Article
Chemistry, Inorganic & Nuclear
Rebekah N. Duffin, Philip C. Andrews
Summary: Six novel organogallium complexes have been synthesized and characterized, showing promising anti-leishmanial activity and selectivity.
DALTON TRANSACTIONS
(2023)
Article
Engineering, Environmental
Katarzyna Mizio, Donata Wawrzycka, Jacek Staszewski, Robert Wysocki, Ewa Maciaszczyk-Dziubinska
Summary: The Acr3 protein family is important for metalloid detoxification and consists of members from bacteria to higher plants. Most Acr3 transporters are specific for arsenite, but budding yeast Acr3 also has some capacity for antimonite transport. This study identified critical residues that determine substrate specificity, providing a valuable starting point for further research and potential applications in bioremediation.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Multidisciplinary Sciences
Surendra Rajit Prasad, Prakash Kumar, Saptarshi Mandal, Anu Mohan, Radhika Chaurasia, Ashish Shrivastava, Pallaprolu Nikhil, Dande Aishwarya, P. Ramalingam, Rahul Gajbhiye, Shriya Singh, Arunava Dasgupta, Mukesh Chourasia, V. Ravichandiran, Prolay Das, Debabrata Mandal
Summary: In this study, we evaluated the effectiveness of different types of saturated medium-chain fatty acids against Leishmania. We found that caprylic acid (CA) showed the most potent anti-leishmanial effect. Further investigation revealed that CA mediates cell death by depleting ergosterol through inhibiting the enzyme mevalonate kinase (MevK) in the ergosterol biosynthesis pathway. This study provides insights into the mechanism of CA against visceral leishmaniasis.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Koushik Mondal, Shantanabha Das, Khudiram Naskar, Syamal Roy
Summary: The study found that in antimony-resistant L. donovani infection, there is an increase in Transitional T3 B cells and B1a B cells in the spleen, accompanied by alterations in the Follicular B cell population. Additionally, the drug-resistant strain induced elevated levels of IL-10 from B1a B cells and IL-6 from Transitional T3 B cell subsets in the spleen.
Review
Medicine, General & Internal
Ganesh Yadagiri, Aakriti Singh, Kanika Arora, Shyam Lal Mudavath
Summary: Visceral leishmaniasis (VL) is a vector-borne disease caused by an intracellular parasite of the genus Leishmania. It is a deadly disease with high fatality in tropical regions, and the lack of vaccines, inadequate vector control measures, and the rise of drug-resistant parasites and HIV-VL co-infections make it difficult to treat and control. Therefore, the development of safe and effective therapies, such as immunotherapy, is urgently needed.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Renata Rocha da Silva, Fernanda de Santana Fontes Vasconcelos, Debora dos Santos Tavares, Priscila Lima dos Santos
Summary: This study conducted a systematic review and meta-analysis to investigate the association between IL-10 single nucleotide polymorphisms (SNPs) and the progression of leishmaniasis. The results showed that IL-10 SNPs were not significantly associated with leishmaniasis progression and were not considered a risk factor.
SCIENTIFIC REPORTS
(2022)
Review
Dermatology
S. Pradhan, R. A. Schwartz, A. Patil, S. Grabbe, M. Goldust
Summary: Leishmaniasis is classified into cutaneous, mucocutaneous, and visceral forms, with the visceral form being the most dangerous. Treatment of leishmaniasis remains challenging with various drugs available, each differing in cost, toxicity, treatment duration, and emergence of drug resistance. Ongoing research is focused on exploring new drugs and treatment options for leishmaniasis.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Review
Immunology
Patricia Sampaio Tavares Veras, Maria Borges Rabelo de Santana, Claudia Ida Brodskyn, Deborah Bittencourt Mothe Fraga, Manuela Silva Solca, Juliana Perrone Bezerra De Menezes, Bruna Martins Macedo Leite, Helena Mariana Pitangueira Teixeira
Summary: Leishmaniasis is a widespread group of infectious diseases that significantly impact global health. The causative agents are protozoan parasites that give rise to various clinical manifestations. Visceral leishmaniasis is the most severe form and can be life-threatening if left untreated.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Marco Antonio Cabrera Gonzalez, Ana Alice Maia Goncalves, Jennifer Ottino, Jaqueline Costa Leite, Lucilene Aparecida Resende, Otoni Alves Melo-Junior, Patricia Silveira, Mariana Santos Cardoso, Ricardo Toshio Fujiwara, Lilian Lacerda Bueno, Renato Lima Santos, Tatiane Furtado de Carvalho, Giani Martins Garcia, Paulo Ricardo de Oliveira Paes, Alexsandro Sobreira Galdino, Miguel Angel Chavez-Fumagalli, Marilia Martins Melo, Denise Silveira-Lemos, Olindo Assis Martins-Filho, Walderez Ornelas Dutra, Vanessa Carla Furtado Mosqueira, Rodolfo Cordeiro Giunchetti
Summary: Visceral leishmaniasis (VL) is a fatal disease caused by Leishmania infantum, and dogs are the main reservoirs. A vaccine against canine visceral leishmaniasis (CVL) is important in controlling human and CVL infections by reducing L. infantum infection. This study evaluated the potential of two polymeric nanoformulations loaded with Leishmania amazonensis antigens as a VL vaccine using golden hamsters as a model. The results showed that the vaccines had no adverse reactions and significantly reduced the parasitic load in the liver and spleen. These vaccines may be promising candidates for a VL vaccine.
Review
Immunology
Katiuska Passelli, Oaklyne Billion, Fabienne Tacchini-Cottier
Summary: Leishmania parasites, transmitted by infected sand flies, cause a range of diseases in mammals. Neutrophils are crucial in the defense against these parasites, although some Leishmania species have developed ways to survive within them. Neutrophils also play a role in shaping the skin microenvironment during infection, influencing the adaptive immune response and disease outcome.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Joao Carlos Franca-Silva, Rodolfo Cordeiro Giunchetti, Reysla Maria da Silveira Mariano, George Luiz Lins Machado-Coelho, Luciana de Almeida Silva Teixeira, Ricardo Andrade Barata, Erika Monteiro Michalsky, Marilia Fonseca Rocha, Consuelo Latorre Fortes-Dias, Edelberto Santos Dias
Summary: This study evaluated the impact of canine euthanasia on the incidence of visceral leishmaniasis in humans and canines. The findings showed that screening and culling measures for canines can reduce the incidence of the disease in both humans and canines.
Article
Multidisciplinary Sciences
Hermali Silva, Achala Liyanage, Theja Deerasinghe, Vasana Chandrasekara, Kalaivani Chellappan, Nadira D. Karunaweera
Summary: This study is the first detailed investigation of treatment failures in CL in Sri Lanka, revealing a relatively high rate of treatment failure especially in patients over 20 years old. It underscores the importance of further research into the pathogenesis of treatment failures and the need to review existing treatment protocols to introduce more effective strategies.
Article
Immunology
Joao Paulo Araujo de Sousa, Julyanne Maria Saraiva de Sousa, Raiza Raianne Luz Rodrigues, Thais Amanda de Lima Nunes, Yasmim Alves Aires Machado, Alexandre Carvalho de Araujo, Ingrid Gracielle Martins da Silva, Karine Brenda Barros-Cordeiro, Sonia Nair Bao, Michel Mualem de Moraes Alves, Francisco Jaime Bezerra Mendonca-Junior, Klinger Antonio da Franca Rodrigues
Summary: Leishmaniasis, one of the most serious Neglected Tropical Diseases (NTDs), requires urgent therapeutic alternatives due to the problems with currently available drugs. This study found that a thiophene derivative, SB-200, showed promising anti-leishmanial activity and low toxicity in mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Santhi John Tharakan, Dincy C. Peter, Rajiv Karthik, Vedantam Rupa, Winsley Rose, Meera Thomas, Malathi Manuel, Priscilla Rupali, Susanne Pulimood, Sitara Swarna Rao Ajjampur
Summary: This study reports on 52 suspected cases of cutaneous and mucosal leishmaniasis in a tertiary care setting in southern India from 2008 to 2018. Of the 12 confirmed cases, seven had mucocutaneous leishmaniasis, two had cutaneous leishmaniasis, and three had post-kala-azar dermal leishmaniasis. The emerging trend of atypical MCL caused by L. donovani variants highlights the importance of a high index of suspicion combined with PCR-based diagnostics for accurate diagnosis of different manifestations of leishmaniasis.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Engineering, Environmental
Qianhui Gong, Li Xiang, Botao Ye, Deng Liu, Hongmei Wang, Liyuan Ma, Xiaolu Lu
Summary: In this study, an antimony-resistant fungus, Sarocladium kiliense ZJ-1, was isolated from a slag sample collected in an antimony mine in China. The fungus showed high resistance to both Sb(III) and Sb(V), and whole genomic analysis revealed the presence of multiple antimony-resistant genes. The study also quantified the biosorption capacity of the fungus for Sb and investigated the adsorption mechanism using Fourier transformation infrared spectroscopy and X-ray photoelectron spectroscopy.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Chemistry, Physical
Omkar Hegde, Ritika Chatterjee, Abdur Rasheed, Dipshikha Chakravortty, Saptarshi Basu
Summary: This study demonstrates the control of biofluid droplet deposition and bacterial aggregation by manipulating the flow dynamics using non-contact vapor-mediated interactions. The findings show that the nucleation sites and crystal formation can be controlled through the preferential transfer of solutes in the droplets. This methodology has potential implications in biomedical applications such as disease detection and bacterial segregation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Agriculture, Multidisciplinary
Kapudeep Karmakar, Rohan Bhattacharya, Abhishek Sharma, Kirti Parmar, Utpal Nath, Karaba N. Nataraja, N. Earanna, Gaurav Sharma, Dipshikha Chakravortty
Summary: The study analyzed the colonization of Salmonella in plant roots and the importance of attachment factors, finding that a competitive bacterium inhibited its biofilm to reduce colonization in roots. It classified Salmonella with Rdar morphotypes as good plant colonizers and suggested that Lysinibacillus macroides could serve as a biocontrol agent to reduce the burden of Salmonella in various vegetables.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Mechanics
Gautham Vadlamudi, S. K. Thirumalaikumaran, Dipshikha Chakravortty, Abhishek Saha, Saptarshi Basu
Summary: This study investigates the effectiveness of different types of masks in blocking droplet transmission. It shows that masks are not able to completely prevent the penetration of larger droplets and can cause atomization, leading to increased risk of virus transmission. The study also examines the filtration and entrapment of virus-like particles in masks, as well as their efficacy for susceptible individuals.
Article
Biochemistry & Molecular Biology
Shaik Mohammed Jasmine, Seelam Mohan, Kota Neela Mani Kanta, Kiranmai Chadipiralla, Karumanchi Deepthi, Praveena Ketha, Prasada Rao Kammela, Uday Sankar Allam
Summary: Cyanamides, tetrazole, and their derivatives are of pharmaceutical interest due to their broad range of biological activities. In this study, synthesized aryl/alkyl cyanamides and substituted tetrazole compounds were found to effectively inhibit bacteria, with further modification potentially leading to even more valuable biological activities.
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
(2022)
Article
Microbiology
Kasturi Chandra, Atish Roy Chowdhury, Ritika Chatterjee, Dipshikha Chakravortty
Summary: This study reveals the important role of chitinase in Salmonella pathogenesis. It promotes intestinal epithelium remodeling and host system access. In phagocytes, chitinase-mediated upregulation of nitric oxide inhibits MHC-I bound antigen presentation and CD8(+) T cell proliferation. The absence of chitinase impairs bacterial adhesion and colonization. In the murine host, chitinase prevents immune activation and antimicrobial responses. In C. elegans, Salmonella chitinase promotes bacterial attachment to the intestinal epithelium and enhances pathogen colonization and persistence.
Article
Physics, Applied
N. Punith, Ashish K. Singh, J. Ananthanarasimhan, Bhavadharini Boopathy, Ritika Chatterjee, M. Hemanth, Dipshikha Chakravortty, Lakshminarayana Rao
Summary: This study demonstrates the successful generation of neutral pH high-strength plasma-activated water through pin to water discharge, which exhibits excellent bactericidal activity against hypervirulent multidrug resistance pathogens.
PLASMA PROCESSES AND POLYMERS
(2023)
Article
Chemistry, Physical
Abdur Rasheed, Omkar Hegde, Ritika Chatterjee, Srinivas Rao Sampathirao, Dipshikha Chakravortty, Saptarshi Basu
Summary: In naturally evaporating droplets, bacteria self-assemble into unique patterns based on their spatial location, resulting in varying physical forces and affecting their viability and infectivity. Self-assembly favors bacteria at the edge of the droplet, which has significant implications for understanding bacterial infection through droplets.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jayantika Bhowmick, Manish Nag, Pritha Ghosh, Raju S. Rajmani, Ritika Chatterjee, Kapudeep Karmakar, Kasturi Chandra, Jayanta Chatterjee, Dipshikha Chakravortty, Raghavan Varadarajan
Summary: This study tests the effect of a 24-mer peptide derived from CcdB (CP1-WT) on bacterial growth in Escherichia coli, Salmonella Typhimurium, Staphylococcus aureus, and a carbapenem- and tigecycline-resistant strain of Acinetobacter baumannii. The CP1-WT peptide shows significant improvement over ciprofloxacin in treating established infections of S. Typhimurium, S. aureus, and A. baumannii. The study validates the CcdB binding site on bacterial DNA Gyrase as a viable alternative target to the fluoroquinolone binding site.
Article
Immunology
Ritika Chatterjee, Debalina Chaudhuri, Subba Rao Gangi Setty, Dipshikha Chakravortty
Summary: Salmonella is a stealthy intracellular pathogen that evades host immune responses and establishes a replicative niche in hostile environments like macrophages. It escapes autophagy by inhibiting the fusion of Salmonella-containing vacuoles with lysosomes/autophagosomes and downregulates lysosomal biogenesis, facilitating its survival in macrophages and systemic dissemination.
MICROBES AND INFECTION
(2023)
Article
Cell Biology
Ritika Chatterjee, Abhilash Vijay Nair, Anmol Singh, Nishi Mehta, Subba Rao Gangi Setty, Dipshikha Chakravortty
Summary: Intracellular membrane fusion is mediated by SNARE complexes. Salmonella modulates host SNARE machinery to escape lysosomal fusion and maintain its division in the Salmonella-containing vacuole (SCV). Syntaxin 3 (STX3) is critical for bacterial proliferation and fusion of SCV with intracellular vesicles. The interaction of STX3 with SCV is impaired in SPI-2 encoded T3SS mutant. These findings highlight the importance of SPI-2 encoded effectors in the interaction with host SNAREs for Salmonella pathogenesis.
Article
Multidisciplinary Sciences
Vishnu Hariharan, Atish Roy Chowdhury, S. Srinivas Rao, Dipshikha Chakravortty, Saptarshi Basu
Summary: This study reveals the impact of bacteria-laden droplets on solid surfaces and subsequent desiccation on the virulence of Salmonella typhimurium. The research explores the deformation, cell-cell interactions, adhesion energy, and roughness in bacteria induced by impact velocity and low moisture. The findings show that mechanical stress induced by impact velocity decreases the in vitro viability of Salmonella while promoting bacterial proliferation in macrophages. The role of phoP in sensing mechanical stress and maintaining the virulence of Salmonella is also highlighted.
Article
Microbiology
Kasturi Chandra, Abhilash Vijay Nair, Ritika Chatterjee, Prerana Muralidhara, Anmol Singh, Sathisha Kamanna, Utpal S. Tatu, Dipshikha Chakravortty
Summary: Salmonella is a widespread Gram negative bacteria that causes a significant proportion of global diarrheal morbidity and mortality. It can cause typhoid fever and gastroenteritis by entering the host gut through contaminated food and water. Salmonella's biofilm lifestyle allows it to resist antibiotics and persist in the host, and inhibiting biofilm initiation is challenging.
MICROBIOLOGICAL RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Ritika Chatterjee, Atish Roy Chowdhury, Debapriya Mukherjee, Dipshikha Chakravortty
Summary: Salmonella Typhi is a serious threat to global health, causing typhoid fever in humans and resulting in high morbidity and mortality in developing countries. It can be transmitted to healthy individuals through contaminated food and water. This Review focuses on a comparative analysis of the virulence and pathogenesis of typhoidal and nontyphoidal serovars of Salmonella enterica.
Article
Chemistry, Physical
Siddhant Jain, Anmol Singh, Nivedita Tiwari, Aparna Naik, Ritika Chatterjee, Dipshikha Chakravortty, Saptarshi Basu
Summary: This study experimentally investigates the effects of stress generated by flowing fluid on bacterial morphology and virulence. The results show that increased stress conditions lead to significant changes in bacterial structure and decreased viability. Importantly, stressed bacteria proliferate faster inside macrophages. These findings shed light on the complex relationship between flow stresses and bacterial pathogenicity.
Review
Biochemistry & Molecular Biology
Sukriyo Chakraborty, Ritika Chatterjee, Dipshikha Chakravortty
Summary: Antimicrobial peptides, or host defense peptides, show promise as therapeutic candidates for combating infections, but their clinical trials have been hindered by toxicity and hemolytic activity. Rational peptide engineering based on evolutionary principles and activity determinants offers new avenues for developing peptides targeted at specific microbes.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)