Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors

Ketamine and Rapid-Acting Antidepressants: A Window into a New Neurobiology for Mood Disorder Therapeutics

(2015) Chadi G. Abdallah et al.   Annual Review of Medicine

An excitatory synapse hypothesis of depression

(2015) Scott M. Thompson et al.   TRENDS IN NEUROSCIENCES

Restoring Mood Balance in Depression: Ketamine Reverses Deficit in Dopamine-Dependent Synaptic Plasticity

(2014) Pauline Belujon et al.   BIOLOGICAL PSYCHIATRY

NEUROBIOLOGY OF STRESS, DEPRESSION, AND RAPID ACTING ANTIDEPRESSANTS: REMODELING SYNAPTIC CONNECTIONS

(2014) Ronald S. Duman   DEPRESSION AND ANXIETY

What Did STAR*D Teach Us? Results From a Large-Scale, Practical, Clinical Trial for Patients With Depression

(2014) Bradley N. Gaynes et al.   PSYCHIATRIC SERVICES

Synaptic Mechanisms Underlying Rapid Antidepressant Action of Ketamine

(2013) Ege T. Kavalali et al.   AMERICAN JOURNAL OF PSYCHIATRY

Scopolamine Rapidly Increases Mammalian Target of Rapamycin Complex 1 Signaling, Synaptogenesis, and Antidepressant Behavioral Responses

(2013) Bhavya Voleti et al.   BIOLOGICAL PSYCHIATRY

Activation of Mammalian Target of Rapamycin and Synaptogenesis: Role in the Actions of Rapid-Acting Antidepressants

(2013) Jason M. Dwyer et al.   BIOLOGICAL PSYCHIATRY

Chronic Stress Induces a Selective Decrease in AMPA Receptor-Mediated Synaptic Excitation at Hippocampal Temporoammonic-CA1 Synapses

(2013) A. J. Kallarackal et al.   JOURNAL OF NEUROSCIENCE

Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression

(2013) Xiang Cai et al.   NATURE NEUROSCIENCE

The Impact of NMDA Receptor Blockade on Human Working Memory-Related Prefrontal Function and Connectivity

(2013) Naomi R Driesen et al.   NEUROPSYCHOPHARMACOLOGY

Synaptic Potentiation Is Critical for Rapid Antidepressant Response to Ketamine in Treatment-Resistant Major Depression

(2012) Brian R. Cornwell et al.   BIOLOGICAL PSYCHIATRY

Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens

(2012) Byung Kook Lim et al.   NATURE

Repeated Stress Causes Cognitive Impairment by Suppressing Glutamate Receptor Expression and Function in Prefrontal Cortex

(2012) Eunice Y. Yuen et al.   NEURON

Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents

(2012) Ronald S. Duman et al.   TRENDS IN NEUROSCIENCES

Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure

(2011) Nanxin Li et al.   BIOLOGICAL PSYCHIATRY

Comparison of the effects of acute and chronic administration of ketamine on hippocampal oscillations: relevance for the NMDA receptor hypofunction model of schizophrenia

(2011) Kara Kittelberger et al.   Brain Structure & Function

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

Differential effects produced by ketamine on oscillatory activity recorded in the rat hippocampus, dorsal striatum and nucleus accumbens

(2010) Mark J Hunt et al.   JOURNAL OF PSYCHOPHARMACOLOGY

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Etomidate Targets α5 γ-Aminobutyric Acid Subtype A Receptors to Regulate Synaptic Plasticity and Memory Blockade

(2009) Loren J. Martin et al.   ANESTHESIOLOGY

In Vitro and in Vivo Properties of 3-tert-Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA Receptor  5 Subtype-Selective Inverse Agonist

(2009) J. R. Atack et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Ketamine and the next generation of antidepressants with a rapid onset of action

(2009) Rodrigo Machado-Vieira et al.   PHARMACOLOGY & THERAPEUTICS

GABAA Receptor α5 Subunits Contribute to GABAA,slow Synaptic Inhibition in Mouse Hippocampus

(2008) Ewa D. Zarnowska et al.   JOURNAL OF NEUROPHYSIOLOGY

NMDA receptor-dependent switching between different gamma rhythm-generating microcircuits in entorhinal cortex

(2008) S. Middleton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors

(2008) Theresa M. Ballard et al.   PSYCHOPHARMACOLOGY

Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

(2007) Sungho Maeng et al.   BIOLOGICAL PSYCHIATRY