-catenin (CTNNB1) induces Bmp expression in urogenital sinus epithelium and participates in prostatic bud initiation and patterning

(2013) Vatsal Mehta et al.   DEVELOPMENTAL BIOLOGY

The small molecule indirubin-3′-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity

(2013) O M Choi et al.   INTERNATIONAL JOURNAL OF OBESITY

Wnt16 is Involved in Intramembranous Ossification and Suppresses Osteoblast Differentiation Through the Wnt/β-Catenin Pathway

(2013) Zheng Jiang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

2,3,7,8-TCDD induces neurotoxicity and neuronal apoptosis in the rat brain cortex and PC12 cell line through the down-regulation of the Wnt/β-catenin signaling pathway

(2013) Guangfei Xu et al.   NEUROTOXICOLOGY

TCDD Inhibition of Canonical Wnt Signaling Disrupts Prostatic Bud Formation in Mouse Urogenital Sinus

(2013) Amanda M. Branam et al.   TOXICOLOGICAL SCIENCES

Role of the Aryl Hydrocarbon Receptor in Carcinogenesis and Potential as a Drug Target

(2013) Stephen Safe et al.   TOXICOLOGICAL SCIENCES

Early Dioxin Exposure Causes Toxic Effects in Adult Zebrafish

(2013) Tracie R. Baker et al.   TOXICOLOGICAL SCIENCES

Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice

(2013) Joshua A. Harrill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

2,3,7,8-Tetrachlorodibenzo-p-dioxin stimulates proliferation of HAPI microglia by affecting the Akt/GSK-3β/cyclin D1 signaling pathway

(2013) Guangfei Xu et al.   TOXICOLOGY LETTERS

β-Catenin Is Required for Prostate Development and Cooperates with Pten Loss to Drive Invasive Carcinoma

(2013) Jeffrey C. Francis et al.   PLoS Genetics

Neuronal Target Identification Requires AHA-1-Mediated Fine-Tuning of Wnt Signaling in C. elegans

(2013) Jingyan Zhang et al.   PLoS Genetics

Mediating Effects of Aryl-Hydrocarbon Receptor and RhoA in Altering Brain Vascular Integrity

(2012) Chih-Cheng Chang et al.   AMERICAN JOURNAL OF PATHOLOGY

Polycyclic aromatic hydrocarbons and dibutyl phthalate disrupt dorsal–ventral axis determination via the Wnt/β-catenin signaling pathway in zebrafish embryos

(2012) Elise A. Fairbairn et al.   AQUATIC TOXICOLOGY

AhR-mediated changes in global gene expression in rat liver progenitor cells

(2012) Dagmar Faust et al.   ARCHIVES OF TOXICOLOGY

Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex

(2012) Vivian S.W. Li et al.   CELL

Interplay of β-Catenin with Xenobiotic-Sensing Receptors and its Role in Glutathione S-Transferase Expression

(2012) Albert Braeuning   CURRENT DRUG METABOLISM

Differential requirements for  -catenin during mouse development

(2012) S. Rudloff et al.   DEVELOPMENT

Wnt signaling though beta-catenin is required for prostate lineage specification

(2012) Brian W. Simons et al.   DEVELOPMENTAL BIOLOGY

Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development

(2012) Renée van Amerongen et al.   DEVELOPMENTAL BIOLOGY

The many faces and functions of β-catenin

(2012) Tomas Valenta et al.   EMBO JOURNAL

Wnt Inhibitory Factor 1 (Wif1) Is Regulated by Androgens and Enhances Androgen-Dependent Prostate Development

(2012) Kimberly P. Keil et al.   ENDOCRINOLOGY

Characterization of a Wnt-binding site of the WIF-domain of Wnt inhibitory factor-1

(2012) László Bányai et al.   FEBS LETTERS

Frizzled homolog proteins, microRNAs and Wnt signaling in cancer

(2012) Koji Ueno et al.   INTERNATIONAL JOURNAL OF CANCER

Roles of Heparan Sulfate Sulfation in Dentinogenesis

(2012) Satoru Hayano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidermal Wnt Controls Hair Follicle Induction by Orchestrating Dynamic Signaling Crosstalk between the Epidermis and Dermis

(2012) Jiang Fu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

LGR5 Interacts and Cointernalizes with Wnt Receptors To Modulate Wnt/ -Catenin Signaling

(2012) K. S. Carmon et al.   MOLECULAR AND CELLULAR BIOLOGY

ShRNA-mediated gene silencing of AHR promotes the differentiation of P19 mouse embryonic carcinoma cells into cardiomyocytes

(2012) CHUN ZHU et al.   Molecular Medicine Reports

Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B

(2012) Yu Sun et al.   NATURE MEDICINE

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AHR2 Mutant Reveals Functional Diversity of Aryl Hydrocarbon Receptors in Zebrafish

(2012) Britton C. Goodale et al.   PLoS One

Recombinant R-spondin2 and Wnt3a Up- and Down-Regulate Novel Target Genes in C57MG Mouse Mammary Epithelial Cells

(2012) Bolormaa Baljinnyam et al.   PLoS One

Dioxin Inhibits Zebrafish Epicardium and Proepicardium Development

(2012) Jessica Plavicki et al.   TOXICOLOGICAL SCIENCES

Inherent and Benzo[a]pyrene-Induced Differential Aryl Hydrocarbon Receptor Signaling Greatly Affects Life Span, Atherosclerosis, Cardiac Gene Expression, and Body and Heart Growth in Mice

(2012) Joanna S. Kerley-Hamilton et al.   TOXICOLOGICAL SCIENCES

Ahr2-dependence of PCB126 effects on the swim bladder in relation to expression of CYP1 and cox-2 genes in developing zebrafish

(2012) Maria E. Jönsson et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Wnt Signaling in Cancer

(2012) P. Polakis   Cold Spring Harbor Perspectives in Biology

The  -Catenin Destruction Complex

(2012) J. L. Stamos et al.   Cold Spring Harbor Perspectives in Biology

Activation of the aryl hydrocarbon receptor represses mammosphere formation in MCF-7 cells

(2011) Shuai Zhao et al.   CANCER LETTERS

Modulation of Wnt/ -catenin signaling pathway by bioactive food components

(2011) R. S. Tarapore et al.   CARCINOGENESIS

Cellular signaling and biological functions of R-spondins

(2011) Jeong Kyo Yoon et al.   CELLULAR SIGNALLING

A high-resolution molecular atlas of the fetal mouse lower urogenital tract

(2011) Lisa L. Abler et al.   DEVELOPMENTAL DYNAMICS

Dynamic Expression of Lgr5, a Wnt Target Gene, in the Developing and Mature Mouse Cochlea

(2011) Renjie Chai et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Genetic Regulation of Prostate Development

(2011) J. J. Meeks et al.   JOURNAL OF ANDROLOGY

Reproductive and developmental toxicity of dioxin in fish

(2011) Tisha C. King-Heiden et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

LEF1 Identifies Androgen-Independent Epithelium in the Developing Prostate

(2011) Xinyu Wu et al.   MOLECULAR ENDOCRINOLOGY

A somitic Wnt16/Notch pathway specifies haematopoietic stem cells

(2011) Wilson K. Clements et al.   NATURE

Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1

(2011) Tomas Malinauskas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) suppresses spheroids attachment on endometrial epithelial cells through the down-regulation of the Wnt-signaling pathway

(2011) Hilda Tsang et al.   REPRODUCTIVE TOXICOLOGY

Coordinate Regulation of Cytochrome P450 1A1 Expression in Mouse Liver by the Aryl Hydrocarbon Receptor and the β-Catenin Pathway

(2011) Albert Braeuning et al.   TOXICOLOGICAL SCIENCES

The Interplay of the Aryl Hydrocarbon Receptor and β-Catenin Alters Both AhR-Dependent Transcription and Wnt/β-Catenin Signaling in Liver Progenitors

(2011) Jiřina Procházková et al.   TOXICOLOGICAL SCIENCES

Hepatic transcriptomic responses to TCDD in dioxin-sensitive and dioxin-resistant rats during the onset of toxicity

(2011) Paul C. Boutros et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands

(2011) Eva Hrubá et al.   TOXICOLOGY LETTERS

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

(2011) Graciana Diez-Roux et al.   PLOS BIOLOGY

An introduction to the molecular basics of aryl hydrocarbon receptor biology

(2010) Josef Abel et al.   BIOLOGICAL CHEMISTRY

Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities

(2010) Ivy D Moffat et al.   BMC GENOMICS

WNT5A antagonizes WNT/β-catenin signaling and is frequently silenced by promoter CpG methylation in esophageal squamous cell carcinoma

(2010) Jisheng Li et al.   CANCER BIOLOGY & THERAPY

The aryl hydrocarbon receptor (AhR) in the regulation of cell-cell contact and tumor growth

(2010) C. Dietrich et al.   CARCINOGENESIS

Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors

(2010) L. Grumolato et al.   GENES & DEVELOPMENT

Wnt/β-catenin Signaling in Oral Tissue Development and Disease

(2010) F. Liu et al.   JOURNAL OF DENTAL RESEARCH

Expression of Aryl Hydrocarbon Receptor in Human Placentas and Fetal Tissues

(2010) Yi-zhou Jiang et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Molecular targets that link dioxin exposure to toxicity phenotypes

(2010) Wataru Yoshioka et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations

(2010) Mandayam O Nandan et al.   Molecular Cancer

In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces disruption of glands of the prostate and fibrosis in rhesus monkeys

(2010) Akihiro Arima et al.   REPRODUCTIVE TOXICOLOGY

Human and Rat Primary Hepatocyte CYP1A1 and 1A2 Induction with 2,3,7,8-Tetrachlorodibenzo-p-dioxin, 2,3,7,8-Tetrachlorodibenzofuran, and 2,3,4,7,8-Pentachlorodibenzofuran

(2010) Robert A. Budinsky et al.   TOXICOLOGICAL SCIENCES

A Wnt-Frz/Ror-Dsh Pathway Regulates Neurite Outgrowth in Caenorhabditis elegans

(2010) Song Song et al.   PLoS Genetics

WNT10A Mutations Are a Frequent Cause of a Broad Spectrum of Ectodermal Dysplasias with Sex-Biased Manifestation Pattern in Heterozygotes

(2009) Axel Bohring et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Transcriptomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in liver: Comparison of rat and mouse

(2009) Paul C Boutros et al.   BMC GENOMICS

WNT16B Is a New Marker of Cellular Senescence That Regulates p53 Activity and the Phosphoinositide 3-Kinase/AKT Pathway

(2009) R. Binet et al.   CANCER RESEARCH

The Aryl Hydrocarbon Receptor Functions as a Tumor Suppressor of Liver Carcinogenesis

(2009) Y. Fan et al.   CANCER RESEARCH

The role of Wnt5a in prostate gland development

(2009) Liwei Huang et al.   DEVELOPMENTAL BIOLOGY

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Inducibility of Drug-Metabolizing Enzymes by Xenobiotics in Mice with Liver-Specific Knockout of Ctnnb1

(2009) A. Braeuning et al.   DRUG METABOLISM AND DISPOSITION

Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation

(2009) Florian Witte et al.   GENE EXPRESSION PATTERNS

The aryl hydrocarbon receptor: a perspective on potential roles in the immune system

(2009) Emily A. Stevens et al.   IMMUNOLOGY

Expression of Wnts in the developing murine secondary palate

(2009) Dennis R. Warner et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells

(2009) Haluk Yuzugullu et al.   Molecular Cancer

Activation of the Aryl-Hydrocarbon Receptor Inhibits Invasive and Metastatic Features of Human Breast Cancer Cells and Promotes Breast Cancer Cell Differentiation

(2009) Julie M. Hall et al.   MOLECULAR ENDOCRINOLOGY

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands

(2009) K. Kawajiri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TCDD and a Putative Endogenous AhR Ligand, ITE, Elicit the Same Immediate Changes in Gene Expression in Mouse Lung Fibroblasts

(2009) Ellen C. Henry et al.   TOXICOLOGICAL SCIENCES

Dioxin-Dependent and Dioxin-Independent Gene Batteries: Comparison of Liver and Kidney in AHR-Null Mice

(2009) Paul C. Boutros et al.   TOXICOLOGICAL SCIENCES

Selective activation mechanisms of Wnt signaling pathways

(2009) Akira Kikuchi et al.   TRENDS IN CELL BIOLOGY

Interplay of Cadherin-Mediated Cell Adhesion and Canonical Wnt Signaling

(2009) J. Heuberger et al.   Cold Spring Harbor Perspectives in Biology

AHR signaling in prostate growth, morphogenesis, and disease

(2008) Chad M. Vezina et al.   BIOCHEMICAL PHARMACOLOGY

The androgen receptor can signal through Wnt/β-Catenin in prostate cancer cells as an adaptation mechanism to castration levels of androgens

(2008) Liang Schweizer et al.   BMC CELL BIOLOGY

Timing of Wingless signalling distinguishes maxillary and antennal identities in Drosophila melanogaster

(2008) G. Lebreton et al.   DEVELOPMENT

WNT5A selectively inhibits mouse ventral prostate development

(2008) Sarah Hicks Allgeier et al.   DEVELOPMENTAL BIOLOGY

Molecular signaling pathways that regulate prostate gland development

(2008) Gail S. Prins et al.   DIFFERENTIATION

Mesenchymal mechanisms in prostate organogenesis

(2008) Axel A. Thomson   DIFFERENTIATION

Prostate development: a historical perspective

(2008) Barry G. Timms   DIFFERENTIATION

β-catenin is involved in N-cadherin–dependent adhesion, but not in canonical Wnt signaling in E2A-PBX1–positive B acute lymphoblastic leukemia cells

(2008) Marit Kveine Nygren et al.   EXPERIMENTAL HEMATOLOGY

Crosstalk between AHR and Wnt signaling through R-Spondin1 impairs tissue regeneration in zebrafish

(2008) Lijoy K. Mathew et al.   FASEB JOURNAL

Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of  -catenin in mice

(2008) T. Grigoryan et al.   GENES & DEVELOPMENT

Targeted Suppression of β-Catenin Blocks Intestinal Adenoma Formation in APC Min Mice

(2008) Paul J. Foley et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Lung Development in the Holtzman Rat is Adversely Affected by Gestational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

(2008) Kevin M. Kransler et al.   TOXICOLOGICAL SCIENCES

Dioxin Causes Ventral Prostate Agenesis by Disrupting Dorsoventral Patterning in Developing Mouse Prostate

(2008) Chad M. Vezina et al.   TOXICOLOGICAL SCIENCES

The Search for Endogenous Activators of the Aryl Hydrocarbon Receptor

(2007) Linh P. Nguyen et al.   CHEMICAL RESEARCH IN TOXICOLOGY