Article
Multidisciplinary Sciences
Zhuming Fan, Zhiyang Liu, Nan Zhang, Wenyu Wei, Ke Cheng, Hongyan Sun, Quan Hao
Summary: Lysine lactylation (Kla) is a newly discovered histone post-translational modification. HDAC1-3 have been identified as effective Kla erasers. SIRT3 shows higher eraser activity against H4K16la site and its binding mechanisms have been revealed. Chemical probes have been developed to capture potential Kla erasers and detect Kla for further research on its roles in gene transcription regulation.
Review
Biochemistry & Molecular Biology
Patrycja Zietara, Marta Dziewiecka, Maria Augustyniak
Summary: The sirtuin system, consisting of seven highly conserved regulatory enzymes, plays a crucial role in metabolism, antioxidant protection, and cell cycle regulation. Sirtuins have attracted great interest due to their potential impact on life extension. This article provides a summary of the latest research on the activity of sirtuins and their involvement in the aging process. The effectiveness of compounds that modulate sirtuin activity has been demonstrated in numerous studies, highlighting the importance of carefully considering the risks associated with their manipulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Sanxing Guo, Fengying Li, Yixuan Liang, Yufei Zheng, Yingyi Mo, Deyao Zhao, Zhixiong Jiang, Mengmeng Cui, Lixia Qi, Jiaxing Chen, Lixin Wan, Guoyong Chen, Sidong Wei, Qi Yang, Junqi Liu
Summary: AIFM2 upregulation plays a crucial role in the promotion of HCC metastasis by activating SIRT1/PGC-1α signaling, suggesting it as a potential target for HCC treatment.
Article
Cell Biology
Mehrshad Sadria, Anita T. Layton
Summary: Cells adapt their metabolism and activities in response to signals from their surroundings, and proteins like mTOR, AMPK, and sirtuins play essential roles in regulating metabolic stress and energy balance. The computational model developed in this study sheds light on complex interactions among signaling pathways, offering insights for novel treatment approaches in diseases such as cancer.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Endocrinology & Metabolism
Sara Amjad, Sabah Nisar, Ajaz A. Bhat, Ab Rauf Shah, Michael P. Frenneaux, Khalid Fakhro, Mohammad Haris, Ravinder Reddy, Zoltan Patay, Joseph Baur, Puneet Bagga
Summary: NAD(+) plays a critical role in cellular bioenergetics and its depletion is associated with various diseases, making boosting NAD(+) levels a potential therapeutic strategy. However, the specific mechanisms of NAD(+) action require further investigation.
MOLECULAR METABOLISM
(2021)
Article
Immunology
Amin Izadpanah, Joseph C. Mudd, Joe G. N. Garcia, Sudesh Srivastav, Mohamed Abdel-Mohsen, Clovis Palmer, Aaron R. Goldman, Jay K. Kolls, Xuebin Qin, Jay Rappaport
Summary: Severe COVID-19 infection can lead to persistent symptoms such as pulmonary dysfunction, fatigue, and neurocognitive abnormalities. Dysregulated NAD metabolism may contribute to these abnormalities. By studying transgenic mice and sequencing data from SARS-CoV-2 infected patients, it was found that NAD biosynthetic enzymes and consuming enzymes are dysregulated in the infection. Modulating NAD pathways with nicotinamide riboside (NR) and anti-NAMPT antibody may offer therapeutic benefits for SARS-CoV-2 infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Krish Chandrasekaran, Neda Najimi, Avinash R. Sagi, Sushuma Yarlagadda, Mohammad Salimian, Muhammed Ikbal Arvas, Ahmad F. Hedayat, Yanni Kevas, Anand Kadakia, James W. Russell
Summary: Administration of NAD(+) precursors, NMN or NR, can prevent diabetic peripheral neuropathy, improve sensory function, and prevent nerve fiber loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Oyvind Stromland, Joseph Diab, Eugenio Ferrario, Lars J. Sverkeli, Mathias Ziegler
Summary: NAD(+) is an important coenzyme in redox reactions and cellular signaling, regulating essential processes like DNA repair, immune cell function, senescence, and chromatin remodeling. The decline of NAD(+) levels with age has been linked to various age-related diseases such as metabolic diseases and cognitive decline. Therapeutic augmentation of NAD(+) levels can halt or reverse the progression of age-related diseases.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Review
Cell Biology
Yongyuan He, Yinghong Su, Chengcheng Duan, Siyuan Wang, Wei He, Yingting Zhang, Xiaofei An, Ming He
Summary: With the global aging population, nonalcoholic fatty liver disease (NAFLD) has dramatically increased in recent decades. It is a progressive disease that ranges from simple fatty liver to liver cirrhosis and hepatocellular carcinoma (HCC). Aging plays a crucial role in the development and progression of NAFLD, HCC, and other age-related liver diseases. The involvement of senescent cells and aging-related factors, such as NAD+, sirtuins, and mTOR, in the development of NAFLD has been explored, although their significance remains underestimated. This review summarizes current research on the roles of aging, cellular senescence, and aging-related factors in the evolution of NAFLD to HCC, with the aim of identifying potential therapeutic targets for aging-related NAFLD and its progression.
AGEING RESEARCH REVIEWS
(2023)
Editorial Material
Cell Biology
Pawel Kordowitzki, Wing-Hong Jonathan Ho, Dave R. Listijono
Summary: The search for an anti-aging miracle drug is ongoing worldwide, with an increasing number of older women relying on assisted reproductive technologies for pregnancy, resulting in a significant increase in the age of women having their first child.
Review
Multidisciplinary Sciences
Wei Yao, Zuowei Pei, Xiaoqing Zhang
Summary: This review summarizes the role of NAD+ signaling in SIRTs in alleviating myocardial infarction.
Article
Biochemistry & Molecular Biology
Shivcharan Prasad, Ipsita Roy, Anusha Rani Pallapati
Summary: The aim of this work was to identify elements of adaptive regulatory mechanism for basal level of yeast histone deacetylase Sir2. Heat shock response (HSR) was altered in the absence of the NAD-dependent glycerol 3-phosphate dehydrogenase (Gpd1). Increase in HSR was lower in delta Gpd1 cells than wild-type cells. An inverse correlation existed between Gpd1 and Sir2; Sir2-deleted cells showed higher expression of Gpd1 while deletion of Gpd1 led to higher expression of Sir2. In the absence of Gpd1, basal activity of Sir2 promoter was higher and was increased further upon heat shock, suggesting higher Sir2 levels. No interaction between Gpd1 and Sir2 was detected without or with heat shock using immunoprecipitation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Review
Nutrition & Dietetics
Ekaterina Podyacheva, Yana Toropova
Summary: Despite the progress in developing new anticancer strategies, the issue of doxorubicin cardiotoxicity remains unresolved. Nicotinamide riboside, a precursor to NAD(+), shows potential in addressing this problem, although there is limited research on its effects on cardiomyopathy.
Article
Biochemistry & Molecular Biology
Su Hyoun Lee, Yun Ju Lee, Sungyeon Jung, Kwang Chul Chung
Summary: Parkinson's disease is a degenerative disorder of the central nervous system that affects 1% of the population over the age of 60. Mutations in the FBXO7 gene have been found to cause familial PD, and this study identified FBXO7 as an E3 ligase that negatively regulates SIRT7 stability. These findings suggest that FBXO7 may suppress the cytoprotective effects of SIRT7 during hydrogen peroxide-induced cell death.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Review
Physiology
Yu-Jen Wang, Francesco Paneni, Sokrates Stein, Christian M. Matter
Summary: Sirtuins are a family of deacetylases that are linked to cell energy metabolism and beneficial effects in cardiovascular diseases. Activation of Sirtuins by increasing NAD(+) can provide cardiometabolic protection and improve endothelial dysfunction.
FRONTIERS IN PHYSIOLOGY
(2021)