Cerebral microvascular endothelium and the pathogenesis of neurodegenerative diseases

Multiple Sclerosis - A Vascular Etiology?

(2016) Bryce Weir   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Dyad of CD40/CD40 Ligand Fosters Neuroinflammation at the Blood-Brain Barrier and Is Regulated via JNK Signaling: Implications for HIV-1 Encephalitis

(2013) S. H. Ramirez et al.   JOURNAL OF NEUROSCIENCE

Oxidative Stress and Altered Mitochondrial Function in Neurodegenerative Diseases: Lessons From Mouse Models

(2012) J.C. Fernandez-Checa et al.   CNS & Neurological Disorders-Drug Targets

Multiple Defects in Energy Metabolism in Alzheimers Disease

(2012) I. L. Ferreira et al.   CURRENT DRUG TARGETS

Delivery of molecularly targeted therapy to malignant glioma, a disease of the whole brain

(2011) Sagar Agarwal et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

ABC Transporters and Drug Efflux at the Blood-Brain Barrier

(2011) Shanshan Shen et al.   REVIEWS IN THE NEUROSCIENCES

Peripheral endothelial dysfunction in patients suffering from acute schizophrenia: A potential marker for cardiovascular morbidity?

(2011) Anna-Karoline Israel et al.   SCHIZOPHRENIA RESEARCH

Brain Endothelial Cells Synthesize Neurotoxic Thrombin in Alzheimer’s Disease

(2010) Xiangling Yin et al.   AMERICAN JOURNAL OF PATHOLOGY

The neurovascular unit, matrix proteases, and innate inflammation

(2010) Gregory J. Del Zoppo   Annals of the New York Academy of Sciences

The blood–brain barrier, chemokines and multiple sclerosis

(2010) David W. Holman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Reduction of L-Type Amino Acid Transporter 1 mRNA Expression in Brain Capillaries in a Mouse Model of Parkinson's Disease

(2010) Sumio Ohtsuki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Autosomal recessive mutations in the development of Parkinson’s disease

(2010) Grisel Lopez et al.   Biomarkers in Medicine

Rat brain endothelial cells are a target of manganese toxicity

(2010) Ana Paula Marreilha dos Santos et al.   BRAIN RESEARCH

The vascular contribution to Alzheimer's disease

(2010) Robin Altman et al.   CLINICAL SCIENCE

Microparticles, vascular function and hypertension

(2010) Chantal M Boulanger   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

CRP-induced levels of oxidative stress are higher in brain than aortic endothelial cells

(2010) Dorothea Closhen et al.   CYTOKINE

ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2

(2010) Steve Pedrini et al.   HUMAN MOLECULAR GENETICS

Matrix metalloproteinases in peripheral blood and cerebrospinal fluid in patients with Alzheimer's disease

(2010) Solveig Horstmann et al.   INTERNATIONAL PSYCHOGERIATRICS

 -Synuclein Activates Microglia by Inducing the Expressions of Matrix Metalloproteinases and the Subsequent Activation of Protease-Activated Receptor-1

(2010) E.-J. Lee et al.   JOURNAL OF IMMUNOLOGY

Neuroinflammation is a key player in Parkinson’s disease and a prime target for therapy

(2010) Li Qian et al.   JOURNAL OF NEURAL TRANSMISSION

Cerebrovascular expression of proteins related to inflammation, oxidative stress and neurotoxicity is altered with aging

(2010) Debjani Tripathy et al.   Journal of Neuroinflammation

A possible haemodynamic mechanism for Amyotrophic Lateral Sclerosis

(2010) Roger W. Arhart   MEDICAL HYPOTHESES

Endothelial progenitor cells in vascular health: Focus on lifestyle

(2010) Emeline M. Van Craenenbroeck et al.   MICROVASCULAR RESEARCH

Mitochondrial Dysfunction: Common Final Pathway in Brain Aging and Alzheimer’s Disease—Therapeutic Aspects

(2010) Walter E. Müller et al.   MOLECULAR NEUROBIOLOGY

Glial and neuronal control of brain blood flow

(2010) David Attwell et al.   NATURE

Neurodegeneration and the neurovascular unit

(2010) Berislav V Zlokovic   NATURE MEDICINE

Matrix Metalloproteinases and Neurotrauma: Evolving Roles in Injury and Reparative Processes

(2010) Haoqian Zhang et al.   NEUROSCIENTIST

Endothelial dysfunction: a strategic target in the treatment of hypertension?

(2010) Eva H. C. Tang et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Circulating endothelial microparticles as a marker of cerebrovascular disease

(2009) Keun-Hwa Jung et al.   ANNALS OF NEUROLOGY

Lipopolysaccharide alters the blood–brain barrier transport of amyloid β protein: A mechanism for inflammation in the progression of Alzheimer’s disease

(2009) Laura B. Jaeger et al.   BRAIN BEHAVIOR AND IMMUNITY

Impaired blood–brain and blood–spinal cord barriers in mutant SOD1-linked ALS rat

(2009) Charles Nicaise et al.   BRAIN RESEARCH

Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease

(2009) R. Deane et al.   CNS & Neurological Disorders-Drug Targets

Endothelial Dysfunction as a Target for Prevention of Cardiovascular Disease

(2009) D. Versari et al.   DIABETES CARE

Blood-based biomarkers of microvascular pathology in Alzheimer’s disease

(2009) Michael Ewers et al.   EXPERIMENTAL GERONTOLOGY

PPARα and PPARγ attenuate HIV-induced dysregulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities

(2009) Wen Huang et al.   FASEB JOURNAL

Involvement of ROS in BBB dysfunction

(2009) Pamela B. L. Pun et al.   FREE RADICAL RESEARCH

CNS pericytes: Concepts, misconceptions, and a way out

(2009) Martin Krueger et al.   GLIA

Genetic analysis of coding SNPs in blood-brain barrier transporter MDR1 in European Parkinson’s disease patients

(2009) Claudia Funke et al.   JOURNAL OF NEURAL TRANSMISSION

Matrix Metalloprotease-9 Inhibition Improves Amyloid  -Mediated Cognitive Impairment and Neurotoxicity in Mice

(2009) H. Mizoguchi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

(2009) Gary A Rosenberg   LANCET NEUROLOGY

Matrix metalloproteinase-3 contributes to vulnerability of the nigral dopaminergic neurons

(2009) Sung Tae Kim et al.   NEUROCHEMISTRY INTERNATIONAL

Association of a polymorphism in the ABCB1 gene with Parkinson's disease

(2009) Marie Westerlund et al.   PARKINSONISM & RELATED DISORDERS

Generation of Procoagulant Microparticles in Cerebrospinal Fluid and Peripheral Blood After Traumatic Brain Injury

(2009) Nicolas Morel et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Age related mitochondrial degenerative disorders in humans

(2008) Amy K. Reeve et al.   Biotechnology Journal

Activation of protease-activated receptor1 mediates induction of matrix metalloproteinase-9 by thrombin in rat primary astrocytes

(2008) Min Sik Choi et al.   BRAIN RESEARCH BULLETIN

Endothelial microparticles in diseases

(2008) Gilles N. Chironi et al.   CELL AND TISSUE RESEARCH

HIV-associated neurocognitive disorders and the impact of combination antiretroviral therapies

(2008) Beau M. Ances et al.   Current Neurology and Neuroscience Reports

Endothelial progenitor cells: Implications for cardiovascular disease

(2008) Sven Möbius-Winkler et al.   CYTOMETRY PART A

Increased α-synuclein aggregation following limited cleavage by certain matrix metalloproteinases

(2008) Johannes Levin et al.   EXPERIMENTAL NEUROLOGY

Post-ischemic brain damage: pathophysiology and role of inflammatory mediators

(2008) Diana Amantea et al.   FEBS Journal

Tight junctions and the modulation of barrier function in disease

(2008) Carola Förster   HISTOCHEMISTRY AND CELL BIOLOGY

Reassessing the amyloid cascade hypothesis of Alzheimer's disease

(2008) Sanjay W. Pimplikar   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Decreased blood–brain barrier P-glycoprotein function in the progression of Parkinson’s disease, PSP and MSA

(2008) A. L. Bartels et al.   JOURNAL OF NEURAL TRANSMISSION

JAK2-STAT3 signaling pathway mediates thrombin-induced proinflammatory actions of microglia in vitro☆

(2008) C HUANG et al.   JOURNAL OF NEUROIMMUNOLOGY

Endothelial Progenitor Cells: Therapeutic Target for Cardiovascular Diseases

(2008) Takashi Umemura et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Strategies to advance translational research into brain barriers

(2008) Edward Neuwelt et al.   LANCET NEUROLOGY

HIV-1 gp120 induces cytokine expression, leukocyte adhesion, and transmigration across the blood–brain barrier: modulatory effects of STAT1 signaling

(2008) Bo Yang et al.   MICROVASCULAR RESEARCH

SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells

(2008) Robert D. Bell et al.   NATURE CELL BIOLOGY

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

(2008) Zhihui Zhong et al.   NATURE NEUROSCIENCE

Neurovascular signalling defects in neurodegeneration

(2008) Serena Zacchigna et al.   NATURE REVIEWS NEUROSCIENCE

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

Dysfunctional Cell-Cell Signaling in the Neurovascular Unit as a Paradigm for Central Nervous System Disease

(2008) S. Guo et al.   STROKE