Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis

Modeling Adult Gliomas Using RCAS/t-va Technology

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"Activated" STAT Proteins: A Paradoxical Consequence of Inhibited JAK-STAT Signaling in Cytomegalovirus-Infected Cells

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CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Breakpoint Features of Genomic Rearrangements in Neuroblastoma with Unbalanced Translocations and Chromothripsis

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Reduced microglial CX3CR1 expression delays neurofibromatosis-1 glioma formation

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Macrophages in Tumor Microenvironments and the Progression of Tumors

(2012) Ning-Bo Hao et al.   Clinical & Developmental Immunology

Polymorphism in protein tyrosine phosphatase receptor delta is associated with the risk of clear cell renal cell carcinoma

(2012) Yan Du et al.   GENE

Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase a oncogene

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Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

The molecular profile of microglia under the influence of glioma

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Characteristics of the Alternative Phenotype of Microglia/Macrophages and its Modulation in Experimental Gliomas

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Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

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Neurofibromatosis-1 Heterozygosity Increases Microglia in a Spatially and Temporally Restricted Pattern Relevant to Mouse Optic Glioma Formation and Growth

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The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

PTEN/PI3K/Akt Pathway Regulates the Side Population Phenotype and ABCG2 Activity in Glioma Tumor Stem-like Cells

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Self-regulation of Stat3 activity coordinates cell-cycle progression and neural crest specification

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Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice

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CCL2 and Interleukin-6 Promote Survival of Human CD11b+Peripheral Blood Mononuclear Cells and Induce M2-type Macrophage Polarization

(2009) Hernan Roca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced Stat3 Activation in POMC Neurons Provokes Negative Feedback Inhibition of Leptin and InsulinSignaling in Obesity

(2009) M. B. Ernst et al.   JOURNAL OF NEUROSCIENCE

The transcriptional network for mesenchymal transformation of brain tumours

(2009) Maria Stella Carro et al.   NATURE

The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers

(2009) S. Veeriah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutational Inactivation of PTPRD in Glioblastoma Multiforme and Malignant Melanoma

(2008) D. A. Solomon et al.   CANCER RESEARCH

Gli Activity Correlates with Tumor Grade in Platelet-Derived Growth Factor-Induced Gliomas

(2008) O. J. Becher et al.   CANCER RESEARCH

Signal Transducer and Activator of Transcription-3: A Molecular Hub for Signaling Pathways in Gliomas

(2008) E. C. Brantley et al.   MOLECULAR CANCER RESEARCH

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

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