Consequences of glycan truncation on Fc structural integrity

Automated, High-Throughput IgG-Antibody Glycoprofiling Platform

(2013) Henning Stöckmann et al.   ANALYTICAL CHEMISTRY

A cost-effective plate-based sample preparation for antibody N-glycan analysis

(2013) Irina Burnina et al.   JOURNAL OF CHROMATOGRAPHY A

The Role of Amino Acid Sequence in the Self-Association of Therapeutic Monoclonal Antibodies: Insights from Coarse-Grained Modeling

(2013) Anuj Chaudhri et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG

(2013) Rebecca J. Rose et al.   mAbs

Correct primary structure assessment and extensive glyco-profiling of cetuximab by a combination of intact, middle-up, middle-down and bottom-up ESI and MALDI mass spectrometry techniques

(2013) Daniel Ayoub et al.   mAbs

Boosting ADCC and CDC activity by Fc engineering and evaluation of antibody effector functions

(2013) Christian Kellner et al.   METHODS

General mechanism for modulating immunoglobulin effector function

(2013) P. Sondermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of deglycosylation and thermal stress on conformational stability of a full length murine igG2a monoclonal antibody: Observations from molecular dynamics simulations

(2013) Xiaoling Wang et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Isotype and glycoform selection for antibody therapeutics

(2012) Roy Jefferis   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

NMR Characterization of Immunoglobulin G Fc Glycan Motion on Enzymatic Sialylation

(2012) Adam W. Barb et al.   BIOCHEMISTRY

The impact of glycosylation on monoclonal antibody conformation and stability

(2012) Kai Zheng et al.   mAbs

Marketing approval of mogamulizumab

(2012) Alain Beck et al.   mAbs

Insights into the potential aggregation liabilities of the b12 Fab fragment via elevated temperature molecular dynamics

(2012) P. M. Buck et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Coarse-grained models for protein aggregation

(2011) Chun Wu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Elucidation of Acid-induced Unfolding and Aggregation of Human Immunoglobulin IgG1 and IgG2 Fc

(2011) Ramil F. Latypov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic Fc-fusion proteins and peptides as successful alternatives to antibodies

(2011) Alain Beck et al.   mAbs

NMR analysis demonstrates immunoglobulin G N-glycans are accessible and dynamic

(2011) Adam W Barb et al.   Nature Chemical Biology

Disulfide Scrambling in IgG2 Monoclonal Antibodies: Insights from Molecular Dynamics Simulations

(2011) Xiaoling Wang et al.   PHARMACEUTICAL RESEARCH

A Novel Role for the IgG Fc Glycan: The Anti-inflammatory Activity of Sialylated IgG Fcs

(2010) Robert M. Anthony et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Prediction of Aggregation Prone Regions of Therapeutic Proteins

(2010) Naresh Chennamsetty et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Targeted cancer therapies

(2010) Saurabh Aggarwal   NATURE REVIEWS DRUG DISCOVERY

Characterization of IgG1 Conformation and Conformational Dynamics by Hydrogen/Deuterium Exchange Mass Spectrometry

(2009) Damian Houde et al.   ANALYTICAL CHEMISTRY

Visualisation of cyclic and multi-branched molecules with VMD

(2009) Simon Cross et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

Dynamic Fluctuations of Protein-Carbohydrate Interactions Promote Protein Aggregation

(2009) Vladimir Voynov et al.   PLoS One

Terminal sugars of Fc glycans influence antibody effector functions of IgGs

(2008) T Shantha Raju   CURRENT OPINION IN IMMUNOLOGY

Effects of glycosylation on the stability of protein pharmaceuticals

(2008) Ricardo J. Solá et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

(2008) R. M. Anthony et al.   SCIENCE