Review
Biochemistry & Molecular Biology
Xin-Yi Chen, Cui Liu, Yan Xue, Lei Chen
Summary: Parkinson's disease is characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta. The altered firing activity of these neurons, such as decreased spontaneous firing frequency and increased burst firing, is associated with the disease. Various ionic mechanisms contribute to the changes in firing activity. This review provides a comprehensive summary of the altered firing activity and possible mechanisms of nigra dopaminergic neurons in Parkinson's disease.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Neurosciences
Young Hee Sung, Young Noh, Eung Yeop Kim
Summary: Thin-section neuromelanin-sensitive MRI provides insights into the affected regions of the substantia nigra pars compacta in early-stage Parkinson's disease, with specific areas (nigrosome 1 and 2) showing significant spatial differences between patients and healthy subjects.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Cui Liu, Nan-Wei Kang, Ying Wang, Yan Xue, Xin-Yi Chen, Lei Chen
Summary: The present study investigated the effects of apelin on the spontaneous firing activity of nigral dopaminergic neurons and found that it may serve as a neuroprotective factor in Parkinson's disease.
Article
Neurosciences
Cui Liu, Nan-Wei Kang, Ying Wang, Yan Xue, Xin-Yi Chen, Lei Chen
Summary: The neuropeptide apelin modulates the firing activity of nigral dopaminergic neurons and may serve as a neuroprotective factor in Parkinson's disease.
Article
Biochemistry & Molecular Biology
Yining Gao, Hongxia Li, Huoqing Luo, You Ni, Yifan Feng, Lu He, Qinming Zhou, Ji Hu, Sheng Chen
Summary: This study investigated the underlying mechanisms of movement disorders caused by anti-IgLON5 antibodies. The results showed that mice injected with these antibodies exhibited persistent movement impairments for up to 3 months, which may be related to impaired dopaminergic pathway and neurodegenerative changes induced by the antibodies.
Article
Cell Biology
Gian-Carlo Eyer, Stefano Di Santo, Ekkehard Hewer, Lukas Andereggen, Stefanie Seiler, Hans Rudolf Widmer
Summary: The study revealed that co-expression of Nogo-A in nigral dopaminergic neurons of patients with Parkinson's disease decreases significantly with age, contrary to observations in normal aging and the animal model of Parkinson's disease. This suggests that Nogo-A may play a substantial role in the vulnerability of dopaminergic neurons in Parkinson's disease.
Article
Neurosciences
Mojtaba Jokar, Zhijia Jin, Pei Huang, Ying Wang, Youmin Zhang, Yan Li, Zenghui Cheng, Yu Liu, Rongbiao Tang, Xiaofeng Shi, Jihua Min, Fangtao Liu, Shengdi Chen, Naying He, E. Mark Haacke, Fuhua Yan
Summary: This study developed a comprehensive imaging biomarker for diagnosing Parkinson's disease by using a template-based, automatic segmentation method to detect the features of neuromelanin and iron in the substantia nigra. The combination of the N1 sign with other quantitative measures significantly improved the accuracy of Parkinson's disease diagnosis.
Article
Chemistry, Multidisciplinary
Jiang-Peng Fan, Hui-Zhen Geng, Ya-Wei Ji, Tao Jia, Jennifer B. Treweek, An-An Li, Chun-Yi Zhou, Viviana Gradinaru, Cheng Xiao
Summary: Key components in the nigrostriatal DA system exhibit distinct aging patterns and may contribute to age-related alterations in locomotion and coordination.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Bok-Seok Kim, Taeik Jang, Sung-Eun Yoo, Jae Moon Lee, Eunhee Kim
Summary: The impairment of protein clearance mechanisms in dopaminergic neurons leads to the accumulation of alpha-synuclein, contributing to the pathogenesis of Parkinson's disease. Fas-associated factor 1 (FAF1) was found to disrupt alpha-synuclein clearance through the autophagy-lysosome pathway, indicating a novel role as a negative regulator of autophagic alpha-synuclein clearance. This disturbance ultimately leads to alpha-synuclein accumulation and autophagy dysregulation in PD model mice.
Article
Neurosciences
Virginie J. Oberto, Jumpei Matsumoto, Marco N. Pompili, Ralitsa Todorova, Francesco Papaleo, Hisao Nishijo, Laurent Venance, Marie Vandecasteele, Sidney I. Wiener
Summary: This study compares the oscillations of different frequencies in dopaminergic neurons and their relationship with behavior. It shows that dopaminergic neurons have stronger activity in the moderate to fast frequency bands and play an important role in operant olfactory and visual discrimination tasks.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Jason Langley, Kristy S. Hwang, Xiaoping P. Hu, Daniel E. Huddleston
Summary: In this study, MRI measures were used to differentiate SWEDD and PD individuals, and it was found that SWEDD individuals had similar nigral volume and free water content as controls, while PD individuals showed reduction in nigral volume and increased free water content compared to SWEDD and control participants. These results suggest that MRI measures can be explored as a cost-effective alternative to DaTScan for evaluating the nigrostriatal system.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Cell Biology
Amrita Kulkarni, Kumari Preeti, Kamatham Pushpa Tryphena, Saurabh Srivastava, Shashi Bala Singh, Dharmendra Kumar Khatri
Summary: Protein dyshomeostasis plays a key role in age-related neurodegenerative disorders, such as Parkinson's disease, characterized by the deposition of Lewy bodies composed of alpha-synuclein protein aggregates. The proper functioning of proteostasis, including unfolded protein response, ubiquitin-proteasome system, and autophagy-lysosome pathway, is crucial for protein synthesis, folding, confirmation, and degradation. Mutational changes in the genes involved in these pathways, as well as epigenetic modifications and microRNA-mediated transcriptional changes, contribute to proteostasis dysregulation. Defective proteostasis leads to the deposition of proteins, which can serve as potential biomarkers for early diagnosis of Parkinson's disease. Targeting different aspects of proteostasis machinery holds promise for delaying the accumulation of pathological hallmarks.
AGEING RESEARCH REVIEWS
(2023)
Article
Cell Biology
Veronica Company, Abraham Andreu-Cervera, M. Pilar Madrigal, Belen Andres, Francisca Almagro-Garcia, Alain Chedotal, Guillermina Lopez-Bendito, Salvador Martinez, Diego Echevarria, Juan A. Moreno-Bravo, Eduardo Puelles
Summary: The fasciculus retroflexus is crucial for reward-related behaviors and psychiatric diseases, with proper navigation relying on mesodiencephalic dopaminergic neurons. Netrin 1 attraction, mediated by the receptor DCC, plays a key role in guiding medial habenular axons along the anteroposterior axis. Understanding these guidance mechanisms could potentially illuminate the connection between altered fasciculus retroflexus trajectory and mental health symptoms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Physiology
Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Shouta Serizawa, Fumiko Kihara-Negishi, Koichi J. J. Homma, Shinji Yamaguchi
Summary: The study revealed the reciprocal regulation between dopaminergic and serotonergic neurons in birds, with 5-HTR1A and 5-HTR1B receptors expressed in midbrain dopaminergic nuclei playing a role in the serotonergic regulation of the dopaminergic system. This finding enhances our understanding of the interaction between dopamine and serotonin systems in birds at the molecular level.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Carmela Conte, Angela Ingrassia, John Breve, John J. J. Bol, Evelien Timmermans-Huisman, Anne-Marie van Dam, Tommaso Beccari, Wilma D. J. van de Berg
Summary: This study found an increased expression of Toll-like receptor 4 (TLR4) in the brains of Parkinson's disease (PD) patients, which colocalized with phosphorylated α-synuclein (pSer129-aSyn) at the site of damage, suggesting a potential role in mediating the neuroinflammatory response in PD.
Article
Clinical Neurology
Tanya Simuni, Liz Uribe, Hyunkeun Ryan Cho, Chelsea Caspell-Garcia, Christopher S. Coffey, Andrew Siderowf, John Q. Trojanowski, Leslie M. Shaw, John Seibyl, Andrew Singleton, Arthur W. Toga, Doug Galasko, Tatiana Foroud, Duygu Tosun, Kathleen Poston, Daniel Weintraub, Brit Mollenhauer, Caroline M. Tanner, Karl Kieburtz, Lana M. Chahine, Alyssa Reimer, Samantha J. Hutten, Susan Bressman, Kenneth Marek, Vanessa Arnedo, Adrienne Clark, Mark Fraiser, Catherine Kopil, Sohini Chowdhury, Todd Sherer, Nichole Daegele, Christina Salerno, Cynthia Casaceli, Ray Dorsey, Renee Wilson, Sugi Mahes, Karen Crawford, Paola Casalin, Giulia Malferrari, Mali GaniWeisz, Avi Orr-Urtreger, Thomas Montine, Chris Baglieri, Amanda Christini, David Russell, Nabila Dahodwala, Nir Giladi, Stewart Factor, Penelope Hogarth, David Standaert, Robert Hauser, Joseph Jankovic, Marie Saint-Hilaire, Irene Richard, David Shprecher, Hubert Fernandez, Katrina Brockmann, Liana Rosenthal, Paolo Barone, Alberto Espay, Dominic Rowe, Karen Marder, Anthony Santiago, Shu-Ching Hu, Stuart Isaacson, Jean-Christophe Corvol, Javiar Ruiz Martinez, Eduardo Tolosa, Yen Tai, Marios Politis, Debra Smejdir, Linda Rees, Karen Williams, Farah Kausar, Karen Williams, Whitney Richardson, Diana Willeke, Shawnees Peacock, Barbara Sommerfeld, Alison Freed, Katrina Wakeman, Courtney Blair, Stephanie Guthrie, Leigh Harrell, Christine Hunter, Cathi-Ann Thomas, Raymond James, Grace Zimmerman, Victoria Brown, Jennifer Mule, Ella Hilt, Kori Ribb, Susan Ainscough, Misty Wethington, Madelaine Ranola, Helen Mejia Santana, Juliana Moreno, Deborah Raymond, Krista Speketer, Stephanie Carvalo, Ioana Croitoru, Alicia Garrido, Laura Marie Payne, Veena Viswanth, Lawrence Severt, Maurizio Facheris, Holly Soares, Mark A. Mintun, Jesse Cedarbaum, Peggy Taylor, Kevin Biglan, Emily Vandenbroucke, Zulfiqar Haider Sheikh, Baris Bingol, Tanya Fischer, Pablo Sardi, Remi Forrat, Alastair Reith, Jan Egebjerg, Gabrielle Ahlberg Hillert, Barbara Saba, Chris Min, Robert Umek, Joe Mather, Susan De Santi, Anke Post, Frank Boess, Kirsten Taylor, Igor Grachev, Andreja Avbersek, Pierandrea Muglia, Kaplana Merchant, Johannes Tauscher
Editorial Material
Clinical Neurology
A. Jon Stoessl, Kailash P. Bhatia, Marcelo Merello
MOVEMENT DISORDERS
(2020)
Article
Clinical Neurology
Zahinoor Ismail, Sandra E. Black, Richard Camicioli, Howard Chertkow, Nathan Herrmann, Robert Laforce, Manuel Montero-Odasso, Kenneth Rockwood, Pedro Rosa-Neto, Dallas Seitz, Saskia Sivananthan, Eric E. Smith, Jean-Paul Soucy, Isabelle Vedel, Serge Gauthier
ALZHEIMERS & DEMENTIA
(2020)
Editorial Material
Clinical Neurology
A. Jon Stoessl
Review
Neurosciences
Roger A. Barker, Anders Bjorklund, Don M. Gash, Alan Whone, Amber Van Laar, Jeffrey H. Kordower, Krystof Bankiewicz, Karl Kieburtz, Mart Saarma, Sigrid Booms, Henri J. Huttunen, Adrian P. Kells, Massimo S. Fiandaca, A. Jon Stoessl, David Eidelberg, Howard Federoff, Merja H. Voutilainen, David T. Dexter, Jamie Eberling, Patrik Brundin, Lyndsey Isaacs, Leah Mursaleen, Eros Bresolin, Camille Carroll, Alasdair Coles, Brian Fiske, Helen Matthews, Codrin Lungu, Richard K. Wyse, Simon Stott, Anthony E. Lang
JOURNAL OF PARKINSONS DISEASE
(2020)
Letter
Clinical Neurology
Alexandra Pavel, Danielle K. Murray, A. Jon Stoessl
Editorial Material
Clinical Neurology
A. Jon Stoessl
MOVEMENT DISORDERS
(2021)
Article
Neurosciences
Megan P. Feeney, Danny Bega, Benzi M. Kluger, A. Jon Stoessl, Christiana M. Evers, Rebeca De Leon, James C. Beck
Summary: A survey found that approximately a quarter of people with Parkinson's disease in the United States had used cannabis in the past six months, primarily to alleviate non-motor symptoms such as anxiety, pain, and sleep disorders. Lack of scientific evidence supporting the efficacy of cannabis for PD has led to cautious attitudes towards its use among patients.
NPJ PARKINSONS DISEASE
(2021)
Review
Clinical Neurology
Valtteri Kaasinen, Tero Vahlberg, A. Jon Stoessl, Antonio P. Strafella, Angelo Antonini
Summary: This study conducted a systematic review and meta-analysis on the expression of dopamine receptors in PD, PSP, and MSA, revealing differences in binding values of dopamine receptors among patients with different diseases.
MOVEMENT DISORDERS
(2021)
Review
Clinical Neurology
Trina Mitchell, Stephane Lehericy, Shannon Y. Chiu, Antonio P. Strafella, A. Jon Stoessl, David E. Vaillancourt
Summary: Imaging biomarkers for different stages of Parkinson's disease are crucial for monitoring progression in clinical trials and improving clinical care. This review highlights the importance of considering disease stage when implementing diagnostic and progression biomarkers in both clinical trials and clinical care settings.
Editorial Material
Clinical Neurology
A. Jon Stoessl
MOVEMENT DISORDERS
(2022)
Article
Multidisciplinary Sciences
Mariya V. Cherkasova, Jessie F. Fu, Michael Jarrett, Poljanka Johnson, Shawna Abel, Roger Tam, Alexander Rauscher, Vesna Sossi, Shannon Kolind, David K. B. Li, A. Dessa Sadovnick, Lindsay Machan, J. Marc Girard, Francois Emond, Reza Vosoughi, Anthony Traboulsee, A. Jon Stoessl
Summary: Despite limited therapeutic effects, certain multiple sclerosis patients demonstrated a transient improvement in health-related quality of life, indicating a placebo response. The study found that placebo responders had higher lesion activity and exhibited a different cortical architecture compared to non-responders.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Clinical Neurology
A. Jon Stoessl
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Jessie F. Fu, Michele Matarazzo, Jessamyn McKenzie, Nicole Neilson, Nasim Vafai, Katie Dinelle, Andre C. Felicio, Martin J. McKeown, A. Jon Stoessl, Vesna Sossi
Summary: The study found that the serotonergic system contributes to dopamine release and increases the risk for motor complications in early Parkinson's disease. Moreover, this contribution fails to provide sustained therapeutic advantage in early disease.
MOVEMENT DISORDERS
(2021)
Article
Neuroimaging
Jessie Fanglu Fu, Ivan S. Klyuzhin, Martin J. McKeown, A. Jon Stoessl, Vesna Sossi
NEUROIMAGE-CLINICAL
(2020)