Article
Neurosciences
Daiki Nakatsuka, Takaya Izumi, Tasuku Tsukamoto, Miki Oyama, Kohei Nishitomi, Yuichi Deguchi, Kazuki Niidome, Hidekuni Yamakawa, Hisanori Ito, Koichi Ogawa
Summary: Studies suggest that HDAC2 inhibition has disease-modifying effects in treating Alzheimer's disease (AD) and has the potential to slow disease progression. Knockdown of HDAC2 in transgenic mouse models can improve synaptic morphology and memory function.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Zijuan Zhang, Ziyang Yu, Ye Yuan, Jing Yang, Shijie Wang, He Ma, Li Hao, Jinlian Ma, Zhonghua Li, Zhenqiang Zhang, Christian Hölscher
Summary: Synaptic impairment and loss are important in Alzheimer's disease (AD), and can cause cognitive dysfunction and memory loss. In this study, a novel CCK analogue was found to improve synaptic plasticity, spatial learning, and memory in an AD mouse model. This effect was achieved through the activation of the PI3K/Akt and PKA/CREB-BDNF/TrkB signaling pathways, leading to protection of synapses and cognition.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Victoria Gomez-Murcia, Kevin Carvalho, Bryan Thiroux, Raphaelle Caillierez, Melanie Besegher, Nicolas Sergeant, Luc Buee, Emile Faivre, David Blum
Summary: Due to the complexity of Alzheimer's disease, it is of interest to find multitarget approaches that can mitigate multiple pathogenic mechanisms. In this study, the potential of Doxycycline (Dox), a second-generation tetracycline, in the APP/PS1 mouse model of amyloidogenesis was evaluated. The results showed that Dox moderately improved spatial memory in APP/PS1 mice without major effect on amyloid lesions. The study also found that Dox enhanced the amyloid-dependent upregulation of neuroinflammatory markers. Overall, chronic Dox delivery did not provide significant pathophysiological improvements in the APP/PS1 mouse model.
Article
Neurosciences
Suzanne D. Lanooij, W. H. I. M. Drinkenburg, U. L. M. Eisel, E. A. van der Zee, Martien J. H. Kas
Summary: Social factors are linked to the risk of developing Alzheimer's Disease. Social housing conditions have a significant effect on amyloid plaques and microglia, particularly in certain genotypes.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Behavioral Sciences
Martina Stazi, Oliver Wirths
Summary: The research demonstrates that prolonged physical activity and cognitive stimulation in a mouse model of AD overexpressing only Aβ(4-42) peptides lead to preservation of recognition and spatial memory, rescue of motor deficits, and improvement of phenotypes in the Morris water maze task. These findings support the notion that physical activity and cognitive stimulation could be effective strategies in preventing age-related neurodegenerative disorders like AD.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Ming-Chih Fang, Irene Han-Juo Cheng, Chien-Li Chen
Summary: This study found that ankaflavin and monascin in the fermented product of Monascus purpureus can improve Alzheimer's disease (AD) by modifying several pathogenic factors, including improving cognitive function, reversing behavioral deficits, reducing amyloid burden in the brain, decreasing abnormal protein phosphorylation, and reducing neuroinflammation. The fermented product of Monascus purpureus could be a promising therapeutic strategy for AD.
FERMENTATION-BASEL
(2022)
Article
Food Science & Technology
Yu-Shi Gong, Fang-Li Hou, Juan Guo, Lin Lin, Fu-Yong Zhu
Summary: The study found that high-dose alcohol intake impairs learning and memory abilities, increases A beta content and deposition, and promotes the progression of AD; while low-dose alcohol can mitigate excessive production of A beta and counteract the development of AD.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Clinical Neurology
Qingyou Chen, Yue Yin, Li Li, Yanjiao Zhang, Wei He, Yan Shi
Summary: Milrinone ameliorates memory loss and cognitive deficits in AD mice by repressing multiple pathological processes of AD, suggesting its potential as an effective drug for treating AD clinically.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Clinical Neurology
Guilian Xu, Brittany S. Ulm, John Howard, Susan E. Fromholt, Qing Lu, Brian Benedict Lee, Ariel Walker, David R. Borchelt, Jada Lewis
Summary: The study aims to investigate the pathological interaction between amyloidosis and tauopathy in Alzheimer's disease, and found that the development of tauopathy is exacerbated by the presence of newly forming amyloid deposits in younger brains and mature deposits in older brains.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiang Chen, Anran Fan, Song Li, Yan Xiao, Yanlin Fu, Jun-Sheng Chen, Dan Zi, Ling-Hui Zeng, Jun Tan
Summary: Alzheimer's disease (AD), the most common type of dementia, is characterized by the presence of extracellular senile plaques composed of beta-amyloid peptides and intracellular neurofibrillary tangles containing phosphorylated-tau protein. This study has demonstrated the interaction between soluble tau and the N-terminal of amyloid precursor protein (APP) in vitro and in vivo, as well as the involvement of APP in the cellular uptake of tau through endocytosis. Targeting the pathological interaction between N-terminal APP and tau could be a promising therapeutic strategy for AD.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Behavioral Sciences
Andrea Locci, Hector Orellana, Guadalupe Rodriguez, Meredith Gottliebson, Bryan McClarty, Sky Dominguez, Rachel Keszycki, Hongxin Dong
Summary: The study compared memory and affective behavior in different mouse models of Alzheimer's disease and found that APP(NLGF) and 5xFAD mice exhibit anxiety and depressive behavior, while APP/PS1 mice do not. Aβ plaque quantification showed differences between the models, with APP(NLGF) mice having the lowest plaque levels. Overall, the severity of Aβ neuropathology did not directly correlate with memory and affective behavior impairments in these mouse models.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xiaojing Zhou, Abdullah Md. Sheikh, Ken-ichi Matsumoto, Shingo Mitaki, Abu Zaffar Shibly, Yuchi Zhang, A. Garu, Shozo Yano, Atsushi Nagai
Summary: Through proteomic analysis of urine exosomes in AD model mice, we identified proteins related to lipid metabolism and A beta metabolism in the early stages of AD, providing new insights into the underlying pathological mechanism of early AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Mariko Sawa, Cassia Overk, Ann Becker, Dominique Derse, Ricardo Albay, Kim Weldy, Ahmad Salehi, Thomas G. Beach, Eric Doran, Elizabeth Head, Y. Eugene Yu, William C. Mobley
Summary: DS and AD-DS show differences in all APP products compared to ND and AD. In AD-DS, levels of A beta 42 and A beta 40 exceed those in AD. Increased APP products in the Dp16 model are linked to loss of vulnerable neurons, tau pathology, and activation of astrocytes and microglia, highlighting the importance of APP gene dose in Alzheimer's disease associated with Down syndrome.
ALZHEIMERS & DEMENTIA
(2022)
Article
Biochemistry & Molecular Biology
Amandine Jullienne, Ryan Quan, Jenny Szu, Michelle Trinh, Erik J. Behringer, Andre Obenaus
Summary: This study utilized the 3xTg-AD mouse model to examine the role of vascular dysfunction and structural abnormalities in the progression of Alzheimer's disease. The findings demonstrate progressive alterations in individual cortical vessels and the cortical vascular network, potentially identifying unique diagnostic signatures of AD progression.
Article
Biochemistry & Molecular Biology
Marta Zamarbide, Eva Martinez-Pinilla, Francisco Gil-Bea, Masashi Yanagisawa, Rafael Franco, Alberto Perez-Mediavilla
Summary: The study demonstrates the presence of the FFA3 receptor in the human brain and its involvement in cognitive processes. Inactivating the FFA3 gene can prevent AD-like cognitive decline and pathological hallmarks.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Fabian Kreilaus, Rebecca Masanetz, Georgia Watt, Magdalena Przybyla, Arne Ittner, Lars Ittner, Tim Karl
Summary: TAU58/2 transgenic female mice at 14 months of age showed significant motor deficits and lower bodyweight compared to WT littermates. They failed to habituate to the test arena in the light-dark test, and exhibited impaired long-term spatial memory while showing intact intermediate-term spatial learning in the cheeseboard test.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Clinical Neurology
Rose Chesworth, Rossana Rosa-Porto, Sofia Yao, Tim Karl
Summary: The study found that overexpression of Nrg1 type III modulates schizophrenia-relevant behaviors, which may help explain the increased sensitivity to the psychoactive effects of METH in patients with schizophrenia.
JOURNAL OF PSYCHOPHARMACOLOGY
(2021)
Article
Biochemical Research Methods
Liting Deng, Vivek K. Gupta, Yunqi Wu, Kanishka Pushpitha, Nitin Chitranshi, Veer B. Gupta, Matthew J. Fitzhenry, Masoud Zabet Moghaddam, Tim Karl, Ghasem Hosseini Salekdeh, Stuart L. Graham, Paul A. Haynes, Mehdi Mirzaei
Summary: Distinct areas of the brain are affected uniquely at various stages of Alzheimer's disease pathogenesis, with fundamental compositional and functional shifts even in the early stages of the disease. This study highlights unique proteome and biochemical pathway alterations in specific brain regions underlying early stages of AD pathology, providing a framework for future longitudinal studies. The proteomics data have been deposited in the ProteomeXchange Consortium via PRIDE with the identifier PXD019192.
Article
Behavioral Sciences
Stefan Guerra, Rose Chesworth, Cynthia Shannon Weickert, Tim Karl
Summary: Handling methods significantly affect various behavioral domains, thus the impact of routine handling procedures should be considered when testing behavioral phenotypes. Handling did not alter the main schizophrenia-relevant characteristics of Nrg1 III tg mice but did affect the acoustic startle response in a genotype- and sex-specific manner. Future research should assess the effect of handling on other genetic models.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Behavioral Sciences
Stefan Guerra, Roger Chung, Justin Yerbury, Tim Karl
Summary: The study demonstrates that the individually ventilated cage (IVC) housing system has a moderate impact on the neuro-behavioural phenotype of SOD1(G93A) mice, particularly accelerating the development of motor impairments in females. However, central behavioral deficits were still evident across housing conditions.
GENES BRAIN AND BEHAVIOR
(2021)
Article
Neurosciences
Rustam Asgarov, Monokesh K. Sen, Meena Mikhael, Tim Karl, Erika Gyengesi, David A. Mahns, Chandra S. Malladi, Gerald W. Munch
Summary: The study investigated the cerebellum proteome of GFAP-IL6 transgenic mice and found that changes in protein form levels associated with IL-6 overexpression may contribute to motor function deficits. Analysis revealed differentially expressed proteoforms in three classes related to metabolism, neurodegenerative processes, and protein aggregation in the cerebellum. Additionally, impaired motor skills in transgenic mice were correlated with specific proteoform expression levels.
Article
Neurosciences
Rose Chesworth, Rashmi Gamage, Faheem Ullah, Sandra Sonego, Christopher Millington, Amanda Fernandez, Huazheng Liang, Tim Karl, Gerald Munch, Garry Niedermayer, Erika Gyengesi
Summary: Chronic neuroinflammation characterized by microglia reactivity plays a key role in the development of neurodegenerative diseases. Although chronic apigenin treatment reduced microglia activation in the hippocampus of GFAP-IL6 mice, it did not lead to an improvement in spatial memory.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Immunology
Utpal Kumar Adhikari, Elif Sakiz, Xian Zhou, Umma Habiba, Sachin Kumar, Meena Mikhael, Matteo Senesi, Chun Guang Li, Gilles J. Guillemin, Lezanne Ooi, Monique Antoinette David, Steven Collins, Tim Karl, Mourad Tayebi
Summary: This study demonstrated that cross-linking PrP(C) with anti-PrP antibodies triggers a neuronal hypersensitivity response and emphasizes the crucial role of microglia in initiating an IgG-mediated neuronal hypersensitivity response. Furthermore, it suggests the importance of including allergenic evaluation of therapeutic antibodies for neurodegenerative disorders to develop safe and targeted biotherapeutics.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Behavioral Sciences
Fabian Kreilaus, Magdalena Przybyla, Lars Ittner, Tim Karl
Summary: This study investigated the therapeutic effects of CBD on transgenic mice and found that CBD can improve behavioural deficits and cognitive impairments associated with FTD and AD.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Multidisciplinary Sciences
Jeremy S. Lum, Mikayla L. Brown, Natalie E. Farrawell, Luke McAlary, Diane Ly, Christen G. Chisholm, Josh Snow, Kara L. Vine, Tim Karl, Fabian Kreilaus, Lachlan E. McInnes, Sara Nikseresht, Paul S. Donnelly, Peter J. Crouch, Justin J. Yerbury
Summary: CuATSM has shown therapeutic efficacy in ALS treatment, but high dosage may lead to clinical toxicity. Lower doses could slow disease progression. Assessment of treatments in previously unassessed mouse models should consider dosage and tolerability.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Behavioral Sciences
Tim Karl, Jess Nithianantharajah, Ulrike Weber-Stadlbauer
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Yuanyuan Deng, Mian Bi, Fabien Delerue, Shelley L. Forrest, Gabriella Chan, Julia van der Hoven, Annika van Hummel, Astrid F. Feiten, Seojin Lee, Ivan Martinez-Valbuena, Tim Karl, Gabor G. Kovacs, Grant Morahan, Yazi D. Ke, Lars M. Ittner
Summary: In Alzheimer's disease, hyperexcitation of neuronal networks is an underlying disease mechanism. The study identifies LAMP5 as a novel regulator of hyperexcitation in mice, critical for the survival of distinct interneuron populations.
ACTA NEUROPATHOLOGICA
(2022)
Article
Neurosciences
Gabriela Visini, Samara Brown, Katrina Weston-Green, Cynthia Shannon Weickert, Rose Chesworth, Tim Karl
Summary: This study aimed to investigate the effect of CBD given during adolescence on the development of schizophrenia-relevant phenotypes and sensitivity to THC. The results showed that CBD increased locomotion and had anxiolytic effects, while also enhancing social behavior in response to THC. However, CBD did not alleviate schizophrenia-relevant phenotypes in mutant mice and increased vulnerability to THC-induced behaviors.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Neurosciences
Madilyn Coles, Genevieve Z. Steiner-Lim, Tim Karl
Summary: Alzheimer's disease is a debilitating neurodegenerative disease characterized by cognitive decline and behavioral impairment. The endocannabinoid system is affected in Alzheimer's disease and phytocannabinoids such as CBD and THC have shown therapeutic potential in ameliorating the pathologies associated with the disease. Using multi-cannabinoid formulations for treatment may be more effective than isolating individual cannabinoids.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Rose Chesworth, David Cheng, Chloe Staub, Tim Karl
Summary: Cannabidiol (CBD) therapy shows potential in preventing cognitive impairment in female genetically modified mouse models of Alzheimer's disease (AD), suggesting a preventive therapeutic effect in female familial AD patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)