On the Role of Aggregation Prone Regions in Protein Evolution, Stability, and Enzymatic Catalysis: Insights from Diverse Analyses

Impact of deglycosylation and thermal stress on conformational stability of a full length murine igG2a monoclonal antibody: Observations from molecular dynamics simulations

(2013) Xiaoling Wang et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Familial amyloidotic polyneuropathy type IV – gelsolin amyloidosis

(2012) Tiia Pihlamaa et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Effective inter-residue contact definitions for accurate protein fold recognition

(2012) Chao Yuan et al.   BMC BIOINFORMATICS

Structure-Based Design of Supercharged, Highly Thermoresistant Antibodies

(2012) Aleksandr E. Miklos et al.   CHEMISTRY & BIOLOGY

Proteome folding and aggregation

(2012) Michele Vendruscolo   CURRENT OPINION IN STRUCTURAL BIOLOGY

Relationship Between Potential Aggregation-Prone Regions and HLA-DR-Binding T-Cell Immune Epitopes: Implications for Rational Design of Novel and Follow-on Therapeutic Antibodies

(2012) Sandeep Kumar et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Mechanisms of Intramolecular Communication in a Hyperthermophilic Acylaminoacyl Peptidase: A Molecular Dynamics Investigation

(2012) Elena Papaleo et al.   PLoS One

The distribution of ligand-binding pockets around protein-protein interfaces suggests a general mechanism for pocket formation

(2012) M. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aggregation gatekeepers modulate protein homeostasis of aggregating sequences and affect bacterial fitness

(2012) J. Beerten et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Insights into the potential aggregation liabilities of the b12 Fab fragment via elevated temperature molecular dynamics

(2012) P. M. Buck et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Quality Control Compartments Coming of Age

(2012) Tziona Ben-Gedalya et al.   TRAFFIC

Computational Methods for Identification of Functional Residues in Protein Structures

(2011) Fuxiao Xin et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Aggregation in Protein-Based Biotherapeutics: Computational Studies and Tools to Identify Aggregation-Prone Regions

(2011) Neeraj J. Agrawal et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Coupling of Aggregation and Immunogenicity in Biotherapeutics: T- and B-Cell Immune Epitopes May Contain Aggregation-Prone Regions

(2011) Sandeep Kumar et al.   PHARMACEUTICAL RESEARCH

Dysfunction of constitutive and inducible ubiquitin-proteasome system in amyotrophic lateral sclerosis: Implication for protein aggregation and immune response

(2011) Caterina Bendotti et al.   PROGRESS IN NEUROBIOLOGY

How do thermophilic proteins resist aggregation?

(2011) Anthony Mary Thangakani et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

An Evolutionary Trade-Off between Protein Turnover Rate and Protein Aggregation Favors a Higher Aggregation Propensity in Fast Degrading Proteins

(2011) Greet De Baets et al.   PLoS Computational Biology

Proteome-Level Interplay between Folding and Aggregation Propensities of Proteins

(2010) Gian Gaetano Tartaglia et al.   JOURNAL OF MOLECULAR BIOLOGY

Potential aggregation prone regions in biotherapeutics

(2010) Xiaoling Wang et al.   mAbs

Exploring the sequence determinants of amyloid structure using position-specific scoring matrices

(2010) Sebastian Maurer-Stroh et al.   NATURE METHODS

Potential Aggregation-Prone Regions in Complementarity-Determining Regions of Antibodies and Their Contribution Towards Antigen Recognition: A Computational Analysis

(2010) Xiaoling Wang et al.   PHARMACEUTICAL RESEARCH

Prediction of protein binding regions

(2010) Naresh Chennamsetty et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Protein sequences encode safeguards against aggregation

(2009) Joke Reumers et al.   HUMAN MUTATION

A Relationship between mRNA Expression Levels and Protein Solubility in E. coli

(2009) Gian Gaetano Tartaglia et al.   JOURNAL OF MOLECULAR BIOLOGY

Design of therapeutic proteins with enhanced stability

(2009) N. Chennamsetty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physicochemical principles that regulate the competition between functional and dysfunctional association of proteins

(2009) S. Pechmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloidogenic sequences in native protein structures

(2009) Susan Tzotzos et al.   PROTEIN SCIENCE

Amyloidogenic Regions and Interaction Surfaces Overlap in Globular Proteins Related to Conformational Diseases

(2009) Virginia Castillo et al.   PLoS Computational Biology