Live Cell Analysis and Mathematical Modeling Identify Determinants of Attenuation of Dengue Virus 2’-O-Methylation Mutant

Single-cell analysis shows that paracrine signaling by first responder cells shapes the interferon-β response to viral infection

(2015) Sonali Patil et al.   Science Signaling

Single-cell analysis shows that paracrine signaling by first responder cells shapes the interferon-β response to viral infection

(2015) Sonali Patil et al.   Science Signaling

Activation of an Immunoregulatory and Antiviral Gene Expression Program in Poly(I:C)-Transfected Human Neutrophils

(2014) N. Tamassia et al.   JOURNAL OF IMMUNOLOGY

Targeting the viral Achilles’ heel: recognition of 5′-triphosphate RNA in innate anti-viral defence

(2013) Jan Rehwinkel et al.   CURRENT OPINION IN MICROBIOLOGY

Nuclear Localization of Dengue Virus Nonstructural Protein 5 Does Not Strictly Correlate with Efficient Viral RNA Replication and Inhibition of Type I Interferon Signaling

(2013) A. Kumar et al.   JOURNAL OF VIROLOGY

Ifit1 Inhibits Japanese Encephalitis Virus Replication through Binding to 5' Capped 2'-O Unmethylated RNA

(2013) T. Kimura et al.   JOURNAL OF VIROLOGY

Rational Design of a Flavivirus Vaccine by Abolishing Viral RNA 2'-O Methylation

(2013) S.-H. Li et al.   JOURNAL OF VIROLOGY

Structural basis for viral 5′-PPP-RNA recognition by human IFIT proteins

(2013) Yazan M. Abbas et al.   NATURE

The global distribution and burden of dengue

(2013) Samir Bhatt et al.   NATURE

A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

(2013) Ludmila Prokunina-Olsson et al.   NATURE GENETICS

Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life

(2013) J. Guedj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Surprising New Dengue Virus Throws a Spanner in Disease Control Efforts

(2013) D. Normile   SCIENCE

Replication Vesicles are Load- and Choke-Points in the Hepatitis C Virus Lifecycle

(2013) Marco Binder et al.   PLoS Pathogens

Dengue Virus Co-opts UBR4 to Degrade STAT2 and Antagonize Type I Interferon Signaling

(2013) Juliet Morrison et al.   PLoS Pathogens

Sequestration by IFIT1 Impairs Translation of 2′O-unmethylated Capped RNA

(2013) Matthias Habjan et al.   PLoS Pathogens

Rational Design of a Live Attenuated Dengue Vaccine: 2′-O-Methyltransferase Mutants Are Highly Attenuated and Immunogenic in Mice and Macaques

(2013) Roland Züst et al.   PLoS Pathogens

IFITM Proteins Restrict Viral Membrane Hemifusion

(2013) Kun Li et al.   PLoS Pathogens

Persistence of HCV in Quiescent Hepatic Cells Under Conditions of an Interferon-Induced Antiviral Response

(2012) Oliver Bauhofer et al.   GASTROENTEROLOGY

The JAK-STAT Pathway at Twenty

(2012) George R. Stark et al.   IMMUNITY

Multi-layered stochasticity and paracrine signal propagation shape the type-I interferon response

(2012) Ulfert Rand et al.   Molecular Systems Biology

Early Dengue Virus Protein Synthesis Induces Extensive Rearrangement of the Endoplasmic Reticulum Independent of the UPR and SREBP-2 Pathway

(2012) José Peña et al.   PLoS One

Modeling and Dynamical Analysis of Virus-Triggered Innate Immune Signaling Pathways

(2012) Jinying Tan et al.   PLoS One

Dengue reporter viruses reveal viral dynamics in interferon receptor-deficient mice and sensitivity to interferon effectors in vitro

(2012) J. W. Schoggins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential role of RIG-I in the activation of endothelial cells by dengue virus

(2012) Thaís Moraes da Conceição et al.   VIROLOGY

Modeling Within-Host Dynamics of Influenza Virus Infection Including Immune Responses

(2012) Kasia A. Pawelek et al.   PLoS Computational Biology

2′-O Methylation of Internal Adenosine by Flavivirus NS5 Methyltransferase

(2012) Hongping Dong et al.   PLoS Pathogens

2′-O Methylation of the Viral mRNA Cap by West Nile Virus Evades Ifit1-Dependent and -Independent Mechanisms of Host Restriction In Vivo

(2012) Kristy J. Szretter et al.   PLoS Pathogens

Recruitment and Activation of a Lipid Kinase by Hepatitis C Virus NS5A Is Essential for Integrity of the Membranous Replication Compartment

(2011) Simon Reiss et al.   Cell Host & Microbe

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

(2011) Roland Züst et al.   NATURE IMMUNOLOGY

IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA

(2011) Andreas Pichlmair et al.   NATURE IMMUNOLOGY

Role of Cell-to-Cell Variability in Activating a Positive Feedback Antiviral Response in Human Dendritic Cells

(2011) Jianzhong Hu et al.   PLoS One

Pattern Recognition Receptors and the Innate Immune Response to Viral Infection

(2011) Mikayla R. Thompson et al.   Viruses-Basel

Activation of the Innate Immune Response against DENV in Normal Non-Transformed Human Fibroblasts

(2011) José Bustos-Arriaga et al.   PLoS Neglected Tropical Diseases

RIG-I, MDA5 and TLR3 Synergistically Play an Important Role in Restriction of Dengue Virus Infection

(2011) A. M. A. Nasirudeen et al.   PLoS Neglected Tropical Diseases

Combining theoretical analysis and experimental data generation reveals IRF9 as a crucial factor for accelerating interferon α-induced early antiviral signalling

(2010) Tim Maiwald et al.   FEBS Journal

2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

(2010) Stephane Daffis et al.   NATURE

The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus

(2009) Abraham L. Brass et al.   CELL

Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites

(2009) Sonja Welsch et al.   Cell Host & Microbe

Dengue Virus NS5 Inhibits Interferon‐α Signaling by Blocking Signal Transducer and Activator of Transcription 2 Phosphorylation

(2009) Michela Mazzon et al.   JOURNAL OF INFECTIOUS DISEASES

NS5 of Dengue Virus Mediates STAT2 Binding and Degradation

(2009) J. Ashour et al.   JOURNAL OF VIROLOGY

The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure

(2009) M. Issur et al.   RNA

Virus Infection Induces NF-κB-Dependent Interchromosomal Associations Mediating Monoallelic IFN-β Gene Expression

(2008) Effie Apostolou et al.   CELL

Single-cell-based image analysis of high-throughput cell array screens for quantification of viral infection

(2008) Petr Matula et al.   CYTOMETRY PART A

Mutagenesis of the Dengue Virus Type 2 NS5 Methyltransferase Domain

(2008) Helga Kroschewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals

(2008) Ina Poser et al.   NATURE METHODS

Rapid detection of dengue virus in serum using magnetic separation and fluorescence detection

(2007) Won-Suk Chang et al.   ANALYST