Article
Oncology
Zhen Yang, Lianshuang Liu, Kaiming Leng, Guangjun Shi
Summary: This study aimed to investigate the incidence, characteristics, treatment, and survival of splenic marginal zone lymphoma (SMZL). A total of 2790 SMZL patients were analyzed using the SEER-18 database. The study found a decreasing use of splenectomy but a relatively stable survival in SMZL patients. The study highlights the need for a better understanding of the role of splenectomy and its associated outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Juan Pablo Alderuccio, Jorge A. Florindez, Isildinha M. Reis, Wei Zhao, Izidore S. Lossos
Summary: Extranodal marginal zone lymphoma (EMZL) is a rare disease commonly diagnosed at an early stage and remains localized for prolonged periods of time. The use of radiation therapy (RT) has shown excellent results, especially in stage I EMZL patients. Survival rates differ by primary disease location, but RT-treated patients show similar survival to the general U.S. population. Factors such as age, grade transformation, and primary location influence lymphoma-specific survival in EMZL patients.
Article
Hematology
Gabriela Bastidas-Mora, Silvia Bea, Alba Navarro, Eva Gine, Dolors Costa, Julio Delgado, Tycho Baumann, Laura Magnano, Alfredo Rivas-Delgado, Neus Villamor, Dolors Colomer, Monica Lopez-Guerra, Maria Rozman, Olga Balague, Daniel Martinez, Maria Joao Baptista, Lourdes Escoda, Miguel Alcoceba, Margarita Blanes, Fina Climent, Elias Campo, Andrew Wotherspoon, Armando Lopez-Guillermo, Estella Matutes
Summary: The study describes 36 patients with splenic marginal zone lymphoma (SMZL) with transformation, with predictors including cytopenias, hypoalbuminaemia, and complex karyotype. Patients with SMZL-T have a higher risk of death, mostly developing diffuse large B-cell lymphoma post transformation, with predictors for worse survival being high-risk International Prognostic Index and lack of complete response.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Hematology
Rui Lyu, Tingyu Wang, Yi Wang, Wenjie Xiong, Huijun Wang, Yuting Yan, Qi Wang, Wei Liu, Gang An, Wenyang Huang, Weiwei Sui, Yan Xu, Dehui Zou, Jianxiang Wang, Lugui Qiu, Shuhua Yi
Summary: This study found that undetectable minimal residual disease (uMRD) in splenic marginal zone lymphoma (SMZL) patients is an independent prognostic factor, helping to predict patient survival.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Review
Oncology
Roberto Castelli, Monica Balzarotti, Emanuele Salvi, Roberta Simona Rossi, Giorgio Lambertenghi Deliliers, Luigi Bergamaschini, Antonio Gidaro
Summary: Splenic marginal zone lymphoma (SMZL) is a rare lymphoproliferative disease affecting elderly patients. It primarily involves the peripheral blood, bone marrow, and spleen, while sparing the lymph nodes. The prolonged antigen stimulation of B lymphocytes and microenvironment play a crucial role in the development of SMZL. NOTCH2 and NFk-B signaling integration has been identified as the primary mechanism of neoplastic proliferation in SMZL. The prognosis of SMZL depends on individual risk factors and patients' health status.
Article
Oncology
Hailing Liu, Jing Zhang, Lin Quan, Lei Cao, Yi Miao, Xiaoli Zhao, Haorui Shen, Li Wang, Wei Xu, Jianyong Li, Lei Fan
Summary: Primary breast marginal zone lymphoma (PBMZL) is a rare disease with limited knowledge about its characteristics, treatments, and outcomes. The study revealed an indolent behavior of early-stage PBMZL with long-term survival. Conventional oncological treatments did not improve survival, and chemotherapy was found to be detrimental to survival. Observation and further research on novel targeted agents are recommended for managing early-stage PBMZL.
FRONTIERS IN ONCOLOGY
(2021)
Article
Hematology
Andreea Sima, Peter Hollander, Eva Baecklund, Karin E. Smedby, Gunilla Enblad, Rose-Marie Amini
Summary: This study assessed the prevalence of viral hepatitis and AID in SMZL patients in a Swedish population and their treatment outcomes. The study found that upfront splenectomy was associated with better overall survival and progression-free survival. History of viral hepatitis and AID did not impact the outcomes of SMZL.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Medicine, Research & Experimental
Kei Nakayama, Takeshi Yoshida, Yoshiaki Nakayama, Noriaki Iguchi, Yuta Namba, Morichika Konishi, Hiroshi Hasegawa
Summary: This study focused on investigating the impact of malnutrition on the spleen, revealing significant reductions in spleen weight and red pulp ratio in dietary-restricted mice. It was found that macrophages in the marginal zone of the spleen play a crucial role in the dietary restriction-induced splenic involution.
Letter
Oncology
Narendranath Epperla, Rina Li Welkie, Pallawi Torka, Geoffrey Shouse, Reem Karmali, Lauren Shea, Andrea Anampa-Guzman, Timothy S. Oh, Heather Reaves, Montreh Tavakkoli, Kathryn Lindsey, Irl Brian Greenwell, Emily Hansinger, Colin Thomas, Sayan Mullick Chowdhury, Kaitlin Annunzio, Beth Christian, Stefan K. Barta, Praveen Ramakrishnan Geethakumari, Nancy L. Bartlett, Alex F. Herrera, Natalie S. Grover, Adam J. Olszewski
Summary: The progression of disease within 24 months from diagnosis in marginal zone lymphoma (MZL) is associated with poor outcomes. This study aims to evaluate the prognostic relevance of early relapse or progression within 24 months from systemic therapy initiation and examine factors predictive of POD24 in MZL patients. The results show that POD24 is associated with inferior overall survival and higher risk of histologic transformation in MZL patients.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Review
Oncology
Juan Pablo Alderuccio, Izidore S. Lossos
Summary: NOTCH signaling, particularly NOTCH2, plays a critical role in the pathogenesis of splenic marginal zone lymphoma (SMZL). Frequent mutations of NOTCH2 in SMZL underscore its importance in the disease. While NOTCH signaling presents an appealing target for drug discovery in SMZL, previous efforts have not shown meaningful clinical benefit or faced safety concerns.
LEUKEMIA & LYMPHOMA
(2022)
Article
Oncology
Yu Du, Ying Wang, Qinlu Li, Xiaona Chang, Kefeng Shen, Heng Zhang, Min Xiao, Shugang Xing
Summary: This population-based study found that some patients with marginal zone lymphoma (MZL) undergo histological transformation to diffuse large B-cell lymphoma (DLBCL). Transformation significantly decreases survival rates, with splenic MZL (SMZL) patients having the highest risk of transformation.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Pathology
Alberto Zamo, Michiel van den Brand, Fina Climent, Laurence de Leval, Stefan Dirnhofer, Lorenzo Leoncini, Siok-Bian Ng, Sarah L. Ondrejka, Leticia Quintanilla-Martinez, Lorinda Soma, Andrew Wotherspoon
Summary: Session 3 of the lymphoma workshop at the joint meeting of the European Association for Haematopathology and the Society for Hematopathology discussed splenic and nodal marginal zone lymphomas, transformation in marginal zone lymphomas, and pediatric nodal marginal zone lymphomas. The case review emphasized the challenges in diagnosing marginal zone lymphomas, including distinguishing between different types and the need for molecular studies to establish a final diagnosis. The workshop also addressed the overlapping spectrum between pediatric nodal marginal zone lymphoma and pediatric-type follicular lymphoma.
Article
Genetics & Heredity
Audrey N. Jajosky, Anna L. Mitchell, Mahmut Akgul, Shashirekha Shetty, Jennifer M. Yoest, Stanton L. Gerson, Navid Sadri, Kwadwo A. Oduro
Summary: Germline disruptive variants in the POT1 gene predispose individuals to multiple types of cancer. We report a case of splenic marginal zone lymphoma in a 65-year-old male with a germline POT1 variant. This likely pathogenic variant represents one of the most deleterious POT1 variants linked to familial cancer.
Article
Pathology
Simona Righi, Domenico Novero, Laura Godio, Clara Bertuzzi, Francesco Bacci, Claudio Agostinelli, Carlo Sagramoso, Maura Rossi, Milena Piccioli, Anna Gazzola, Claudia Mannu, Giovanna Roncador, Elena Sabattini
Summary: By studying multiple cases of LPL and SMZL, it was found that MNDA expression significantly supports the diagnosis of SMZL, especially in cases where MYD88 p.Leu265Pro mutation status and/or SMZL-related genetic aberrations are unavailable.
Article
Oncology
Junguo Cao, Weijia Yan, Guihong Li, Zhixin Zhan, Xinyu Hong, Hong Yan
Summary: This study conducted a systematic epidemiological and clinical analysis of meningiomas. The study found that most meningioma patients were over the age of 60, and the incidence rates were higher in females, black individuals, and non-Hispanic individuals, and increased with age. Older age, male sex, black race, and tumor size may be important prognostic factors for meningioma cases, and tumor resection can substantially improve survival among meningioma patients.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Engineering, Biomedical
Xietian Wang, Aiping Liu, Le Wu, Chang Li, Yu Liu, Xun Chen
Summary: A generalized zero-shot learning scheme for SSVEP classification is proposed. The target classes are divided into seen and unseen classes, and the classifier is trained only using the seen classes. The EEG data and sine waves are embedded into the same latent space using convolutional neural networks, and the correlation coefficient of the two outputs in the latent space is used for classification. The proposed method achieves high accuracy on both seen and unseen classes, showing promise for building an SSVEP classification system without the need for training data of all targets.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Review
Automation & Control Systems
Yongjie Cheng, Yanshuang Wang, Jianghai Lin, Shuhui Xu, Pu Zhang
Summary: The surface integrity of bearing steel materials determines the life of mechanical parts. Optimizing process parameters or using surface modification technology can improve the surface integrity. This paper reviews the evaluation parameters and characteristics of surface integrity and their impact on mechanical part performance. It summaries the effects of machining processes and surface modification technologies on parameters related to surface integrity. Two new surface modification technologies for bearing steel materials are also introduced. This paper provides research directions and theoretical references for improving the surface integrity of bearing steel material.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2023)
Article
Infectious Diseases
Yi Guo, Hao Wang, Mingzhong Xiao, Xin Guan, Yanshou Lei, Tingyue Diao, Pinpin Long, Rui Zeng, Xuefeng Lai, Hao Cai, Yutong You, Yuying Wen, Wenhui Li, Xi Wang, Yufei Wang, Qinlin Chen, Yuchan Yang, Yutong Qiu, Jishuai Chen, Huidan Zeng, Wei Ni, Youyun Zhao, Kani Ouyang, Jingzhi Wang, Qi Wang, Li Liu, Lulu Song, Youjie Wang, Huan Guo, Xiaodong Li, Tangchun Wu, Yu Yuan
Summary: This study aimed to describe the long-term outcomes and ongoing pathophysiological alterations among COVID-19 survivors. A longitudinal cohort of 208 convalescents were followed up at different time points. Most convalescents showed improved physical and psychological health, but a small proportion still had sequelae symptoms, residual lung lesions, exercise impairment, and mental health disorders at 18.5 months.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Materials Science, Biomaterials
Jie Mao, Yalei Liu, Lijun Chen, Sui Wang
Summary: In this study, PVA/BDA/ADH gels with excellent mechanical properties and self-healing capabilities were prepared using PVA, BDA, and ADH. The hydrogel network achieved chemical-physical double cross-linking through acylhydrazone bonds and hydrogen bonds. The resulting PVA/BDA/ADH gels exhibited superior mechanical properties and more stable self-healing properties compared to pure PVA hydrogel.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2023)
Article
Chemistry, Analytical
Xue Wang, Ling Song, Yan Zhuang, Lin Han, Ke Chen, Jiangli Lin, Yan Luo
Summary: This study proposed a hierarchical Siamese network that combines liver and spleen ultrasound images to improve the accuracy of liver fibrosis grading.
Article
Engineering, Chemical
Rui Xu, Jie Liu, Wei Sun, Li Wang
Summary: In this study, the flotation behaviors and mechanisms of mixed sodium dodecylsulfonate (SDS)/dodecylamine (DDA) collectors on biotite surface were systematically investigated. The results showed that the recovery of biotite increased to above 90% with the addition of mixed collectors at alkaline pH, while the recovery of quartz was below 10%.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Clinical Neurology
Tian-Tian Ma, Zixuan Wang, Xiwen Qin, Chengsheng Ju, Wallis C. Y. Lau, Kenneth K. C. Man, David Castle, Wing Chung Chang, Adrienne Y. L. Chan, Edmund C. L. Cheung, Celine Sze Ling Chui, Ian C. K. Wong
Summary: This study investigated the trends in the consumption of benzodiazepines and Z-drugs across 67 countries and regions from 2008 to 2018. It found distinct differences in consumption levels and trends among different countries and regions. Increased consumption was associated with higher GDP and increased prevalence of various medical conditions.
Article
Chemistry, Multidisciplinary
Bingyan Liu, Wei Jiang, Yiyuan Ye, Ling Liu, Xiaoran Wei, Qiu Zhang, Baoshan Xing
Summary: This study reveals that MoS2 nanosheets induce ferroptosis in vivo and in vitro, which is caused by the nanosheet themselves rather than by the dissolved ions. MoS2 nanosheets enter the cells through macropinocytosis and localize to the lysosome, causing an increase in lysosomal membrane permeability. This leads to the activation of NCOA4-dependent ferritinophagy and the inhibition of FPN, resulting in the leakage of Fe2+ into the cytoplasm and ultimately ferroptosis. The inhibition of FPN further aggravates the overload of Fe2+ in the cell.
Article
Instruments & Instrumentation
Yingze Yuan, Fengfeng Li, Jianglong Guo, Liwu Liu, Yanju Liu, Jinsong Leng
Summary: Electrostatic layer jamming is a lightweight, low energy consumption, electrically tunable, and cost-effective variable stiffness structure. However, there is a lack of comprehensive and experimentally validated theoretical variable stiffness models for flexible parallel electroadhesive structures. This paper presents the first variable stiffness model for flexible parallel electroadhesive structures under different bending conditions, considering friction and slip between layers. The results provide useful insights for understanding the variable stiffness mechanism and optimizing the structural design for practical applications.
SMART MATERIALS AND STRUCTURES
(2023)
Article
Chemistry, Analytical
Kuicheng Zhao, Ruihua Xie, Zile Zhou, Shiying Chen, Xiaohua Zhu, Cuiyan Wu, Youyu Zhang, Haitao Li
Summary: Oxidative stress is closely related to crop health under stress conditions, and H2O2 serves as an important signaling molecule in plants. However, there is a lack of fluorescent probes for tracking H2O2 fluctuations in crops. In this study, a turn-on NIR fluorescent probe was designed to detect and image H2O2 in living cells and crops. The probe showed good detection performance and the ability to visualize H2O2 in cabbage roots under abiotic stress. The visualization of H2O2 upregulation in response to adverse environments provides a new method for risk-assessing oxidative stress and guiding the development of antioxidant defense strategies.
Article
Engineering, Environmental
Yanjie Wang, Liying Yang, Oliver Wild, Song Zhang, Kai Yang, Wenwen Wang, Lin Li
Summary: This study investigates the production characteristics of bioaerosols in municipal wastewater treatment plants and simulates their diffusion using the Atmospheric Dispersion Modelling System method. The concentration of bacteria and soluble chemicals in the bioaerosols varied across different treatment plants and the main factors influencing bioaerosol production were identified. The study highlights the importance of considering wind speed, direction, and aeration mode when predicting bioaerosol risks and selecting safe sites for wastewater treatment plants.
Article
Biotechnology & Applied Microbiology
Jia Guo, Yan-Fang Liu, Chuan-Hong Tang, Jing-Song Zhang, Jie Feng
Summary: This study aimed to explore the key technologies and scale-up preparation of Ganoderma lucidum liquid spawn. The results showed that the plate broth volume significantly affected mycelial growth rate, and the picking position of plate mycelium significantly influenced biomass in the primary shake flask culture. Optimization of carbon and nitrogen sources concentration increased biomass and substrate utilization. The liquid spawn prepared by the fermentor showed better metabolic activity, indicating its suitability for large-scale industrial production.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2023)
Article
Virology
Chenang Lyu, Jingwen Li, Zhentao Shi, Ran An, Yanfei Wang, Guangda Luo, Dapeng Wang
Summary: Human norovirus (HuNoV) is a major foodborne pathogen causing nonbacterial gastroenteritis worldwide. Oysters, especially GI.1 HuNoV, play a crucial role in the transmission of HuNoV. Previous studies identified oyster heat shock protein 70 (oHSP 70) as a protein ligand for GII.4 HuNoV, along with carbohydrate ligands. However, the distribution pattern did not match with GI.1 HuNoV, suggesting the presence of other ligands. In this study, protein ligands for GI.1 HuNoV were discovered in oyster tissues through a bacterial cell surface display system.
Article
Geosciences, Multidisciplinary
Yuan Cheng, Gang Hai, Xiangbin Cui, Da Lv, Gang Qiao, Rongxing Li
Summary: Using satellite observations, we developed a new method to estimate the mass balance of the Antarctic Ice Sheet. Our findings show that the ice sheet has been losing mass for the past 4 decades, contributing to the rise in global sea level. We estimated the mass balance from 2013 to 2018 and observed an accelerated ice loss in West Antarctica and a mass gain in East Antarctica.
SCIENCE CHINA-EARTH SCIENCES
(2023)
Article
Engineering, Chemical
Xuran Liu, Xianli Yang, Jingnan Yang, Yanxin Wu, Dongbo Wang
Summary: This study proposes an environmentally friendly strategy using zero valent iron (ZVI) activating sulfite pretreatment to enhance short chain fatty acids (SCFAs) production from anaerobic fermentation of sewage sludge. The results showed that ZVI-sulfite pretreatment significantly increased SCFAs production and acetate proportion. Mechanism analysis revealed that ZVI-sulfite pretreatment accelerated sludge-floc disintegration and provided more easily- and bio-available substances for functional anaerobes. The pretreatment also enriched functional anaerobes related to hydrolysis, acidogenesis, and acetogenesis, and boosted the functional genes abundance involved in butyrate and acetate formation pathways.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
