期刊
IMMUNOLOGY
卷 140, 期 2, 页码 143-152出版社
WILEY
DOI: 10.1111/imm.12123
关键词
homeostasis; immunity; innate immunity; kinase AKT; modulation; molecular mechanisms
类别
资金
- National Natural Science Foundation for General Programmes of China [C31171407, C8127301]
- Excellent Youth Foundation of Chinese Academy of Sciences [KSCX2- EW-Q-7-1]
- Key Basic Research Project of the Science and Technology Commission of Shanghai Municipality [12JC1400900]
Summary The critical roles of kinase AKT in tumour cell proliferation, apoptosis and protein synthesis have been widely recognized. But AKT also plays an important role in immune modulation. Recent studies have confirmed that kinase AKT can regulate the development and functions of innate immune cells (neutrophil, macrophage and dendritic cell). Studies have shown that different isoforms of kinase AKT have different effects in regulating immunity-related diseases, mainly through the mammalian target of rapamycin-dependent or -independent pathways. The purpose of this review is to illustrate the immune modulating effects of kinase AKT on innate immune cell development, survival and function.
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