Small Molecule Structure Correctors Abolish Detrimental Effects of Apolipoprotein E4 in Cultured Neurons
出版年份 2011 全文链接
标题
Small Molecule Structure Correctors Abolish Detrimental Effects of Apolipoprotein E4 in Cultured Neurons
作者
关键词
-
出版物
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 287, Issue 8, Pages 5253-5266
出版商
American Society for Biochemistry & Molecular Biology (ASBMB)
发表日期
2011-12-13
DOI
10.1074/jbc.m111.276162
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Structure-dependent Impairment of Intracellular Apolipoprotein E4 Trafficking and Its Detrimental Effects Are Rescued by Small-molecule Structure Correctors
- (2011) Jens Brodbeck et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid- (A ) and acts in concert with A to elicit neuronal and behavioral deficits in mice
- (2011) N. Bien-Ly et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Influence of cell background on pharmacological rescue of mutant CFTR
- (2010) Nicoletta Pedemonte et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease
- (2010) Lisa Mosconi et al. Annals of the New York Academy of Sciences
- Apolipoprotein E4 Domain Interaction Mediates Detrimental Effects on Mitochondria and Is a Potential Therapeutic Target for Alzheimer Disease
- (2010) Hung-Kai Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening
- (2010) Ori Kalid et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- Pharmacological reactivation of mutant p53: from protein structure to the cancer patient
- (2010) K G Wiman ONCOGENE
- Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1
- (2010) Keith A. Vossel et al. SCIENCE
- Aβ-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease
- (2010) Yadong Huang TRENDS IN MOLECULAR MEDICINE
- Alzheimer disease: Multiple causes, multiple effects of apolipoprotein E4, and multiple therapeutic approaches
- (2009) Robert W. Mahley et al. ANNALS OF NEUROLOGY
- PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain
- (2009) Jeremy M.R. Lambert et al. CANCER CELL
- GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knockin Mice
- (2009) Gang Li et al. Cell Stem Cell
- Restoration of p53 to limit tumor growth
- (2009) Wenge Wang et al. CURRENT OPINION IN ONCOLOGY
- The pharmacological chaperone 1-deoxygalactonojirimycin increases α-galactosidase A levels in Fabry patient cell lines
- (2009) E. R. Benjamin et al. JOURNAL OF INHERITED METABOLIC DISEASE
- Research Highlights
- (2009) MOLECULAR THERAPY
- The Pharmacological Chaperone 1-Deoxygalactonojirimycin Reduces Tissue Globotriaosylceramide Levels in a Mouse Model of Fabry Disease
- (2009) Richie Khanna et al. MOLECULAR THERAPY
- Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis
- (2009) J M R Lambert et al. ONCOGENE
- Apolipoprotein E4 domain interaction: Synaptic and cognitive deficits in mice
- (2008) Ning Zhong et al. Alzheimers & Dementia
- CFTR Function and Prospects for Therapy
- (2008) John R. Riordan Annual Review of Biochemistry
- Understanding the Association of Apolipoprotein E4 with Alzheimer Disease: Clues from Its Structure
- (2008) Ning Zhong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS
- (2008) Robert W. Mahley et al. JOURNAL OF LIPID RESEARCH
- Chemical function-based pharmacophore development for novel, selective kappa opioid receptor agonists
- (2008) Nidhi Singh et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- Fabry's disease
- (2008) Yuri A Zarate et al. LANCET
- Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons
- (2008) J. Brodbeck et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeted rescue of a destabilized mutant of p53 by an in silico screened drug
- (2008) F. M. Boeckler et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecule-pharmacophore superpositioning and pattern matching in computational drug design
- (2007) G WOLBER DRUG DISCOVERY TODAY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started