Clinical utility of recently identified diagnostic, prognostic, and predictive molecular biomarkers in mature B-cell neoplasms

Methodologic Considerations in the Application of Next-Generation Sequencing of Human TRB Repertoires for Clinical Use

(2017) Liwen Xu et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Waldenström’s Macroglobulinemia/Lymphoplasmacytic Lymphoma, Version 2.2013

(2017) Kenneth C. Anderson et al.   Journal of the National Comprehensive Cancer Network

Genome-wide analysis of pediatric-type follicular lymphoma reveals low genetic complexity and recurrent alterations of TNFRSF14 gene

(2016) J. Schmidt et al.   BLOOD

The genetics of nodal marginal zone lymphoma

(2016) V. Spina et al.   BLOOD

Pediatric-type nodal follicular lymphoma: a biologically distinct lymphoma with frequent MAPK pathway mutations

(2016) A. Louissaint et al.   BLOOD

The 2016 revision of the World Health Organization classification of lymphoid neoplasms

(2016) S. H. Swerdlow et al.   BLOOD

Long-term durable remission by cladribine followed by rituximab in patients with hairy cell leukaemia: update of a phase II trial

(2016) Dai Chihara et al.   BRITISH JOURNAL OF HAEMATOLOGY

MYD88 L265P Mutations, But No Other Variants, Identify a Subpopulation of DLBCL Patients of Activated B-cell Origin, Extranodal Involvement, and Poor Outcome

(2016) J. Rovira et al.   CLINICAL CANCER RESEARCH

Chronic Lymphocytic Leukemia and Other Lymphoproliferative Disorders

(2016) Sarah Wall et al.   CLINICS IN GERIATRIC MEDICINE

NovelIGHandMYCTranslocation Partners in Diffuse Large B-Cell Lymphomas

(2016) Claudia Otto et al.   GENES CHROMOSOMES & CANCER

PD-L1 and PD-L2 Genetic Alterations Define Classical Hodgkin Lymphoma and Predict Outcome

(2016) Margaretha G.M. Roemer et al.   JOURNAL OF CLINICAL ONCOLOGY

NCCN Guidelines Insights: Multiple Myeloma, Version 3.2016

(2016) Kenneth C. Anderson et al.   Journal of the National Comprehensive Cancer Network

NCCN Guidelines Insights: Non-Hodgkin's Lymphomas, Version 3.2016

(2016) Steven M. Horwitz et al.   Journal of the National Comprehensive Cancer Network

Splenic marginal zone lymphoma: Prognostic factors, role of watch and wait policy, and other therapeutic approaches in the rituximab era

(2016) Salvatore Perrone et al.   LEUKEMIA RESEARCH

Characterization of a variant of t(14;18) negative nodal diffuse follicular lymphoma with CD23 expression, 1p36/TNFRSF14 abnormalities and STAT6 mutations

(2016) Imran N Siddiqi et al.   MODERN PATHOLOGY

Recurrent mutations in NF-κB pathway components, KMT2D, and NOTCH1/2 in ocular adnexal MALT-type marginal zone lymphomas

(2016) Patricia Johansson et al.   Oncotarget

Correction: Non-Canonical NF-κB Activation and Abnormal B Cell Accumulation in Mice Expressing Ubiquitin Protein Ligase-Inactive c-IAP2

(2016) Dietrich B. Conze et al.   PLOS BIOLOGY

Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study

(2016) Robert Kridel et al.   PLOS MEDICINE

Non-Hodgkin lymphoma subtype distribution, geodemographic patterns, and survival in the US: A longitudinal analysis of the National Cancer Data Base from 1998 to 2011

(2015) Mohammed Al-Hamadani et al.   AMERICAN JOURNAL OF HEMATOLOGY

IgH-V(D)J NGS-MRD measurement pre- and early post-allotransplant defines very low- and very high-risk ALL patients

(2015) M. A. Pulsipher et al.   BLOOD

Genomic and epigenomic heterogeneity in chronic lymphocytic leukemia

(2015) R. Guieze et al.   BLOOD

MYD88L265P andCXCR4mutations in lymphoplasmacytic lymphoma identify cases with high disease activity

(2015) Janine Schmidt et al.   BRITISH JOURNAL OF HAEMATOLOGY

Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing

(2015) M. Parry et al.   CLINICAL CANCER RESEARCH

Post-transplant molecularly defined Burkitt lymphomas are frequently MYC-negative and characterized by the 11q-gain/loss pattern

(2015) J. F. Ferreiro et al.   HAEMATOLOGICA

Hairy Cell Leukemia with Systemic Lymphadenopathy: Detection of BRAF Mutations in Both Lymph Node and Peripheral Blood Specimens

(2015) Kazuya Okada et al.   INTERNAL MEDICINE

Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma

(2015) Brian A. Walker et al.   JOURNAL OF CLINICAL ONCOLOGY

Non-coding recurrent mutations in chronic lymphocytic leukaemia

(2015) Xose S. Puente et al.   NATURE

Mutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomas

(2015) M A Lunning et al.   Blood Cancer Journal

Frequencies of SF3B1, NOTCH1, MYD88, BIRC3 and IGHV mutations and TP53 disruptions in Chinese with chronic lymphocytic leukemia: disparities with Europeans

(2015) Yi Xia et al.   Oncotarget

Virus-encoded microRNA contributes to the molecular profile of EBV-positive Burkitt lymphomas

(2015) Pier Paolo Piccaluga et al.   Oncotarget

Post-transplant molecularly defined Burkitt lymphomas are frequently MYC-negative and characterized by the 11q-gain/loss pattern

(2015) J. F. Ferreiro et al.   HAEMATOLOGICA

Combination therapy with BRAF and MEK inhibitors for melanoma: latest evidence and place in therapy

(2015) Zeynep Eroglu et al.   Therapeutic Advances in Medical Oncology

Burkitt lymphomagenesis linked to MYC plus PI3K in germinal center B cells

(2015) Sandrine Sander et al.   Oncotarget

Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial

(2014) S. Stilgenbauer et al.   BLOOD

The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells

(2014) J. Zhang et al.   BLOOD

A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma

(2014) I. Salaverria et al.   BLOOD

Mutations in TLR/MYD88 pathway identify a subset of young chronic lymphocytic leukemia patients with favorable outcome

(2014) A. Martinez-Trillos et al.   BLOOD

Widespread Genetic Heterogeneity in Multiple Myeloma: Implications for Targeted Therapy

(2014) Jens G. Lohr et al.   CANCER CELL

Liquid Biopsies: Genotyping Circulating Tumor DNA

(2014) Luis A. Diaz et al.   JOURNAL OF CLINICAL ONCOLOGY

The WHIM-like CXCR4S338X somatic mutation activates AKT and ERK and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom’s Macroglobulinemia

(2014) Y Cao et al.   LEUKEMIA

The Krüppel-like factor 2 transcription factor gene is recurrently mutated in splenic marginal zone lymphoma

(2014) R Piva et al.   LEUKEMIA

Recurrent mutations refine prognosis in chronic lymphocytic leukemia

(2014) P Baliakas et al.   LEUKEMIA

NOTCH1, SF3B1, BIRC3andTP53mutations in patients with chronic lymphocytic leukemia undergoing first-line treatment: correlation with biological parameters and response to treatment

(2014) Sabina Chiaretti et al.   LEUKEMIA & LYMPHOMA

Recurrent somatic mutations of PTPN1 in primary mediastinal B cell lymphoma and Hodgkin lymphoma

(2014) Jay Gunawardana et al.   NATURE GENETICS

Resistance Mechanisms for the Bruton's Tyrosine Kinase Inhibitor Ibrutinib

(2014) Jennifer A. Woyach et al.   NEW ENGLAND JOURNAL OF MEDICINE

Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis

(2014) B. Ortiz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolving Understanding of the CLL Genome

(2014) Michaela Gruber et al.   SEMINARS IN HEMATOLOGY

Activation of TAK1 by MYD88 L265P drives malignant B-cell Growth in non-Hodgkin lymphoma

(2014) S M Ansell et al.   Blood Cancer Journal

Genetics of Follicular Lymphoma Transformation

(2014) Laura Pasqualucci et al.   Cell Reports

Detection of MYD88 L265P Mutation by Real-Time Allele-Specific Oligonucleotide Polymerase Chain Reaction

(2014) Cristina Jiménez et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Genetic Abnormalities in Chronic Lymphocytic Leukemia: Where We Are and Where We Go

(2014) Anna Puiggros et al.   Biomed Research International

MYC/BCL2 Double-Hit High-Grade B-Cell Lymphoma

(2013) Shaoying Li et al.   ADVANCES IN ANATOMIC PATHOLOGY

Prevalence and clinical significance of the MYD88 (L265P) somatic mutation in Waldenstrom's macroglobulinemia and related lymphoid neoplasms

(2013) M. Varettoni et al.   BLOOD

The genomic landscape of Waldenstrom macroglobulinemia is characterized by highly recurring MYD88 and WHIM-like CXCR4 mutations, and small somatic deletions associated with B-cell lymphomagenesis

(2013) Z. R. Hunter et al.   BLOOD

MYD88 L265P in Waldenstrom macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction

(2013) L. Xu et al.   BLOOD

Targeted resequencing for analysis of clonal composition of recurrent gene mutations in chronic lymphocytic leukaemia

(2013) Alexander Jethwa et al.   BRITISH JOURNAL OF HAEMATOLOGY

Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia

(2013) Dan A. Landau et al.   CELL

Recurrent loss of heterozygosity in 1p36 associated with TNFRSF14 mutations in IRF4 translocation negative pediatric follicular lymphomas

(2013) I. Martin-Guerrero et al.   HAEMATOLOGICA

Clinical implications of the molecular genetics of chronic lymphocytic leukemia

(2013) R. Foa et al.   HAEMATOLOGICA

Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome

(2013) Giulia Fabbri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Whole-exome sequencing in splenic marginal zone lymphoma reveals mutations in genes involved in marginal zone differentiation

(2013) N Martínez et al.   LEUKEMIA

Consolidation and maintenance therapy with lenalidomide, bortezomib and dexamethasone (RVD) in high-risk myeloma patients

(2013) A K Nooka et al.   LEUKEMIA

On the way towards a ‘CLL prognostic index’: focus on TP53, BIRC3, SF3B1, NOTCH1 and MYD88 in a population-based cohort

(2013) D Cortese et al.   LEUKEMIA

Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs

(2013) D Cirstea et al.   LEUKEMIA

Next-generation sequencing and real-time quantitative PCR for minimal residual disease detection in B-cell disorders

(2013) M Ladetto et al.   LEUKEMIA

SF3B1 mutations correlated to cytogenetics and mutations in NOTCH1, FBXW7, MYD88, XPO1 and TP53 in 1160 untreated CLL patients

(2013) S Jeromin et al.   LEUKEMIA

Minimal residual disease quantification using consensus primers and high-throughput IGH sequencing predicts post-transplant relapse in chronic lymphocytic leukemia

(2013) A C Logan et al.   LEUKEMIA

High prevalence of MAP2K1 mutations in variant and IGHV4-34–expressing hairy-cell leukemias

(2013) Joshua J Waterfall et al.   NATURE GENETICS

Pharmacological and genomic profiling identifies NF-κB–targeted treatment strategies for mantle cell lymphoma

(2013) Rami Rahal et al.   NATURE MEDICINE

Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia

(2013) John C. Byrd et al.   NEW ENGLAND JOURNAL OF MEDICINE

Landscape of somatic mutations and clonal evolution in mantle cell lymphoma

(2013) S. Bea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High prevalence of oncogenic MYD88 and CD79B mutations in diffuse large B-cell lymphomas presenting at immune-privileged sites

(2013) W Kraan et al.   Blood Cancer Journal

Survival outcomes with and without splenectomy in splenic marginal zone lymphoma

(2012) Adam J. Olszewski   AMERICAN JOURNAL OF HEMATOLOGY

Pediatric-type nodal follicular lymphoma: an indolent clonal proliferation in children and adults with high proliferation index and no BCL2 rearrangement

(2012) A. Louissaint et al.   BLOOD

Dysfunction of the TP53 tumor suppressor gene in lymphoid malignancies

(2012) Z. Y. Xu-Monette et al.   BLOOD

Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab-CHOP Consortium Program Study

(2012) Z. Y. Xu-Monette et al.   BLOOD

Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia

(2012) D. Rossi et al.   BLOOD

The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial

(2012) D. G. Oscier et al.   BLOOD

Deep-sequencing approach for minimal residual disease detection in acute lymphoblastic leukemia

(2012) M. Faham et al.   BLOOD

The prognostic impact of clinical and molecular features in hairy cell leukaemia variant and splenic marginal zone lymphoma

(2012) Sarah L. Hockley et al.   BRITISH JOURNAL OF HAEMATOLOGY

Synergy between PI3K Signaling and MYC in Burkitt Lymphomagenesis

(2012) Sandrine Sander et al.   CANCER CELL

Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

(2012) A. Navarro et al.   CANCER RESEARCH

The impact of cyclin D1 mRNA isoforms, morphology and p53 in mantle cell lymphoma: p53 alterations and blastoid morphology are strong predictors of a high proliferation index

(2012) J. Slotta-Huspenina et al.   HAEMATOLOGICA

Patients with diffuse large B-cell lymphoma of germinal center origin with BCL2 translocations have poor outcome, irrespective of MYC status: a report from an International DLBCL rituximab-CHOP Consortium Program Study

(2012) C. Visco et al.   HAEMATOLOGICA

Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies

(2012) Kian-Huat Lim et al.   IMMUNOLOGICAL REVIEWS

Targeting B-Cell Receptor Signaling for Anticancer Therapy: The Bruton's Tyrosine Kinase Inhibitor Ibrutinib Induces Impressive Responses in B-Cell Malignancies

(2012) Adrian Wiestner   JOURNAL OF CLINICAL ONCOLOGY

The coding genome of splenic marginal zone lymphoma: activation ofNOTCH2and other pathways regulating marginal zone development

(2012) Davide Rossi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Whole-genome sequencing identifies recurrent somaticNOTCH2mutations in splenic marginal zone lymphoma

(2012) Mark J. Kiel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Over 30% of patients with splenic marginal zone lymphoma express the same immunoglobulin heavy variable gene: ontogenetic implications

(2012) V Bikos et al.   LEUKEMIA

Non-nodal type of mantle cell lymphoma is a specific biological and clinical subgroup of the disease

(2012) C Royo et al.   LEUKEMIA

IGHV gene features and MYD88 L265P mutation separate the three marginal zone lymphoma entities and Waldenström macroglobulinemia/lymphoplasmacytic lymphomas

(2012) N Gachard et al.   LEUKEMIA

ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia

(2012) S Pospisilova et al.   LEUKEMIA

Splenic marginal zone lymphoma: a population-based study on the 2001–2008 incidence and survival in the United States

(2012) Lihua Liu et al.   LEUKEMIA & LYMPHOMA

Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics

(2012) Roland Schmitz et al.   NATURE

The genetic landscape of mutations in Burkitt lymphoma

(2012) Cassandra Love et al.   NATURE GENETICS

Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing

(2012)   NATURE GENETICS

MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia

(2012) Steven P. Treon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic approaches to modulating Notch signaling: Current challenges and future prospects

(2012) Casper Groth et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma

(2011) R. Kridel et al.   BLOOD

Alteration of BIRC3 and multiple other NF- B pathway genes in splenic marginal zone lymphoma

(2011) D. Rossi et al.   BLOOD

Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness

(2011) D. Rossi et al.   BLOOD

Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia

(2011) D. Rossi et al.   BLOOD

Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults

(2011) I. Salaverria et al.   BLOOD

High resolution melting analysis for detection of BRAF exon 15 mutations in hairy cell leukaemia and other lymphoid malignancies

(2011) Elaine M. Boyd et al.   BRITISH JOURNAL OF HAEMATOLOGY

Indolent mantle cell leukemia: a clinicopathological variant characterized by isolated lymphocytosis, interstitial bone marrow involvement, kappa light chain restriction, and good prognosis

(2011) S. L. Ondrejka et al.   HAEMATOLOGICA

ATM gene alterations in chronic lymphocytic leukemia patients induce a distinct gene expression profile and predict disease progression

(2011) A. Guarini et al.   HAEMATOLOGICA

A Cancer and Leukemia Group B multi-center study of DA-EPOCH-rituximab in untreated diffuse large B-cell lymphoma with analysis of outcome by molecular subtype

(2011) W. H. Wilson et al.   HAEMATOLOGICA

Analysis of the chronic lymphocytic leukemia coding genome: role ofNOTCH1mutational activation

(2011) Giulia Fabbri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Impact of TP53 mutation and 17p deletion in mantle cell lymphoma

(2011) A M Halldórsdóttir et al.   LEUKEMIA

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

(2011) Ryan D. Morin et al.   NATURE

MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers

(2011) Christian Steidl et al.   NATURE

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

(2011) Xose S. Puente et al.   NATURE

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

(2011) Víctor Quesada et al.   NATURE GENETICS

BRAFMutations in Hairy-Cell Leukemia

(2011) Enrico Tiacci et al.   NEW ENGLAND JOURNAL OF MEDICINE

SF3B1and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia

(2011) Lili Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

cIAP1/2 Are Direct E3 Ligases Conjugating Diverse Types of Ubiquitin Chains to Receptor Interacting Proteins Kinases 1 to 4 (RIP1–4)

(2011) Mathieu J. M. Bertrand et al.   PLoS One

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF- B-dependent lymphoma

(2010) M. A. Milhollen et al.   BLOOD

Pathway discovery in mantle cell lymphoma by integrated analysis of high-resolution gene expression and copy number profiling

(2010) E. M. Hartmann et al.   BLOOD

Advances in the understanding of MYC-induced lymphomagenesis

(2010) Kay Klapproth et al.   BRITISH JOURNAL OF HAEMATOLOGY

Genomic and Gene Expression Profiling Defines Indolent Forms of Mantle Cell Lymphoma

(2010) V. Fernandez et al.   CANCER RESEARCH

Mantle cell lymphoma: The promise of new treatment options

(2010) Andre Goy et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

TP53Mutation and Survival in Chronic Lymphocytic Leukemia

(2010) Thorsten Zenz et al.   JOURNAL OF CLINICAL ONCOLOGY

PTENtumor suppressor plays less prognostic role thanP53tumor suppressor in diffuse large B-cell lymphoma

(2010) Yan-Yan Liu et al.   LEUKEMIA & LYMPHOMA

Oncogenically active MYD88 mutations in human lymphoma

(2010) Vu N. Ngo et al.   NATURE

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

(2010) R. Eric Davis et al.   NATURE

B Cell Receptor Signaling: Picky About PI3Ks

(2010) J. J. Limon et al.   Science Signaling

Non-Canonical NF-κB Activation and Abnormal B Cell Accumulation in Mice Expressing Ubiquitin Protein Ligase-Inactive c-IAP2

(2010) Dietrich B. Conze et al.   PLOS BIOLOGY

VH4-34+ hairy cell leukemia, a new variant with poor prognosis despite standard therapy

(2009) E. Arons et al.   BLOOD

The Prognostic Value of TP53 Mutations in Chronic Lymphocytic Leukemia Is Independent of Del17p13: Implications for Overall Survival and Chemorefractoriness

(2009) D. Rossi et al.   CLINICAL CANCER RESEARCH

Outcome of Deferred Initial Therapy in Mantle-Cell Lymphoma

(2009) Peter Martin et al.   JOURNAL OF CLINICAL ONCOLOGY

Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

(2009) Mara Compagno et al.   NATURE

A distinctive subtype of t(14;18)-negative nodal follicular non-Hodgkin lymphoma characterized by a predominantly diffuse growth pattern and deletions in the chromosomal region 1p36

(2008) T. Katzenberger et al.   BLOOD

The presence of TP53 mutation at diagnosis of follicular lymphoma identifies a high-risk group of patients with shortened time to disease progression and poorer overall survival

(2008) D. O'Shea et al.   BLOOD

Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study

(2008) K. H. Young et al.   BLOOD

MYC translocation in chronic lymphocytic leukaemia is associated with increased prolymphocytes and a poor prognosis

(2008) Yang O. Huh et al.   BRITISH JOURNAL OF HAEMATOLOGY

Phase II Study of Dose-Adjusted EPOCH and Rituximab in Untreated Diffuse Large B-Cell Lymphoma With Analysis of Germinal Center and Post-Germinal Center Biomarkers

(2008) Wyndham H. Wilson et al.   JOURNAL OF CLINICAL ONCOLOGY

Structural aberrations affecting the MYC locus indicate a poor prognosis independent of clinical risk factors in diffuse large B-cell lymphomas treated within randomized trials of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL)

(2008) W Klapper et al.   LEUKEMIA

Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

(2008) Brian J Zarnegar et al.   NATURE IMMUNOLOGY

Stromal Gene Signatures in Large-B-Cell Lymphomas

(2008) G. Lenz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oncogenic CARD11 Mutations in Human Diffuse Large B Cell Lymphoma

(2008) G. Lenz et al.   SCIENCE

Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor- B pathways in subtypes of diffuse large B-cell lymphoma

(2007) L. T. Lam et al.   BLOOD