期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 15, 期 27, 页码 5824-5830出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob01101f
关键词
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资金
- SERB, Department of Science and Technology, New Delhi, India
- IIT Ropar
A highly efficient protocol for the synthesis of 3-(2-thiopyridyl) indoles via the ruthenium(II) catalyzed [2 + 2 + 2] cycloaddition reaction of alpha,omega-diynes with 3-thiocyanatoindoles under mild reaction conditions has been developed. A variety of 3-(2-thiopyridyl) indole derivatives were prepared by the reaction of the aforesaid substrates in the presence of a readily available chloro(pentamethylcyclopentadienyl)(cyclooctadiyne) ruthenium(II) catalyst in ethanol with good to excellent yields. This atom economical methodology provides us efficient access to 3-(2-thiopyridyl) indole skeletons with close structural similarity to other pyridyl indole thioethers that have potential medicinal value.
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