GLYX-13 Produces Rapid Antidepressant Responses with Key Synaptic and Behavioral Effects Distinct from Ketamine
出版年份 2016 全文链接
标题
GLYX-13 Produces Rapid Antidepressant Responses with Key Synaptic and Behavioral Effects Distinct from Ketamine
作者
关键词
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出版物
NEUROPSYCHOPHARMACOLOGY
Volume 42, Issue 6, Pages 1231-1242
出版商
Springer Nature
发表日期
2016-09-16
DOI
10.1038/npp.2016.202
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- GLYX-13 (rapastinel) ameliorates subchronic phencyclidine- and ketamine-induced declarative memory deficits in mice
- (2016) Lakshmi Rajagopal et al. BEHAVIOURAL BRAIN RESEARCH
- Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation
- (2016) M M Harraz et al. MOLECULAR PSYCHIATRY
- Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
- (2016) Ronald S Duman et al. NATURE MEDICINE
- Ketamine and Rapid-Acting Antidepressants: A Window into a New Neurobiology for Mood Disorder Therapeutics
- (2015) Chadi G. Abdallah et al. Annual Review of Medicine
- Rapastinel (GLYX-13) has therapeutic potential for the treatment of post-traumatic stress disorder: Characterization of a NMDA receptor-mediated metaplasticity process in the medial prefrontal cortex of rats
- (2015) Jeffrey Burgdorf et al. BEHAVIOURAL BRAIN RESEARCH
- The Mood Stabilizer Lithium Potentiates the Antidepressant-Like Effects and Ameliorates Oxidative Stress Induced by Acute Ketamine in a Mouse Model of Stress
- (2015) Chi-Tso Chiu et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Ketamine Strengthens CRF-Activated Amygdala Inputs to Basal Dendrites in mPFC Layer V Pyramidal Cells in the Prelimbic but not Infralimbic Subregion, A Key Suppressor of Stress Responses
- (2015) Rong-Jian Liu et al. NEUROPSYCHOPHARMACOLOGY
- The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus
- (2015) J. Burgdorf et al. NEUROSCIENCE
- Optogenetic stimulation of infralimbic PFC reproduces ketamine’s rapid and sustained antidepressant actions
- (2015) Manabu Fuchikami et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- (R,S)-Ketamine Metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine Increase the Mammalian Target of Rapamycin Function
- (2014) Rajib K. Paul et al. ANESTHESIOLOGY
- REDD1 is essential for stress-induced synaptic loss and depressive behavior
- (2014) Kristie T Ota et al. NATURE MEDICINE
- 5-HT2A and mGlu2 receptor binding levels are related to differences in impulsive behavior in the Roman Low- (RLA) and High- (RHA) avoidance rat strains
- (2014) A.B. Klein et al. NEUROSCIENCE
- Chronic nicotine attenuates phencyclidine-induced impulsivity in a mouse serial reaction time task
- (2013) Daniel Scott et al. BEHAVIOURAL BRAIN RESEARCH
- Role of Orexin in the Pathophysiology of Depression: Potential for Pharmacological Intervention
- (2013) Mathieu Nollet et al. CNS DRUGS
- Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex
- (2013) W. Zhou et al. EUROPEAN PSYCHIATRY
- Involvement of Serotonin Receptor Mechanisms in the Discriminative Stimulus Effects of Ketamine in Rats
- (2013) Kazumi Yoshizawa et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Sex differences in the antidepressant-like effects of ketamine
- (2013) Nicole Carrier et al. NEUROPHARMACOLOGY
- GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Induces Antidepressant-Like Effects Without Ketamine-Like Side Effects
- (2013) Jeffrey Burgdorf et al. NEUROPSYCHOPHARMACOLOGY
- GSK-3 Inhibition Potentiates the Synaptogenic and Antidepressant-Like Effects of Subthreshold Doses of Ketamine
- (2013) Rong-Jian Liu et al. NEUROPSYCHOPHARMACOLOGY
- Acute ketamine-induced neuroplasticity
- (2013) Vincenzo Tedesco et al. NEUROREPORT
- Characterization of the head-twitch response induced by hallucinogens in mice
- (2013) Adam L. Halberstadt et al. PSYCHOPHARMACOLOGY
- Antidepressant effects of AMPA and ketamine combination: role of hippocampal BDNF, synapsin, and mTOR
- (2013) Luli Akinfiresoye et al. PSYCHOPHARMACOLOGY
- Synaptic Dysfunction in Depression: Potential Therapeutic Targets
- (2012) R. S. Duman et al. SCIENCE
- Acute administration of ketamine in rats increases hippocampal BDNF and mTOR levels during forced swimming test
- (2012) Chun Yang et al. UPSALA JOURNAL OF MEDICAL SCIENCES
- Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure
- (2011) Nanxin Li et al. BIOLOGICAL PSYCHIATRY
- Brain-Derived Neurotrophic Factor Val66Met Allele Impairs Basal and Ketamine-Stimulated Synaptogenesis in Prefrontal Cortex
- (2011) Rong-Jian Liu et al. BIOLOGICAL PSYCHIATRY
- mTOR activation is required for the antidepressant effects of mGluR2/3 blockade
- (2011) Jason M. Dwyer et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
- (2011) Anita E. Autry et al. NATURE
- The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder
- (2011) Courtney S. Jernigan et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Glutamate Receptor Ion Channels: Structure, Regulation, and Function
- (2010) S. F. Traynelis et al. PHARMACOLOGICAL REVIEWS
- mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
- (2010) N. Li et al. SCIENCE
- The Female Urine Sniffing Test: A Novel Approach for Assessing Reward-Seeking Behavior in Rodents
- (2009) Oz Malkesman et al. BIOLOGICAL PSYCHIATRY
- Modeling “psychosis” in vitro by inducing disordered neuronal network activity in cortical brain slices
- (2009) George K. Aghajanian PSYCHOPHARMACOLOGY
- mTOR signaling: At the crossroads of plasticity, memory and disease
- (2009) Charles A. Hoeffer et al. TRENDS IN NEUROSCIENCES
- The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats
- (2008) Andrea Bari et al. Nature Protocols
- A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral–CA1 synapses in hippocampus
- (2008) Xiao-lei Zhang et al. NEUROPHARMACOLOGY
- Automated Three-Dimensional Detection and Shape Classification of Dendritic Spines from Fluorescence Microscopy Images
- (2008) Alfredo Rodriguez et al. PLoS One
- Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy
- (2008) R.-J. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors
- (2007) Sungho Maeng et al. BIOLOGICAL PSYCHIATRY
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