期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 357, 期 7, 页码 1387-1392出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201500186
关键词
alkynes; benzannulation; cycloaddition; alpha,omega-diynes; ruthenium; solvent-free conditions
资金
- Ministere de l'Education et de la Recherche
- Centre National de la Recherche Scientifique (CNRS)
- Fondation Pierre-Gilles de Gennes pour la Recherche
The solvent-and ligand-free [2+2+2] ruthenium-promoted cycloaddition of alpha,omega-diynes and alkynes provides a facile and efficient strategy for the synthesis of substituted benzene-derived systems. The search for the optimal reaction conditions revealed the unprecedented catalytic activity of ruthenium trichloride for benzannulation reactions and this atom-economical process allowed the synthesis of fused arenes including dihydrobenzofurans, isoindolines, indanes in good to high yields. This practical protocol also gave rise to the preparation of pentasubstituted aromatic derivatives and was applied to the one-gram scale synthesis of a functionalized heterocycle.
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