Synthesis of 2-aminopyridines via ruthenium-catalyzed [2+2+2] cycloaddition of 1,6- and 1,7-diynes with cyanamides: scope and limitations

Synthesis of 3-(2-thiopyridyl)indoles via the ruthenium catalyzed [2 + 2 + 2] cycloaddition of diynes and 3-thiocyanatoindoles

(2017) Hrishikesh Chowdhury et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Ruthenium-Catalyzed [2 + 2 + 2] Cycloaddition Reaction Forming 2-Aminopyridine Derivatives from α,ω-Diynes and Cyanamides

(2017) Fei Ye et al.   ORGANIC LETTERS

Solvent-free ruthenium trichloride-mediated [2 + 2 + 2] cycloaddition of α,ω-diynes and cyanamides: a convenient access to 2-aminopyridines

(2017) Fei Ye et al.   Organic Chemistry Frontiers

A Ruthenium Complex-Catalyzed Cyclotrimerization of Halodiynes with Nitriles. Synthesis of 2- and 3-Halopyridines

(2016) Eva Bednářová et al.   ADVANCED SYNTHESIS & CATALYSIS

The Construction of X-CN (X=N, S, O) Bonds

(2016) Jin-Tao Yu et al.   ADVANCED SYNTHESIS & CATALYSIS

Regioselective Iron-Catalyzed [2 + 2 + 2] Cycloaddition Reaction Forming 4,6-Disubstituted 2-Aminopyridines from Terminal Alkynes and Cyanamides

(2016) Nathan A. Spahn et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of δ- and α-Carbolines via Nickel-Catalyzed [2 + 2 + 2] Cycloaddition of Functionalized Alkyne-Nitriles with Alkynes

(2016) Gaonan Wang et al.   ORGANIC LETTERS

Rhodium-Catalyzed Asymmetric [2 + 2 + 2] Cycloaddition of α,ω-Diynes with Unsymmetrical 1,2-Disubstituted Alkenes

(2016) Yukimasa Aida et al.   ORGANIC LETTERS

Access toward Fluorenone Derivatives through Solvent-Free Ruthenium Trichloride Mediated [2 + 2 + 2] Cycloadditions

(2016) Fei Ye et al.   ORGANIC LETTERS

Design, synthesis and biological evaluation of tetracyclic azafluorenone derivatives with topoisomerase I inhibitory properties as potential anticancer agents

(2016) Tsung-Chih Chen et al.   Arabian Journal of Chemistry

Practical Solvent-Free Ruthenium Trichloride-Mediated Benzannulation Approach to Fused Functionalized Arenes

(2015) Jeremy Jacquet et al.   ADVANCED SYNTHESIS & CATALYSIS

Iridium-Catalyzed [2+2+2] Cycloaddition of α,ω-Diynes with Cyanamides

(2015) Toru Hashimoto et al.   ADVANCED SYNTHESIS & CATALYSIS

Structure–activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors

(2015) Son T. Nguyen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Niobium Complexes in Organic Transformations: From Stoichiometric Reactions to Catalytic [2+2+2] Cycloaddition Reactions

(2015) Yasushi Satoh et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Metal-Free Multicomponent Syntheses of Pyridines

(2014) Christophe Allais et al.   CHEMICAL REVIEWS

Recent Advances in Stereoselective [2+2+2] Cycloadditions

(2014) Muriel Amatore et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Highly Functionalized Terpyridines as Competitive Inhibitors of AKAP-PKA Interactions

(2013) Gesa Schäfer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Characterization of a Novel Pyranopyridine Inhibitor of the AcrAB Efflux Pump of Escherichia coli

(2013) Timothy J. Opperman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Iridium(III)-Catalyzed Approach for the Synthesis of Fused Arenes: Access to Isoindolines, Indanes, and Dihydroisobenzofurans

(2013) Anne-Laure Auvinet et al.   ChemCatChem

Iron(ii)-catalysed [2+2+2] cycloaddition for pyridine ring construction

(2013) Vincent Richard et al.   CHEMICAL COMMUNICATIONS

Transition Metal-Mediated Synthesis of Monocyclic Aromatic Heterocycles

(2013) Anton V. Gulevich et al.   CHEMICAL REVIEWS

Selection of boron reagents for Suzuki–Miyaura coupling

(2013) Alastair J. J. Lennox et al.   CHEMICAL SOCIETY REVIEWS

Syntheses of Heterocycles via Alkyne Cycloadditions Catalyzed by Cyclopentadienylruthenium-Type Complexes

(2013) Yoshihiko Yamamoto   HETEROCYCLES

Lead Optimization of Ethyl 6-Aminonicotinate Acyl Sulfonamides as Antagonists of the P2Y12 Receptor. Separation of the Antithrombotic Effect and Bleeding for Candidate Drug AZD1283

(2013) Peter Bach et al.   JOURNAL OF MEDICINAL CHEMISTRY

Iron-Catalyzed Cycloaddition Reaction of Diynes and Cyanamides at Room Temperature

(2013) Chunxiang Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective, Desymmetrizing Bromolactonization of Alkynes

(2013) Michael Wilking et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic Evaluation of the Ni(IPr)2-Catalyzed Cycloaddition of Alkynes and Nitriles To Afford Pyridines: Evidence for the Formation of a Key η1-Ni(IPr)2(RCN) Intermediate

(2013) Ryan M. Stolley et al.   ORGANOMETALLICS

From the Development of Catalysts for Alkyne and Alkyne-Nitrile [2+2+2] Cycloaddition Reactions to Their Use in Polymerization Reactions

(2013) Sentaro Okamoto et al.   SYNLETT

Ruthenium-Catalyzed Reductive Coupling of 1,3-Enynes and Aldehydes by Transfer Hydrogenation:anti-Diastereoselective Carbonyl Propargylation

(2012) Laina M. Geary et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Aminopyridines and Aminopyridones by Cobalt-Catalyzed [2+2+2] Cycloadditions Involving Yne-Ynamides: Scope, Limitations, and Mechanistic Insights

(2012) Pierre Garcia et al.   CHEMISTRY-A EUROPEAN JOURNAL

Practical and Efficient Iridium Catalysis for Benzannulation: An Entry To Isoindolines

(2012) Anne-Laure Auvinet et al.   ChemSusChem

Ruthenium-catalyzed [2+2+2] Cycloaddition of Diynes with Nitriles in Pure Water

(2012) Fen Xu et al.   ChemSusChem

Recent advances in the iron-catalyzed cycloaddition reactions

(2012) ChunXiang Wang et al.   CHINESE SCIENCE BULLETIN

Synthesis of Ruthenium Half-Sandwich Complexes by Naphthalene Replacement in [CpRu(C10H8)]+

(2012) Dmitry S. Perekalin et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Synthesis of 2,2’-Bipyridines by Transition Metal-Catalyzed Alkyne/Nitrile [2 + 2 + 2] Cycloaddition Reactions

(2012) Sentaro Okamoto   HETEROCYCLES

Rhodium-Catalyzed [2+2+2] Cycloaddition for the Synthesis of Substituted Pyridines, Pyridones, and Thiopyranimines

(2012) Ken Tanaka   HETEROCYCLES

Design and Synthesis of a Novel Series of Bicyclic Heterocycles As Potent γ-Secretase Modulators

(2012) Francois Bischoff et al.   JOURNAL OF MEDICINAL CHEMISTRY

Iron-Catalyzed Formation of 2-Aminopyridines from Diynes and Cyanamides

(2012) Timothy K. Lane et al.   JOURNAL OF ORGANIC CHEMISTRY

Cycloisomerization of dienes and enynes catalysed by a modified ruthenium carbene species

(2012) Álvaro Mallagaray et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Efficient Generation of Pyridines by Ruthenium Carbene Mediated [2 + 2 + 2] Cyclotrimerization

(2012) Sandra Medina et al.   ORGANIC LETTERS

Rhodium-Catalysed Alkoxycarbonylative Cyclisation Reactions of 1,6-Enynes

(2011) Fırat Ziyanak et al.   ADVANCED SYNTHESIS & CATALYSIS

A Serendipitous Discovery: Nickel Catalyst for the Cycloaddition of Diynes with Unactivated Nitriles

(2011) Puneet Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in [2+2+2] cycloaddition reactions

(2011) Gema Domínguez et al.   CHEMICAL SOCIETY REVIEWS

Preparation and synthetic applications of alkene complexes of group 9 transition metals in [2+2+2] cycloaddition reactions

(2011) Nico Weding et al.   CHEMICAL SOCIETY REVIEWS

Gold Catalysis: Domino Reaction of En-Diynes to Highly Substituted Phenols

(2011) A. Stephen K. Hashmi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cycloaddition of Alkynes: Atom-Economic Protocols for Constructing Six-Membered Cycles

(2011) Ruimao Hua et al.   CURRENT ORGANIC CHEMISTRY

Total Synthesis of Lavendamycin by a [2+2+2] Cycloaddition

(2011) Felix Nissen et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

[2+2+2] Cycloadditions of Alkynylynamides - A Total Synthesis of Perlolyrine and the First Total Synthesis of “Isoperlolyrine”

(2011) Benjamin Dassonneville et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Transition-Metal-Mediated or -Catalyzed Syntheses of Steroids and Steroid-Like Compounds

(2011) Martin Kotora et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Nickel-Catalyzed [2+2+2] Cycloaddition of Diynes and Cyanamides

(2011) Ryan M. Stolley et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal–Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)

(2011) J. Jean Cui et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of the Pyridine Core of Cyclothiazomycin

(2011) Yan Zou et al.   ORGANIC LETTERS

Regioselective Cobalt-Catalyzed Formation of Bicyclic 3- and 4-Aminopyridines

(2011) Pierre Garcia et al.   ORGANIC LETTERS

Construction of fused heterocycles by metal-mediated [2+2+2] cyclotrimerization of alkynes and/or nitriles

(2011) Mohamed R. Shaaban et al.   TETRAHEDRON

Recent Strategies for the Synthesis of Pyridine Derivatives

(2010) Matthew D. Hill   CHEMISTRY-A EUROPEAN JOURNAL

Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives

(2010) Haitao Ji et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Evaluation of 17α-Arylestradiols as Ligands for Estrogen Receptor α and β

(2010) David Sedlák et al.   JOURNAL OF MEDICINAL CHEMISTRY

Asymmetric Synthesis of Axially Chiral 1-Aryl-5,6,7,8-tetrahydroquinolines by Cobalt-Catalyzed [2 + 2 + 2] Cycloaddition Reaction of 1-Aryl-1,7-octadiynes and Nitriles

(2010) Marko Hapke et al.   JOURNAL OF ORGANIC CHEMISTRY

Steroids: partial synthesis in medicinal chemistry

(2010) James R. Hanson   NATURAL PRODUCT REPORTS

Gold catalysed cyclisation reactions of 1,6-diynes triggered by the addition of methanol

(2010) Christian Sperger et al.   TETRAHEDRON

Air-tolerant C–C bond formation via organometallic ruthenium catalysis: diverse catalytic pathways involving (C5Me5)Ru or (C5H5)Ru are robust to molecular oxygen

(2009) Lukáš Severa et al.   TETRAHEDRON LETTERS

Transition-Metal-Catalyzed Enantioselective [2+2+2] Cycloadditions for the Synthesis of Axially Chiral Biaryls

(2008) Ken Tanaka   Chemistry-An Asian Journal

A Novel Route to 1-Substituted 3-(Dialkylamino)-9-oxo-9H-indeno[2,1-c]pyridine-4-carbonitriles

(2008) Thomas Landmesser et al.   HELVETICA CHIMICA ACTA