Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders
出版年份 2017 全文链接
标题
Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders
作者
关键词
-
出版物
Frontiers in Neuroscience
Volume 11, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2017-09-04
DOI
10.3389/fnins.2017.00451
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Potassium channel abnormalities are consistent with early axon degeneration of motor axons in the G127X SOD1 mouse model of amyotrophic lateral sclerosis
- (2017) Rikke Maglemose et al. EXPERIMENTAL NEUROLOGY
- Wildtype motoneurons, ALS-Linked SOD1 mutation and glutamate profoundly modify astrocyte metabolism and lactate shuttling
- (2017) Blandine Madji Hounoum et al. GLIA
- Sex specific activation of the ERα axis of the mitochondrial UPR (UPRmt) in the G93A-SOD1 mouse model of familial ALS
- (2017) Amanjot K Riar et al. HUMAN MOLECULAR GENETICS
- GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration
- (2017) Shuji Wakatsuki et al. JOURNAL OF CELL BIOLOGY
- Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy
- (2017) Elliot Turkiew et al. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
- The axon degeneration gene SARM1 is evolutionarily distinct from other TIR domain-containing proteins
- (2017) Harsha Malapati et al. MOLECULAR GENETICS AND GENOMICS
- Longitudinal changes of tau PET imaging in relation to hypometabolism in prodromal and Alzheimer’s disease dementia
- (2017) K Chiotis et al. MOLECULAR PSYCHIATRY
- A clinicopathological approach to the diagnosis of dementia
- (2017) Fanny M. Elahi et al. Nature Reviews Neurology
- Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease
- (2017) Zhuoran Yin et al. NEUROBIOLOGY OF AGING
- Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice
- (2017) Kathryn P. MacPherson et al. NEUROBIOLOGY OF DISEASE
- Neural stem cell therapy for neurodegenerative disorders: The role of neurotrophic support
- (2017) Samuel E. Marsh et al. NEUROCHEMISTRY INTERNATIONAL
- The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration
- (2017) Kow Essuman et al. NEURON
- Old and new challenges in Parkinson's disease therapeutics
- (2017) Ana O. Pires et al. PROGRESS IN NEUROBIOLOGY
- Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease
- (2017) Min Wei et al. Science Translational Medicine
- Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms
- (2017) Jesse S. Kerr et al. TRENDS IN NEUROSCIENCES
- Caloric restriction improves health and survival of rhesus monkeys
- (2017) Julie A. Mattison et al. Nature Communications
- Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study
- (2017) Stuart G. Snowden et al. PLOS MEDICINE
- An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients
- (2017) Ebbe T. Poulsen et al. Frontiers in Molecular Neuroscience
- Decreased Levels of Foldase and Chaperone Proteins Are Associated with an Early-Onset Amyotrophic Lateral Sclerosis
- (2017) Melania Filareti et al. Frontiers in Molecular Neuroscience
- ALS Along the Axons – Expression of Coding and Noncoding RNA Differs in Axons of ALS models
- (2017) Nimrod Rotem et al. Scientific Reports
- Progressive supranuclear palsy (PSP): Richardson syndrome and other PSP variants
- (2016) G. Lopez et al. ACTA NEUROLOGICA SCANDINAVICA
- Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease
- (2016) Katherine R. Sadleir et al. ACTA NEUROPATHOLOGICA
- 2016 Alzheimer's disease facts and figures
- (2016) Alzheimers & Dementia
- Improved proteostasis in the secretory pathway rescues Alzheimer’s disease in the mouse
- (2016) Yajing Peng et al. BRAIN
- The unfolded protein response: mechanisms and therapy of neurodegeneration
- (2016) Heather L. Smith et al. BRAIN
- Gene therapy to target ER stress in brain diseases
- (2016) Vicente Valenzuela et al. BRAIN RESEARCH
- Could Sirtuin Activities Modify ALS Onset and Progression?
- (2016) Bor Luen Tang CELLULAR AND MOLECULAR NEUROBIOLOGY
- Caloric Restriction in Older Adults—Differential Effects of Weight Loss and Reduced Weight on Brain Structure and Function
- (2016) Kristin Prehn et al. CEREBRAL CORTEX
- The Pathophysiology of Concussion
- (2016) Meeryo C. Choe Current Pain and Headache Reports
- The amyloid hypothesis of Alzheimer's disease at 25 years
- (2016) Dennis J Selkoe et al. EMBO Molecular Medicine
- C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells
- (2016) Rustam Esanov et al. EXPERIMENTAL NEUROLOGY
- Epigenetic changes in T-cell and monocyte signatures and production of neurotoxic cytokines in ALS patients
- (2016) Larry Lam et al. FASEB JOURNAL
- Axonal transport defects are a common phenotype inDrosophilamodels of ALS
- (2016) Katie R. Baldwin et al. HUMAN MOLECULAR GENETICS
- Reduced levels of alpha-1-antitrypsin in cerebrospinal fluid of amyotrophic lateral sclerosis patients: a novel approach for a potential treatment
- (2016) Uri Wormser et al. Journal of Neuroinflammation
- Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal Endoplasmic Reticulum Stress Molecules
- (2016) L. Yang et al. JOURNAL OF NEUROSCIENCE
- Oxidative damage to myelin proteins accompanies peripheral nerve motor dysfunction in aging C57BL/6 male mice
- (2016) Ryan Hamilton et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Effect of dietary fat and the circadian clock on the expression of brain-derived neurotrophic factor (BDNF)
- (2016) Yoni Genzer et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer’s Disease
- (2016) M. S. Unger et al. MOLECULAR NEUROBIOLOGY
- The transcription factor XBP1s restores hippocampal synaptic plasticity and memory by control of the Kalirin-7 pathway in Alzheimer model
- (2016) M Cissé et al. MOLECULAR PSYCHIATRY
- Reparative inflammation takes charge of tissue regeneration
- (2016) Michael Karin et al. NATURE
- Gene discovery in amyotrophic lateral sclerosis: implications for clinical management
- (2016) Ammar Al-Chalabi et al. Nature Reviews Neurology
- Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain
- (2016) Adam R. Smith et al. NEUROBIOLOGY OF AGING
- Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis
- (2016) Mohamad J. Alshikho et al. NEUROLOGY
- Poly(GR) in C9ORF72 -Related ALS/FTD Compromises Mitochondrial Function and Increases Oxidative Stress and DNA Damage in iPSC-Derived Motor Neurons
- (2016) Rodrigo Lopez-Gonzalez et al. NEURON
- Therapeutic Advances and Future Prospects in Progressive Forms of Multiple Sclerosis
- (2016) Afsaneh Shirani et al. Neurotherapeutics
- Body fat distribution in Parkinson's disease: An MRI-based body fat quantification study
- (2016) Denise Bernhardt et al. PARKINSONISM & RELATED DISORDERS
- SARM1-specific motifs in the TIR domain enable NAD+loss and regulate injury-induced SARM1 activation
- (2016) Daniel W. Summers et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autophagy induction stabilizes microtubules and promotes axon regeneration after spinal cord injury
- (2016) Miao He et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage
- (2016) Sarah J. Hill et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS
- (2016) Yasushi Ito et al. SCIENCE
- Mechanisms linking circadian clocks, sleep, and neurodegeneration
- (2016) Erik S. Musiek et al. SCIENCE
- How neuroinflammation contributes to neurodegeneration
- (2016) R. M. Ransohoff SCIENCE
- α-Synuclein enhances histone H3 lysine-9 dimethylation and H3K9me2-dependent transcriptional responses
- (2016) Naoto Sugeno et al. Scientific Reports
- Regulation of global gene expression and cell proliferation by APP
- (2016) Yili Wu et al. Scientific Reports
- CRTC1 gene is differentially methylated in the human hippocampus in Alzheimer’s disease
- (2016) Maite Mendioroz et al. Alzheimers Research & Therapy
- Inefficient DNA Repair Is an Aging-Related Modifier of Parkinson’s Disease
- (2016) Sara Sepe et al. Cell Reports
- Retrograde Axonal Degeneration in Parkinson Disease
- (2016) Patricia Tagliaferro et al. Journal of Parkinsons Disease
- Is Axonal Degeneration a Key Early Event in Parkinson’s Disease?
- (2016) Zuzanna Kurowska et al. Journal of Parkinsons Disease
- Mitochondria and Caspases Tune Nmnat-Mediated Stabilization to Promote Axon Regeneration
- (2016) Li Chen et al. PLoS Genetics
- NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion
- (2016) Yo Sasaki et al. eLife
- Primary open-angle glaucoma
- (2016) Robert N. Weinreb et al. Nature Reviews Disease Primers
- Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury
- (2016) Maritza Oñate et al. Scientific Reports
- The C9orf72 repeat expansion itself is methylated in ALS and FTLD patients
- (2015) Zhengrui Xi et al. ACTA NEUROPATHOLOGICA
- The Biology of Proteostasis in Aging and Disease
- (2015) Johnathan Labbadia et al. Annual Review of Biochemistry
- Widespread Proteome Remodeling and Aggregation in Aging C. elegans
- (2015) Dirk M. Walther et al. CELL
- Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration
- (2015) Lucy Liu et al. CELL
- Biological theories of aging
- (2015) Martin S. Lipsky et al. DM DISEASE-A-MONTH
- Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson's disease patients
- (2015) R. Fernandez-Santiago et al. EMBO Molecular Medicine
- 20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans
- (2015) Niki Chondrogianni et al. FASEB JOURNAL
- Analysis of YFP(J16)-R6/2 reporter mice and postmortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington's disease
- (2015) Rodolfo G. Gatto et al. HUMAN MOLECULAR GENETICS
- Essential role for autophagy in life span extension
- (2015) Frank Madeo et al. JOURNAL OF CLINICAL INVESTIGATION
- The Unfolded Protein Response and Cholesterol Biosynthesis Link Luman/CREB3 to Regenerative Axon Growth in Sensory Neurons
- (2015) Z. Ying et al. JOURNAL OF NEUROSCIENCE
- Signal integration by Ca2+ regulates intestinal stem-cell activity
- (2015) Hansong Deng et al. NATURE
- Single-cell epigenomics: techniques and emerging applications
- (2015) Omer Schwartzman et al. NATURE REVIEWS GENETICS
- Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice
- (2015) Byung Hee Han et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SARM1 activation triggers axon degeneration locally via NAD+ destruction
- (2015) J. Gerdts et al. SCIENCE
- DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice
- (2015) Elsa Suberbielle et al. Nature Communications
- Drosophila Spaghetti and Doubletime Link the Circadian Clock and Light to Caspases, Apoptosis and Tauopathy
- (2015) John C. Means et al. PLoS Genetics
- Network Analyses Reveal Novel Aspects of ALS Pathogenesis
- (2015) Mario Sanhueza et al. PLoS Genetics
- Alpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons Disease
- (2015) Ting Wang et al. Frontiers in Neuroscience
- Huntington disease
- (2015) Gillian P. Bates et al. Nature Reviews Disease Primers
- Augmenting peripheral nerve regeneration using stem cells: A review of current opinion
- (2015) Neil G Fairbairn World Journal of Stem Cells
- Autophagy induction halts axonal degeneration in a mouse model of X-adrenoleukodystrophy
- (2014) Nathalie Launay et al. ACTA NEUROPATHOLOGICA
- Genome-wide screening identifies new genes required for stress-induced phase 2 detoxification gene expression in animals
- (2014) Helen M Crook-McMahon et al. BMC BIOLOGY
- Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients
- (2014) Veronique V. Belzil et al. BRAIN RESEARCH
- Metabolic Control of Autophagy
- (2014) Lorenzo Galluzzi et al. CELL
- Geroscience: Linking Aging to Chronic Disease
- (2014) Brian K. Kennedy et al. CELL
- Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal
- (2014) Deqiang Sun et al. Cell Stem Cell
- Mechanisms of developmental neurite pruning
- (2014) Oren Schuldiner et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Autophagosome Biogenesis in Primary Neurons Follows an Ordered and Spatially Regulated Pathway
- (2014) Sandra Maday et al. DEVELOPMENTAL CELL
- Calcium Release from Intra-Axonal Endoplasmic Reticulum Leads to Axon Degeneration through Mitochondrial Dysfunction
- (2014) R. Villegas et al. JOURNAL OF NEUROSCIENCE
- The Role of Macromolecular Damage in Aging and Age-related Disease
- (2014) A. G. Richardson et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Analytical tools and current challenges in the modern era of neuroepigenomics
- (2014) Ian Maze et al. NATURE NEUROSCIENCE
- Tau promotes neurodegeneration through global chromatin relaxation
- (2014) Bess Frost et al. NATURE NEUROSCIENCE
- 'The clocks that time us'—circadian rhythms in neurodegenerative disorders
- (2014) Aleksandar Videnovic et al. Nature Reviews Neurology
- Age-related axonal swellings precede other neuropathological hallmarks in a knock-in mouse model of Huntington's disease
- (2014) Martina Marangoni et al. NEUROBIOLOGY OF AGING
- Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations
- (2014) Nael H. Alami et al. NEURON
- Exome-wide Rare Variant Analysis Identifies TUBA4A Mutations Associated with Familial ALS
- (2014) Bradley N. Smith et al. NEURON
- Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1
- (2014) P. Valdes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Diverse cellular and molecular modes of axon degeneration
- (2014) Lukas J. Neukomm et al. TRENDS IN CELL BIOLOGY
- SIRT1 and other sirtuins in metabolism
- (2014) Hung-Chun Chang et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models
- (2014) Mathew Blurton-Jones et al. Stem Cell Research & Therapy
- Alzheimer’s disease drug-development pipeline: few candidates, frequent failures
- (2014) Jeffrey L Cummings et al. Alzheimers Research & Therapy
- A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease
- (2014) Marc Brehme et al. Cell Reports
- Lifespan Extension Conferred by Endoplasmic Reticulum Secretory Pathway Deficiency Requires Induction of the Unfolded Protein Response
- (2014) Vyacheslav M. Labunskyy et al. PLoS Genetics
- Neuronal endoplasmic reticulum stress in axon injury and neurodegeneration
- (2013) Shaohua Li et al. ANNALS OF NEUROLOGY
- Epigenetic induction of the Ink4a/Arf locus prevents Schwann cell overproliferation during nerve regeneration and after tumorigenic challenge
- (2013) Jose Antonio Gomez-Sanchez et al. BRAIN
- Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling
- (2013) Edward Owusu-Ansah et al. CELL
- Sirtuins as therapeutic targets of ALS
- (2013) Giulio Maria Pasinetti et al. CELL RESEARCH
- Resveratrol delays Wallerian degeneration in a NAD+ and DBC1 dependent manner
- (2013) Aldo Calliari et al. EXPERIMENTAL NEUROLOGY
- A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis
- (2013) I. Fogh et al. HUMAN MOLECULAR GENETICS
- Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models
- (2013) Jordi Magrané et al. HUMAN MOLECULAR GENETICS
- Activation of the Innate Signaling Molecule MAVS by Bunyavirus Infection Upregulates the Adaptor Protein SARM1, Leading to Neuronal Death
- (2013) Piyali Mukherjee et al. IMMUNITY
- Neuronally-expressed Sarm1 regulates expression of inflammatory and antiviral cytokines in brains
- (2013) Chia-Wen Lin et al. Innate Immunity
- Developing dopaminergic cell therapy for Parkinson's disease-give up or move forward?
- (2013) Olle Lindvall MOVEMENT DISORDERS
- Longevity focuses on NAD+
- (2013) Heinrich Jasper Nature Chemical Biology
- Altered DNA methylation and RNA splicing could be key mechanisms in Huntington disease
- (2013) Heather Wood Nature Reviews Neurology
- The mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice
- (2013) Lee J. Martin et al. NEUROBIOLOGY OF AGING
- Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease
- (2013) Laura Dunn et al. NEUROBIOLOGY OF AGING
- Extensive changes in DNA methylation are associated with expression of mutant huntingtin
- (2013) C. W. Ng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification and Rescue of -Synuclein Toxicity in Parkinson Patient-Derived Neurons
- (2013) C. Y. Chung et al. SCIENCE
- Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice
- (2013) J. A. Moreno et al. Science Translational Medicine
- Epigenomics and the regulation of aging
- (2013) Jerome D Boyd-Kirkup et al. Epigenomics
- Overexpression of Atg5 in mice activates autophagy and extends lifespan
- (2013) Jong-Ok Pyo et al. Nature Communications
- Metabolic profiling of Alzheimer's disease brains
- (2013) Koichi Inoue et al. Scientific Reports
- Neuropathological Alterations in Alzheimer Disease
- (2013) A. Serrano-Pozo et al. Cold Spring Harbor Perspectives in Medicine
- Intestinal inflammation and stem cell homeostasis in aging Drosophila melanogaster
- (2013) Arshad Ayyaz et al. Frontiers in Cellular and Infection Microbiology
- Effects of aging and reproduction on protein quality control in soma and gametes of Drosophila melanogaster
- (2012) Åsa Fredriksson et al. AGING CELL
- Amyloid β-Peptide (1–42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression
- (2012) D. Allan Butterfield et al. ANTIOXIDANTS & REDOX SIGNALING
- AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington’s disease
- (2012) Amparo Zuleta et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Alterations in axonal transport motor proteins in sporadic and experimental Parkinson’s disease
- (2012) Yaping Chu et al. BRAIN
- Resveratrol upregulated heat shock proteins and extended the survival of G93A-SOD1 mice
- (2012) Soyoung Han et al. BRAIN RESEARCH
- Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock
- (2012) Thomas A. Rando et al. CELL
- A Novel Drosophila Model of Nerve Injury Reveals an Essential Role of Nmnat in Maintaining Axonal Integrity
- (2012) Yanshan Fang et al. CURRENT BIOLOGY
- Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis
- (2012) Kimmy G. Su et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Axonopathy in Huntington's disease
- (2012) Jia-Yi Li et al. EXPERIMENTAL NEUROLOGY
- Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy
- (2012) Rene L. Vidal et al. HUMAN MOLECULAR GENETICS
- α-Synuclein Induces Alterations in Adult Neurogenesis in Parkinson Disease Models via p53-mediated Repression of Notch1
- (2012) Paula Desplats et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study
- (2012) David H Cribbs et al. Journal of Neuroinflammation
- Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
- (2012) Peter T. Nelson et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- A Reversible Early Oxidized Redox State That Precedes Macromolecular ROS Damage in Aging Nontransgenic and 3xTg-AD Mouse Neurons
- (2012) D. Ghosh et al. JOURNAL OF NEUROSCIENCE
- The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice
- (2012) B. Zhang et al. JOURNAL OF NEUROSCIENCE
- Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of -Synuclein and LRRK2 in the Brain
- (2012) L. G. Friedman et al. JOURNAL OF NEUROSCIENCE
- Circadian Dbp Transcription Relies on Highly Dynamic BMAL1-CLOCK Interaction with E Boxes and Requires the Proteasome
- (2012) Markus Stratmann et al. MOLECULAR CELL
- Neural Stem Cells Enhance Nerve Regeneration after Sciatic Nerve Injury in Rats
- (2012) Lin Xu et al. MOLECULAR NEUROBIOLOGY
- RPN-6 determines C. elegans longevity under proteotoxic stress conditions
- (2012) David Vilchez et al. NATURE
- Sustained translational repression by eIF2α-P mediates prion neurodegeneration
- (2012) Julie A. Moreno et al. NATURE
- Recruiting adaptive cellular stress responses for successful brain ageing
- (2012) Alexis M. Stranahan et al. NATURE REVIEWS NEUROSCIENCE
- A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease
- (2012) Yoshihiro Kashiwaya et al. NEUROBIOLOGY OF AGING
- Differential Sirtuin Expression Patterns in Amyotrophic Lateral Sclerosis (ALS) Postmortem Tissue: Neuroprotective or Neurotoxic Properties of Sirtuins in ALS?
- (2012) Sonja Körner et al. Neurodegenerative Diseases
- Differential Effects of Unfolded Protein Response Pathways on Axon Injury-Induced Death of Retinal Ganglion Cells
- (2012) Yang Hu et al. NEURON
- Review: Axon pathology in age-related neurodegenerative disorders
- (2012) R. Adalbert et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Variant of TREM2 Associated with the Risk of Alzheimer's Disease
- (2012) Thorlakur Jonsson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Postnatal development- and age-related changes in DNA-methylation patterns in the human genome
- (2012) Paraskevi Salpea et al. NUCLEIC ACIDS RESEARCH
- Caprylic Triglyceride as a Novel Therapeutic Approach to Effectively Improve the Performance and Attenuate the Symptoms Due to the Motor Neuron Loss in ALS Disease
- (2012) Wei Zhao et al. PLoS One
- dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway
- (2012) J. M. Osterloh et al. SCIENCE
- Circadian Rhythm of Redox State Regulates Excitability in Suprachiasmatic Nucleus Neurons
- (2012) T. A. Wang et al. SCIENCE
- Mitochondria as a central sensor for axonal degenerative stimuli
- (2012) Felipe A. Court et al. TRENDS IN NEUROSCIENCES
- Activation of the unfolded protein response enhances motor recovery after spinal cord injury
- (2012) V Valenzuela et al. Cell Death & Disease
- Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue
- (2012) Yoichi Imaizumi et al. Molecular Brain
- Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration In Vivo
- (2012) Thomas M. Wishart et al. PLoS Genetics
- Diapause Formation and Downregulation of Insulin-Like Signaling via DAF-16/FOXO Delays Axonal Degeneration and Neuronal Loss
- (2012) Andrea Calixto et al. PLoS Genetics
- Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus
- (2011) Raquel Sanchez-Varo et al. ACTA NEUROPATHOLOGICA
- Sciatic Nerve Regeneration by Microporous Nerve Conduits Seeded With Glial Cell Line-Derived Neurotrophic Factor or Brain-Derived Neurotrophic Factor Gene Transfected Neural Stem Cells
- (2011) Keng-Yen Fu et al. ARTIFICIAL ORGANS
- Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence
- (2011) Porkodi Panneerselvam et al. BIOCHEMICAL JOURNAL
- Widespread Tau and Amyloid-Beta Pathology Many Years After a Single Traumatic Brain Injury in Humans
- (2011) Victoria E. Johnson et al. BRAIN PATHOLOGY
- Autophagy and Aging
- (2011) David C. Rubinsztein et al. CELL
- Autophagy and BiP level decrease are early key events in retrograde degeneration of motoneurons
- (2011) C Penas et al. CELL DEATH AND DIFFERENTIATION
- Age-related loss of CpG methylation in the tumour necrosis factor promoter
- (2011) Isobel R. Gowers et al. CYTOKINE
- Distinct DNA methylation changes highly correlated with chronological age in the human brain
- (2011) Dena G. Hernandez et al. HUMAN MOLECULAR GENETICS
- Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology
- (2011) Chiung-Ya Chen et al. JOURNAL OF CELL BIOLOGY
- Akt Suppresses Retrograde Degeneration of Dopaminergic Axons by Inhibition of Macroautophagy
- (2011) H.-C. Cheng et al. JOURNAL OF NEUROSCIENCE
- The Unfolded Protein Response Is a Major Mechanism by Which LRP1 Regulates Schwann Cell Survival after Injury
- (2011) E. Mantuano et al. JOURNAL OF NEUROSCIENCE
- Axonal Degeneration Is Mediated by the Mitochondrial Permeability Transition Pore
- (2011) S. A. Barrientos et al. JOURNAL OF NEUROSCIENCE
- Intermittent Fasting Improves Functional Recovery after Rat Thoracic Contusion Spinal Cord Injury
- (2011) Mi-ae Jeong et al. JOURNAL OF NEUROTRAUMA
- Caloric restriction
- (2011) John R. Speakman et al. MOLECULAR ASPECTS OF MEDICINE
- AAV Transduction of Dopamine Neurons With Constitutively Active Rheb Protects From Neurodegeneration and Mediates Axon Regrowth
- (2011) Sang Ryong Kim et al. MOLECULAR THERAPY
- Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
- (2011) Camilla Burnett et al. NATURE
- Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis
- (2011) Laura Ferraiuolo et al. Nature Reviews Neurology
- Evaluation of Markers of Oxidative Stress, Antioxidant Function and Astrocytic Proliferation in the Striatum and Frontal Cortex of Parkinson’s Disease Brains
- (2011) Rajeswara Babu Mythri et al. NEUROCHEMICAL RESEARCH
- Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
- (2011) Laura A. Volpicelli-Daley et al. NEURON
- The origin and development of plaques and phosphorylated tau are associated with axonopathy in Alzheimer’s disease
- (2011) Ai-Wu Xiao et al. Neuroscience Bulletin
- Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae
- (2011) Undine Kruegel et al. PLoS Genetics
- Wallerian Degeneration, WldS, and Nmnat
- (2010) Michael P. Coleman et al. Annual Review of Neuroscience
- Wallerian degeneration of zebrafish trigeminal axons in the skin is required for regeneration and developmental pruning
- (2010) S. M. Martin et al. DEVELOPMENT
- Altered microRNA regulation in Huntington's disease models
- (2010) Soon-Tae Lee et al. EXPERIMENTAL NEUROLOGY
- The Endoplasmic Reticulum Stress Sensor, ATF6α, Protects against Neurotoxin-induced Dopaminergic Neuronal Death
- (2010) Naohiro Egawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The “Dying-Back” Phenomenon of Motor Neurons in ALS
- (2010) Michal Dadon-Nachum et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Cell-Mediated Neuroprotection in a Mouse Model of Human Tauopathy
- (2010) D. W. Hampton et al. JOURNAL OF NEUROSCIENCE
- Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains
- (2010) A. Jowaed et al. JOURNAL OF NEUROSCIENCE
- The molecular basis by which dietary restricted feeding reduces mitochondrial reactive oxygen species generation
- (2010) C.E. Ash et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Hypoxia-Inducible Factors and the Response to Hypoxic Stress
- (2010) Amar J. Majmundar et al. MOLECULAR CELL
- Nutrigenomics
- (2010) Michelle Grayson NATURE
- Reversing EphB2 depletion rescues cognitive functions in Alzheimer model
- (2010) Moustapha Cissé et al. NATURE
- PTEN deletion enhances the regenerative ability of adult corticospinal neurons
- (2010) Kai Liu et al. NATURE NEUROSCIENCE
- Hyperglycemia Induces Oxidative Stress and Impairs Axonal Transport Rates in Mice
- (2010) Ruchi Sharma et al. PLoS One
- Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity
- (2010) S. Henis-Korenblit et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
- (2010) M. M. Lipinski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus
- (2009) Jeroen J.M. Hoozemans et al. AMERICAN JOURNAL OF PATHOLOGY
- Ketogenic diet protects dopaminergic neurons against 6-OHDA neurotoxicity via up-regulating glutathione in a rat model of Parkinson's disease
- (2009) Baohua Cheng et al. BRAIN RESEARCH
- Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD
- (2009) Tanea T. Reed et al. BRAIN RESEARCH
- Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories
- (2009) Gregory J. Brewer EXPERIMENTAL GERONTOLOGY
- The mitochondrial permeability transition pore in motor neurons: Involvement in the pathobiology of ALS mice
- (2009) Lee J. Martin et al. EXPERIMENTAL NEUROLOGY
- XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
- (2009) C. Hetz et al. GENES & DEVELOPMENT
- WldSrequires Nmnat1 enzymatic activity and N16–VCP interactions to suppress Wallerian degeneration
- (2009) Michelle A. Avery et al. JOURNAL OF CELL BIOLOGY
- Human neural stem cell grafts in the spinal cord of SOD1 transgenic rats: Differentiation and structural integration into the segmental motor circuitry
- (2009) Leyan Xu et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Dynamic Changes in Presynaptic and Axonal Transport Proteins Combined with Striatal Neuroinflammation Precede Dopaminergic Neuronal Loss in a Rat Model of AAV -Synucleinopathy
- (2009) C. Y. Chung et al. JOURNAL OF NEUROSCIENCE
- Telomere Shortening in Neural Stem Cells Disrupts Neuronal Differentiation and Neuritogenesis
- (2009) S. R. Ferron et al. JOURNAL OF NEUROSCIENCE
- Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease
- (2009) X. Wang et al. JOURNAL OF NEUROSCIENCE
- Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord
- (2009) K. A. Kigerl et al. JOURNAL OF NEUROSCIENCE
- Aging and dietary restriction alter proteasome biogenesis and composition in the brain and liver
- (2009) Kalavathi Dasuri et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease
- (2009) Yanping Li et al. NATURE NEUROSCIENCE
- Intermittent fasting alleviates the neuropathic phenotype in a mouse model of Charcot–Marie–Tooth disease
- (2009) Irina Madorsky et al. NEUROBIOLOGY OF DISEASE
- Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients
- (2009) Yoshiro Saito et al. NEUROSCIENCE LETTERS
- Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration
- (2009) F. Cicchetti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1
- (2009) Y. Nakahata et al. SCIENCE
- Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context
- (2009) Brock C. Christensen et al. PLoS Genetics
- Molecular inflammation: Underpinnings of aging and age-related diseases
- (2008) Hae Young Chung et al. AGEING RESEARCH REVIEWS
- Severely dystrophic axons at amyloid plaques remain continuous and connected to viable cell bodies
- (2008) Robert Adalbert et al. BRAIN
- Motor axon excitability during Wallerian degeneration
- (2008) M. Moldovan et al. BRAIN
- Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease
- (2008) M. C. Pott Godoy et al. BRAIN
- Aging Impairs the Unfolded Protein Response to Sleep Deprivation and Leads to Proapoptotic Signaling
- (2008) N. Naidoo et al. JOURNAL OF NEUROSCIENCE
- Neuroinflammation and Oxidation/Nitration of -Synuclein Linked to Dopaminergic Neurodegeneration
- (2008) H.-M. Gao et al. JOURNAL OF NEUROSCIENCE
- Mitochondrial DNA repair in aging and disease
- (2008) Nadiya M. Druzhyna et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease
- (2008) Melanie Meyer-Luehmann et al. NATURE
- Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease
- (2008) Heng Du et al. NATURE MEDICINE
- Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway
- (2008) K. K. Park et al. SCIENCE
- Hormesis defined
- (2007) Mark P. Mattson AGEING RESEARCH REVIEWS
- Axonal -synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease
- (2007) S. Orimo et al. BRAIN
- Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice
- (2007) Pu Wu et al. NEUROBIOLOGY OF AGING
- A microRNA-based gene dysregulation pathway in Huntington's disease
- (2007) Rory Johnson et al. NEUROBIOLOGY OF DISEASE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search