HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma

A Modified HSP70 Inhibitor Shows Broad Activity as an Anticancer Agent

(2013) Gregor M. Balaburski et al.   MOLECULAR CANCER RESEARCH

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Inhibition of HSP70: A challenging anti-cancer strategy

(2012) Anastasia R. Goloudina et al.   CANCER LETTERS

Autophagy and cancer

(2012) Kyeong Sook Choi   EXPERIMENTAL AND MOLECULAR MEDICINE

Heat shock proteins in hematopoietic malignancies

(2012) Hajare Mjahed et al.   EXPERIMENTAL CELL RESEARCH

Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis

(2012) Kai Zhao et al.   JOURNAL OF LIPID RESEARCH

Suppression of HSP70 expression sensitizes NSCLC cell lines to TRAIL-induced apoptosis by upregulating DR4 and DR5 and downregulating c-FLIP-L expressions

(2012) Hongqin Zhuang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Primary Effusion Lymphoma Cell Death Induced by Bortezomib and AG 490 Activates Dendritic Cells through CD91

(2012) Mara Cirone et al.   PLoS One

Targeting COX-2/PGE2 Pathway in HIPK2 Knockdown Cancer Cells: Impact on Dendritic Cell Maturation

(2012) Alessia Garufi et al.   PLoS One

JNK2 is activated during ER stress and promotes cell survival

(2012) M Raciti et al.   Cell Death & Disease

Hsp90 Inhibitors Are Efficacious against Kaposi Sarcoma by Enhancing the Degradation of the Essential Viral Gene LANA, of the Viral Co-Receptor EphA2 as well as Other Client Proteins

(2012) Wuguo Chen et al.   PLoS Pathogens

Pleiotropic Effects of Cathepsin D

(2012) Aruna Vashishta et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Activation of dendritic cells by tumor cell death

(2012) Mara Cirone et al.   OncoImmunology

Inflammatory Mediators Hold the Key to Dendritic Cell Suppression and Tumor Progression

(2011) K. C. Sheng et al.   CURRENT MEDICINAL CHEMISTRY

HSP70 Inhibition by the Small-Molecule 2-Phenylethynesulfonamide Impairs Protein Clearance Pathways in Tumor Cells

(2011) J. I.-J. Leu et al.   MOLECULAR CANCER RESEARCH

Antileukemic activity of the HSP70 inhibitor pifithrin-μ in acute leukemia

(2011) M Kaiser et al.   Blood Cancer Journal

Connecting Hsp70, sphingolipid metabolism and lysosomal stability

(2010) Nikolaj H.T. Petersen et al.   CELL CYCLE

Lucanthone Is a Novel Inhibitor of Autophagy That Induces Cathepsin D-mediated Apoptosis

(2010) Jennifer S. Carew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

(2010) Thomas Kirkegaard et al.   NATURE

Mutational analysis of TP53, PTEN, PIK3CA and CTNNB1/ -catenin genes in human herpesvirus 8-associated primary effusion lymphoma

(2009) E. Boulanger et al.   HAEMATOLOGICA

Granulysin Induces Cathepsin B Release from Lysosomes of Target Tumor Cells to Attack Mitochondria through Processing of Bid Leading to Necroptosis

(2009) H. Zhang et al.   JOURNAL OF IMMUNOLOGY

A Small Molecule Inhibitor of Inducible Heat Shock Protein 70

(2009) J. I-Ju Leu et al.   MOLECULAR CELL

Sensitization to the Lysosomal Cell Death Pathway by Oncogene-Induced Down-regulation of Lysosome-Associated Membrane Proteins 1 and 2

(2008) N. Fehrenbacher et al.   CANCER RESEARCH

Chaperones in control of protein disaggregation

(2008) Krzysztof Liberek et al.   EMBO JOURNAL

Suppression of dendritic cell differentiation through cytokines released by Primary Effusion Lymphoma cells

(2008) M CIRONE et al.   IMMUNOLOGY LETTERS

Lysosomal membrane permeabilization in cell death

(2008) P Boya et al.   ONCOGENE

Tumor-induced modulation of dendritic cell function

(2007) E GOTTFRIED et al.   CYTOKINE & GROWTH FACTOR REVIEWS