Article
Clinical Neurology
Wei Zheng, Li-Mei Gu, Chen-Hui Sun, Yan-Ling Zhou, Cheng-Yu Wang, Xiao-Feng Lan, Bin Zhang, Yu-Ping Ning
Summary: This study found that repeated ketamine infusions appeared to be effective at rapidly ameliorating anhedonia in Chinese individuals suffering from MDD and BD, with similar efficacy between the two groups.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Behavioral Sciences
Maria Camila Acero-Castillo, Maria Camila Ardila-Figueroa, Silvia Botelho de Oliveira
Summary: The study evaluated the effect of Chronic Social Isolation (CSI) on male Wistar rats, showing that exposure to CSI leads to anhedonic-type behavior and an anxiogenic profile. It was also demonstrated that resocialization does not reverse these behaviors.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Psychiatry
Wei Zheng, Xin-Hu Yang, Li-Mei Gu, Jian-Qiang Tan, Yan-Ling Zhou, Cheng-Yu Wang, Yu-Ping Ning
Summary: The rates of antianhedonic response and remission to multiple ketamine infusions for the treatment of depression were similar between males and females. However, females reported a significantly larger reduction in anhedonic symptoms than males at the 2-week follow-up.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Alina Wilkowska, Mariusz Stanislaw Wiglusz, Maria Galuszko-Wegielnik, Adam Wlodarczyk, Wieslaw Jerzy Cubala
Summary: Ketamine treatment significantly reduces anhedonia symptoms in patients with treatment resistant depression, especially among those who do not use benzodiazepines. The alleviation of anhedonia symptoms mediates the antidepressive effect of ketamine. Replication of these results in a larger randomized placebo controlled trial is needed.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Behavioral Sciences
Narges Sotoudeh, Mohammad Reza Namavar, Farshid Bagheri, Asadollah Zarifkar
Summary: This study investigated the effect of aging and sex on the connectivity between the medial prefrontal cortex (mPFC) and medial amygdala (MeA) and its association with anxiety-like behavior. The results showed that old individuals had less anxiety-like behavior and a stronger mPFC-MeA connection. Young female rats were less anxious and had a stronger mPFC-amygdala connection than young males. The study suggests a negative relationship between anxiety levels and the mPFC-MeA connection based on the rat's performance in the open field test apparatus.
BRAIN AND BEHAVIOR
(2022)
Article
Clinical Neurology
Xiaoqin Wang, Yi Xia, Rui Yan, Hao Sun, Yinghong Huang, Haowen Zou, Yishan Du, Lingling Hua, Hao Tang, Hongliang Zhou, Zhijian Yao, Qing Lu
Summary: This study aimed to explore the sex differences in the regional brain neuroimaging features of anhedonia in the context of major depressive disorder (MDD). The results showed significant differences in brain activity between males and females in relation to anhedonia, which may have clinical implications for treating anhedonia symptoms in MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Ege Kingir, Cem Sevinc, Gunes Unal
Summary: Chronic oral ketamine prevents the reduction of daily activity and loss of desire caused by chronic unpredictable mild stress. This preventive effect is achieved by altering neuronal activation in the lateral habenula and nucleus accumbens shell.
Article
Clinical Neurology
Simone Cunningham, Raegan Mazurka, Katherine E. Wynne-Edwards, Roumen Milev, Diego A. Pizzagalli, Sidney Kennedy, Kate L. Harkness
Summary: The study found that in men, response to rewards is more positively associated with response to acute stress, and among individuals with depression, the response to rewards is more closely related to stress reactivity.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Neurosciences
Danica Nogo, Ashitija K. Jasrai, Haeun Kim, Flora Nasri, Felicia Ceban, Leanna M. W. Lui, Joshua D. Rosenblat, Maj Vinberg, Roger Ho, Roger S. McIntyre
Summary: This article mainly introduces a particularly delicious strawberry in a strawberry shop, describing its fragrance and attractive appearance. This prompts people to buy this strawberry involuntarily and experience its unique taste and deliciousness.
PSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Laith Alexander, Peter C. T. Hawkins, Jennifer W. Evans, Mitul A. Mehta, Carlos A. Zarate Jr
Summary: This study investigated the effects of ketamine on different subregions of the anterior cingulate cortex (ACC) using resting-state functional connectivity (rsFC) analyses. The results showed that ketamine had differential effects on the connectivity between the ACC and other brain regions, and these effects were associated with improvements in depression and anhedonia symptoms. Accurate segmentation of the ACC is crucial for understanding the precise effects of ketamine in treating depression.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Arti Gandhi, Jasmine Mote, Daniel Fulford
Summary: The research found that individuals with Major Depressive Disorder (MDD) and Schizophrenia Spectrum Disorder (SSDs) experience higher levels of physical and social anhedonia compared to controls. Depressive symptom severity influences the differences in physical anhedonia, while age moderates the differences between social and physical anhedonia in the SSD group.
PSYCHIATRY RESEARCH
(2022)
Article
Neurosciences
Jordan Logue, Kristin Schoepfer, Alfonso Brea Guerrero, Yi Zhou, Mohamed Kabbaj
Summary: Our study found that social isolation stress inhibits hippocampal LTP in male rats but does not affect PPF, an effect rescued by KET. In female rats, isolation stress does not alter LTP, but does reduce PPF - especially in diestrus - an effect rescued by KET at the highest dose. This suggests sex differences in the contribution of pre- and postsynaptic hippocampal compartments in response to stress and KET.
NEUROSCIENCE LETTERS
(2022)
Article
Psychology, Multidisciplinary
Huang Lin, Shujuan Xiao, Lei Shi, Xiao Zheng, Yaqing Xue, Qilong Yun, Ping Ouyang, Dong Wang, Hong Zhu, Chichen Zhang
Summary: The study found that multimorbidity is significantly positively associated with depression, anxiety, and stress symptoms in older adults, especially in females. Therefore, promoting access to multimorbidity treatment for older adults of different sexes may effectively promote mental health in China.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Behavioral Sciences
Diana Fonseca-Rodrigues, Joana Goncalves, Ines Laranjeira, Armando Almeida, Filipa Pinto-Ribeiro
Summary: This study compared six commonly used sucrose preference test (SPT) protocols in male and female Wistar Han rats and found that water/food deprivation did not significantly affect sucrose intake and preference, increasing the duration of the test was associated with increased sucrose preference, and there were no sex-specific differences in the basal sucrose preference of Wistar Han rats. The results suggest the need for protocol standardization and recommend a protocol without food/water deprivation and a 12-hour duration for measuring anhedonia in rodents.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Neurosciences
Yong -Yu Yin, Zhao -Kai Lai, Jiao-Zhao Yan, Qian-Qian Wei, Bin Wang, Li -Ming Zhang, Yun-Feng Li
Summary: Social hierarchy has a significant impact on physical and mental health, but its relationship with depression/anxiety and the underlying neural mechanism is still unclear. This study used a tube test and behavioral tests to explore the effects of social hierarchy on depression-like and anxiety-like behaviors in mice. The results indicated an inverse relationship between social hierarchy and depression/anxiety, with subordinate mice displaying more depression-like and anxiety-like behaviors. The study also identified the excitability of pyramidal neurons and gamma oscillation in the medial prefrontal cortex as potential neural bases for this association.
NEUROBIOLOGY OF STRESS
(2023)
Article
Neurosciences
Amanda M. Dossat, Hussam Jourdi, Katherine N. Wright, Caroline E. Strong, Ambalika Sarkar, Mohamed Kabbaj
Article
Neurosciences
Deepika Suri, Vandana Veenit, Ambalika Sarkar, Devi Thiagarajan, Arvind Kumar, Eric J. Nestler, Sanjeev Galande, Vidita A. Vaidya
BIOLOGICAL PSYCHIATRY
(2013)
Article
Neurosciences
Ambalika Sarkar, Parul Chachra, Vidita A. Vaidya
BIOLOGICAL PSYCHIATRY
(2014)
Article
Neurosciences
Ambalika Sarkar, Parul Chachra, Pamela Kennedy, Catherine J. Pena, Lynette A. Desouza, Eric J. Nestler, Vidita A. Vaidya
NEUROPSYCHOPHARMACOLOGY
(2014)
Article
Multidisciplinary Sciences
Ambalika Sarkar, Kayode Balogun, Monica S. Guzman Lenis, Sebastian Acosta, Howard T. Mountid, Lena Serghides
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)