Discovery of Marinopyrrole A (Maritoclax) as a Selective Mcl-1 Antagonist that Overcomes ABT-737 Resistance by Binding to and Targeting Mcl-1 for Proteasomal Degradation

Pharmacological Properties of the Marine Natural Product Marinopyrrole A against Methicillin-Resistant Staphylococcus aureus

(2011) Nina M. Haste et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction

(2011) Patricia Gomez-Bougie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia

(2011) A. Liao et al.   BLOOD

Targeting Mcl-1 for the therapy of cancer

(2011) Bridget A Quinn et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Multiple BH3 Mimetics Antagonize Antiapoptotic MCL1 Protein by Inducing the Endoplasmic Reticulum Stress Response and Up-regulating BH3-only Protein NOXA

(2011) Tina C. Albershardt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular dynamics study of small molecule inhibitors of the Bcl-2 family

(2011) Stéphane Acoca et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1

(2010) D. Yecies et al.   BLOOD

The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib

(2010) Hayato Hikita et al.   HEPATOLOGY

The BH3 α-Helical Mimic BH3-M6 Disrupts Bcl-XL, Bcl-2, and MCL-1 Protein-Protein Interactions with Bax, Bak, Bad, or Bim and Induces Apoptosis in a Bax- and Bim-dependent Manner

(2010) Aslamuzzaman Kazi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Total Synthesis of (±)-Marinopyrrole A and Its Library as Potential Antibiotic and Anticancer Agents

(2010) Chunwei Cheng et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

ARC Synergizes with ABT-737 to Induce Apoptosis in Human Cancer Cells

(2010) U. G. Bhat et al.   MOLECULAR CANCER THERAPEUTICS

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

(2010) Michelle L Stewart et al.   Nature Chemical Biology

Simultaneous targeting ofMCL1andABCB1as a novel strategy to overcome drug resistance in human leukaemia

(2009) Min Ji et al.   BRITISH JOURNAL OF HAEMATOLOGY

Marinopyrrole A Target Elucidation by Acyl Dye Transfer

(2009) Chambers C. Hughes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Bcl-2 inhibitors: small molecules with a big impact on cancer therapy

(2008) M Vogler et al.   CELL DEATH AND DIFFERENTIATION

Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1

(2008) Catherine L. Day et al.   JOURNAL OF MOLECULAR BIOLOGY

Bcl-XL-Templated Assembly of Its Own Protein−Protein Interaction Modulator from Fragments Decorated with Thio Acids and Sulfonyl Azides

(2008) Xiangdong Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bcl-2 family proteins and cancer

(2008) K W Yip et al.   ONCOGENE

The Marinopyrroles, Antibiotics of an Unprecedented Structure Class from a MarineStreptomycessp.

(2008) Chambers C. Hughes et al.   ORGANIC LETTERS