Regulation of Wnt/β-catenin signaling by posttranslational modifications

ARTD10 substrate identification on protein microarrays: regulation of GSK3β by mono-ADP-ribosylation

(2013) Karla LH Feijs et al.   Cell Communication and Signaling

Lipid modification in Wnt structure and function

(2013) Jiyuan Ke et al.   CURRENT OPINION IN LIPIDOLOGY

HectD1 E3 Ligase Modifies Adenomatous Polyposis Coli (APC) with Polyubiquitin to Promote the APC-Axin Interaction

(2013) Hoanh Tran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HECT Domain-containing E3 Ubiquitin Ligase NEDD4L Negatively Regulates Wnt Signaling by Targeting Dishevelled for Proteasomal Degradation

(2013) Yi Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Consequences of Wnt-induced Dishevelled 2 Phosphorylation in Canonical and Noncanonical Wnt Signaling

(2013) José M. González-Sancho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smurf1-Mediated Lys29-Linked Nonproteolytic Polyubiquitination of Axin Negatively Regulates Wnt/ -Catenin Signaling

(2013) C. Fei et al.   MOLECULAR AND CELLULAR BIOLOGY

Acetylation of Human TCF4 (TCF7L2) Proteins Attenuates Inhibition by the HBP1 Repressor and Induces a Conformational Change in the TCF4::DNA Complex

(2013) Susanne Elfert et al.   PLoS One

Wnt Stabilization of  -Catenin Reveals Principles for Morphogen Receptor-Scaffold Assemblies

(2013) S.-E. Kim et al.   SCIENCE

Phosphorylation of Dishevelled by Protein Kinase RIPK4 Regulates Wnt Signaling

(2013) X. Huang et al.   SCIENCE

RNA Helicase DDX3 Is a Regulatory Subunit of Casein Kinase 1 in Wnt- -Catenin Signaling

(2013) C.-M. Cruciat et al.   SCIENCE

Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling

(2013) H Jung et al.   Oncogenesis

Lysine 394 is a novel Rad6B-induced ubiquitination site on beta-catenin

(2012) Brigitte Gerard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

FANCL ubiquitinates  -catenin and enhances its nuclear function

(2012) K.-H. T. Dao et al.   BLOOD

Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex

(2012) Vivian S.W. Li et al.   CELL

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Three decades of Wnts: a personal perspective on how a scientific field developed

(2012) Roel Nusse et al.   EMBO JOURNAL

Drugging Wnt signalling in cancer

(2012) Paul Polakis   EMBO JOURNAL

Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination

(2012) Z. Wang et al.   GENES & DEVELOPMENT

Reversible Modification of Adenomatous Polyposis Coli (APC) with K63-linked Polyubiquitin Regulates the Assembly and Activity of the β-Catenin Destruction Complex

(2012) Hoanh Tran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Malin Regulates Wnt Signaling Pathway through Degradation of Dishevelled2

(2012) Jaiprakash Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of ubiquitylation in receptor endocytosis and endosomal sorting

(2012) K. Haglund et al.   JOURNAL OF CELL SCIENCE

Non-canonical ubiquitin-based signals for proteasomal degradation

(2012) Y. Kravtsova-Ivantsiv et al.   JOURNAL OF CELL SCIENCE

The E3 Ubiquitin Ligase ITCH Negatively Regulates Canonical Wnt Signaling by Targeting Dishevelled Protein

(2012) W. Wei et al.   MOLECULAR AND CELLULAR BIOLOGY

Sequential Posttranslational Modifications Program FEN1 Degradation during Cell-Cycle Progression

(2012) Zhigang Guo et al.   MOLECULAR CELL

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

(2012) Bon-Kyoung Koo et al.   NATURE

Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages

(2012) Yogesh Kulathu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Beta-Catenin Phosphorylated at Threonine 120 Antagonizes Generation of Active Beta-Catenin by Spatial Localization in trans-Golgi Network

(2012) Cheng Du et al.   PLoS One

WIKI4, a Novel Inhibitor of Tankyrase and Wnt/ß-Catenin Signaling

(2012) Richard G. James et al.   PLoS One

Canonical Wnt suppressor, Axin2, promotes colon carcinoma oncogenic activity

(2012) Z.-Q. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetic Responses of  -Catenin Specify the Sites of Wnt Control

(2012) A. R. Hernandez et al.   SCIENCE

Proteomic Analysis of Lysine Acetylation Sites in Rat Tissues Reveals Organ Specificity and Subcellular Patterns

(2012) Alicia Lundby et al.   Cell Reports

Wnt/Ca2+ signaling pathway: a brief overview

(2011) Antara De   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Phosphorylation of TCF Proteins by Homeodomain-interacting Protein Kinase 2

(2011) Hiroki Hikasa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ubiquitin-Specific Protease USP34 Regulates Axin Stability and Wnt/ -Catenin Signaling

(2011) T. T. H. Lui et al.   MOLECULAR AND CELLULAR BIOLOGY

Reversible SUMOylation of TBL1-TBLR1 Regulates β-Catenin-Mediated Wnt Signaling

(2011) Hyo-Kyoung Choi et al.   MOLECULAR CELL

Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation

(2011) Yuji Kubota et al.   NATURE CELL BIOLOGY

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

(2011) Yue Zhang et al.   NATURE CELL BIOLOGY

Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling

(2011) Marinella G. Callow et al.   PLoS One

Dissecting Molecular Differences between Wnt Coreceptors LRP5 and LRP6

(2011) Bryan T. MacDonald et al.   PLoS One

Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin

(2011) Marc Fiedler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage

(2011) H. C. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Traf2- and Nck-Interacting Kinase Is Essential for Wnt Signaling and Colorectal Cancer Growth

(2010) Miki Shitashige et al.   CANCER RESEARCH

p53-Ubl fusions as models of ubiquitination, sumoylation and neddylation of p53

(2010) Stephanie A. Carter et al.   CELL CYCLE

Regulation of Lrp6 phosphorylation

(2010) Christof Niehrs et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of TCF3 by Wnt-Dependent Phosphorylation during Vertebrate Axis Specification

(2010) Hiroki Hikasa et al.   DEVELOPMENTAL CELL

Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt

(2010) Akiko Mukai et al.   EMBO JOURNAL

The Protein Stability of Axin, a Negative Regulator of Wnt Signaling, Is Regulated by Smad Ubiquitination Regulatory Factor 2 (Smurf2)

(2010) Sewoon Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Noncatalytic Domain of Glycogen Synthase Kinase-3 (GSK-3) Is Essential for Activity

(2010) Jessica L. Buescher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitogen-Activated Protein Kinases Promote WNT/ -Catenin Signaling via Phosphorylation of LRP6

(2010) I. Cervenka et al.   MOLECULAR AND CELLULAR BIOLOGY

The EDD E3 ubiquitin ligase ubiquitinates and up-regulates β-catenin

(2010) Avital Hay-Koren et al.   MOLECULAR BIOLOGY OF THE CELL

Loss of the Tumor Suppressor CYLD Enhances Wnt/β-Catenin Signaling through K63-Linked Ubiquitination of Dvl

(2010) Daniele V.F. Tauriello et al.   MOLECULAR CELL

Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation

(2010) Chan Gao et al.   NATURE CELL BIOLOGY

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

(2010) Jaclyn R. Gareau et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Post-translational modifications in signal integration

(2010) Yonathan Lissanu Deribe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of intermediary metabolism by protein acetylation

(2010) Kun-Liang Guan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression

(2009) Laura Arce et al.   BMC CANCER

Dishevelled: The hub of Wnt signaling

(2009) Chan Gao et al.   CELLULAR SIGNALLING

Cell Cycle Control of Wnt Receptor Activation

(2009) Gary Davidson et al.   DEVELOPMENTAL CELL

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

The kinase TNIK is an essential activator of Wnt target genes

(2009) Tokameh Mahmoudi et al.   EMBO JOURNAL

G Protein-coupled Receptor Kinases Phosphorylate LRP6 in the Wnt Pathway

(2009) Minyong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The COP9 Signalosome Mediates β-Catenin Degradation by Deneddylation and Blocks Adenomatous Polyposis coli Destruction via USP15

(2009) Xiaohua Huang et al.   JOURNAL OF MOLECULAR BIOLOGY

Nonproteolytic Functions of Ubiquitin in Cell Signaling

(2009) Zhijian J. Chen et al.   MOLECULAR CELL

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

(2009) Fuminori Tokunaga et al.   NATURE CELL BIOLOGY

Inhibition of GSK3 Phosphorylation of β-Catenin via Phosphorylated PPPSPXS Motifs of Wnt Coreceptor LRP6

(2009) Geng Wu et al.   PLoS One

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Rad6B Is a Positive Regulator of  -Catenin Stabilization

(2008) M. P.V. Shekhar et al.   CANCER RESEARCH

Rac1 Activation Controls Nuclear Localization of β-catenin during Canonical Wnt Signaling

(2008) Ximei Wu et al.   CELL

Wnt/β-catenin signaling: new (and old) players and new insights

(2008) He Huang et al.   CURRENT OPINION IN CELL BIOLOGY

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Fumiyo Ikeda et al.   EMBO REPORTS

SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability

(2008) Min Jung Kim et al.   FASEB JOURNAL

Parathyroid hormone signaling through low-density lipoprotein-related protein 6

(2008) M. Wan et al.   GENES & DEVELOPMENT

Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains

(2008) H. Tran et al.   GENES & DEVELOPMENT

Acetylation of non-histone proteins modulates cellular signalling at multiple levels

(2008) Stephanie Spange et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Wnt Signal Amplification via Activity, Cooperativity, and Regulation of Multiple Intracellular PPPSP Motifs in the Wnt Co-receptor LRP6

(2008) Bryan T. MacDonald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMOylation and De-SUMOylation: Wrestling with Life's Processes

(2008) Edward T. H. Yeh   JOURNAL OF BIOLOGICAL CHEMISTRY

p38 mitogen-activated protein kinase regulates canonical Wnt- -catenin signaling by inactivation of GSK3 

(2008) R. K. Bikkavilli et al.   JOURNAL OF CELL SCIENCE

PCAF Acetylates β-Catenin and Improves Its Stability

(2008) Xinjian Ge et al.   MOLECULAR BIOLOGY OF THE CELL

Lysine Acetylation: Codified Crosstalk with Other Posttranslational Modifications

(2008) Xiang-Jiao Yang et al.   MOLECULAR CELL

TBL1–TBLR1 and β-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis

(2008) Jiong Li et al.   NATURE CELL BIOLOGY

Jade-1 inhibits Wnt signalling by ubiquitylating β-catenin and mediates Wnt pathway inhibition by pVHL

(2008) Vipul C. Chitalia et al.   NATURE CELL BIOLOGY

The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth

(2008) Ron Firestein et al.   PLoS One

Direct Inhibition of GSK3β by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt/β-Catenin Signaling

(2008) Shunfu Piao et al.   PLoS One

Palmitoylation and ubiquitination regulate exit of the Wnt signaling protein LRP6 from the endoplasmic reticulum

(2008) L. Abrami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of  -catenin

(2008) C. S. Cselenyi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt3a-Mediated Formation of Phosphatidylinositol 4,5-Bisphosphate Regulates LRP6 Phosphorylation

(2008) W. Pan et al.   SCIENCE

Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3  Inactivation

(2008) T. M. Thornton et al.   SCIENCE