标题
Mechanisms of ketamine action as an antidepressant
作者
关键词
-
出版物
MOLECULAR PSYCHIATRY
Volume 23, Issue 4, Pages 801-811
出版商
Springer Nature
发表日期
2018-03-13
DOI
10.1038/mp.2017.255
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Intracellular Signaling Pathways Involved in ( S )- and ( R )-Ketamine Antidepressant Actions
- (2018) Panos Zanos et al. BIOLOGICAL PSYCHIATRY
- Lateral habenula in the pathophysiology of depression
- (2018) Yan Yang et al. CURRENT OPINION IN NEUROBIOLOGY
- Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression
- (2018) Yihui Cui et al. NATURE
- Ketamine blocks bursting in the lateral habenula to rapidly relieve depression
- (2018) Yan Yang et al. NATURE
- Selective Pharmacological Augmentation of Hippocampal Activity Produces a Sustained Antidepressant-Like Response without Abuse-Related or Psychotomimetic Effects
- (2017) Flavia R. Carreno et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Anhedonia as a clinical correlate of suicidal thoughts in clinical ketamine trials
- (2017) Elizabeth D. Ballard et al. JOURNAL OF AFFECTIVE DISORDERS
- Antidepressant Potential of ( R )-Ketamine in Rodent Models: Comparison with ( S )-Ketamine
- (2017) Kenichi Fukumoto et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Zanos et al. reply
- (2017) Panos Zanos et al. NATURE
- Effects of a ketamine metabolite on synaptic NMDAR function
- (2017) Kanzo Suzuki et al. NATURE
- Brain-derived neurotrophic factor in mood disorders and antidepressant treatments
- (2017) Eero Castrén et al. NEUROBIOLOGY OF DISEASE
- Synthesis and N-Methyl-d-aspartate (NMDA) Receptor Activity of Ketamine Metabolites
- (2017) Patrick J. Morris et al. ORGANIC LETTERS
- GLYX-13 (rapastinel) ameliorates subchronic phencyclidine- and ketamine-induced declarative memory deficits in mice
- (2016) Lakshmi Rajagopal et al. BEHAVIOURAL BRAIN RESEARCH
- Ketamine for Depression: An Update
- (2016) James W. Murrough BIOLOGICAL PSYCHIATRY
- Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment
- (2016) Zhen Ren et al. BIOLOGICAL PSYCHIATRY
- Intravenous Esketamine in Adult Treatment-Resistant Depression: A Double-Blind, Double-Randomization, Placebo-Controlled Study
- (2016) Jaskaran B. Singh et al. BIOLOGICAL PSYCHIATRY
- Sex Differences in Effects of Ketamine on Behavior, Spine Density, and Synaptic Proteins in Socially Isolated Rats
- (2016) Ambalika Sarkar et al. BIOLOGICAL PSYCHIATRY
- The Development of Rapastinel (Formerly GLYX-13); A Rapid Acting and Long Lasting Antidepressant
- (2016) Joseph Moskal et al. Current Neuropharmacology
- Antidepressant Effects of (+)-MK-801 and (-)-MK-801 in the Social Defeat Stress Model
- (2016) Bangkun Yang et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- The Role of GluN2C-Containing NMDA Receptors in Ketamine's Psychotogenic Action and in Schizophrenia Models
- (2016) E. Khlestova et al. JOURNAL OF NEUROSCIENCE
- Habenula-Induced Inhibition of Midbrain Dopamine Neurons Is Diminished by Lesions of the Rostromedial Tegmental Nucleus
- (2016) P. Leon Brown et al. JOURNAL OF NEUROSCIENCE
- Disrupted habenula function in major depression
- (2016) R P Lawson et al. MOLECULAR PSYCHIATRY
- Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state
- (2016) T Fuchs et al. MOLECULAR PSYCHIATRY
- Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects
- (2016) G M I Chowdhury et al. MOLECULAR PSYCHIATRY
- NMDAR inhibition-independent antidepressant actions of ketamine metabolites
- (2016) Panos Zanos et al. NATURE
- Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
- (2016) Ronald S Duman et al. NATURE MEDICINE
- Synaptic AMPA receptor composition in development, plasticity and disease
- (2016) Jeremy M. Henley et al. NATURE REVIEWS NEUROSCIENCE
- BDNF – a key transducer of antidepressant effects
- (2016) Carl Björkholm et al. NEUROPHARMACOLOGY
- Adjunctive Lanicemine (AZD6765) in Patients with Major Depressive Disorder and History of Inadequate Response to Antidepressants: A Randomized, Placebo-Controlled Study
- (2016) Gerard Sanacora et al. NEUROPSYCHOPHARMACOLOGY
- GLYX-13 Produces Rapid Antidepressant Responses with Key Synaptic and Behavioral Effects Distinct from Ketamine
- (2016) Rong-Jian Liu et al. NEUROPSYCHOPHARMACOLOGY
- Rapamycin blocks the antidepressant effect of ketamine in task-dependent manner
- (2016) Kristina Holubova et al. PSYCHOPHARMACOLOGY
- Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression
- (2016) Bangkun Yang et al. PSYCHOPHARMACOLOGY
- Essential roles of AMPA receptor GluA1 phosphorylation and presynaptic HCN channels in fast-acting antidepressant responses of ketamine
- (2016) K. Zhang et al. Science Signaling
- What Are We Learning From Early-Phase Clinical Trials With Glutamate Targeting Medications for the Treatment of Major Depressive Disorder
- (2016) Gerard Sanacora JAMA Psychiatry
- Essential roles of AMPA receptor GluA1 phosphorylation and presynaptic HCN channels in fast-acting antidepressant responses of ketamine
- (2016) K. Zhang et al. Science Signaling
- Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression
- (2015) D. Jeffrey Newport et al. AMERICAN JOURNAL OF PSYCHIATRY
- NMDA receptor subunits and associated signaling molecules mediating antidepressant-related effects of NMDA-GluN2B antagonism
- (2015) Carly Kiselycznyk et al. BEHAVIOURAL BRAIN RESEARCH
- Dopamine D2/D3 but not dopamine D1 receptors are involved in the rapid antidepressant-like effects of ketamine in the forced swim test
- (2015) Yan Li et al. BEHAVIOURAL BRAIN RESEARCH
- Ketamine-like effects of a combination of olanzapine and fluoxetine on AMPA and NMDA receptor-mediated transmission in the medial prefrontal cortex of the rat
- (2015) Carl Björkholm et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Contributions of Diverse Excitatory and Inhibitory Neurons to Recurrent Network Activity in Cerebral Cortex
- (2015) G. T. Neske et al. JOURNAL OF NEUROSCIENCE
- Evidence that Subanesthetic Doses of Ketamine Cause Sustained Disruptions of NMDA and AMPA-Mediated Frontoparietal Connectivity in Humans
- (2015) Suresh D. Muthukumaraswamy et al. JOURNAL OF NEUROSCIENCE
- Neural correlates of change in major depressive disorder anhedonia following open-label ketamine
- (2015) Níall Lally et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Impact of subanesthetic doses of ketamine on AMPA-mediated responses in rats: An in vivo electrophysiological study on monoaminergic and glutamatergic neurons
- (2015) Kareem S El Iskandrani et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors
- (2015) Jonathan Fischell et al. NEUROPSYCHOPHARMACOLOGY
- The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus
- (2015) J. Burgdorf et al. NEUROSCIENCE
- An excitatory synapse hypothesis of depression
- (2015) Scott M. Thompson et al. TRENDS IN NEUROSCIENCES
- R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects
- (2015) C Yang et al. Translational Psychiatry
- (R,S)-Ketamine Metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine Increase the Mammalian Target of Rapamycin Function
- (2014) Rajib K. Paul et al. ANESTHESIOLOGY
- Requirement of AMPA receptor stimulation for the sustained antidepressant activity of ketamine and LY341495 during the forced swim test in rats
- (2014) Hiroyuki Koike et al. BEHAVIOURAL BRAIN RESEARCH
- A Randomized Controlled Trial of Intranasal Ketamine in Major Depressive Disorder
- (2014) Kyle A.B. Lapidus et al. BIOLOGICAL PSYCHIATRY
- EFFECTS OF KETAMINE ON EXPLICIT AND IMPLICIT SUICIDAL COGNITION: A RANDOMIZED CONTROLLED TRIAL IN TREATMENT-RESISTANT DEPRESSION
- (2014) Rebecca B. Price et al. DEPRESSION AND ANXIETY
- What is hydroxynorketamine and what can it bring to neurotherapeutics?
- (2014) Nagendra S Singh et al. Expert Review of Neurotherapeutics
- Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons
- (2014) Sung Woo Park et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Improvement in suicidal ideation after ketamine infusion: Relationship to reductions in depression and anxiety
- (2014) Elizabeth D. Ballard et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Akt Mediates GSK-3� Phosphorylation in the Rat Prefrontal Cortex during the Process of Ketamine Exerting Rapid Antidepressant Actions
- (2014) Wei Zhou et al. NEUROIMMUNOMODULATION
- The Role of GluN2A and GluN2B Subunits on the Effects of NMDA Receptor Antagonists in Modeling Schizophrenia and Treating Refractory Depression
- (2014) Laura Jiménez-Sánchez et al. NEUROPSYCHOPHARMACOLOGY
- Involvement of NMDA and AMPA receptors in the antidepressant-like activity of antidepressant drugs in the forced swim test
- (2014) Małgorzata Wolak et al. Pharmacological Reports
- SynGAP Regulates Protein Synthesis and Homeostatic Synaptic Plasticity in Developing Cortical Networks
- (2014) Chih-Chieh Wang et al. PLoS One
- Mice Lacking NMDA Receptors in Parvalbumin Neurons Display Normal Depression-Related Behavior and Response to Antidepressant Action of NMDAR Antagonists
- (2014) Laura Pozzi et al. PLoS One
- Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses
- (2014) E. S. Gideons et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The STAR*D Trial: Revealing the Need for Better Treatments
- (2014) Thomas R. Insel et al. PSYCHIATRIC SERVICES
- Serotonin-1A receptor stimulation mediates effects of a metabotropic glutamate 2/3 receptor antagonist, 2S-2-amino-2-(1S,2S-2-carboxycycloprop-1-yl)-3-(xanth-9-yl)propanoic acid (LY341495), and an N-methyl-D-aspartate receptor antagonist, ketamine, in the novelty-suppressed feeding test
- (2014) Kenichi Fukumoto et al. PSYCHOPHARMACOLOGY
- Anti-anhedonic effect of ketamine and its neural correlates in treatment-resistant bipolar depression
- (2014) N Lally et al. Translational Psychiatry
- Age dependence of the rapid antidepressant and synaptic effects of acute NMDA receptor blockade
- (2014) Elena Nosyreva et al. Frontiers in Molecular Neuroscience
- Antidepressant Efficacy of Ketamine in Treatment-Resistant Major Depression: A Two-Site Randomized Controlled Trial
- (2013) James W. Murrough et al. AMERICAN JOURNAL OF PSYCHIATRY
- Ketamine: Use in Anesthesia
- (2013) Susan Marland et al. CNS Neuroscience & Therapeutics
- Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex
- (2013) W. Zhou et al. EUROPEAN PSYCHIATRY
- Acute Suppression of Spontaneous Neurotransmission Drives Synaptic Potentiation
- (2013) E. Nosyreva et al. JOURNAL OF NEUROSCIENCE
- Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects
- (2013) G Sanacora et al. MOLECULAR PSYCHIATRY
- The role of eEF2 pathway in learning and synaptic plasticity
- (2013) Elham Taha et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- Sex differences in the antidepressant-like effects of ketamine
- (2013) Nicole Carrier et al. NEUROPHARMACOLOGY
- GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Induces Antidepressant-Like Effects Without Ketamine-Like Side Effects
- (2013) Jeffrey Burgdorf et al. NEUROPSYCHOPHARMACOLOGY
- GSK-3 Inhibition Potentiates the Synaptogenic and Antidepressant-Like Effects of Subthreshold Doses of Ketamine
- (2013) Rong-Jian Liu et al. NEUROPSYCHOPHARMACOLOGY
- NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice
- (2013) Adam K Walker et al. NEUROPSYCHOPHARMACOLOGY
- R (−)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine
- (2013) Ji-chun Zhang et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Ketamine elicits sustained antidepressant-like activity via a serotonin-dependent mechanism
- (2013) Valentina Gigliucci et al. PSYCHOPHARMACOLOGY
- Ketamine alters oscillatory coupling in the hippocampus
- (2013) Fábio V. Caixeta et al. Scientific Reports
- Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Antidepressant Efficacy of Ketamine in Depressed Patients
- (2012) Gonzalo Laje et al. BIOLOGICAL PSYCHIATRY
- Relationship of Ketamine's Plasma Metabolites with Response, Diagnosis, and Side Effects in Major Depression
- (2012) Carlos A. Zarate et al. BIOLOGICAL PSYCHIATRY
- Replication of Ketamine's Antidepressant Efficacy in Bipolar Depression: A Randomized Controlled Add-On Trial
- (2012) Carlos A. Zarate et al. BIOLOGICAL PSYCHIATRY
- A Randomized Trial of a Low-Trapping Nonselective N-Methyl-D-Aspartate Channel Blocker in Major Depression
- (2012) Carlos A. Zarate et al. BIOLOGICAL PSYCHIATRY
- Sub-anesthetic concentrations of (R,S)-ketamine metabolites inhibit acetylcholine-evoked currents in α7 nicotinic acetylcholine receptors
- (2012) Ruin Moaddel et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- A randomized add-on trial of high-dose d-cycloserine for treatment-resistant depression
- (2012) Uriel Heresco-Levy et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- A Randomized, Placebo-Controlled, Crossover Pilot Trial of the Oral Selective NR2B Antagonist MK-0657 in Patients With Treatment-Resistant Major Depressive Disorder
- (2012) Lobna Ibrahim et al. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- Acute administration of ketamine in rats increases hippocampal BDNF and mTOR levels during forced swimming test
- (2012) Chun Yang et al. UPSALA JOURNAL OF MEDICAL SCIENCES
- Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression
- (2011) Hiroyuki Koike et al. BEHAVIOURAL BRAIN RESEARCH
- Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure
- (2011) Nanxin Li et al. BIOLOGICAL PSYCHIATRY
- Differential Role of NR2A and NR2B Subunits in N-Methyl-D-Aspartate Receptor Antagonist-Induced Aberrant Cortical Gamma Oscillations
- (2011) Bernat Kocsis BIOLOGICAL PSYCHIATRY
- Brain-Derived Neurotrophic Factor Val66Met Allele Impairs Basal and Ketamine-Stimulated Synaptogenesis in Prefrontal Cortex
- (2011) Rong-Jian Liu et al. BIOLOGICAL PSYCHIATRY
- Memantine for late-life depression and apathy after a disabling medical event: a 12-week, double-blind placebo-controlled pilot study
- (2011) Eric J. Lenze et al. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
- A complex interaction between glycine/NMDA receptors and serotonergic/noradrenergic antidepressants in the forced swim test in mice
- (2011) Ewa Poleszak et al. JOURNAL OF NEURAL TRANSMISSION
- Resilience to Chronic Stress Is Mediated by Hippocampal Brain-Derived Neurotrophic Factor
- (2011) D. Taliaz et al. JOURNAL OF NEUROSCIENCE
- Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice
- (2011) E Beurel et al. MOLECULAR PSYCHIATRY
- Synaptic potentiation onto habenula neurons in the learned helplessness model of depression
- (2011) Bo Li et al. NATURE
- NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
- (2011) Anita E. Autry et al. NATURE
- Distinct Modes of AMPA Receptor Suppression at Developing Synapses by GluN2A and GluN2B: Single-Cell NMDA Receptor Subunit Deletion In Vivo
- (2011) John A. Gray et al. NEURON
- A Critical Role for GluN2B-Containing NMDA Receptors in Cortical Development and Function
- (2011) Chih-Chieh Wang et al. NEURON
- Signaling pathways underlying the rapid antidepressant actions of ketamine
- (2011) Ronald S. Duman et al. NEUROPHARMACOLOGY
- Ketamine perturbs perception of the flow of time in healthy volunteers
- (2011) Jennifer T Coull et al. PSYCHOPHARMACOLOGY
- A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression
- (2010) Nancy Diazgranados et al. ARCHIVES OF GENERAL PSYCHIATRY
- Rapid Resolution of Suicidal Ideation After a Single Infusion of anN-Methyl-D-Aspartate Antagonist in Patients With Treatment-Resistant Major Depressive Disorder
- (2010) Nancy DiazGranados et al. JOURNAL OF CLINICAL PSYCHIATRY
- Transient inactivation of the infralimbic cortex induces antidepressant-like effects in the rat
- (2010) David A Slattery et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders
- (2010) Giles E. Hardingham et al. NATURE REVIEWS NEUROSCIENCE
- The habenula: from stress evasion to value-based decision-making
- (2010) Okihide Hikosaka NATURE REVIEWS NEUROSCIENCE
- Peripheral BDNF Produces Antidepressant-Like Effects in Cellular and Behavioral Models
- (2010) Heath D Schmidt et al. NEUROPSYCHOPHARMACOLOGY
- Glutamate Receptor Ion Channels: Structure, Regulation, and Function
- (2010) S. F. Traynelis et al. PHARMACOLOGICAL REVIEWS
- mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
- (2010) N. Li et al. SCIENCE
- Effects of Intravenous Ketamine on Explicit and Implicit Measures of Suicidality in Treatment-Resistant Depression
- (2009) Rebecca B. Price et al. BIOLOGICAL PSYCHIATRY
- The Sigma Enigma: Can Sigma Receptors Provide a Novel Target for Disorders of Mood and Cognition?
- (2009) Stephen M. Stahl JOURNAL OF CLINICAL PSYCHIATRY
- Comments on "An Innovative Design to Establish Proof of Concept of the Antidepressant Effects of the NR2B Subunit Selective N-Methyl-d-Aspartate Antagonist, CP-101,606, in Patients With Treatment-Refractory Major Depressive Disorder"
- (2009) Kenji Hashimoto JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- The mesopontine rostromedial tegmental nucleus: A structure targeted by the lateral habenula that projects to the ventral tegmental area of Tsai and substantia nigra compacta
- (2009) Thomas C. Jhou et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Mg2+ Imparts NMDA Receptor Subtype Selectivity to the Alzheimer's Drug Memantine
- (2009) S. E. Kotermanski et al. JOURNAL OF NEUROSCIENCE
- Gamma and Delta Neural Oscillations and Association with Clinical Symptoms under Subanesthetic Ketamine
- (2009) L Elliot Hong et al. NEUROPSYCHOPHARMACOLOGY
- mTOR signaling: At the crossroads of plasticity, memory and disease
- (2009) Charles A. Hoeffer et al. TRENDS IN NEUROSCIENCES
- Wnt and beyond Wnt: Multiple mechanisms control the transcriptional property of β-catenin
- (2008) Tianru Jin et al. CELLULAR SIGNALLING
- An Innovative Design to Establish Proof of Concept of the Antidepressant Effects of the NR2B Subunit Selective N-Methyl-D-Aspartate Antagonist, CP-101,606, in Patients With Treatment-Refractory Major Depressive Disorder
- (2008) Sheldon H. Preskorn et al. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- Losing inhibition with ketamine
- (2008) Jeremy Seamans Nature Chemical Biology
- Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD
- (2008) Sungjin Park et al. NEURON
- N-methyl-d-aspartic acid receptor antagonist–induced frequency oscillations in mice recreate pattern of electrophysiological deficits in schizophrenia
- (2008) R.S. Ehrlichman et al. NEUROSCIENCE
- N-Methyl d-Aspartate Receptor Antagonists Ketamine and MK-801 Induce Wake-Related Aberrant γ Oscillations in the Rat Neocortex
- (2007) Didier Pinault BIOLOGICAL PSYCHIATRY
- Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors
- (2007) Sungho Maeng et al. BIOLOGICAL PSYCHIATRY
- Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus
- (2007) Lêda S.B. Garcia et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started