Article
Neurosciences
Suzanne D. Lanooij, W. H. I. M. Drinkenburg, U. L. M. Eisel, E. A. van der Zee, Martien J. H. Kas
Summary: Social factors are linked to the risk of developing Alzheimer's Disease. Social housing conditions have a significant effect on amyloid plaques and microglia, particularly in certain genotypes.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Holly C. Hunsberger, Sharay E. Setti, Carolyn C. Rudy, Daniel S. Weitzner, Jeremiah C. Pfitzer, Kelli L. McDonald, Hao Hong, Subhrajit Bhattacharya, Vishnu Suppiramaniam, Miranda N. Reed
Summary: This study using a mouse model found that increased expression of P301L Tau in aged mice leads to memory deficits, potentially due to late-stage tau pathology and dysregulation of glutamate release and uptake.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Luana Cristina Camargo, Dominik Honold, Robert Bauer, N. Jon Shah, Karl-Josef Langen, Dieter Willbold, Janine Kutzsche, Antje Willuweit, Sarah Schemmert
Summary: Research on the Tau-P301L mouse model revealed that male mice exhibit olfactory and motor deficits, increased Tau pathology, while female mice did not show these changes. Both male and female Tau-P301L mice showed phenotypic alterations, as well as cognitive deficits in behavioral tests.
Article
Neurosciences
Neha Soni, Rodrigo Medeiros, Khawlah Alateeq, Xuan Vinh To, Fatima A. Nasrallah
Summary: This study is the first to investigate the effects of TBI in tau-transgenic mice using DTI. The results show that changes in the DTI signal are associated with glial activity following TBI and may reflect changes that occur with or without phosphorylated-tau. Additionally, FA may be a promising measure to identify discrete pathological processes such as increased astroglia activation, tau hyperphosphorylation, or both in the brain following TBI.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jiang Chen, Anran Fan, Song Li, Yan Xiao, Yanlin Fu, Jun-Sheng Chen, Dan Zi, Ling-Hui Zeng, Jun Tan
Summary: Alzheimer's disease (AD), the most common type of dementia, is characterized by the presence of extracellular senile plaques composed of beta-amyloid peptides and intracellular neurofibrillary tangles containing phosphorylated-tau protein. This study has demonstrated the interaction between soluble tau and the N-terminal of amyloid precursor protein (APP) in vitro and in vivo, as well as the involvement of APP in the cellular uptake of tau through endocytosis. Targeting the pathological interaction between N-terminal APP and tau could be a promising therapeutic strategy for AD.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Genetics & Heredity
Jiankui Wang, Kai Cui, Guoying Hua, Deping Han, Zu Yang, Tun Li, Xue Yang, Yuanyuan Zhang, Ganxian Cai, Xiaotian Deng, Xuemei Deng
Summary: In this study, transgenic mice with skin-specific overexpression of ovine beta-catenin were generated through pronuclear microinjection. The successful transfer of the ovine beta-catenin gene into mice and its inheritance through multiple generations were confirmed by PCR testing and Southern blot analysis. The specific expression of beta-catenin mRNA in the skin of transgenic mice was demonstrated through qRT-PCR and Western blot analysis. The overexpression of beta-catenin was found to promote hair follicle development in mice by prematurely transitioning from catagen to anagen, thus increasing hair follicle density.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Jaime Lasheras, Rosario Pardo, Marc Velilla, Marcos Poncelas, Nuria Salvatella, Rafael Simo, Marisol Ruiz-Meana, Monica Zamora, Josep A. Villena
Summary: Proper cardiac function relies on the coordinated expression of multiple gene networks related to fuel utilization, mitochondrial ATP production, heart contraction, and ion transport. Transcriptional regulators like ERRs play a crucial role in regulating these gene networks. Overexpression of ERR gamma in the heart may lead to cardiac pathogenic responses, including heart failure and dilated cardiomyopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Guilian Xu, Brittany S. Ulm, John Howard, Susan E. Fromholt, Qing Lu, Brian Benedict Lee, Ariel Walker, David R. Borchelt, Jada Lewis
Summary: The study aims to investigate the pathological interaction between amyloidosis and tauopathy in Alzheimer's disease, and found that the development of tauopathy is exacerbated by the presence of newly forming amyloid deposits in younger brains and mature deposits in older brains.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Neurosciences
Sha Han, Dongyang Zhang, Qiang Dong, Xu Wang, Liang Wang
Summary: The study shows that overexpression of neuroserpin leads to different behavioral phenotypes in larval and adult zebrafish, including hypoactivity in larvae and anxiety-like behavior in adult fish. Additionally, RNA sequencing analysis indicates that neuroserpin overexpression affects gene expression related to neurodegeneration.
NEUROSCIENCE LETTERS
(2021)
Article
Pharmacology & Pharmacy
Paula Bollmann, Franziska Werner, Marko Jaron, Tom A. Bruns, Hartmut Wache, Jochen Runte, Peter Boknik, Uwe Kirchhefer, Frank U. Mueller, Igor B. Buchwalow, Sven Rothemund, Joachim Neumann, Ulrich Gergs
Summary: Overexpression of PP2C beta in the heart was found to lead to cardiac fibrosis and reduced resistance to hypoxia, but also improved adaptation to certain stressors like lipopolysaccharide or chronic beta-adrenergic stimulation. The effect of PP2C beta appears to be context sensitive.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Narumi Hashikawa-Hobara, Ami Otsuka, Chihiro Okujima, Naoya Hashikawa
Summary: The study found that CGRP-overexpressing mice have normal sensitivity to stress, but the Akt/mTOR/p70S6K pathways in the hippocampus are down-regulated, displaying a depressive-like phenotype.
Review
Biochemistry & Molecular Biology
Tara Alami, Jun-Li Liu
Summary: CCN5/WISP2 is a matricellular protein regulated by Wnt signaling and IGF-1, playing a role in promoting pancreatic beta-cell proliferation and survival while affecting adipocyte development and metabolic regulation. Experimental results showed that CCN5 deficiency led to adipocyte hypertrophy and insulin resistance, while overexpression increased lean body mass and improved insulin sensitivity. Further research is needed to explore other aspects of CCN5 physiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Min Chu, Deming Jiang, Li Liu, Binbin Nie, Bo Cui, Yihao Wang, Pedro Rosa-Neto, Liyong Wu
Summary: This study found that asymptomatic carriers of the P301L mutation of the MAPT gene showed altered metabolic connectivity in the sub-insula, even before the occurrence of atrophy, hypometabolism, and clinical symptoms. Patients with bvFTD exhibited significant atrophy, hypometabolism, and decreased metabolic connectivity in the whole brain. These findings highlight the importance of metabolic connectivity in the development of bvFTD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Pharmacology & Pharmacy
Sara Cimini, Giorgio Giaccone, Fabrizio Tagliavini, Matteo Costantino, Paola Perego, Giacomina Rossi
Summary: Tau protein, which plays a key role in neurons, is associated with neurodegenerative diseases and has been found to be linked to cancer. Mutations in the MAPT gene, which codes for tau, lead to dysregulation of cancer-relevant processes and decreased sensitivity to microtubule and DNA perturbation.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Diana Kindler, Cinzia Maschio, Ruiqing Ni, Valerio Zerbi, Daniel Razansky, Jan Klohs
Summary: The study found no significant differences in regional cerebral blood flow between P301L mice and non-transgenic littermates at different disease stages, indicating that hypoperfusion and neurodegeneration are not phenotypes of P301L mice. Additional research is needed to further understand the relationship between tau, neurodegeneration, vascular dysfunction, and modulators in Alzheimer's disease and primary tauopathies.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)