Article
Psychiatry
Manish Dama, Michelle Wu, Vanessa K. Tassone, Ilya Demchenko, Benicio N. Frey, Roumen Milev, Arun Ravindran, Sagar Parikh, Susan Rotzinger, Wendy Lou, Raymond W. Lam, Sidney H. Kennedy, Venkat Bhat
Summary: This study examined the changes in insomnia symptoms during the acute treatment of major depressive disorder with antidepressant medication. The results showed that monitoring subjective sleep-onset and mid-nocturnal insomnia throughout the treatment can predict acute remission of depression.
PSYCHIATRY RESEARCH
(2023)
Article
Clinical Neurology
Valentina Kieseppa, Niina Markkula, Heidi Taipale, Minna Holm, Markus Jokela, Jaana Suvisaari, Antti Tanskanen, Mika Gissler, Venla Lehti
Summary: Immigrants in Finland are more likely to initiate antidepressant use compared to Finnish-born population, but they also discontinue them earlier. Immigrants from Sub Saharan Africa, the Middle East and Northern Africa are most likely to discontinue antidepressants earlier. More severe depression and longer length of residence in Finland are associated with decreased risk of discontinuation.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Antonio Del Casale, Maurizio Simmaco, Martina Nicole Modesti, Clarissa Zocchi, Jan Francesco Arena, Irene Bilotta, Alessandro Alcibiade, Giuseppe Sarli, Lorenzo Cutillo, Giulia Antonelli, Enrico La Spina, Ottavia De Luca, Robert Preissner, Marina Borro, Giovanna Gentile, Paolo Girardi, Maurizio Pompili
Summary: This study investigates the correlation between DRD2, DRD3, and HTR2A genes and resistance to antipsychotic medication, and finds that a diagnosis of schizophrenia and specific genotypes are significantly associated with high treatment resistance.
Article
Psychiatry
Neslihan Altunsoy, Didem Suculluoglu Dikici, Fikret Poyraz Cokmus, Huseyin Murat Ozkan, Kadir Ascibasi, Deniz Alci, Erkan Kuru, Serra Yuzeren, Omer Aydemir
Summary: This study aimed to evaluate the outcome of acute term treatment for major depressive disorder in terms of psychosocial functioning. Results showed significant improvements in symptoms and disabilities for patients with MDD, but they still did not reach the normative level. Different antidepressant options may have varied effects on treatment outcomes, with SNRI users scoring higher in pain and physical functioning, and SSRI users showing better outcomes in mental health and vitality.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Anna Kruyer, Jeffrey Parrilla-Carrero, Courtney Powell, Lasse Brandt, Stefan Gutwinski, Ariana Angelis, Reda M. Chalhoub, Thomas C. Jhou, Peter W. Kalivas, Davide Amato
Summary: Antipsychotic-induced dopamine supersensitivity is a problematic consequence of long-term antipsychotic treatment, characterized by motor abnormalities, refractory symptoms, and rebound psychosis. This phenomenon is associated with long-lasting synaptic plasticity and hyperexcitability in a subpopulation of D2 receptor-expressing neurons, leading to behavioral endophenotypes of treatment resistance and substance use disorder. Chemogenetic restoration of inhibitory postsynaptic currents may offer a novel therapeutic direction for preventing antipsychotic-induced supersensitivity.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Yang Yang, Sang-Min Lee, Fumiaki Imamura, Krishne Gowda, Shantu Amin, Richard B. Mailman
Summary: This study compared two different D-1 agonists and found that 2-methyldihydrexidine was more effective in enhancing cognition compared to CY208,243, based on its impact on neural activity and cognitive performance.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Aida Khadivi, Parnian Shobeiri, Sara Momtazmaneh, Farhaneh-Sadat Samsami, Mohammadreza Shalbafan, Elham Shirazi, Shahin Akhondzadeh
Summary: This study investigated the safety and efficacy of combining phosphodiesterase-3 inhibitor cilostazol with sertraline in the treatment of major depressive disorder (MDD). The results showed that patients in the cilostazol group had lower depression severity scores, higher remission rate, and faster response time compared to the placebo group. No serious adverse effects were observed.
PSYCHOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Elisabeth Jufresa-Blanch, Neus Carrilero, Anna Garcia-Altes
Summary: This retrospective cohort study aims to determine the influence of general practitioner (GP) and patient sex on the treatment of major depression. It found that female patients were more likely to be prescribed an antidepressant at the time of diagnosis, regardless of the GP's sex. Furthermore, both male and female GPs were influenced by biases and stereotypes that led to differential antidepressant-prescribing behaviors based on the patient's sex and characteristics.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Richard B. Mailman, Yang Yang, Xuemei Huang
Summary: Research suggests that selective D-1 agonists may play a critical role in the treatment of Parkinson's disease, providing profound symptomatic relief even when current drugs are ineffective. Existing Parkinson's medications have limited efficacy in severe cases, but high intrinsic activity D-1 agonists could offer a major therapeutic advance in improving patients' quality of life.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Li Xue, Junneng Shao, Huan Wang, Xinyi Wang, Rongxin Zhu, Zhijian Yao, Qing Lu
Summary: This study used DTI data and LDA model to determine the clinical homogeneous and heterogeneous sets among depressive patients. The results showed that patients targeted by different types of antidepressant drugs have unique imaging characteristics that are related to different symptoms.
EUROPEAN RADIOLOGY
(2023)
Review
Neurosciences
Maxime Assous
Summary: Acetylcholine plays a critical role in the basal ganglia, particularly in patients with Parkinson's disease, Tourette syndrome, and dystonia. The striatum's cholinergic interneurons are responsible for the bulk of acetylcholine in the structure, and acetylcholine modulates striatal circuits through muscarinic and nicotinic receptors in various combinations. Understanding the expression and function of striatal nicotinic receptors may help develop targeted pharmacological interventions for brain disorders like Parkinson's disease, Tourette syndrome, dystonia, and nicotine addiction.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Psychiatry
Adam Wysokinski, Elzbieta Kozlowska, Ewa Szczepocka, Anna Lucka, Justyna Agier, Ewa Brzezinska-Blaszczyk, Katarzyna Sobierajska
Summary: Schizophrenia patients exhibit a distinctive mRNA expression profile of dopamine and serotonin receptors in peripheral blood mononuclear cells. This expression is minimally affected by antipsychotic treatment, suggesting it may serve as a useful diagnostic biomarker for schizophrenia.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Pharmacology & Pharmacy
Dorota Danielak
Summary: Depressive disorders are common in older patients with a prevalence rate of up to 17.1%. Treatment for elderly patients should consider medication preference, safety, and tolerability. Vortioxetine, a multimodal antidepressant, has shown effectiveness in treating major depressive disorders in elderly patients and may have unique properties compared to commonly used antidepressants.
EXPERT OPINION ON PHARMACOTHERAPY
(2021)
Review
Medicine, General & Internal
Rebecca L. Dean, Claudia Hurducas, Keith Hawton, Styliani Spyridi, Philip J. Cowen, Sarah Hollingsworth, Tahnee Marquardt, Annabelle Barnes, Rebecca Smith, Rupert McShane, Erick H. Turner, Andrea Cipriani
Summary: The findings suggest that ketamine and esketamine may be more effective than placebo in alleviating acute symptoms of depression. However, there is limited evidence for other glutamate receptor modulators, highlighting the need for more long-term randomized controlled trials to establish comprehensive data on safety and efficacy.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Xin Wen, Yuxin Xi, Yuanzhou Zhang, Lijie Jiao, Sa Shi, Shuzhi Bai, Fengqi Sun, Guiquan Chang, Ren Wu, Jinghui Hao, Hongzhu Li
Summary: Hydrogen sulfide (H2S) plays an important role in inhibiting proliferation and promoting apoptosis of vascular smooth muscle cells. The dopamine D1 receptor (DR1) suppresses atherosclerosis by inducing endogenous hydrogen sulfide production. Hyperglycemia decreases the expression of DR1 and endogenous hydrogen sulfide, leading to increased apoptosis of vascular smooth muscle cells in diabetic mice.
Article
Clinical Neurology
Monica M. Marcus, Carl Bjorkholm, Anna Malmerfelt, Annie Moller, Ninni Pahlsson, Asa Konradsson-Geuken, Kristin Feltmann, Kent Jardemark, Bjorn Schilstrom, Torgny H. Svensson
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2016)
Review
Neurosciences
Carl Bjorkholm, Lisa M. Monteggia
Article
Biochemistry & Molecular Biology
Jenny Haggkvist, Carl Bjorkholm, Pia Steensland, Sara Lindholm, Johan Franck, Bjorn Schilstrom
Article
Clinical Neurology
Carl Bjorkholm, Kent Jardemark, Monica M. Marcus, Anna Malmerfelt, Svante Nyberg, Bjorn Schilstrom, Torgny H. Svensson
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2013)
Article
Clinical Neurology
Carl Bjorkholm, Olivia Franberg, Anna Malmerfelt, Monica M. Marcus, Asa Konradsson-Geuken, Bjorn Schilstrom, Kent Jardemark, Torgny H. Svensson
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2015)
Article
Neurosciences
Monica M. Marcus, Kent Jardemark, Anna Malmerfelt, Carl Bjorkholm, Torgny H. Svensson
NEUROPSYCHOPHARMACOLOGY
(2010)
Article
Neurosciences
Ji-Woon Kim, Anita E. Autry, Elisa S. Na, Megumi Adachi, Carl Bjorkholm, Ege T. Kavalali, Lisa M. Monteggia
Summary: This study shows that MeCP2 phosphorylation at a specific site downstream of BDNF is essential for the sustained antidepressant effects of ketamine and scopolamine, and plays a critical role in long-term regulation of synaptic strength. These findings highlight the importance of MeCP2 and associated synaptic plasticity in mediating sustained antidepressant effects of ketamine and scopolamine.
NATURE NEUROSCIENCE
(2021)
Article
Clinical Neurology
Carl Bjorkholm, Monica M. Marcus, Asa Konradsson-Geuken, Kent Jardemark, Torgny H. Svensson
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2017)
Article
Clinical Neurology
Hannah Meijs, Helena Voetterl, Alexander T. Sack, Hanneke van Dijk, Bieke De Wilde, Jan Van Hecke, Peter Niemegeers, Evian Gordon, Jurjen J. Luykx, Martijn Arns
Summary: This study used a polygenic score (PGS) and electroencephalography (EEG) data analysis to identify potential predictors for treatment outcomes in major depressive disorder (MDD). The results suggest the existence of a stable EEG network related to antidepressant-response that has potential as a predictor for MDD treatment, particularly in the case of venlafaxine.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2024)